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isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+

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catalystActivity	[CatalystActivity:11266119] isocitrate dehydrogenase (NAD+) activity of IDH (NAD) complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11264714] Elser, Justin, 2025-03-26
dbId	11266121
displayName	isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+
eventOf	[Pathway:R-CCI-1119533] TCA cycle (plant) - Corymbia citriodora
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-CCI-1120492] 2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - Corymbia citriodora
inferredFrom	[Reaction:R-OSA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza sativa
input	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ Isocitrate dehydrogenase (NAD+)
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-CCI-1119632] citrate <=> isocitrate - Corymbia citriodora
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9823442] Corymbia citriodora
stId	R-CCI-1120194
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-CCI-1119533] TCA cycle (plant) - Corymbia citriodora
(precedingEvent)	[Reaction:R-CCI-1120492] 2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - Corymbia citriodora
(inferredTo)	[Reaction:R-OSA-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Oryza sativa