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Cholesterol biosynthesis III (via desmosterol)

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compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1148039] RiceCyc:PWY66-4
dbId	1119439
displayName	Cholesterol biosynthesis III (via desmosterol)
edited	[InstanceEdit:4720510] Amoss, Kindra, 2013-05-17 [InstanceEdit:4720511] Dharmawardhana, DP, 2013-08-01
eventOf	[Pathway:R-OSA-3906998] Fatty acid and lipid metabolism - Oryza sativa
goBiologicalProcess	[GO_BiologicalProcess:262807] cholesterol biosynthetic process via desmosterol
hasDiagram	true
hasEvent	[Reaction:R-OSA-1119792] Farnesyl-diphosphate farnesyltransferase - Oryza sativa [Reaction:R-OSA-1120616] presqualene diphosphate+NAD(P)H->squalene+NAD(P)++diphosphate - Oryza sativa [Reaction:R-OSA-1120707] squalene+NADPH+O2->(S)-2,3-Epoxysqualene+NADP++H2O - Oryza sativa [Reaction:R-OSA-1121018] Lanosterol synthase - Oryza sativa [Reaction:R-OSA-1120767] lanosterol+NADPH+O2->4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP++H2O - Oryza sativa [Reaction:R-OSA-1121216] 4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol+NADPH+O2->4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol+NADP++H2O - Oryza sativa [Reaction:R-OSA-1121474] 4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol+NADPH+O2->4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol+NADP++H2O+formate - Oryza sativa [Reaction:R-OSA-1120304] 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol+NADPH->4,4-dimethyl-5alpha-cholesta-8,24-dien-3-beta-ol+NADP+ - Oryza sativa [Reaction:R-OSA-1120472] 4,4-dimethyl-5alpha-cholesta-8,24-dien-3-beta-ol+NAD(P)H+O2->4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)++H2O - Oryza sativa [Reaction:R-OSA-1121133] 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)H+O2->4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)++H2O - Oryza sativa [Reaction:R-OSA-1119749] 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)H+O2->4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)++H2O - Oryza sativa [Reaction:R-OSA-1120979] 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)+->4alpha-methyl-5alpha-cholesta-8,24-dien-3-one+NAD(P)H+CO2 - Oryza sativa [Reaction:R-OSA-1120411] 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one+NADPH->4-alpha-methyl zymosterol+NADP+ - Oryza sativa [Reaction:R-OSA-1121120] 4-alpha-methyl zymosterol+NAD(P)H+O2->4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)++H2O - Oryza sativa [Reaction:R-OSA-1121309] 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)H+O2->4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)++H2O - Oryza sativa [Reaction:R-OSA-1120443] 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)H+O2->4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)++H2O - Oryza sativa [Reaction:R-OSA-1120059] 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol+NAD(P)+->5alpha-cholesta-8,24-dien-3-one+NAD(P)H+CO2 - Oryza sativa [Reaction:R-OSA-1121540] 5alpha-cholesta-8,24-dien-3-one+NADPH->zymosterol+NADP+ - Oryza sativa [Reaction:R-OSA-1121173] zymosterol->5alpha-cholesta-7,24-dien-3beta-ol - Oryza sativa [Reaction:R-OSA-1121038] 5alpha-cholesta-7,24-dien-3beta-ol+O2+NAD(P)H->7-dehydrodesmosterol+H2O+NAD(P)+ - Oryza sativa [Reaction:R-OSA-1121323] 7-dehydrodesmosterol+NADPH->desmosterol+NADP+ - Oryza sativa [Reaction:R-OSA-1119700] desmosterol+NADPH->cholesterol+NADP+ - Oryza sativa
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4719709] Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis [LiteratureReference:4719746] Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Cholesterol biosynthesis III (via desmosterol) pathway100379
orthologousEvent	[Pathway:R-CSC-1119439] Cholesterol biosynthesis III (via desmosterol) - Cannabis sativa [Pathway:R-OOF-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza officinalis [Pathway:R-ATH-1119439] Cholesterol biosynthesis III (via desmosterol) - Arabidopsis thaliana [Pathway:R-FVE-1119439] Cholesterol biosynthesis III (via desmosterol) - Fragaria vesca [Pathway:R-OLU-1119439] Cholesterol biosynthesis III (via desmosterol) - Ostreococcus lucimarinus [Pathway:R-DRO-1119439] Cholesterol biosynthesis III (via desmosterol) - Dioscorea rotundata [Pathway:R-PPE-1119439] Cholesterol biosynthesis III (via desmosterol) - Prunus persica [Pathway:R-SCR-1119439] Cholesterol biosynthesis III (via desmosterol) - Secale cereale [Pathway:R-CME-1119439] Cholesterol biosynthesis III (via desmosterol) - Cyanidioschyzon merolae [Pathway:R-PVE-1119439] Cholesterol biosynthesis III (via desmosterol) - Pistacia vera [Pathway:R-CBA-1119439] Cholesterol biosynthesis III (via desmosterol) - Chara braunii [Pathway:R-CRE-1119439] Cholesterol biosynthesis III (via desmosterol) - Chlamydomonas reinhardtii [Pathway:R-GMA-1119439] Cholesterol biosynthesis III (via desmosterol) - Glycine max [Pathway:R-OGL-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza glaberrima [Pathway:R-CCD-1119439] Cholesterol biosynthesis III (via desmosterol) - Cynara cardunculus var. scolymus [Pathway:R-CSK-1119439] Cholesterol biosynthesis III (via desmosterol) - Cannabis sativa subsp. indica [Pathway:R-SLY-1119439] Cholesterol biosynthesis III (via desmosterol) - Solanum lycopersicum [Pathway:R-BNA-1119439] Cholesterol biosynthesis III (via desmosterol) - Brassica napus [Pathway:R-PVU-1119439] Cholesterol biosynthesis III (via desmosterol) - Phaseolus vulgaris [Pathway:R-AIP-1119439] Cholesterol biosynthesis III (via desmosterol) - Arachis ipaensis [Pathway:R-SPC-1119439] Cholesterol biosynthesis III (via desmosterol) - Synechocystis sp. PCC 6803 [Pathway:R-TPR-1119439] Cholesterol biosynthesis III (via desmosterol) - Trifolium pratense [Pathway:R-DCA-1119439] Cholesterol biosynthesis III (via desmosterol) - Daucus carota [Pathway:R-ONI-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza nivara [Pathway:R-OBA-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza barthii [Pathway:R-OME-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza meridionalis [Pathway:R-ZMY-1119439] Cholesterol biosynthesis III (via desmosterol) - Zea mays ver5 [Pathway:R-LST-1119439] Cholesterol biosynthesis III (via desmosterol) - Lathyrus sativus [Pathway:R-JCU-1119439] Cholesterol biosynthesis III (via desmosterol) - Jatropha curcas [Pathway:R-AOF-1119439] Cholesterol biosynthesis III (via desmosterol) - Asparagus officinalis [Pathway:R-HAN-1119439] Cholesterol biosynthesis III (via desmosterol) - Helianthus annuus [Pathway:R-PSA-1119439] Cholesterol biosynthesis III (via desmosterol) - Pisum sativum [Pathway:R-BDI-1119439] Cholesterol biosynthesis III (via desmosterol) - Brachypodium distachyon [Pathway:R-VVN-1119439] Cholesterol biosynthesis III (via desmosterol) - Vitis vinifera [Pathway:R-LPE-1119439] Cholesterol biosynthesis III (via desmosterol) - Leersia perrieri [Pathway:R-ECU-1119439] Cholesterol biosynthesis III (via desmosterol) - Eragrostis curvula [Pathway:R-SIN-1119439] Cholesterol biosynthesis III (via desmosterol) - Sesamum indicum [Pathway:R-CCR-1119439] Cholesterol biosynthesis III (via desmosterol) - Chondrus crispus [Pathway:R-NNU-1119439] Cholesterol biosynthesis III (via desmosterol) - Nelumbo nucifera [Pathway:R-ASA-1119439] Cholesterol biosynthesis III (via desmosterol) - Avena sativa [Pathway:R-RCH-1119439] Cholesterol biosynthesis III (via desmosterol) - Rosa chinensis [Pathway:R-HLP-1119439] Cholesterol biosynthesis III (via desmosterol) - Humulus lupulus var. lupulus [Pathway:R-OAU-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza australiensis [Pathway:R-CAR-1119439] Cholesterol biosynthesis III (via desmosterol) - Cicer arietinum [Pathway:R-AHA-1119439] Cholesterol biosynthesis III (via desmosterol) - Arabidopsis halleri [Pathway:R-GSU-1119439] Cholesterol biosynthesis III (via desmosterol) - Galdieria sulphuraria [Pathway:R-ACH-1119439] Cholesterol biosynthesis III (via desmosterol) - Actinidia chinensis [Pathway:R-OPU-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza punctata [Pathway:R-NAT-1119439] Cholesterol biosynthesis III (via desmosterol) - Nicotiana attenuata [Pathway:R-AUM-1119439] Cholesterol biosynthesis III (via desmosterol) - Aegilops umbellulata [Pathway:R-CCN-1119439] Cholesterol biosynthesis III (via desmosterol) - Coffea canephora [Pathway:R-VAN-1119439] Cholesterol biosynthesis III (via desmosterol) - Vigna angularis [Pathway:R-ZJA-1119439] Cholesterol biosynthesis III (via desmosterol) - Zoysia japonica [Pathway:R-PHH-1119439] Cholesterol biosynthesis III (via desmosterol) - Panicum hallii var. hallii ("HAL2") [Pathway:R-HLH-1119439] Cholesterol biosynthesis III (via desmosterol) - Humulus lupulus [Pathway:R-ALY-1119439] Cholesterol biosynthesis III (via desmosterol) - Arabidopsis lyrata [Pathway:R-CRU-1119439] Cholesterol biosynthesis III (via desmosterol) - Capsella rubella [Pathway:R-MTR-1119439] Cholesterol biosynthesis III (via desmosterol) - Medicago truncatula [Pathway:R-VFA-1119439] Cholesterol biosynthesis III (via desmosterol) - Vicia faba var. faba [Pathway:R-PED-1119439] Cholesterol biosynthesis III (via desmosterol) - Phyllostachys edulis [Pathway:R-QSU-1119439] Cholesterol biosynthesis III (via desmosterol) - Quercus suber [Pathway:R-BOL-1119439] Cholesterol biosynthesis III (via desmosterol) - Brassica oleracea [Pathway:R-ITR-1119439] Cholesterol biosynthesis III (via desmosterol) - Ipomoea triloba [Pathway:R-ECG-1119439] Cholesterol biosynthesis III (via desmosterol) - Echinochloa crus-galli [Pathway:R-OBR-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza brachyantha [Pathway:R-OMI-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza minuta [Pathway:R-QLO-1119439] Cholesterol biosynthesis III (via desmosterol) - Quercus lobata [Pathway:R-CML-1119439] Cholesterol biosynthesis III (via desmosterol) - Cucumis melo [Pathway:R-FCR-1119439] Cholesterol biosynthesis III (via desmosterol) - Ficus carica [Pathway:R-VUN-1119439] Cholesterol biosynthesis III (via desmosterol) - Vigna unguiculata [Pathway:R-PSO-1119439] Cholesterol biosynthesis III (via desmosterol) - Papaver somniferum [Pathway:R-CCI-1119439] Cholesterol biosynthesis III (via desmosterol) - Corymbia citriodora [Pathway:R-CSI-1119439] Cholesterol biosynthesis III (via desmosterol) - Citrus sinensis [Pathway:R-ORU-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza rufipogon [Pathway:R-PHA-1119439] Cholesterol biosynthesis III (via desmosterol) - Panicum hallii ("FIL2") [Pathway:R-NCO-1119439] Cholesterol biosynthesis III (via desmosterol) - Nymphaea colorata [Pathway:R-ATA-1119439] Cholesterol biosynthesis III (via desmosterol) - Aegilops tauschii [Pathway:R-OSI-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza sativa Indica Group [Pathway:R-ETE-1119439] Cholesterol biosynthesis III (via desmosterol) - Eragrostis tef [Pathway:R-SHI-1119439] Cholesterol biosynthesis III (via desmosterol) - Salvia hispanica [Pathway:R-TSP-1119439] Cholesterol biosynthesis III (via desmosterol) - Triticum spelta subsp. spelta [Pathway:R-PAB-1119439] Cholesterol biosynthesis III (via desmosterol) - Picea abies [Pathway:R-TAE-1119439] Cholesterol biosynthesis III (via desmosterol) - Triticum aestivum [Pathway:R-GSO-1119439] Cholesterol biosynthesis III (via desmosterol) - Glycine soja [Pathway:R-CST-1119439] Cholesterol biosynthesis III (via desmosterol) - Camelina sativa [Pathway:R-COL-1119439] Cholesterol biosynthesis III (via desmosterol) - Corchorus olitorius [Pathway:R-OGU-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza glumaepatula [Pathway:R-TUR-1119439] Cholesterol biosynthesis III (via desmosterol) - Triticum urartu [Pathway:R-TTU-1119439] Cholesterol biosynthesis III (via desmosterol) - Triticum turgidum [Pathway:R-ACO-1119439] Cholesterol biosynthesis III (via desmosterol) - Ananas comosus [Pathway:R-OES-1119439] Cholesterol biosynthesis III (via desmosterol) - Olea europaea var. sylvestris [Pathway:R-SVI-1119439] Cholesterol biosynthesis III (via desmosterol) - Setaria viridis [Pathway:R-ZMA-1119439] Cholesterol biosynthesis III (via desmosterol) - Zea mays [Pathway:R-VRA-1119439] Cholesterol biosynthesis III (via desmosterol) - Vigna radiata [Pathway:R-SIT-1119439] Cholesterol biosynthesis III (via desmosterol) - Setaria italica [Pathway:R-BRA-1119439] Cholesterol biosynthesis III (via desmosterol) - Brassica rapa [Pathway:R-SSP-1119439] Cholesterol biosynthesis III (via desmosterol) - Saccharum spontaneum [Pathway:R-LSA-1119439] Cholesterol biosynthesis III (via desmosterol) - Lactuca sativa [Pathway:R-SBI-1119439] Cholesterol biosynthesis III (via desmosterol) - Sorghum bicolor [Pathway:R-ATR-1119439] Cholesterol biosynthesis III (via desmosterol) - Amborella trichopoda [Pathway:R-PDA-1119439] Cholesterol biosynthesis III (via desmosterol) - Phoenix dactylifera [Pathway:R-CLA-1119439] Cholesterol biosynthesis III (via desmosterol) - Citrullus lanatus [Pathway:R-CQI-1119439] Cholesterol biosynthesis III (via desmosterol) - Chenopodium quinoa [Pathway:R-MDO-1119439] Cholesterol biosynthesis III (via desmosterol) - Malus domestica [Pathway:R-PAV-1119439] Cholesterol biosynthesis III (via desmosterol) - Prunus avium [Pathway:R-GRA-1119439] Cholesterol biosynthesis III (via desmosterol) - Gossypium raimondii [Pathway:R-BJU-1119439] Cholesterol biosynthesis III (via desmosterol) - Brassica juncea [Pathway:R-STU-1119439] Cholesterol biosynthesis III (via desmosterol) - Solanum tuberosum [Pathway:R-TDI-1119439] Cholesterol biosynthesis III (via desmosterol) - Triticum dicoccoides [Pathway:R-TCA-1119439] Cholesterol biosynthesis III (via desmosterol) - Theobroma cacao [Pathway:R-OLO-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza longistaminata [Pathway:R-MAC-1119439] Cholesterol biosynthesis III (via desmosterol) - Musa acuminata [Pathway:R-CCA-1119439] Cholesterol biosynthesis III (via desmosterol) - Cajanus cajan [Pathway:R-ADU-1119439] Cholesterol biosynthesis III (via desmosterol) - Arachis duranensis [Pathway:R-DEX-1119439] Cholesterol biosynthesis III (via desmosterol) - Digitaria exilis [Pathway:R-TTI-1119439] Cholesterol biosynthesis III (via desmosterol) - Triticum timopheevii subsp. timopheevii [Pathway:R-CCP-1119439] Cholesterol biosynthesis III (via desmosterol) - Corchorus capsularis [Pathway:R-LPR-1119439] Cholesterol biosynthesis III (via desmosterol) - Lolium perenne [Pathway:R-PTA-1119439] Cholesterol biosynthesis III (via desmosterol) - Pinus taeda [Pathway:R-PTI-1119439] Cholesterol biosynthesis III (via desmosterol) - Populus trichocarpa [Pathway:R-CCL-1119439] Cholesterol biosynthesis III (via desmosterol) - Citrus clementina [Pathway:R-MES-1119439] Cholesterol biosynthesis III (via desmosterol) - Manihot esculenta [Pathway:R-MPO-1119439] Cholesterol biosynthesis III (via desmosterol) - Marchantia polymorpha [Pathway:R-OGR-1119439] Cholesterol biosynthesis III (via desmosterol) - Oryza meyeriana var. granulata [Pathway:R-HVU-1119439] Cholesterol biosynthesis III (via desmosterol) - Hordeum vulgare [Pathway:R-JRE-1119439] Cholesterol biosynthesis III (via desmosterol) - Juglans regia [Pathway:R-SMO-1119439] Cholesterol biosynthesis III (via desmosterol) - Selaginella moellendorffii [Pathway:R-OEU-1119439] Cholesterol biosynthesis III (via desmosterol) - Olea europaea [Pathway:R-CAN-1119439] Cholesterol biosynthesis III (via desmosterol) - Capsicum annuum [Pathway:R-CSA-1119439] Cholesterol biosynthesis III (via desmosterol) - Cucumis sativus [Pathway:R-LAN-1119439] Cholesterol biosynthesis III (via desmosterol) - Lupinus angustifolius [Pathway:R-BVU-1119439] Cholesterol biosynthesis III (via desmosterol) - Beta vulgaris [Pathway:R-PPA-1119439] Cholesterol biosynthesis III (via desmosterol) - Physcomitrella patens [Pathway:R-FEX-1119439] Cholesterol biosynthesis III (via desmosterol) - Fraxinus excelsior (European ash) [Pathway:R-AHY-1119439] Cholesterol biosynthesis III (via desmosterol) - Arachis hypogaea [Pathway:R-MGU-1119439] Cholesterol biosynthesis III (via desmosterol) - Erythranthe guttata [Pathway:R-EGR-1119439] Cholesterol biosynthesis III (via desmosterol) - Eucalyptus grandis
schemaClass	Pathway
species	[Species:186860] Oryza sativa
stId	R-OSA-1119439
summation	[Summation:4720513] cholesterol biosynthesis III (via desmosterol) [Summation:2850146] Developed by Gramene.org

Referrals

(hasEvent)

[Pathway:R-OSA-3906998] Fatty acid and lipid metabolism - Oryza sativa