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oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH

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catalystActivity	[CatalystActivity:1118718] citrate (Si)-synthase activity of CSY [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1140381] RiceCyc:CITSYN-RXN
dbId	1120092
displayName	oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH
eventOf	[Pathway:R-OSA-1119533] TCA cycle (plant) - Oryza sativa
followingEvent	[Reaction:R-OSA-1119632] citrate <=> isocitrate - Oryza sativa
input	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH citrate synthesis
orthologousEvent	[Reaction:R-PSA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Pisum sativum [Reaction:R-SSP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Saccharum spontaneum [Reaction:R-DCA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Daucus carota [Reaction:R-ITR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Ipomoea triloba [Reaction:R-LPE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Leersia perrieri [Reaction:R-CBA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Chara braunii [Reaction:R-ADU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Arachis duranensis [Reaction:R-LSA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Lactuca sativa [Reaction:R-CQI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Chenopodium quinoa [Reaction:R-BNA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Brassica napus [Reaction:R-BOL-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Brassica oleracea [Reaction:R-PHH-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Panicum hallii var. hallii ("HAL2") [Reaction:R-CSK-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cannabis sativa subsp. indica [Reaction:R-DEX-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Digitaria exilis [Reaction:R-ATR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Amborella trichopoda [Reaction:R-VUN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Vigna unguiculata [Reaction:R-SVI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Setaria viridis [Reaction:R-PAB-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Picea abies [Reaction:R-CME-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cyanidioschyzon merolae [Reaction:R-CAN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Capsicum annuum [Reaction:R-PTI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Populus trichocarpa [Reaction:R-PAV-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Prunus avium [Reaction:R-FEX-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Fraxinus excelsior (European ash) [Reaction:R-PPE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Prunus persica [Reaction:R-CCD-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cynara cardunculus var. scolymus [Reaction:R-ATA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Aegilops tauschii [Reaction:R-CST-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Camelina sativa [Reaction:R-NCO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Nymphaea colorata [Reaction:R-CCA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cajanus cajan [Reaction:R-OES-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Olea europaea var. sylvestris [Reaction:R-SBI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Sorghum bicolor [Reaction:R-OBA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza barthii [Reaction:R-CSI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Citrus sinensis [Reaction:R-ECG-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Echinochloa crus-galli [Reaction:R-OMI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza minuta [Reaction:R-SHI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Salvia hispanica [Reaction:R-TUR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Triticum urartu [Reaction:R-VAN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Vigna angularis [Reaction:R-FCR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Ficus carica [Reaction:R-GSO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Glycine soja [Reaction:R-TTI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Triticum timopheevii subsp. timopheevii [Reaction:R-CML-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cucumis melo [Reaction:R-BVU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Beta vulgaris [Reaction:R-PVE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Pistacia vera [Reaction:R-CLA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Citrullus lanatus [Reaction:R-TTU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Triticum turgidum [Reaction:R-MDO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Malus domestica [Reaction:R-COL-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Corchorus olitorius [Reaction:R-TSP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Triticum spelta subsp. spelta [Reaction:R-SMO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Selaginella moellendorffii [Reaction:R-SCR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Secale cereale [Reaction:R-OGR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza meyeriana var. granulata [Reaction:R-DRO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Dioscorea rotundata [Reaction:R-AHA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Arabidopsis halleri [Reaction:R-QLO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Quercus lobata [Reaction:R-PSO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Papaver somniferum [Reaction:R-TPR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Trifolium pratense [Reaction:R-OLU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Ostreococcus lucimarinus [Reaction:R-VFA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Vicia faba var. faba [Reaction:R-MPO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Marchantia polymorpha [Reaction:R-HVU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Hordeum vulgare [Reaction:R-ACH-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Actinidia chinensis [Reaction:R-JRE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Juglans regia [Reaction:R-PHA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Panicum hallii ("FIL2") [Reaction:R-ETE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Eragrostis tef [Reaction:R-OGL-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza glaberrima [Reaction:R-ALY-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Arabidopsis lyrata [Reaction:R-RCH-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Rosa chinensis [Reaction:R-MGU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Erythranthe guttata [Reaction:R-ATH-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Arabidopsis thaliana [Reaction:R-AUM-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Aegilops umbellulata [Reaction:R-SIT-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Setaria italica [Reaction:R-MES-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Manihot esculenta [Reaction:R-PVU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Phaseolus vulgaris [Reaction:R-HLP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Humulus lupulus var. lupulus [Reaction:R-CCL-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Citrus clementina [Reaction:R-LST-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Lathyrus sativus [Reaction:R-CRE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Chlamydomonas reinhardtii [Reaction:R-HAN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Helianthus annuus [Reaction:R-ORU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza rufipogon [Reaction:R-OGU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza glumaepatula [Reaction:R-ZJA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Zoysia japonica [Reaction:R-BJU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Brassica juncea [Reaction:R-CAR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cicer arietinum [Reaction:R-CSC-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cannabis sativa [Reaction:R-OBR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza brachyantha [Reaction:R-LPR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Lolium perenne [Reaction:R-EGR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Eucalyptus grandis [Reaction:R-FVE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Fragaria vesca [Reaction:R-VVN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Vitis vinifera [Reaction:R-ONI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza nivara [Reaction:R-CSA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cucumis sativus [Reaction:R-ECU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Eragrostis curvula [Reaction:R-BRA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Brassica rapa [Reaction:R-PED-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Phyllostachys edulis [Reaction:R-SLY-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Solanum lycopersicum [Reaction:R-OOF-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza officinalis [Reaction:R-OME-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza meridionalis [Reaction:R-CCN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Coffea canephora [Reaction:R-ASA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Avena sativa [Reaction:R-ZMY-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Zea mays ver5 [Reaction:R-PTA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Pinus taeda [Reaction:R-NNU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Nelumbo nucifera [Reaction:R-OAU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza australiensis [Reaction:R-OPU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza punctata [Reaction:R-TDI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Triticum dicoccoides [Reaction:R-AIP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Arachis ipaensis [Reaction:R-ZMA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Zea mays [Reaction:R-LAN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Lupinus angustifolius [Reaction:R-TCA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Theobroma cacao [Reaction:R-MTR-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Medicago truncatula [Reaction:R-PPA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Physcomitrella patens [Reaction:R-AOF-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Asparagus officinalis [Reaction:R-OEU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Olea europaea [Reaction:R-ACO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Ananas comosus [Reaction:R-CRU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Capsella rubella [Reaction:R-NAT-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Nicotiana attenuata [Reaction:R-GRA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Gossypium raimondii [Reaction:R-CCI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Corymbia citriodora [Reaction:R-BDI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Brachypodium distachyon [Reaction:R-GMA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Glycine max [Reaction:R-VRA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Vigna radiata [Reaction:R-CCP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Corchorus capsularis [Reaction:R-GSU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Galdieria sulphuraria [Reaction:R-STU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Solanum tuberosum [Reaction:R-SIN-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Sesamum indicum [Reaction:R-OSI-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza sativa Indica Group [Reaction:R-PDA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Phoenix dactylifera [Reaction:R-TAE-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Triticum aestivum [Reaction:R-HLH-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Humulus lupulus [Reaction:R-AHY-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Arachis hypogaea [Reaction:R-QSU-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Quercus suber [Reaction:R-OLO-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza longistaminata
output	[SimpleEntity:R-ALL-29654] CIT [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:R-OSA-1120787] malate + NAD+ <=> oxaloacetate + NADH + H+ - Oryza sativa [Reaction:R-OSA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza sativa [Reaction:R-OSA-5146774] PYR [mitochondrial matrix]->Ac-CoA [mitochondrial matrix] - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120092
summation	[Summation:1173228] Citrate synthase in the mitochondrial matrix catalyzes the r...

Referrals

(hasEvent)	[Pathway:R-OSA-1119533] TCA cycle (plant) - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1119632] citrate <=> isocitrate - Oryza sativa