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pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+

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catalystActivity	[CatalystActivity:1118896] pyruvate dehydrogenase activity of PDH complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1169104] D'Eustachio, P, 2011-01-11
crossReference	[DatabaseIdentifier:1134476] RiceCyc:RXN0-1133 [DatabaseIdentifier:1152645] RiceCyc:RXN0-1132 [DatabaseIdentifier:1136107] RiceCyc:RXN0-1134
dbId	1169121
displayName	pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+
edited	[InstanceEdit:1169171] D'Eustachio, P, 2011-01-12
eventOf	[Pathway:R-OSA-1119351] Mitochondrial pyruvate metabolism - Oryza sativa
followingEvent	[Reaction:R-OSA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza sativa
input	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169161] Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis [LiteratureReference:1169167] The complex fate of alpha-ketoacids [LiteratureReference:1169168] Analysis of the rice mitochondrial carrier family reveals anaerobic accumulation of a basic amino acid carrier involved in arginine metabolism during seed germination
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+
orthologousEvent	[Reaction:R-OPU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza punctata [Reaction:R-AHA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Arabidopsis halleri [Reaction:R-ETE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Eragrostis tef [Reaction:R-ZMA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Zea mays [Reaction:R-SCR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Secale cereale [Reaction:R-CCN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Coffea canephora [Reaction:R-HLP-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Humulus lupulus var. lupulus [Reaction:R-VAN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Vigna angularis [Reaction:R-PSA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Pisum sativum [Reaction:R-ATA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Aegilops tauschii [Reaction:R-AUM-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Aegilops umbellulata [Reaction:R-LPR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Lolium perenne [Reaction:R-VRA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Vigna radiata [Reaction:R-ADU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Arachis duranensis [Reaction:R-CSA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cucumis sativus [Reaction:R-AHY-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Arachis hypogaea [Reaction:R-CRE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Chlamydomonas reinhardtii [Reaction:R-FEX-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Fraxinus excelsior (European ash) [Reaction:R-PTA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Pinus taeda [Reaction:R-SBI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Sorghum bicolor [Reaction:R-OLO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza longistaminata [Reaction:R-PVU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Phaseolus vulgaris [Reaction:R-CCD-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cynara cardunculus var. scolymus [Reaction:R-ZJA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Zoysia japonica [Reaction:R-RCH-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Rosa chinensis [Reaction:R-CAR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cicer arietinum [Reaction:R-CST-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Camelina sativa [Reaction:R-OAU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza australiensis [Reaction:R-BOL-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Brassica oleracea [Reaction:R-QSU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Quercus suber [Reaction:R-CBA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Chara braunii [Reaction:R-MTR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Medicago truncatula [Reaction:R-HVU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Hordeum vulgare [Reaction:R-MDO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Malus domestica [Reaction:R-OSI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza sativa Indica Group [Reaction:R-ASA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Avena sativa [Reaction:R-VVN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Vitis vinifera [Reaction:R-PTI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Populus trichocarpa [Reaction:R-DEX-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Digitaria exilis [Reaction:R-OOF-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza officinalis [Reaction:R-FVE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Fragaria vesca [Reaction:R-MES-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Manihot esculenta [Reaction:R-ZMY-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Zea mays ver5 [Reaction:R-SVI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Setaria viridis [Reaction:R-CSK-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cannabis sativa subsp. indica [Reaction:R-SIT-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Setaria italica [Reaction:R-VFA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Vicia faba var. faba [Reaction:R-AOF-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Asparagus officinalis [Reaction:R-NCO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Nymphaea colorata [Reaction:R-QLO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Quercus lobata [Reaction:R-OBR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza brachyantha [Reaction:R-OLU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Ostreococcus lucimarinus [Reaction:R-BNA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Brassica napus [Reaction:R-COL-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Corchorus olitorius [Reaction:R-ECG-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Echinochloa crus-galli [Reaction:R-JRE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Juglans regia [Reaction:R-PHH-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Panicum hallii var. hallii ("HAL2") [Reaction:R-TUR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Triticum urartu [Reaction:R-CAN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Capsicum annuum [Reaction:R-HAN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Helianthus annuus [Reaction:R-CCA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cajanus cajan [Reaction:R-SHI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Salvia hispanica [Reaction:R-LAN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Lupinus angustifolius [Reaction:R-CCI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Corymbia citriodora [Reaction:R-LPE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Leersia perrieri [Reaction:R-CSC-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cannabis sativa [Reaction:R-BVU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Beta vulgaris [Reaction:R-PHA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Panicum hallii ("FIL2") [Reaction:R-MAC-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Musa acuminata [Reaction:R-ORU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza rufipogon [Reaction:R-BDI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Brachypodium distachyon [Reaction:R-CQI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Chenopodium quinoa [Reaction:R-PPE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Prunus persica [Reaction:R-BRA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Brassica rapa [Reaction:R-TAE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Triticum aestivum [Reaction:R-ATH-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Arabidopsis thaliana [Reaction:R-ECU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Eragrostis curvula [Reaction:R-PVE-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Pistacia vera [Reaction:R-OBA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza barthii [Reaction:R-OES-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Olea europaea var. sylvestris [Reaction:R-DRO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Dioscorea rotundata [Reaction:R-SIN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Sesamum indicum [Reaction:R-TCA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Theobroma cacao [Reaction:R-CCP-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Corchorus capsularis [Reaction:R-NAT-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Nicotiana attenuata [Reaction:R-CSI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Citrus sinensis [Reaction:R-PAB-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Picea abies [Reaction:R-GSO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Glycine soja [Reaction:R-CRU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Capsella rubella [Reaction:R-AIP-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Arachis ipaensis [Reaction:R-OEU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Olea europaea [Reaction:R-BJU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Brassica juncea [Reaction:R-SLY-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Solanum lycopersicum [Reaction:R-STU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Solanum tuberosum [Reaction:R-MPO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Marchantia polymorpha [Reaction:R-PPA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Physcomitrella patens [Reaction:R-OGL-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza glaberrima [Reaction:R-SMO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Selaginella moellendorffii [Reaction:R-CLA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Citrullus lanatus [Reaction:R-TDI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Triticum dicoccoides [Reaction:R-ALY-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Arabidopsis lyrata [Reaction:R-VUN-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Vigna unguiculata [Reaction:R-PED-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Phyllostachys edulis [Reaction:R-PDA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Phoenix dactylifera [Reaction:R-ONI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza nivara [Reaction:R-OMI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza minuta [Reaction:R-TSP-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Triticum spelta subsp. spelta [Reaction:R-TTU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Triticum turgidum [Reaction:R-JCU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Jatropha curcas [Reaction:R-TPR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Trifolium pratense [Reaction:R-OGR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza meyeriana var. granulata [Reaction:R-NNU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Nelumbo nucifera [Reaction:R-LSA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Lactuca sativa [Reaction:R-CCR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Chondrus crispus [Reaction:R-LST-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Lathyrus sativus [Reaction:R-FCR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Ficus carica [Reaction:R-GSU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Galdieria sulphuraria [Reaction:R-EGR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Eucalyptus grandis [Reaction:R-CME-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cyanidioschyzon merolae [Reaction:R-TTI-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Triticum timopheevii subsp. timopheevii [Reaction:R-OGU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza glumaepatula [Reaction:R-PSO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Papaver somniferum [Reaction:R-MGU-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Erythranthe guttata [Reaction:R-ACO-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Ananas comosus [Reaction:R-PAV-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Prunus avium [Reaction:R-HLH-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Humulus lupulus [Reaction:R-GRA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Gossypium raimondii [Reaction:R-GMA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Glycine max [Reaction:R-ATR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Amborella trichopoda [Reaction:R-CCL-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Citrus clementina [Reaction:R-SSP-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Saccharum spontaneum [Reaction:R-CML-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Cucumis melo [Reaction:R-DCA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Daucus carota [Reaction:R-OME-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza meridionalis [Reaction:R-ACH-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Actinidia chinensis [Reaction:R-ITR-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Ipomoea triloba
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-OSA-1169102] Mitochondrial pyruvate uptake - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1169121
summation	[Summation:1169169] The pyruvate dehydrogenase (PDH) complex in the mitochondria...

Referrals

(hasEvent)	[Pathway:R-OSA-1119351] Mitochondrial pyruvate metabolism - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Oryza sativa