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Hydroxymethylglutaryl-CoA reductase (NADPH)

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catalystActivity	[CatalystActivity:1118662] hydroxymethylglutaryl-CoA reductase (NADPH) activity of hydroxymethylglutaryl-CoA reductase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26548] EC:1.1.1.34 [DatabaseIdentifier:1133347] RiceCyc:1.1.1.34-RXN
dbId	1120896
displayName	Hydroxymethylglutaryl-CoA reductase (NADPH)
eventOf	[Pathway:R-OSA-1119615] Mevalonate pathway - Oryza sativa
followingEvent	[Reaction:R-OSA-1119762] mevalonate kinase - Oryza sativa
input	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] 2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Hydroxymethylglutaryl-CoA reductase (NADPH) HMG-CoA reductase 3-hydroxy-3-methylglutaryl-coenzyme A reductase biochemicalReaction94466
orthologousEvent	[Reaction:R-TTI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Triticum timopheevii subsp. timopheevii [Reaction:R-SIN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Sesamum indicum [Reaction:R-LPE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Leersia perrieri [Reaction:R-ITR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Ipomoea triloba [Reaction:R-GSU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Galdieria sulphuraria [Reaction:R-LSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Lactuca sativa [Reaction:R-CCA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cajanus cajan [Reaction:R-TCA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Theobroma cacao [Reaction:R-PSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Pisum sativum [Reaction:R-TSP-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Triticum spelta subsp. spelta [Reaction:R-ORU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza rufipogon [Reaction:R-CCP-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Corchorus capsularis [Reaction:R-ASA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Avena sativa [Reaction:R-CCI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Corymbia citriodora [Reaction:R-CSI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Citrus sinensis [Reaction:R-ETE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Eragrostis tef [Reaction:R-OME-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza meridionalis [Reaction:R-OOF-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza officinalis [Reaction:R-LST-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Lathyrus sativus [Reaction:R-PTI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Populus trichocarpa [Reaction:R-HLH-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Humulus lupulus [Reaction:R-BDI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Brachypodium distachyon [Reaction:R-CSK-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cannabis sativa subsp. indica [Reaction:R-VFA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Vicia faba var. faba [Reaction:R-PED-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Phyllostachys edulis [Reaction:R-VRA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Vigna radiata [Reaction:R-PDA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Phoenix dactylifera [Reaction:R-NCO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Nymphaea colorata [Reaction:R-ECU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Eragrostis curvula [Reaction:R-JCU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Jatropha curcas [Reaction:R-OGU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza glumaepatula [Reaction:R-MPO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Marchantia polymorpha [Reaction:R-CCN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Coffea canephora [Reaction:R-SCR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Secale cereale [Reaction:R-TUR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Triticum urartu [Reaction:R-CRU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Capsella rubella [Reaction:R-PHH-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Panicum hallii var. hallii ("HAL2") [Reaction:R-BOL-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Brassica oleracea [Reaction:R-HLP-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Humulus lupulus var. lupulus [Reaction:R-AUM-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Aegilops umbellulata [Reaction:R-TDI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Triticum dicoccoides [Reaction:R-ATH-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Arabidopsis thaliana [Reaction:R-OBR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza brachyantha [Reaction:R-CCD-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cynara cardunculus var. scolymus [Reaction:R-OGL-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza glaberrima [Reaction:R-HVU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Hordeum vulgare [Reaction:R-AIP-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Arachis ipaensis [Reaction:R-ATA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Aegilops tauschii [Reaction:R-OES-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Olea europaea var. sylvestris [Reaction:R-ATR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Amborella trichopoda [Reaction:R-NNU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Nelumbo nucifera [Reaction:R-ACO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Ananas comosus [Reaction:R-AHY-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Arachis hypogaea [Reaction:R-ACH-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Actinidia chinensis [Reaction:R-HAN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Helianthus annuus [Reaction:R-TTU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Triticum turgidum [Reaction:R-CCL-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Citrus clementina [Reaction:R-ECG-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Echinochloa crus-galli [Reaction:R-DRO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Dioscorea rotundata [Reaction:R-DCA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Daucus carota [Reaction:R-TAE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Triticum aestivum [Reaction:R-ZMA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Zea mays [Reaction:R-BVU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Beta vulgaris [Reaction:R-BRA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Brassica rapa [Reaction:R-OEU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Olea europaea [Reaction:R-JRE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Juglans regia [Reaction:R-VAN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Vigna angularis [Reaction:R-STU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Solanum tuberosum [Reaction:R-CQI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Chenopodium quinoa [Reaction:R-PVE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Pistacia vera [Reaction:R-ZJA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Zoysia japonica [Reaction:R-COL-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Corchorus olitorius [Reaction:R-PVU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Phaseolus vulgaris [Reaction:R-SSP-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Saccharum spontaneum [Reaction:R-AHA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Arabidopsis halleri [Reaction:R-BJU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Brassica juncea [Reaction:R-SVI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Setaria viridis [Reaction:R-FEX-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Fraxinus excelsior (European ash) [Reaction:R-EGR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Eucalyptus grandis [Reaction:R-PHA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Panicum hallii ("FIL2") [Reaction:R-ZMY-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Zea mays ver5 [Reaction:R-OLO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza longistaminata [Reaction:R-QLO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Quercus lobata [Reaction:R-GMA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Glycine max [Reaction:R-SMO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Selaginella moellendorffii [Reaction:R-CSC-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cannabis sativa [Reaction:R-MGU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Erythranthe guttata [Reaction:R-CBA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Chara braunii [Reaction:R-PAB-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Picea abies [Reaction:R-CST-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Camelina sativa [Reaction:R-OPU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza punctata [Reaction:R-VUN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Vigna unguiculata [Reaction:R-TPR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Trifolium pratense [Reaction:R-PSO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Papaver somniferum [Reaction:R-ONI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza nivara [Reaction:R-QSU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Quercus suber [Reaction:R-MDO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Malus domestica [Reaction:R-PPE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Prunus persica [Reaction:R-FVE-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Fragaria vesca [Reaction:R-CAR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cicer arietinum [Reaction:R-DEX-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Digitaria exilis [Reaction:R-SHI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Salvia hispanica [Reaction:R-CML-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cucumis melo [Reaction:R-SLY-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Solanum lycopersicum [Reaction:R-CSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Cucumis sativus [Reaction:R-AOF-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Asparagus officinalis [Reaction:R-GSO-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Glycine soja [Reaction:R-ADU-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Arachis duranensis [Reaction:R-BNA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Brassica napus [Reaction:R-SBI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Sorghum bicolor [Reaction:R-VVN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Vitis vinifera [Reaction:R-FCR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Ficus carica [Reaction:R-CLA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Citrullus lanatus [Reaction:R-ALY-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Arabidopsis lyrata [Reaction:R-CAN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Capsicum annuum [Reaction:R-LAN-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Lupinus angustifolius [Reaction:R-RCH-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Rosa chinensis [Reaction:R-OSI-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza sativa Indica Group [Reaction:R-PPA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Physcomitrella patens [Reaction:R-LPR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Lolium perenne [Reaction:R-MES-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Manihot esculenta [Reaction:R-MTR-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Medicago truncatula [Reaction:R-GRA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Gossypium raimondii [Reaction:R-OBA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza barthii [Reaction:R-SIT-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Setaria italica [Reaction:R-PAV-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Prunus avium [Reaction:R-NAT-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Nicotiana attenuata [Reaction:R-MAC-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Musa acuminata [Reaction:R-PTA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Pinus taeda
output	[SimpleEntity:R-ALL-4789847] (R)-mevalonate [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-OSA-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120896
summation	[Summation:4790375] 3-hydroxy-3-methyl-glutaryl-CoA is converted to (R)-mevalona...

Referrals

(hasEvent)	[Pathway:R-OSA-1119615] Mevalonate pathway - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1119762] mevalonate kinase - Oryza sativa