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dihydrofolate reductase

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catalystActivity	[CatalystActivity:1118877] dihydrofolate reductase activity of dihydrofolate reductase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26862] EC:1.5.1.3 [DatabaseIdentifier:1146742] RiceCyc:DIHYDROFOLATEREDUCT-RXN
dbId	1120019
displayName	dihydrofolate reductase
eventOf	[Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa [Pathway:R-OSA-1119265] Tetrahydrofolate biosynthesis I - Oryza sativa
followingEvent	[Reaction:R-OSA-1121174] Glycine hydroxymethyltransferase - Oryza sativa [Reaction:R-OSA-2871176] Glycine hydroxymethyltransferase II - Oryza sativa [Reaction:R-OSA-1120960] tetrahydrofolate synthase - Oryza sativa [Reaction:R-OSA-1119640] folylpolyglutamate synthetase - Oryza sativa
input	[SimpleEntity:R-ALL-73604] DHF [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11529250] Elser, Justin, 2025-03-27
name	dihydrofolate reductase Tetrahydrofolate dehydrogenase biochemicalReaction79703
orthologousEvent	[Reaction:R-ATA-1120019] dihydrofolate reductase - Aegilops tauschii [Reaction:R-SVI-1120019] dihydrofolate reductase - Setaria viridis [Reaction:R-PSA-1120019] dihydrofolate reductase - Pisum sativum [Reaction:R-FVE-1120019] dihydrofolate reductase - Fragaria vesca [Reaction:R-NAT-1120019] dihydrofolate reductase - Nicotiana attenuata [Reaction:R-VRA-1120019] dihydrofolate reductase - Vigna radiata [Reaction:R-CME-1120019] dihydrofolate reductase - Cyanidioschyzon merolae [Reaction:R-TDI-1120019] dihydrofolate reductase - Triticum dicoccoides [Reaction:R-QSU-1120019] dihydrofolate reductase - Quercus suber [Reaction:R-PPA-1120019] dihydrofolate reductase - Physcomitrella patens [Reaction:R-ORU-1120019] dihydrofolate reductase - Oryza rufipogon [Reaction:R-GMA-1120019] dihydrofolate reductase - Glycine max [Reaction:R-LST-1120019] dihydrofolate reductase - Lathyrus sativus [Reaction:R-CCL-1120019] dihydrofolate reductase - Citrus clementina [Reaction:R-GSU-1120019] dihydrofolate reductase - Galdieria sulphuraria [Reaction:R-OES-1120019] dihydrofolate reductase - Olea europaea var. sylvestris [Reaction:R-HLP-1120019] dihydrofolate reductase - Humulus lupulus var. lupulus [Reaction:R-TTU-1120019] dihydrofolate reductase - Triticum turgidum [Reaction:R-GSO-1120019] dihydrofolate reductase - Glycine soja [Reaction:R-HVU-1120019] dihydrofolate reductase - Hordeum vulgare [Reaction:R-MPO-1120019] dihydrofolate reductase - Marchantia polymorpha [Reaction:R-SCR-1120019] dihydrofolate reductase - Secale cereale [Reaction:R-PED-1120019] dihydrofolate reductase - Phyllostachys edulis [Reaction:R-TSP-1120019] dihydrofolate reductase - Triticum spelta subsp. spelta [Reaction:R-PTA-1120019] dihydrofolate reductase - Pinus taeda [Reaction:R-CCD-1120019] dihydrofolate reductase - Cynara cardunculus var. scolymus [Reaction:R-CCN-1120019] dihydrofolate reductase - Coffea canephora [Reaction:R-MTR-1120019] dihydrofolate reductase - Medicago truncatula [Reaction:R-ALY-1120019] dihydrofolate reductase - Arabidopsis lyrata [Reaction:R-AHA-1120019] dihydrofolate reductase - Arabidopsis halleri [Reaction:R-LSA-1120019] dihydrofolate reductase - Lactuca sativa [Reaction:R-SIN-1120019] dihydrofolate reductase - Sesamum indicum [Reaction:R-OAU-1120019] dihydrofolate reductase - Oryza australiensis [Reaction:R-TCA-1120019] dihydrofolate reductase - Theobroma cacao [Reaction:R-GRA-1120019] dihydrofolate reductase - Gossypium raimondii [Reaction:R-CAR-1120019] dihydrofolate reductase - Cicer arietinum [Reaction:R-LPR-1120019] dihydrofolate reductase - Lolium perenne [Reaction:R-OLU-1120019] dihydrofolate reductase - Ostreococcus lucimarinus [Reaction:R-PVE-1120019] dihydrofolate reductase - Pistacia vera [Reaction:R-OBR-1120019] dihydrofolate reductase - Oryza brachyantha [Reaction:R-ZMA-1120019] dihydrofolate reductase - Zea mays [Reaction:R-OGR-1120019] dihydrofolate reductase - Oryza meyeriana var. granulata [Reaction:R-BDI-1120019] dihydrofolate reductase - Brachypodium distachyon [Reaction:R-QLO-1120019] dihydrofolate reductase - Quercus lobata [Reaction:R-RCH-1120019] dihydrofolate reductase - Rosa chinensis [Reaction:R-OME-1120019] dihydrofolate reductase - Oryza meridionalis [Reaction:R-ASA-1120019] dihydrofolate reductase - Avena sativa [Reaction:R-STU-1120019] dihydrofolate reductase - Solanum tuberosum [Reaction:R-PAV-1120019] dihydrofolate reductase - Prunus avium [Reaction:R-EGR-1120019] dihydrofolate reductase - Eucalyptus grandis [Reaction:R-OLO-1120019] dihydrofolate reductase - Oryza longistaminata [Reaction:R-TTI-1120019] dihydrofolate reductase - Triticum timopheevii subsp. timopheevii [Reaction:R-PAB-1120019] dihydrofolate reductase - Picea abies [Reaction:R-ZMY-1120019] dihydrofolate reductase - Zea mays ver5 [Reaction:R-CCI-1120019] dihydrofolate reductase - Corymbia citriodora [Reaction:R-AIP-1120019] dihydrofolate reductase - Arachis ipaensis [Reaction:R-CLA-1120019] dihydrofolate reductase - Citrullus lanatus [Reaction:R-PTI-1120019] dihydrofolate reductase - Populus trichocarpa [Reaction:R-ONI-1120019] dihydrofolate reductase - Oryza nivara [Reaction:R-CST-1120019] dihydrofolate reductase - Camelina sativa [Reaction:R-SIT-1120019] dihydrofolate reductase - Setaria italica [Reaction:R-PPE-1120019] dihydrofolate reductase - Prunus persica [Reaction:R-CSK-1120019] dihydrofolate reductase - Cannabis sativa subsp. indica [Reaction:R-SLY-1120019] dihydrofolate reductase - Solanum lycopersicum [Reaction:R-ATR-1120019] dihydrofolate reductase - Amborella trichopoda [Reaction:R-JRE-1120019] dihydrofolate reductase - Juglans regia [Reaction:R-MDO-1120019] dihydrofolate reductase - Malus domestica [Reaction:R-CSC-1120019] dihydrofolate reductase - Cannabis sativa [Reaction:R-SSP-1120019] dihydrofolate reductase - Saccharum spontaneum [Reaction:R-CCR-1120019] dihydrofolate reductase - Chondrus crispus [Reaction:R-MAC-1120019] dihydrofolate reductase - Musa acuminata [Reaction:R-LPE-1120019] dihydrofolate reductase - Leersia perrieri [Reaction:R-ITR-1120019] dihydrofolate reductase - Ipomoea triloba [Reaction:R-DEX-1120019] dihydrofolate reductase - Digitaria exilis [Reaction:R-AUM-1120019] dihydrofolate reductase - Aegilops umbellulata [Reaction:R-SMO-1120019] dihydrofolate reductase - Selaginella moellendorffii [Reaction:R-TPR-1120019] dihydrofolate reductase - Trifolium pratense [Reaction:R-CSI-1120019] dihydrofolate reductase - Citrus sinensis [Reaction:R-CCA-1120019] dihydrofolate reductase - Cajanus cajan [Reaction:R-OMI-1120019] dihydrofolate reductase - Oryza minuta [Reaction:R-VUN-1120019] dihydrofolate reductase - Vigna unguiculata [Reaction:R-CSA-1120019] dihydrofolate reductase - Cucumis sativus [Reaction:R-LAN-1120019] dihydrofolate reductase - Lupinus angustifolius [Reaction:R-ACO-1120019] dihydrofolate reductase - Ananas comosus [Reaction:R-FEX-1120019] dihydrofolate reductase - Fraxinus excelsior (European ash) [Reaction:R-BRA-1120019] dihydrofolate reductase - Brassica rapa [Reaction:R-JCU-1120019] dihydrofolate reductase - Jatropha curcas [Reaction:R-ETE-1120019] dihydrofolate reductase - Eragrostis tef [Reaction:R-OOF-1120019] dihydrofolate reductase - Oryza officinalis [Reaction:R-ECU-1120019] dihydrofolate reductase - Eragrostis curvula [Reaction:R-CRE-1120019] dihydrofolate reductase - Chlamydomonas reinhardtii [Reaction:R-CBA-1120019] dihydrofolate reductase - Chara braunii [Reaction:R-CAN-1120019] dihydrofolate reductase - Capsicum annuum [Reaction:R-CQI-1120019] dihydrofolate reductase - Chenopodium quinoa [Reaction:R-TUR-1120019] dihydrofolate reductase - Triticum urartu [Reaction:R-VFA-1120019] dihydrofolate reductase - Vicia faba var. faba [Reaction:R-PHA-1120019] dihydrofolate reductase - Panicum hallii ("FIL2") [Reaction:R-HLH-1120019] dihydrofolate reductase - Humulus lupulus [Reaction:R-ADU-1120019] dihydrofolate reductase - Arachis duranensis [Reaction:R-BVU-1120019] dihydrofolate reductase - Beta vulgaris [Reaction:R-HAN-1120019] dihydrofolate reductase - Helianthus annuus [Reaction:R-FCR-1120019] dihydrofolate reductase - Ficus carica [Reaction:R-PSO-1120019] dihydrofolate reductase - Papaver somniferum [Reaction:R-DRO-1120019] dihydrofolate reductase - Dioscorea rotundata [Reaction:R-OSI-1120019] dihydrofolate reductase - Oryza sativa Indica Group [Reaction:R-MGU-1120019] dihydrofolate reductase - Erythranthe guttata [Reaction:R-PDA-1120019] dihydrofolate reductase - Phoenix dactylifera [Reaction:R-VAN-1120019] dihydrofolate reductase - Vigna angularis [Reaction:R-DCA-1120019] dihydrofolate reductase - Daucus carota [Reaction:R-ATH-1120019] dihydrofolate reductase - Arabidopsis thaliana [Reaction:R-CML-1120019] dihydrofolate reductase - Cucumis melo [Reaction:R-OBA-1120019] dihydrofolate reductase - Oryza barthii [Reaction:R-BNA-1120019] dihydrofolate reductase - Brassica napus [Reaction:R-PHH-1120019] dihydrofolate reductase - Panicum hallii var. hallii ("HAL2") [Reaction:R-OPU-1120019] dihydrofolate reductase - Oryza punctata [Reaction:R-NCO-1120019] dihydrofolate reductase - Nymphaea colorata [Reaction:R-VVN-1120019] dihydrofolate reductase - Vitis vinifera [Reaction:R-COL-1120019] dihydrofolate reductase - Corchorus olitorius [Reaction:R-PVU-1120019] dihydrofolate reductase - Phaseolus vulgaris [Reaction:R-NNU-1120019] dihydrofolate reductase - Nelumbo nucifera [Reaction:R-OEU-1120019] dihydrofolate reductase - Olea europaea [Reaction:R-TAE-1120019] dihydrofolate reductase - Triticum aestivum [Reaction:R-OGL-1120019] dihydrofolate reductase - Oryza glaberrima [Reaction:R-ECG-1120019] dihydrofolate reductase - Echinochloa crus-galli [Reaction:R-SBI-1120019] dihydrofolate reductase - Sorghum bicolor [Reaction:R-AOF-1120019] dihydrofolate reductase - Asparagus officinalis [Reaction:R-CRU-1120019] dihydrofolate reductase - Capsella rubella [Reaction:R-BOL-1120019] dihydrofolate reductase - Brassica oleracea [Reaction:R-AHY-1120019] dihydrofolate reductase - Arachis hypogaea [Reaction:R-OGU-1120019] dihydrofolate reductase - Oryza glumaepatula [Reaction:R-ACH-1120019] dihydrofolate reductase - Actinidia chinensis [Reaction:R-BJU-1120019] dihydrofolate reductase - Brassica juncea
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-OSA-1121366] dihydrofolate synthetase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120019
summation	[Summation:2873191] 7,8-dihydrofolate is converted to tetrahydrofolate by enzyma...

Referrals

(hasEvent)	[Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa [Pathway:R-OSA-1119265] Tetrahydrofolate biosynthesis I - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120960] tetrahydrofolate synthase - Oryza sativa [Reaction:R-OSA-1119640] folylpolyglutamate synthetase - Oryza sativa [Reaction:R-OSA-1121174] Glycine hydroxymethyltransferase - Oryza sativa [Reaction:R-OSA-2871176] Glycine hydroxymethyltransferase II - Oryza sativa