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Hydroxymethylglutaryl-CoA synthase

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catalystActivity	[CatalystActivity:1118957] hydroxymethylglutaryl-CoA synthase activity of hydroxymethylglutaryl-CoA synthase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:74282] EC:2.3.3.10 [DatabaseIdentifier:1148015] RiceCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
dbId	1120444
displayName	Hydroxymethylglutaryl-CoA synthase
eventOf	[Pathway:R-OSA-1119615] Mevalonate pathway - Oryza sativa
followingEvent	[Reaction:R-OSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza sativa
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-191293] ACA-CoA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Hydroxymethylglutaryl-CoA synthase HMG-CoA synthase biochemicalReaction74668
orthologousEvent	[Reaction:R-CCP-1120444] Hydroxymethylglutaryl-CoA synthase - Corchorus capsularis [Reaction:R-CSK-1120444] Hydroxymethylglutaryl-CoA synthase - Cannabis sativa subsp. indica [Reaction:R-LST-1120444] Hydroxymethylglutaryl-CoA synthase - Lathyrus sativus [Reaction:R-SIN-1120444] Hydroxymethylglutaryl-CoA synthase - Sesamum indicum [Reaction:R-NAT-1120444] Hydroxymethylglutaryl-CoA synthase - Nicotiana attenuata [Reaction:R-ONI-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza nivara [Reaction:R-TCA-1120444] Hydroxymethylglutaryl-CoA synthase - Theobroma cacao [Reaction:R-ECG-1120444] Hydroxymethylglutaryl-CoA synthase - Echinochloa crus-galli [Reaction:R-ETE-1120444] Hydroxymethylglutaryl-CoA synthase - Eragrostis tef [Reaction:R-OAU-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza australiensis [Reaction:R-LPE-1120444] Hydroxymethylglutaryl-CoA synthase - Leersia perrieri [Reaction:R-PAB-1120444] Hydroxymethylglutaryl-CoA synthase - Picea abies [Reaction:R-CST-1120444] Hydroxymethylglutaryl-CoA synthase - Camelina sativa [Reaction:R-VAN-1120444] Hydroxymethylglutaryl-CoA synthase - Vigna angularis [Reaction:R-SSP-1120444] Hydroxymethylglutaryl-CoA synthase - Saccharum spontaneum [Reaction:R-NCO-1120444] Hydroxymethylglutaryl-CoA synthase - Nymphaea colorata [Reaction:R-OGU-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza glumaepatula [Reaction:R-PPE-1120444] Hydroxymethylglutaryl-CoA synthase - Prunus persica [Reaction:R-CME-1120444] Hydroxymethylglutaryl-CoA synthase - Cyanidioschyzon merolae [Reaction:R-HLP-1120444] Hydroxymethylglutaryl-CoA synthase - Humulus lupulus var. lupulus [Reaction:R-AHY-1120444] Hydroxymethylglutaryl-CoA synthase - Arachis hypogaea [Reaction:R-PVE-1120444] Hydroxymethylglutaryl-CoA synthase - Pistacia vera [Reaction:R-OLO-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza longistaminata [Reaction:R-PDA-1120444] Hydroxymethylglutaryl-CoA synthase - Phoenix dactylifera [Reaction:R-AOF-1120444] Hydroxymethylglutaryl-CoA synthase - Asparagus officinalis [Reaction:R-ATA-1120444] Hydroxymethylglutaryl-CoA synthase - Aegilops tauschii [Reaction:R-FEX-1120444] Hydroxymethylglutaryl-CoA synthase - Fraxinus excelsior (European ash) [Reaction:R-SVI-1120444] Hydroxymethylglutaryl-CoA synthase - Setaria viridis [Reaction:R-TSP-1120444] Hydroxymethylglutaryl-CoA synthase - Triticum spelta subsp. spelta [Reaction:R-BRA-1120444] Hydroxymethylglutaryl-CoA synthase - Brassica rapa [Reaction:R-OMI-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza minuta [Reaction:R-ZMY-1120444] Hydroxymethylglutaryl-CoA synthase - Zea mays ver5 [Reaction:R-ATH-1120444] Hydroxymethylglutaryl-CoA synthase - Arabidopsis thaliana [Reaction:R-OPU-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza punctata [Reaction:R-ITR-1120444] Hydroxymethylglutaryl-CoA synthase - Ipomoea triloba [Reaction:R-PTI-1120444] Hydroxymethylglutaryl-CoA synthase - Populus trichocarpa [Reaction:R-MGU-1120444] Hydroxymethylglutaryl-CoA synthase - Erythranthe guttata [Reaction:R-VFA-1120444] Hydroxymethylglutaryl-CoA synthase - Vicia faba var. faba [Reaction:R-FCR-1120444] Hydroxymethylglutaryl-CoA synthase - Ficus carica [Reaction:R-CCR-1120444] Hydroxymethylglutaryl-CoA synthase - Chondrus crispus [Reaction:R-MTR-1120444] Hydroxymethylglutaryl-CoA synthase - Medicago truncatula [Reaction:R-TAE-1120444] Hydroxymethylglutaryl-CoA synthase - Triticum aestivum [Reaction:R-EGR-1120444] Hydroxymethylglutaryl-CoA synthase - Eucalyptus grandis [Reaction:R-ASA-1120444] Hydroxymethylglutaryl-CoA synthase - Avena sativa [Reaction:R-CQI-1120444] Hydroxymethylglutaryl-CoA synthase - Chenopodium quinoa [Reaction:R-JCU-1120444] Hydroxymethylglutaryl-CoA synthase - Jatropha curcas [Reaction:R-GRA-1120444] Hydroxymethylglutaryl-CoA synthase - Gossypium raimondii [Reaction:R-SBI-1120444] Hydroxymethylglutaryl-CoA synthase - Sorghum bicolor [Reaction:R-DCA-1120444] Hydroxymethylglutaryl-CoA synthase - Daucus carota [Reaction:R-NNU-1120444] Hydroxymethylglutaryl-CoA synthase - Nelumbo nucifera [Reaction:R-SIT-1120444] Hydroxymethylglutaryl-CoA synthase - Setaria italica [Reaction:R-CAR-1120444] Hydroxymethylglutaryl-CoA synthase - Cicer arietinum [Reaction:R-TTI-1120444] Hydroxymethylglutaryl-CoA synthase - Triticum timopheevii subsp. timopheevii [Reaction:R-BVU-1120444] Hydroxymethylglutaryl-CoA synthase - Beta vulgaris [Reaction:R-ECU-1120444] Hydroxymethylglutaryl-CoA synthase - Eragrostis curvula [Reaction:R-TUR-1120444] Hydroxymethylglutaryl-CoA synthase - Triticum urartu [Reaction:R-AHA-1120444] Hydroxymethylglutaryl-CoA synthase - Arabidopsis halleri [Reaction:R-PSA-1120444] Hydroxymethylglutaryl-CoA synthase - Pisum sativum [Reaction:R-OME-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza meridionalis [Reaction:R-ALY-1120444] Hydroxymethylglutaryl-CoA synthase - Arabidopsis lyrata [Reaction:R-LSA-1120444] Hydroxymethylglutaryl-CoA synthase - Lactuca sativa [Reaction:R-SLY-1120444] Hydroxymethylglutaryl-CoA synthase - Solanum lycopersicum [Reaction:R-OOF-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza officinalis [Reaction:R-MDO-1120444] Hydroxymethylglutaryl-CoA synthase - Malus domestica [Reaction:R-BNA-1120444] Hydroxymethylglutaryl-CoA synthase - Brassica napus [Reaction:R-CCD-1120444] Hydroxymethylglutaryl-CoA synthase - Cynara cardunculus var. scolymus [Reaction:R-GSU-1120444] Hydroxymethylglutaryl-CoA synthase - Galdieria sulphuraria [Reaction:R-BJU-1120444] Hydroxymethylglutaryl-CoA synthase - Brassica juncea [Reaction:R-CRU-1120444] Hydroxymethylglutaryl-CoA synthase - Capsella rubella [Reaction:R-DEX-1120444] Hydroxymethylglutaryl-CoA synthase - Digitaria exilis [Reaction:R-QSU-1120444] Hydroxymethylglutaryl-CoA synthase - Quercus suber [Reaction:R-OBA-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza barthii [Reaction:R-PED-1120444] Hydroxymethylglutaryl-CoA synthase - Phyllostachys edulis [Reaction:R-TDI-1120444] Hydroxymethylglutaryl-CoA synthase - Triticum dicoccoides [Reaction:R-OBR-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza brachyantha [Reaction:R-ACH-1120444] Hydroxymethylglutaryl-CoA synthase - Actinidia chinensis [Reaction:R-PVU-1120444] Hydroxymethylglutaryl-CoA synthase - Phaseolus vulgaris [Reaction:R-OSI-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza sativa Indica Group [Reaction:R-ZJA-1120444] Hydroxymethylglutaryl-CoA synthase - Zoysia japonica [Reaction:R-OGR-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza meyeriana var. granulata [Reaction:R-ADU-1120444] Hydroxymethylglutaryl-CoA synthase - Arachis duranensis [Reaction:R-PHH-1120444] Hydroxymethylglutaryl-CoA synthase - Panicum hallii var. hallii ("HAL2") [Reaction:R-CAN-1120444] Hydroxymethylglutaryl-CoA synthase - Capsicum annuum [Reaction:R-RCH-1120444] Hydroxymethylglutaryl-CoA synthase - Rosa chinensis [Reaction:R-OEU-1120444] Hydroxymethylglutaryl-CoA synthase - Olea europaea [Reaction:R-AIP-1120444] Hydroxymethylglutaryl-CoA synthase - Arachis ipaensis [Reaction:R-GMA-1120444] Hydroxymethylglutaryl-CoA synthase - Glycine max [Reaction:R-OES-1120444] Hydroxymethylglutaryl-CoA synthase - Olea europaea var. sylvestris [Reaction:R-PTA-1120444] Hydroxymethylglutaryl-CoA synthase - Pinus taeda [Reaction:R-PSO-1120444] Hydroxymethylglutaryl-CoA synthase - Papaver somniferum [Reaction:R-MES-1120444] Hydroxymethylglutaryl-CoA synthase - Manihot esculenta [Reaction:R-ATR-1120444] Hydroxymethylglutaryl-CoA synthase - Amborella trichopoda [Reaction:R-VRA-1120444] Hydroxymethylglutaryl-CoA synthase - Vigna radiata [Reaction:R-PHA-1120444] Hydroxymethylglutaryl-CoA synthase - Panicum hallii ("FIL2") [Reaction:R-CLA-1120444] Hydroxymethylglutaryl-CoA synthase - Citrullus lanatus [Reaction:R-CCA-1120444] Hydroxymethylglutaryl-CoA synthase - Cajanus cajan [Reaction:R-CCN-1120444] Hydroxymethylglutaryl-CoA synthase - Coffea canephora [Reaction:R-SHI-1120444] Hydroxymethylglutaryl-CoA synthase - Salvia hispanica [Reaction:R-LPR-1120444] Hydroxymethylglutaryl-CoA synthase - Lolium perenne [Reaction:R-GSO-1120444] Hydroxymethylglutaryl-CoA synthase - Glycine soja [Reaction:R-HAN-1120444] Hydroxymethylglutaryl-CoA synthase - Helianthus annuus [Reaction:R-TPR-1120444] Hydroxymethylglutaryl-CoA synthase - Trifolium pratense [Reaction:R-COL-1120444] Hydroxymethylglutaryl-CoA synthase - Corchorus olitorius [Reaction:R-MAC-1120444] Hydroxymethylglutaryl-CoA synthase - Musa acuminata [Reaction:R-CSI-1120444] Hydroxymethylglutaryl-CoA synthase - Citrus sinensis [Reaction:R-STU-1120444] Hydroxymethylglutaryl-CoA synthase - Solanum tuberosum [Reaction:R-SCR-1120444] Hydroxymethylglutaryl-CoA synthase - Secale cereale [Reaction:R-ZMA-1120444] Hydroxymethylglutaryl-CoA synthase - Zea mays [Reaction:R-BDI-1120444] Hydroxymethylglutaryl-CoA synthase - Brachypodium distachyon [Reaction:R-CCI-1120444] Hydroxymethylglutaryl-CoA synthase - Corymbia citriodora [Reaction:R-CML-1120444] Hydroxymethylglutaryl-CoA synthase - Cucumis melo [Reaction:R-AUM-1120444] Hydroxymethylglutaryl-CoA synthase - Aegilops umbellulata [Reaction:R-HVU-1120444] Hydroxymethylglutaryl-CoA synthase - Hordeum vulgare [Reaction:R-CSA-1120444] Hydroxymethylglutaryl-CoA synthase - Cucumis sativus [Reaction:R-VVN-1120444] Hydroxymethylglutaryl-CoA synthase - Vitis vinifera [Reaction:R-JRE-1120444] Hydroxymethylglutaryl-CoA synthase - Juglans regia [Reaction:R-OGL-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza glaberrima [Reaction:R-TTU-1120444] Hydroxymethylglutaryl-CoA synthase - Triticum turgidum [Reaction:R-CSC-1120444] Hydroxymethylglutaryl-CoA synthase - Cannabis sativa [Reaction:R-ORU-1120444] Hydroxymethylglutaryl-CoA synthase - Oryza rufipogon [Reaction:R-VUN-1120444] Hydroxymethylglutaryl-CoA synthase - Vigna unguiculata [Reaction:R-QLO-1120444] Hydroxymethylglutaryl-CoA synthase - Quercus lobata [Reaction:R-LAN-1120444] Hydroxymethylglutaryl-CoA synthase - Lupinus angustifolius [Reaction:R-PAV-1120444] Hydroxymethylglutaryl-CoA synthase - Prunus avium [Reaction:R-CCL-1120444] Hydroxymethylglutaryl-CoA synthase - Citrus clementina [Reaction:R-DRO-1120444] Hydroxymethylglutaryl-CoA synthase - Dioscorea rotundata [Reaction:R-BOL-1120444] Hydroxymethylglutaryl-CoA synthase - Brassica oleracea
output	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-OSA-1120481] Acetyl-CoA C-acetyltransferase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120444
summation	[Summation:4790374] Acetoacetyl-CoA is converted to 3-hydroxy-3-methyl-glutaryl-...

Referrals

(hasEvent)	[Pathway:R-OSA-1119615] Mevalonate pathway - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120896] Hydroxymethylglutaryl-CoA reductase (NADPH) - Oryza sativa