Plant Reactome Pathway Database - Plant Reactome Pathway Database

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isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+

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catalystActivity	[CatalystActivity:1118918] isocitrate dehydrogenase (NAD+) activity of IDH (NAD) complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1139555] RiceCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN
dbId	1120194
displayName	isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+
eventOf	[Pathway:R-OSA-1119533] TCA cycle (plant) - Oryza sativa
followingEvent	[Reaction:R-OSA-1120492] 2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - Oryza sativa
input	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1173247] Localization of NAD-isocitrate dehydrogenase and glutamate dehydrogenase in rice roots: candidates for providing carbon skeletons to NADH-glutamate synthase
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ Isocitrate dehydrogenase (NAD+)
orthologousEvent	[Reaction:R-TPR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Trifolium pratense [Reaction:R-TDI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Triticum dicoccoides [Reaction:R-FEX-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Fraxinus excelsior (European ash) [Reaction:R-OBR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza brachyantha [Reaction:R-ATH-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Arabidopsis thaliana [Reaction:R-CCD-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cynara cardunculus var. scolymus [Reaction:R-NAT-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Nicotiana attenuata [Reaction:R-SVI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Setaria viridis [Reaction:R-STU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Solanum tuberosum [Reaction:R-OGU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza glumaepatula [Reaction:R-OAU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza australiensis [Reaction:R-CSI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Citrus sinensis [Reaction:R-AHY-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Arachis hypogaea [Reaction:R-SPC-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Synechocystis sp. PCC 6803 [Reaction:R-BNA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Brassica napus [Reaction:R-TTU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Triticum turgidum [Reaction:R-PTI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Populus trichocarpa [Reaction:R-RCH-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Rosa chinensis [Reaction:R-CSK-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cannabis sativa subsp. indica [Reaction:R-LST-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Lathyrus sativus [Reaction:R-MTR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Medicago truncatula [Reaction:R-CCA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cajanus cajan [Reaction:R-ADU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Arachis duranensis [Reaction:R-OME-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza meridionalis [Reaction:R-QSU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Quercus suber [Reaction:R-OGR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza meyeriana var. granulata [Reaction:R-CCL-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Citrus clementina [Reaction:R-CCI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Corymbia citriodora [Reaction:R-AHA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Arabidopsis halleri [Reaction:R-ATA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Aegilops tauschii [Reaction:R-HLH-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Humulus lupulus [Reaction:R-EGR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Eucalyptus grandis [Reaction:R-CRU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Capsella rubella [Reaction:R-CBA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Chara braunii [Reaction:R-ECG-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Echinochloa crus-galli [Reaction:R-NCO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Nymphaea colorata [Reaction:R-ORU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza rufipogon [Reaction:R-QLO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Quercus lobata [Reaction:R-CAR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cicer arietinum [Reaction:R-ECU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Eragrostis curvula [Reaction:R-ALY-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Arabidopsis lyrata [Reaction:R-GSU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Galdieria sulphuraria [Reaction:R-CAN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Capsicum annuum [Reaction:R-OEU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Olea europaea [Reaction:R-OGL-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza glaberrima [Reaction:R-CST-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Camelina sativa [Reaction:R-TCA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Theobroma cacao [Reaction:R-GSO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Glycine soja [Reaction:R-LSA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Lactuca sativa [Reaction:R-DEX-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Digitaria exilis [Reaction:R-JRE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Juglans regia [Reaction:R-CQI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Chenopodium quinoa [Reaction:R-SLY-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Solanum lycopersicum [Reaction:R-CME-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cyanidioschyzon merolae [Reaction:R-CSA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cucumis sativus [Reaction:R-SHI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Salvia hispanica [Reaction:R-OES-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Olea europaea var. sylvestris [Reaction:R-GRA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Gossypium raimondii [Reaction:R-CLA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Citrullus lanatus [Reaction:R-BDI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Brachypodium distachyon [Reaction:R-DCA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Daucus carota [Reaction:R-MPO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Marchantia polymorpha [Reaction:R-PAV-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Prunus avium [Reaction:R-ZMA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Zea mays [Reaction:R-PVU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Phaseolus vulgaris [Reaction:R-PED-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Phyllostachys edulis [Reaction:R-COL-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Corchorus olitorius [Reaction:R-MDO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Malus domestica [Reaction:R-OBA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza barthii [Reaction:R-SBI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Sorghum bicolor [Reaction:R-OOF-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza officinalis [Reaction:R-ITR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Ipomoea triloba [Reaction:R-BOL-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Brassica oleracea [Reaction:R-HAN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Helianthus annuus [Reaction:R-PAB-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Picea abies [Reaction:R-AIP-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Arachis ipaensis [Reaction:R-PHH-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Panicum hallii var. hallii ("HAL2") [Reaction:R-GMA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Glycine max [Reaction:R-ASA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Avena sativa [Reaction:R-OPU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza punctata [Reaction:R-CML-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cucumis melo [Reaction:R-BVU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Beta vulgaris [Reaction:R-CCN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Coffea canephora [Reaction:R-HVU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Hordeum vulgare [Reaction:R-VAN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Vigna angularis [Reaction:R-PDA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Phoenix dactylifera [Reaction:R-SMO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Selaginella moellendorffii [Reaction:R-BRA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Brassica rapa [Reaction:R-SSP-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Saccharum spontaneum [Reaction:R-PPA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Physcomitrella patens [Reaction:R-OLO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza longistaminata [Reaction:R-ACH-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Actinidia chinensis [Reaction:R-PVE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Pistacia vera [Reaction:R-OMI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza minuta [Reaction:R-OSI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza sativa Indica Group [Reaction:R-DRO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Dioscorea rotundata [Reaction:R-TTI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Triticum timopheevii subsp. timopheevii [Reaction:R-ZJA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Zoysia japonica [Reaction:R-PTA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Pinus taeda [Reaction:R-JCU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Jatropha curcas [Reaction:R-CCP-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Corchorus capsularis [Reaction:R-TSP-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Triticum spelta subsp. spelta [Reaction:R-MAC-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Musa acuminata [Reaction:R-MGU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Erythranthe guttata [Reaction:R-NNU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Nelumbo nucifera [Reaction:R-LPR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Lolium perenne [Reaction:R-VRA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Vigna radiata [Reaction:R-LPE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Leersia perrieri [Reaction:R-FCR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Ficus carica [Reaction:R-PHA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Panicum hallii ("FIL2") [Reaction:R-AUM-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Aegilops umbellulata [Reaction:R-ACO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Ananas comosus [Reaction:R-TAE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Triticum aestivum [Reaction:R-VVN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Vitis vinifera [Reaction:R-PPE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Prunus persica [Reaction:R-CCR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Chondrus crispus [Reaction:R-LAN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Lupinus angustifolius [Reaction:R-SIT-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Setaria italica [Reaction:R-VUN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Vigna unguiculata [Reaction:R-CRE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Chlamydomonas reinhardtii [Reaction:R-SIN-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Sesamum indicum [Reaction:R-ZMY-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Zea mays ver5 [Reaction:R-PSA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Pisum sativum [Reaction:R-HLP-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Humulus lupulus var. lupulus [Reaction:R-CSC-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Cannabis sativa [Reaction:R-ATR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Amborella trichopoda [Reaction:R-TUR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Triticum urartu [Reaction:R-AOF-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Asparagus officinalis [Reaction:R-PSO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Papaver somniferum [Reaction:R-SCR-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Secale cereale [Reaction:R-ETE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Eragrostis tef [Reaction:R-ONI-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza nivara [Reaction:R-MES-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Manihot esculenta [Reaction:R-VFA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Vicia faba var. faba [Reaction:R-FVE-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Fragaria vesca [Reaction:R-BJU-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Brassica juncea
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-OSA-1119632] citrate <=> isocitrate - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120194
summation	[Summation:1173249] Mitochondrial isocitrate dehydrogenase catalyzes the reactio...

Referrals

(hasEvent)	[Pathway:R-OSA-1119533] TCA cycle (plant) - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120492] 2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - Oryza sativa