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2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH

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catalystActivity	[CatalystActivity:8986554] L-aminoadipate-semialdehyde dehydrogenase activity of aminoadipate semialdehyde dehydrogenase [mitochondrial matrix]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26752] EC:1.2.1.31 [DatabaseIdentifier:1142381] RiceCyc:ALLYSINE-DEHYDROG-RXN
dbId	1120698
displayName	2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH
edited	[InstanceEdit:8933720] Gupta, Parul, 2016-08-08
eventOf	[Pathway:R-OSA-1119365] Lysine degradation II - Oryza sativa
followingEvent	[Reaction:R-OSA-1121512] alpha-aminoadipate + alpha-ketoglutarate ---> alpha-ketoadipate + L-Glu - Oryza sativa
input	[SimpleEntity:R-ALL-8986585] 2-aminoadipate-6-semialdehyde [mitochondrial matrix] [SimpleEntity:R-ALL-1131965] H2O [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH ALLYSINE-DEHYDROG-RXN biochemicalReaction83439
orthologousEvent	[Reaction:R-ITR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Ipomoea triloba [Reaction:R-ECG-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Echinochloa crus-galli [Reaction:R-VAN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Vigna angularis [Reaction:R-ASA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Avena sativa [Reaction:R-GSO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Glycine soja [Reaction:R-QSU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Quercus suber [Reaction:R-TDI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Triticum dicoccoides [Reaction:R-ATR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Amborella trichopoda [Reaction:R-SIN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Sesamum indicum [Reaction:R-TTU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Triticum turgidum [Reaction:R-VFA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Vicia faba var. faba [Reaction:R-PAB-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Picea abies [Reaction:R-CML-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cucumis melo [Reaction:R-PHA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Panicum hallii ("FIL2") [Reaction:R-DRO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Dioscorea rotundata [Reaction:R-ZMY-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Zea mays ver5 [Reaction:R-TSP-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Triticum spelta subsp. spelta [Reaction:R-AUM-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Aegilops umbellulata [Reaction:R-MPO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Marchantia polymorpha [Reaction:R-ETE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Eragrostis tef [Reaction:R-SHI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Salvia hispanica [Reaction:R-OLO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza longistaminata [Reaction:R-RCH-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Rosa chinensis [Reaction:R-JCU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Jatropha curcas [Reaction:R-CSC-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cannabis sativa [Reaction:R-MAC-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Musa acuminata [Reaction:R-CAN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Capsicum annuum [Reaction:R-CRU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Capsella rubella [Reaction:R-JRE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Juglans regia [Reaction:R-BJU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Brassica juncea [Reaction:R-PPA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Physcomitrella patens [Reaction:R-PVE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Pistacia vera [Reaction:R-BRA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Brassica rapa [Reaction:R-SCR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Secale cereale [Reaction:R-ATH-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Arabidopsis thaliana [Reaction:R-SVI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Setaria viridis [Reaction:R-PTA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Pinus taeda [Reaction:R-OAU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza australiensis [Reaction:R-BOL-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Brassica oleracea [Reaction:R-GSU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Galdieria sulphuraria [Reaction:R-OGL-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza glaberrima [Reaction:R-DCA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Daucus carota [Reaction:R-LST-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Lathyrus sativus [Reaction:R-AHA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Arabidopsis halleri [Reaction:R-CSA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cucumis sativus [Reaction:R-VVN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Vitis vinifera [Reaction:R-CCD-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cynara cardunculus var. scolymus [Reaction:R-TUR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Triticum urartu [Reaction:R-SMO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Selaginella moellendorffii [Reaction:R-HLP-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Humulus lupulus var. lupulus [Reaction:R-TTI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Triticum timopheevii subsp. timopheevii [Reaction:R-DEX-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Digitaria exilis [Reaction:R-GMA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Glycine max [Reaction:R-ECU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Eragrostis curvula [Reaction:R-ATA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Aegilops tauschii [Reaction:R-TCA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Theobroma cacao [Reaction:R-SIT-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Setaria italica [Reaction:R-AIP-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Arachis ipaensis [Reaction:R-AOF-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Asparagus officinalis [Reaction:R-BVU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Beta vulgaris [Reaction:R-NAT-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Nicotiana attenuata [Reaction:R-MGU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Erythranthe guttata [Reaction:R-FCR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Ficus carica [Reaction:R-PVU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Phaseolus vulgaris [Reaction:R-SBI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Sorghum bicolor [Reaction:R-BNA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Brassica napus [Reaction:R-CCA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cajanus cajan [Reaction:R-SLY-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Solanum lycopersicum [Reaction:R-CCL-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Citrus clementina [Reaction:R-OOF-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza officinalis [Reaction:R-OEU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Olea europaea [Reaction:R-PPE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Prunus persica [Reaction:R-BDI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Brachypodium distachyon [Reaction:R-CAR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cicer arietinum [Reaction:R-HAN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Helianthus annuus [Reaction:R-NCO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Nymphaea colorata [Reaction:R-OBA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza barthii [Reaction:R-ONI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza nivara [Reaction:R-OGU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza glumaepatula [Reaction:R-OMI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza minuta [Reaction:R-PED-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Phyllostachys edulis [Reaction:R-MES-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Manihot esculenta [Reaction:R-FVE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Fragaria vesca [Reaction:R-PSA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Pisum sativum [Reaction:R-HVU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Hordeum vulgare [Reaction:R-ZJA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Zoysia japonica [Reaction:R-OES-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Olea europaea var. sylvestris [Reaction:R-STU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Solanum tuberosum [Reaction:R-ZMA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Zea mays [Reaction:R-PAV-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Prunus avium [Reaction:R-LSA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Lactuca sativa [Reaction:R-VRA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Vigna radiata [Reaction:R-SSP-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Saccharum spontaneum [Reaction:R-COL-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Corchorus olitorius [Reaction:R-OPU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza punctata [Reaction:R-CCN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Coffea canephora [Reaction:R-FEX-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Fraxinus excelsior (European ash) [Reaction:R-CST-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Camelina sativa [Reaction:R-NNU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Nelumbo nucifera [Reaction:R-OSI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza sativa Indica Group [Reaction:R-CCI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Corymbia citriodora [Reaction:R-ACH-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Actinidia chinensis [Reaction:R-CLA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Citrullus lanatus [Reaction:R-TAE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Triticum aestivum [Reaction:R-VUN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Vigna unguiculata [Reaction:R-LAN-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Lupinus angustifolius [Reaction:R-OGR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza meyeriana var. granulata [Reaction:R-CSK-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Cannabis sativa subsp. indica [Reaction:R-MDO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Malus domestica [Reaction:R-AHY-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Arachis hypogaea [Reaction:R-PDA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Phoenix dactylifera [Reaction:R-PTI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Populus trichocarpa [Reaction:R-OBR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza brachyantha [Reaction:R-ACO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Ananas comosus [Reaction:R-CCP-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Corchorus capsularis [Reaction:R-LPE-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Leersia perrieri [Reaction:R-ORU-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Oryza rufipogon [Reaction:R-QLO-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Quercus lobata [Reaction:R-EGR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Eucalyptus grandis [Reaction:R-CQI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Chenopodium quinoa [Reaction:R-ALY-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Arabidopsis lyrata [Reaction:R-PHH-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Panicum hallii var. hallii ("HAL2") [Reaction:R-CSI-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Citrus sinensis [Reaction:R-MTR-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Medicago truncatula [Reaction:R-GRA-1120698] 2-aminoadipate-6-semialdehyde + NAD + H2O ---> alpha-aminoadipate + NADH - Gossypium raimondii
output	[SimpleEntity:R-ALL-8986588] alpha-aminoadipate [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-OSA-8986556] Translocation of 2-aminoadipate-6-semialdehyde - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120698

Referrals

(hasEvent)	[Pathway:R-OSA-1119365] Lysine degradation II - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1121512] alpha-aminoadipate + alpha-ketoglutarate ---> alpha-ketoadipate + L-Glu - Oryza sativa