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NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+

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catalystActivity	[CatalystActivity:1119050] saccharopine dehydrogenase (NADP+, L-lysine-forming) activity of LKR/SDH [mitochondrion]
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1154508] EC-NUMBER:1.5.1.8 [DatabaseIdentifier:1143637] RiceCyc:1.5.1.8-RXN
dbId	1121690
displayName	NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+
edited	[InstanceEdit:8933720] Gupta, Parul, 2016-08-08
eventOf	[Pathway:R-OSA-1119365] Lysine degradation II - Oryza sativa
followingEvent	[BlackBoxEvent:R-OSA-8986579] Translocation of saccharopine - Oryza sativa
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29444] L-Lys [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ biochemicalReaction79747
orthologousEvent	[Reaction:R-SCR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Secale cereale [Reaction:R-BJU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Brassica juncea [Reaction:R-STU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Solanum tuberosum [Reaction:R-OME-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza meridionalis [Reaction:R-OPU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza punctata [Reaction:R-SMO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Selaginella moellendorffii [Reaction:R-BNA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Brassica napus [Reaction:R-ORU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza rufipogon [Reaction:R-ECG-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Echinochloa crus-galli [Reaction:R-TUR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Triticum urartu [Reaction:R-SVI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Setaria viridis [Reaction:R-ATH-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Arabidopsis thaliana [Reaction:R-SIN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Sesamum indicum [Reaction:R-PHA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Panicum hallii ("FIL2") [Reaction:R-CCA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cajanus cajan [Reaction:R-MTR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Medicago truncatula [Reaction:R-BRA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Brassica rapa [Reaction:R-ATA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Aegilops tauschii [Reaction:R-ADU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Arachis duranensis [Reaction:R-LPR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Lolium perenne [Reaction:R-AUM-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Aegilops umbellulata [Reaction:R-PVU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Phaseolus vulgaris [Reaction:R-SPC-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Synechocystis sp. PCC 6803 [Reaction:R-ASA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Avena sativa [Reaction:R-SBI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Sorghum bicolor [Reaction:R-VFA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Vicia faba var. faba [Reaction:R-LST-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Lathyrus sativus [Reaction:R-GSU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Galdieria sulphuraria [Reaction:R-GSO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Glycine soja [Reaction:R-OGR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza meyeriana var. granulata [Reaction:R-BOL-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Brassica oleracea [Reaction:R-MDO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Malus domestica [Reaction:R-HVU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Hordeum vulgare [Reaction:R-PTA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Pinus taeda [Reaction:R-MPO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Marchantia polymorpha [Reaction:R-RCH-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Rosa chinensis [Reaction:R-OES-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Olea europaea var. sylvestris [Reaction:R-CCD-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cynara cardunculus var. scolymus [Reaction:R-PED-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Phyllostachys edulis [Reaction:R-MAC-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Musa acuminata [Reaction:R-TDI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Triticum dicoccoides [Reaction:R-ALY-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Arabidopsis lyrata [Reaction:R-SLY-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Solanum lycopersicum [Reaction:R-AHA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Arabidopsis halleri [Reaction:R-ZMY-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Zea mays ver5 [Reaction:R-COL-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Corchorus olitorius [Reaction:R-ITR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Ipomoea triloba [Reaction:R-TTU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Triticum turgidum [Reaction:R-CLA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Citrullus lanatus [Reaction:R-MES-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Manihot esculenta [Reaction:R-VVN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Vitis vinifera [Reaction:R-OMI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza minuta [Reaction:R-VAN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Vigna angularis [Reaction:R-NNU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Nelumbo nucifera [Reaction:R-LSA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Lactuca sativa [Reaction:R-ONI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza nivara [Reaction:R-CSK-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cannabis sativa subsp. indica [Reaction:R-FCR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Ficus carica [Reaction:R-PAB-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Picea abies [Reaction:R-CAN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Capsicum annuum [Reaction:R-TPR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Trifolium pratense [Reaction:R-CML-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cucumis melo [Reaction:R-AHY-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Arachis hypogaea [Reaction:R-OGU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza glumaepatula [Reaction:R-LAN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Lupinus angustifolius [Reaction:R-OOF-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza officinalis [Reaction:R-AOF-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Asparagus officinalis [Reaction:R-OBA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza barthii [Reaction:R-CCP-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Corchorus capsularis [Reaction:R-PAV-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Prunus avium [Reaction:R-ZJA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Zoysia japonica [Reaction:R-ETE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Eragrostis tef [Reaction:R-CSC-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cannabis sativa [Reaction:R-EGR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Eucalyptus grandis [Reaction:R-DCA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Daucus carota [Reaction:R-CST-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Camelina sativa [Reaction:R-CSA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cucumis sativus [Reaction:R-CCN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Coffea canephora [Reaction:R-CCL-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Citrus clementina [Reaction:R-PPE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Prunus persica [Reaction:R-ATR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Amborella trichopoda [Reaction:R-VUN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Vigna unguiculata [Reaction:R-HAN-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Helianthus annuus [Reaction:R-CQI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Chenopodium quinoa [Reaction:R-HLP-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Humulus lupulus var. lupulus [Reaction:R-QLO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Quercus lobata [Reaction:R-CRU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Capsella rubella [Reaction:R-PHH-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Panicum hallii var. hallii ("HAL2") [Reaction:R-OAU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza australiensis [Reaction:R-FEX-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Fraxinus excelsior (European ash) [Reaction:R-TAE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Triticum aestivum [Reaction:R-TSP-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Triticum spelta subsp. spelta [Reaction:R-ZMA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Zea mays [Reaction:R-PVE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Pistacia vera [Reaction:R-CAR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Cicer arietinum [Reaction:R-MGU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Erythranthe guttata [Reaction:R-QSU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Quercus suber [Reaction:R-ECU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Eragrostis curvula [Reaction:R-DEX-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Digitaria exilis [Reaction:R-PTI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Populus trichocarpa [Reaction:R-AIP-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Arachis ipaensis [Reaction:R-OBR-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza brachyantha [Reaction:R-TTI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Triticum timopheevii subsp. timopheevii [Reaction:R-FVE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Fragaria vesca [Reaction:R-JCU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Jatropha curcas [Reaction:R-BVU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Beta vulgaris [Reaction:R-JRE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Juglans regia [Reaction:R-OGL-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza glaberrima [Reaction:R-SHI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Salvia hispanica [Reaction:R-OLO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza longistaminata [Reaction:R-LPE-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Leersia perrieri [Reaction:R-OEU-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Olea europaea [Reaction:R-OKA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Oryza sativa aus subgroup [Reaction:R-GMA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Glycine max [Reaction:R-DRO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Dioscorea rotundata [Reaction:R-NAT-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Nicotiana attenuata [Reaction:R-PPA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Physcomitrella patens [Reaction:R-SIT-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Setaria italica [Reaction:R-ACO-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Ananas comosus [Reaction:R-PSA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Pisum sativum [Reaction:R-CCI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Corymbia citriodora [Reaction:R-VRA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Vigna radiata [Reaction:R-BDI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Brachypodium distachyon [Reaction:R-ACH-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Actinidia chinensis [Reaction:R-TCA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Theobroma cacao [Reaction:R-CSI-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Citrus sinensis [Reaction:R-GRA-1121690] NADPH + L-Lys + alpha-ketoglutarate-----> SACN + H2O + NADP+ - Gossypium raimondii
output	[SimpleEntity:R-ALL-1131965] H2O [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix] [SimpleEntity:R-ALL-30176] SACN [mitochondrial matrix]
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1121690
summation	[Summation:8986583] The first enzyme in the Lys catabolic pathway, Lys-ketogluta...

Referrals

(hasEvent)	[Pathway:R-OSA-1119365] Lysine degradation II - Oryza sativa
(precedingEvent)	[BlackBoxEvent:R-OSA-8986579] Translocation of saccharopine - Oryza sativa