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Lysine degradation II

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authored	[InstanceEdit:8933720] Gupta, Parul, 2016-08-08
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1143601] RiceCyc:LYSINE-DEG1-PWY
dbId	1119365
displayName	Lysine degradation II
edited	[InstanceEdit:8933720] Gupta, Parul, 2016-08-08
eventOf	[Pathway:R-OSA-5655124] Amino acid catabolism - Oryza sativa
hasDiagram	true
hasEvent	[Reaction:R-OSA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza sativa [BlackBoxEvent:R-OSA-8986579] Translocation of saccharopine - Oryza sativa [Reaction:R-OSA-1120644] Saccharopine ---> 2-aminoadipate-6-semialdehyde - Oryza sativa [BlackBoxEvent:R-OSA-8986556] Translocation of 2-aminoadipate-6-semialdehyde - Oryza sativa [Reaction:R-OSA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza sativa [Reaction:R-OSA-1121512] alpha-aminoadipate + alpha-ketoglutarate ---> alpha-ketoadipate + L-Glu - Oryza sativa [Reaction:R-OSA-8986551] 2-ketoadipate + lipoamide ---> S-glutaryldihydroliopamide + CO2 - Oryza sativa [Reaction:R-OSA-8986553] S-glutaryldihydrolipoamide + succinyl-CoA ----> Glutaryl-CoA + S-succinyldihydrolipoamide - Oryza sativa
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8986586] Characterization of the two saccharopine dehydrogenase isozymes of lysine catabolism encoded by the single composite AtLKR/SDH locus of Arabidopsis [LiteratureReference:8986563] Amino Acid Catabolism in Plants [LiteratureReference:1169161] Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis [LiteratureReference:8986548] Lysine catabolism: a stress and development super-regulated metabolic pathway [LiteratureReference:8986562] The Regulation of Essential Amino Acid Synthesis and Accumulation in Plants [LiteratureReference:8986580] Lysine metabolism in higher plants [LiteratureReference:8986564] Regulation of lysine catabolism in higher plants [LiteratureReference:8986565] Regulation of lysine catabolism through lysine-ketoglutarate reductase and saccharopine dehydrogenase in Arabidopsis [LiteratureReference:8986573] Structural and transcriptional analysis of plant genes encoding the bifunctional lysine ketoglutarate reductase saccharopine dehydrogenase enzyme
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Lysine degradation II pathway99564
orthologousEvent	[Pathway:R-OOF-1119365] Lysine degradation II - Oryza officinalis [Pathway:R-CSC-1119365] Lysine degradation II - Cannabis sativa [Pathway:R-ETE-1119365] Lysine degradation II - Eragrostis tef [Pathway:R-MDO-1119365] Lysine degradation II - Malus domestica [Pathway:R-CST-1119365] Lysine degradation II - Camelina sativa [Pathway:R-FVE-1119365] Lysine degradation II - Fragaria vesca [Pathway:R-OGL-1119365] Lysine degradation II - Oryza glaberrima [Pathway:R-PAB-1119365] Lysine degradation II - Picea abies [Pathway:R-ZMA-1119365] Lysine degradation II - Zea mays [Pathway:R-COL-1119365] Lysine degradation II - Corchorus olitorius [Pathway:R-TTU-1119365] Lysine degradation II - Triticum turgidum [Pathway:R-ZJA-1119365] Lysine degradation II - Zoysia japonica [Pathway:R-OBR-1119365] Lysine degradation II - Oryza brachyantha [Pathway:R-CAN-1119365] Lysine degradation II - Capsicum annuum [Pathway:R-JRE-1119365] Lysine degradation II - Juglans regia [Pathway:R-LAN-1119365] Lysine degradation II - Lupinus angustifolius [Pathway:R-BVU-1119365] Lysine degradation II - Beta vulgaris [Pathway:R-PSO-1119365] Lysine degradation II - Papaver somniferum [Pathway:R-CML-1119365] Lysine degradation II - Cucumis melo [Pathway:R-PTI-1119365] Lysine degradation II - Populus trichocarpa [Pathway:R-ITR-1119365] Lysine degradation II - Ipomoea triloba [Pathway:R-AHY-1119365] Lysine degradation II - Arachis hypogaea [Pathway:R-VFA-1119365] Lysine degradation II - Vicia faba var. faba [Pathway:R-QSU-1119365] Lysine degradation II - Quercus suber [Pathway:R-ATA-1119365] Lysine degradation II - Aegilops tauschii [Pathway:R-ORU-1119365] Lysine degradation II - Oryza rufipogon [Pathway:R-CSI-1119365] Lysine degradation II - Citrus sinensis [Pathway:R-CAR-1119365] Lysine degradation II - Cicer arietinum [Pathway:R-FEX-1119365] Lysine degradation II - Fraxinus excelsior (European ash) [Pathway:R-CME-1119365] Lysine degradation II - Cyanidioschyzon merolae [Pathway:R-OKA-1119365] Lysine degradation II - Oryza sativa aus subgroup [Pathway:R-RCH-1119365] Lysine degradation II - Rosa chinensis [Pathway:R-ASA-1119365] Lysine degradation II - Avena sativa [Pathway:R-AHA-1119365] Lysine degradation II - Arabidopsis halleri [Pathway:R-NNU-1119365] Lysine degradation II - Nelumbo nucifera [Pathway:R-PTA-1119365] Lysine degradation II - Pinus taeda [Pathway:R-HLH-1119365] Lysine degradation II - Humulus lupulus [Pathway:R-TTI-1119365] Lysine degradation II - Triticum timopheevii subsp. timopheevii [Pathway:R-LPR-1119365] Lysine degradation II - Lolium perenne [Pathway:R-AUM-1119365] Lysine degradation II - Aegilops umbellulata [Pathway:R-CCN-1119365] Lysine degradation II - Coffea canephora [Pathway:R-HLP-1119365] Lysine degradation II - Humulus lupulus var. lupulus [Pathway:R-CRU-1119365] Lysine degradation II - Capsella rubella [Pathway:R-OLU-1119365] Lysine degradation II - Ostreococcus lucimarinus [Pathway:R-BJU-1119365] Lysine degradation II - Brassica juncea [Pathway:R-SIT-1119365] Lysine degradation II - Setaria italica [Pathway:R-CCA-1119365] Lysine degradation II - Cajanus cajan [Pathway:R-GMA-1119365] Lysine degradation II - Glycine max [Pathway:R-PDA-1119365] Lysine degradation II - Phoenix dactylifera [Pathway:R-TCA-1119365] Lysine degradation II - Theobroma cacao [Pathway:R-STU-1119365] Lysine degradation II - Solanum tuberosum [Pathway:R-MPO-1119365] Lysine degradation II - Marchantia polymorpha [Pathway:R-PVE-1119365] Lysine degradation II - Pistacia vera [Pathway:R-VRA-1119365] Lysine degradation II - Vigna radiata [Pathway:R-CBA-1119365] Lysine degradation II - Chara braunii [Pathway:R-AIP-1119365] Lysine degradation II - Arachis ipaensis [Pathway:R-CSK-1119365] Lysine degradation II - Cannabis sativa subsp. indica [Pathway:R-BRA-1119365] Lysine degradation II - Brassica rapa [Pathway:R-LSA-1119365] Lysine degradation II - Lactuca sativa [Pathway:R-JCU-1119365] Lysine degradation II - Jatropha curcas [Pathway:R-OLO-1119365] Lysine degradation II - Oryza longistaminata [Pathway:R-TPR-1119365] Lysine degradation II - Trifolium pratense [Pathway:R-OSI-1119365] Lysine degradation II - Oryza sativa Indica Group [Pathway:R-CQI-1119365] Lysine degradation II - Chenopodium quinoa [Pathway:R-HAN-1119365] Lysine degradation II - Helianthus annuus [Pathway:R-ATR-1119365] Lysine degradation II - Amborella trichopoda [Pathway:R-ZMY-1119365] Lysine degradation II - Zea mays ver5 [Pathway:R-LST-1119365] Lysine degradation II - Lathyrus sativus [Pathway:R-PPE-1119365] Lysine degradation II - Prunus persica [Pathway:R-SHI-1119365] Lysine degradation II - Salvia hispanica [Pathway:R-TAE-1119365] Lysine degradation II - Triticum aestivum [Pathway:R-DRO-1119365] Lysine degradation II - Dioscorea rotundata [Pathway:R-ATH-1119365] Lysine degradation II - Arabidopsis thaliana [Pathway:R-SVI-1119365] Lysine degradation II - Setaria viridis [Pathway:R-TSP-1119365] Lysine degradation II - Triticum spelta subsp. spelta [Pathway:R-DCA-1119365] Lysine degradation II - Daucus carota [Pathway:R-SCR-1119365] Lysine degradation II - Secale cereale [Pathway:R-CCR-1119365] Lysine degradation II - Chondrus crispus [Pathway:R-SLY-1119365] Lysine degradation II - Solanum lycopersicum [Pathway:R-CCD-1119365] Lysine degradation II - Cynara cardunculus var. scolymus [Pathway:R-ADU-1119365] Lysine degradation II - Arachis duranensis [Pathway:R-GSO-1119365] Lysine degradation II - Glycine soja [Pathway:R-OGU-1119365] Lysine degradation II - Oryza glumaepatula [Pathway:R-PHA-1119365] Lysine degradation II - Panicum hallii ("FIL2") [Pathway:R-SMO-1119365] Lysine degradation II - Selaginella moellendorffii [Pathway:R-OEU-1119365] Lysine degradation II - Olea europaea [Pathway:R-OMI-1119365] Lysine degradation II - Oryza minuta [Pathway:R-NCO-1119365] Lysine degradation II - Nymphaea colorata [Pathway:R-ACH-1119365] Lysine degradation II - Actinidia chinensis [Pathway:R-FCR-1119365] Lysine degradation II - Ficus carica [Pathway:R-OGR-1119365] Lysine degradation II - Oryza meyeriana var. granulata [Pathway:R-EGR-1119365] Lysine degradation II - Eucalyptus grandis [Pathway:R-MGU-1119365] Lysine degradation II - Erythranthe guttata [Pathway:R-MES-1119365] Lysine degradation II - Manihot esculenta [Pathway:R-CSA-1119365] Lysine degradation II - Cucumis sativus [Pathway:R-VUN-1119365] Lysine degradation II - Vigna unguiculata [Pathway:R-QLO-1119365] Lysine degradation II - Quercus lobata [Pathway:R-CCI-1119365] Lysine degradation II - Corymbia citriodora [Pathway:R-BOL-1119365] Lysine degradation II - Brassica oleracea [Pathway:R-PED-1119365] Lysine degradation II - Phyllostachys edulis [Pathway:R-PPA-1119365] Lysine degradation II - Physcomitrella patens [Pathway:R-ECG-1119365] Lysine degradation II - Echinochloa crus-galli [Pathway:R-CCP-1119365] Lysine degradation II - Corchorus capsularis [Pathway:R-TDI-1119365] Lysine degradation II - Triticum dicoccoides [Pathway:R-ECU-1119365] Lysine degradation II - Eragrostis curvula [Pathway:R-VVN-1119365] Lysine degradation II - Vitis vinifera [Pathway:R-GRA-1119365] Lysine degradation II - Gossypium raimondii [Pathway:R-ALY-1119365] Lysine degradation II - Arabidopsis lyrata [Pathway:R-VAN-1119365] Lysine degradation II - Vigna angularis [Pathway:R-BDI-1119365] Lysine degradation II - Brachypodium distachyon [Pathway:R-OAU-1119365] Lysine degradation II - Oryza australiensis [Pathway:R-SPC-1119365] Lysine degradation II - Synechocystis sp. PCC 6803 [Pathway:R-OPU-1119365] Lysine degradation II - Oryza punctata [Pathway:R-CRE-1119365] Lysine degradation II - Chlamydomonas reinhardtii [Pathway:R-PHH-1119365] Lysine degradation II - Panicum hallii var. hallii ("HAL2") [Pathway:R-ACO-1119365] Lysine degradation II - Ananas comosus [Pathway:R-NAT-1119365] Lysine degradation II - Nicotiana attenuata [Pathway:R-HVU-1119365] Lysine degradation II - Hordeum vulgare [Pathway:R-LPE-1119365] Lysine degradation II - Leersia perrieri [Pathway:R-SIN-1119365] Lysine degradation II - Sesamum indicum [Pathway:R-PSA-1119365] Lysine degradation II - Pisum sativum [Pathway:R-PVU-1119365] Lysine degradation II - Phaseolus vulgaris [Pathway:R-TUR-1119365] Lysine degradation II - Triticum urartu [Pathway:R-AOF-1119365] Lysine degradation II - Asparagus officinalis [Pathway:R-SBI-1119365] Lysine degradation II - Sorghum bicolor [Pathway:R-MAC-1119365] Lysine degradation II - Musa acuminata [Pathway:R-MTR-1119365] Lysine degradation II - Medicago truncatula [Pathway:R-SSP-1119365] Lysine degradation II - Saccharum spontaneum [Pathway:R-OBA-1119365] Lysine degradation II - Oryza barthii [Pathway:R-OES-1119365] Lysine degradation II - Olea europaea var. sylvestris [Pathway:R-CLA-1119365] Lysine degradation II - Citrullus lanatus [Pathway:R-OME-1119365] Lysine degradation II - Oryza meridionalis [Pathway:R-ONI-1119365] Lysine degradation II - Oryza nivara [Pathway:R-CCL-1119365] Lysine degradation II - Citrus clementina [Pathway:R-PAV-1119365] Lysine degradation II - Prunus avium [Pathway:R-GSU-1119365] Lysine degradation II - Galdieria sulphuraria [Pathway:R-BNA-1119365] Lysine degradation II - Brassica napus [Pathway:R-DEX-1119365] Lysine degradation II - Digitaria exilis
schemaClass	Pathway
species	[Species:186860] Oryza sativa
stId	R-OSA-1119365
summation	[Summation:8986559] Lysine catabolism is one of the most highly regulated metabo... [Summation:1119236] Data source: RiceCyc

Referrals

(hasEvent)

[Pathway:R-OSA-5655124] Amino acid catabolism - Oryza sativa

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