Plant Reactome Pathway Database - Plant Reactome Pathway Database

Schema > Reaction > Entries

presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate

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catalystActivity	[CatalystActivity:1118686] obsolete farnesyl-diphosphate farnesyltransferase activity of Squalene synthase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:27158] EC:2.5.1.21 [DatabaseIdentifier:1144765] RiceCyc:RXN66-281
dbId	1120616
displayName	presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate
edited	[InstanceEdit:3900246] Beorchia, Dylan, 2013-01-22
eventOf	[Pathway:R-OSA-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza sativa [Pathway:R-OSA-1119286] Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) - Oryza sativa [Pathway:R-OSA-1119559] Cholesterol biosynthesis I - Oryza sativa [Pathway:R-OSA-1119370] Sterol biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120707] squalene+NADPH+O2->(S)-2,3-Epoxysqualene+NADP++H2O - Oryza sativa [Reaction:R-OSA-1121248] Squalene monooxygenase - Oryza sativa
input	[DefinedSet:R-ALL-428206] NAD(P)H [cytosol] [SimpleEntity:R-ALL-191265] PSQPP [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate RXN66-281 biochemicalReaction61167
orthologousEvent	[Reaction:R-ONI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza nivara [Reaction:R-FEX-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Fraxinus excelsior (European ash) [Reaction:R-SPC-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Synechocystis sp. PCC 6803 [Reaction:R-CLA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Citrullus lanatus [Reaction:R-CCL-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Citrus clementina [Reaction:R-CSI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Citrus sinensis [Reaction:R-AIP-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Arachis ipaensis [Reaction:R-SHI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Salvia hispanica [Reaction:R-PPE-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Prunus persica [Reaction:R-CAR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Cicer arietinum [Reaction:R-OBA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza barthii [Reaction:R-CCP-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Corchorus capsularis [Reaction:R-CBA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Chara braunii [Reaction:R-OGU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza glumaepatula [Reaction:R-AOF-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Asparagus officinalis [Reaction:R-LST-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Lathyrus sativus [Reaction:R-JRE-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Juglans regia [Reaction:R-DRO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Dioscorea rotundata [Reaction:R-FCR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Ficus carica [Reaction:R-EGR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Eucalyptus grandis [Reaction:R-TAE-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Triticum aestivum [Reaction:R-ZMY-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Zea mays ver5 [Reaction:R-LPE-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Leersia perrieri [Reaction:R-PTI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Populus trichocarpa [Reaction:R-LAN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Lupinus angustifolius [Reaction:R-HVU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Hordeum vulgare [Reaction:R-OAU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza australiensis [Reaction:R-PSO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Papaver somniferum [Reaction:R-OME-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza meridionalis [Reaction:R-ECU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Eragrostis curvula [Reaction:R-HLH-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Humulus lupulus [Reaction:R-ZJA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Zoysia japonica [Reaction:R-SIN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Sesamum indicum [Reaction:R-CST-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Camelina sativa [Reaction:R-ACH-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Actinidia chinensis [Reaction:R-BNA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Brassica napus [Reaction:R-JCU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Jatropha curcas [Reaction:R-CCA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Cajanus cajan [Reaction:R-TSP-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Triticum spelta subsp. spelta [Reaction:R-ZMA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Zea mays [Reaction:R-CRE-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Chlamydomonas reinhardtii [Reaction:R-ATH-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Arabidopsis thaliana [Reaction:R-BDI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Brachypodium distachyon [Reaction:R-ASA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Avena sativa [Reaction:R-ACO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Ananas comosus [Reaction:R-BRA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Brassica rapa [Reaction:R-OBR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza brachyantha [Reaction:R-PAV-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Prunus avium [Reaction:R-CML-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Cucumis melo [Reaction:R-GRA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Gossypium raimondii [Reaction:R-OES-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Olea europaea var. sylvestris [Reaction:R-HAN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Helianthus annuus [Reaction:R-OLU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Ostreococcus lucimarinus [Reaction:R-SCR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Secale cereale [Reaction:R-TPR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Trifolium pratense [Reaction:R-NNU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Nelumbo nucifera [Reaction:R-SBI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Sorghum bicolor [Reaction:R-TTI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Triticum timopheevii subsp. timopheevii [Reaction:R-SIT-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Setaria italica [Reaction:R-OMI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza minuta [Reaction:R-CAN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Capsicum annuum [Reaction:R-ATA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Aegilops tauschii [Reaction:R-PDA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Phoenix dactylifera [Reaction:R-BOL-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Brassica oleracea [Reaction:R-GMA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Glycine max [Reaction:R-VVN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Vitis vinifera [Reaction:R-ORU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza rufipogon [Reaction:R-CME-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Cyanidioschyzon merolae [Reaction:R-GSO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Glycine soja [Reaction:R-PHA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Panicum hallii ("FIL2") [Reaction:R-CQI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Chenopodium quinoa [Reaction:R-PSA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Pisum sativum [Reaction:R-CSA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Cucumis sativus [Reaction:R-QLO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Quercus lobata [Reaction:R-TTU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Triticum turgidum [Reaction:R-MPO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Marchantia polymorpha [Reaction:R-ECG-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Echinochloa crus-galli [Reaction:R-ADU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Arachis duranensis [Reaction:R-OPU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza punctata [Reaction:R-TUR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Triticum urartu [Reaction:R-ALY-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Arabidopsis lyrata [Reaction:R-OGL-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza glaberrima [Reaction:R-CCN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Coffea canephora [Reaction:R-HLP-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Humulus lupulus var. lupulus [Reaction:R-PVE-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Pistacia vera [Reaction:R-CCD-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Cynara cardunculus var. scolymus [Reaction:R-PAB-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Picea abies [Reaction:R-CRU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Capsella rubella [Reaction:R-NCO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Nymphaea colorata [Reaction:R-COL-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Corchorus olitorius [Reaction:R-DEX-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Digitaria exilis [Reaction:R-SMO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Selaginella moellendorffii [Reaction:R-SLY-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Solanum lycopersicum [Reaction:R-CCR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Chondrus crispus [Reaction:R-MES-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Manihot esculenta [Reaction:R-BVU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Beta vulgaris [Reaction:R-NAT-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Nicotiana attenuata [Reaction:R-VRA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Vigna radiata [Reaction:R-CCI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Corymbia citriodora [Reaction:R-PPA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Physcomitrella patens [Reaction:R-DCA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Daucus carota [Reaction:R-OSI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza sativa Indica Group [Reaction:R-MGU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Erythranthe guttata [Reaction:R-VUN-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Vigna unguiculata [Reaction:R-RCH-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Rosa chinensis [Reaction:R-OEU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Olea europaea [Reaction:R-MAC-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Musa acuminata [Reaction:R-OLO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza longistaminata [Reaction:R-AHY-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Arachis hypogaea [Reaction:R-PHH-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Panicum hallii var. hallii ("HAL2") [Reaction:R-MDO-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Malus domestica [Reaction:R-LSA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Lactuca sativa [Reaction:R-LPR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Lolium perenne [Reaction:R-AUM-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Aegilops umbellulata [Reaction:R-OOF-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza officinalis [Reaction:R-BJU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Brassica juncea [Reaction:R-TCA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Theobroma cacao [Reaction:R-PVU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Phaseolus vulgaris [Reaction:R-TDI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Triticum dicoccoides [Reaction:R-OGR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza meyeriana var. granulata [Reaction:R-QSU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Quercus suber [Reaction:R-AHA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Arabidopsis halleri [Reaction:R-PED-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Phyllostachys edulis [Reaction:R-STU-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Solanum tuberosum [Reaction:R-SVI-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Setaria viridis [Reaction:R-ATR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Amborella trichopoda [Reaction:R-MTR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Medicago truncatula [Reaction:R-VFA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Vicia faba var. faba [Reaction:R-ITR-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Ipomoea triloba [Reaction:R-SSP-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Saccharum spontaneum
output	[DefinedSet:R-ALL-428218] NAD(P)+ [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-191269] SQNE [cytosol]
precedingEvent	[Reaction:R-OSA-1119792] Farnesyl-diphosphate farnesyltransferase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120616
summation	[Summation:3900250] Presqualene diphosphate is converted into squalene by enzyma...

Referrals

(hasEvent)	[Pathway:R-OSA-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza sativa [Pathway:R-OSA-1119286] Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) - Oryza sativa [Pathway:R-OSA-1119559] Cholesterol biosynthesis I - Oryza sativa [Pathway:R-OSA-1119370] Sterol biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120707] squalene+NADPH+O2->(S)-2,3-Epoxysqualene+NADP++H2O - Oryza sativa [Reaction:R-OSA-1121248] Squalene monooxygenase - Oryza sativa