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Hydroxymethylglutaryl-CoA reductase (NADPH)

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catalystActivity	[CatalystActivity:10777795] hydroxymethylglutaryl-CoA reductase (NADPH) activity of hydroxymethylglutaryl-CoA reductase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10774846] Elser, Justin, 2025-03-25
dbId	10777797
displayName	Hydroxymethylglutaryl-CoA reductase (NADPH)
eventOf	[Pathway:R-OBA-1119615] Mevalonate pathway - Oryza barthii
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-OBA-1119762] mevalonate kinase - Oryza barthii
inferredFrom	[Reaction:R-OSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza sativa
input	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] 2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
name	Hydroxymethylglutaryl-CoA reductase (NADPH) HMG-CoA reductase 3-hydroxy-3-methylglutaryl-coenzyme A reductase biochemicalReaction94466
output	[SimpleEntity:R-ALL-4789847] (R)-mevalonate [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-OBA-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza barthii
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9030142] Oryza barthii
stId	R-OBA-1120896
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-OBA-1119615] Mevalonate pathway - Oryza barthii
(precedingEvent)	[Reaction:R-OBA-1119762] mevalonate kinase - Oryza barthii
(inferredTo)	[Reaction:R-OSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza sativa