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folylpolyglutamate synthetase

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catalystActivity	[CatalystActivity:1118617] tetrahydrofolylpolyglutamate synthase activity of tetrahydrofolate synthase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:28138] EC:6.3.2.17 [DatabaseIdentifier:1139496] RiceCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
dbId	1119640
displayName	folylpolyglutamate synthetase
eventOf	[Pathway:R-OSA-1119617] Folate polyglutamylation I - Oryza sativa [Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa
input	[SimpleEntity:R-ALL-1131065] a tetrahydrofolate polyglutamate [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	folylpolyglutamate synthetase folylpolyglutamyl synthetase folate polyglutamate synthetase folylpoly-γ-glutamate synthetase biochemicalReaction6891
orthologousEvent	[Reaction:R-VVN-1119640] folylpolyglutamate synthetase - Vitis vinifera [Reaction:R-SVI-1119640] folylpolyglutamate synthetase - Setaria viridis [Reaction:R-AIP-1119640] folylpolyglutamate synthetase - Arachis ipaensis [Reaction:R-SHI-1119640] folylpolyglutamate synthetase - Salvia hispanica [Reaction:R-PPA-1119640] folylpolyglutamate synthetase - Physcomitrella patens [Reaction:R-MAC-1119640] folylpolyglutamate synthetase - Musa acuminata [Reaction:R-CML-1119640] folylpolyglutamate synthetase - Cucumis melo [Reaction:R-CST-1119640] folylpolyglutamate synthetase - Camelina sativa [Reaction:R-DEX-1119640] folylpolyglutamate synthetase - Digitaria exilis [Reaction:R-MES-1119640] folylpolyglutamate synthetase - Manihot esculenta [Reaction:R-LPR-1119640] folylpolyglutamate synthetase - Lolium perenne [Reaction:R-BRA-1119640] folylpolyglutamate synthetase - Brassica rapa [Reaction:R-AOF-1119640] folylpolyglutamate synthetase - Asparagus officinalis [Reaction:R-OGU-1119640] folylpolyglutamate synthetase - Oryza glumaepatula [Reaction:R-SIN-1119640] folylpolyglutamate synthetase - Sesamum indicum [Reaction:R-VRA-1119640] folylpolyglutamate synthetase - Vigna radiata [Reaction:R-GMA-1119640] folylpolyglutamate synthetase - Glycine max [Reaction:R-TAE-1119640] folylpolyglutamate synthetase - Triticum aestivum [Reaction:R-SLY-1119640] folylpolyglutamate synthetase - Solanum lycopersicum [Reaction:R-CAR-1119640] folylpolyglutamate synthetase - Cicer arietinum [Reaction:R-PSA-1119640] folylpolyglutamate synthetase - Pisum sativum [Reaction:R-PPE-1119640] folylpolyglutamate synthetase - Prunus persica [Reaction:R-ATA-1119640] folylpolyglutamate synthetase - Aegilops tauschii [Reaction:R-HAN-1119640] folylpolyglutamate synthetase - Helianthus annuus [Reaction:R-CRE-1119640] folylpolyglutamate synthetase - Chlamydomonas reinhardtii [Reaction:R-ITR-1119640] folylpolyglutamate synthetase - Ipomoea triloba [Reaction:R-AUM-1119640] folylpolyglutamate synthetase - Aegilops umbellulata [Reaction:R-BJU-1119640] folylpolyglutamate synthetase - Brassica juncea [Reaction:R-ZMA-1119640] folylpolyglutamate synthetase - Zea mays [Reaction:R-ECU-1119640] folylpolyglutamate synthetase - Eragrostis curvula [Reaction:R-RCH-1119640] folylpolyglutamate synthetase - Rosa chinensis [Reaction:R-GRA-1119640] folylpolyglutamate synthetase - Gossypium raimondii [Reaction:R-VFA-1119640] folylpolyglutamate synthetase - Vicia faba var. faba [Reaction:R-PAV-1119640] folylpolyglutamate synthetase - Prunus avium [Reaction:R-LAN-1119640] folylpolyglutamate synthetase - Lupinus angustifolius [Reaction:R-TUR-1119640] folylpolyglutamate synthetase - Triticum urartu [Reaction:R-BDI-1119640] folylpolyglutamate synthetase - Brachypodium distachyon [Reaction:R-OLO-1119640] folylpolyglutamate synthetase - Oryza longistaminata [Reaction:R-CSK-1119640] folylpolyglutamate synthetase - Cannabis sativa subsp. indica [Reaction:R-AHA-1119640] folylpolyglutamate synthetase - Arabidopsis halleri [Reaction:R-PHA-1119640] folylpolyglutamate synthetase - Panicum hallii ("FIL2") [Reaction:R-BVU-1119640] folylpolyglutamate synthetase - Beta vulgaris [Reaction:R-ATH-1119640] folylpolyglutamate synthetase - Arabidopsis thaliana [Reaction:R-HLP-1119640] folylpolyglutamate synthetase - Humulus lupulus var. lupulus [Reaction:R-QSU-1119640] folylpolyglutamate synthetase - Quercus suber [Reaction:R-MPO-1119640] folylpolyglutamate synthetase - Marchantia polymorpha [Reaction:R-OBA-1119640] folylpolyglutamate synthetase - Oryza barthii [Reaction:R-SMO-1119640] folylpolyglutamate synthetase - Selaginella moellendorffii [Reaction:R-SSP-1119640] folylpolyglutamate synthetase - Saccharum spontaneum [Reaction:R-CSA-1119640] folylpolyglutamate synthetase - Cucumis sativus [Reaction:R-ADU-1119640] folylpolyglutamate synthetase - Arachis duranensis [Reaction:R-MTR-1119640] folylpolyglutamate synthetase - Medicago truncatula [Reaction:R-ZJA-1119640] folylpolyglutamate synthetase - Zoysia japonica [Reaction:R-OOF-1119640] folylpolyglutamate synthetase - Oryza officinalis [Reaction:R-PVE-1119640] folylpolyglutamate synthetase - Pistacia vera [Reaction:R-PTI-1119640] folylpolyglutamate synthetase - Populus trichocarpa [Reaction:R-LPE-1119640] folylpolyglutamate synthetase - Leersia perrieri [Reaction:R-STU-1119640] folylpolyglutamate synthetase - Solanum tuberosum [Reaction:R-ETE-1119640] folylpolyglutamate synthetase - Eragrostis tef [Reaction:R-TPR-1119640] folylpolyglutamate synthetase - Trifolium pratense [Reaction:R-CRU-1119640] folylpolyglutamate synthetase - Capsella rubella [Reaction:R-OPU-1119640] folylpolyglutamate synthetase - Oryza punctata [Reaction:R-BNA-1119640] folylpolyglutamate synthetase - Brassica napus [Reaction:R-PTA-1119640] folylpolyglutamate synthetase - Pinus taeda [Reaction:R-LST-1119640] folylpolyglutamate synthetase - Lathyrus sativus [Reaction:R-ALY-1119640] folylpolyglutamate synthetase - Arabidopsis lyrata [Reaction:R-ZMY-1119640] folylpolyglutamate synthetase - Zea mays ver5 [Reaction:R-PHH-1119640] folylpolyglutamate synthetase - Panicum hallii var. hallii ("HAL2") [Reaction:R-OSI-1119640] folylpolyglutamate synthetase - Oryza sativa Indica Group [Reaction:R-COL-1119640] folylpolyglutamate synthetase - Corchorus olitorius [Reaction:R-PVU-1119640] folylpolyglutamate synthetase - Phaseolus vulgaris [Reaction:R-CCP-1119640] folylpolyglutamate synthetase - Corchorus capsularis [Reaction:R-CLA-1119640] folylpolyglutamate synthetase - Citrullus lanatus [Reaction:R-EGR-1119640] folylpolyglutamate synthetase - Eucalyptus grandis [Reaction:R-TCA-1119640] folylpolyglutamate synthetase - Theobroma cacao [Reaction:R-OGR-1119640] folylpolyglutamate synthetase - Oryza meyeriana var. granulata [Reaction:R-ACH-1119640] folylpolyglutamate synthetase - Actinidia chinensis [Reaction:R-FEX-1119640] folylpolyglutamate synthetase - Fraxinus excelsior (European ash) [Reaction:R-OEU-1119640] folylpolyglutamate synthetase - Olea europaea [Reaction:R-CCI-1119640] folylpolyglutamate synthetase - Corymbia citriodora [Reaction:R-MGU-1119640] folylpolyglutamate synthetase - Erythranthe guttata [Reaction:R-ATR-1119640] folylpolyglutamate synthetase - Amborella trichopoda [Reaction:R-TTU-1119640] folylpolyglutamate synthetase - Triticum turgidum [Reaction:R-SIT-1119640] folylpolyglutamate synthetase - Setaria italica [Reaction:R-TTI-1119640] folylpolyglutamate synthetase - Triticum timopheevii subsp. timopheevii [Reaction:R-VUN-1119640] folylpolyglutamate synthetase - Vigna unguiculata [Reaction:R-LSA-1119640] folylpolyglutamate synthetase - Lactuca sativa [Reaction:R-QLO-1119640] folylpolyglutamate synthetase - Quercus lobata [Reaction:R-CBA-1119640] folylpolyglutamate synthetase - Chara braunii [Reaction:R-CSI-1119640] folylpolyglutamate synthetase - Citrus sinensis [Reaction:R-ONI-1119640] folylpolyglutamate synthetase - Oryza nivara [Reaction:R-ORU-1119640] folylpolyglutamate synthetase - Oryza rufipogon [Reaction:R-GSO-1119640] folylpolyglutamate synthetase - Glycine soja [Reaction:R-OMI-1119640] folylpolyglutamate synthetase - Oryza minuta [Reaction:R-PAB-1119640] folylpolyglutamate synthetase - Picea abies [Reaction:R-FCR-1119640] folylpolyglutamate synthetase - Ficus carica [Reaction:R-OAU-1119640] folylpolyglutamate synthetase - Oryza australiensis [Reaction:R-OES-1119640] folylpolyglutamate synthetase - Olea europaea var. sylvestris [Reaction:R-HLH-1119640] folylpolyglutamate synthetase - Humulus lupulus [Reaction:R-OGL-1119640] folylpolyglutamate synthetase - Oryza glaberrima [Reaction:R-DRO-1119640] folylpolyglutamate synthetase - Dioscorea rotundata [Reaction:R-NAT-1119640] folylpolyglutamate synthetase - Nicotiana attenuata [Reaction:R-MDO-1119640] folylpolyglutamate synthetase - Malus domestica [Reaction:R-VAN-1119640] folylpolyglutamate synthetase - Vigna angularis [Reaction:R-ECG-1119640] folylpolyglutamate synthetase - Echinochloa crus-galli [Reaction:R-AHY-1119640] folylpolyglutamate synthetase - Arachis hypogaea [Reaction:R-CQI-1119640] folylpolyglutamate synthetase - Chenopodium quinoa [Reaction:R-BOL-1119640] folylpolyglutamate synthetase - Brassica oleracea [Reaction:R-ACO-1119640] folylpolyglutamate synthetase - Ananas comosus [Reaction:R-OME-1119640] folylpolyglutamate synthetase - Oryza meridionalis [Reaction:R-PED-1119640] folylpolyglutamate synthetase - Phyllostachys edulis [Reaction:R-OLU-1119640] folylpolyglutamate synthetase - Ostreococcus lucimarinus [Reaction:R-ASA-1119640] folylpolyglutamate synthetase - Avena sativa [Reaction:R-NNU-1119640] folylpolyglutamate synthetase - Nelumbo nucifera [Reaction:R-PSO-1119640] folylpolyglutamate synthetase - Papaver somniferum [Reaction:R-DCA-1119640] folylpolyglutamate synthetase - Daucus carota [Reaction:R-FVE-1119640] folylpolyglutamate synthetase - Fragaria vesca [Reaction:R-CAN-1119640] folylpolyglutamate synthetase - Capsicum annuum [Reaction:R-JRE-1119640] folylpolyglutamate synthetase - Juglans regia [Reaction:R-CCD-1119640] folylpolyglutamate synthetase - Cynara cardunculus var. scolymus [Reaction:R-NCO-1119640] folylpolyglutamate synthetase - Nymphaea colorata [Reaction:R-CCN-1119640] folylpolyglutamate synthetase - Coffea canephora [Reaction:R-CSC-1119640] folylpolyglutamate synthetase - Cannabis sativa [Reaction:R-SPC-1119640] folylpolyglutamate synthetase - Synechocystis sp. PCC 6803 [Reaction:R-PDA-1119640] folylpolyglutamate synthetase - Phoenix dactylifera [Reaction:R-CCL-1119640] folylpolyglutamate synthetase - Citrus clementina [Reaction:R-TDI-1119640] folylpolyglutamate synthetase - Triticum dicoccoides [Reaction:R-JCU-1119640] folylpolyglutamate synthetase - Jatropha curcas [Reaction:R-OBR-1119640] folylpolyglutamate synthetase - Oryza brachyantha [Reaction:R-CCA-1119640] folylpolyglutamate synthetase - Cajanus cajan [Reaction:R-SBI-1119640] folylpolyglutamate synthetase - Sorghum bicolor [Reaction:R-SCR-1119640] folylpolyglutamate synthetase - Secale cereale [Reaction:R-TSP-1119640] folylpolyglutamate synthetase - Triticum spelta subsp. spelta [Reaction:R-HVU-1119640] folylpolyglutamate synthetase - Hordeum vulgare
output	[SimpleEntity:R-ALL-1131065] a tetrahydrofolate polyglutamate [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-OSA-1120019] dihydrofolate reductase - Oryza sativa [Reaction:R-OSA-1121174] Glycine hydroxymethyltransferase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1119640
summation	[Summation:2871174] A tetrahydrofolate polyglutamate is converted into A tetrahy...

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