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tetrahydrofolate synthase

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catalystActivity	[CatalystActivity:1118365] tetrahydrofolylpolyglutamate synthase activity of tetrahydrofolate synthase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:28138] EC:6.3.2.17 [DatabaseIdentifier:1152432] RiceCyc:RXN-6102
dbId	1120960
displayName	tetrahydrofolate synthase
eventOf	[Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	tetrahydrofolate synthase tetrahydrofolate+L-glutamate+ATP->THF-L-glutamate+ADP+phosphate RXN-6102 biochemicalReaction6727
orthologousEvent	[Reaction:R-MTR-1120960] tetrahydrofolate synthase - Medicago truncatula [Reaction:R-ZMY-1120960] tetrahydrofolate synthase - Zea mays ver5 [Reaction:R-OGR-1120960] tetrahydrofolate synthase - Oryza meyeriana var. granulata [Reaction:R-CST-1120960] tetrahydrofolate synthase - Camelina sativa [Reaction:R-MES-1120960] tetrahydrofolate synthase - Manihot esculenta [Reaction:R-STU-1120960] tetrahydrofolate synthase - Solanum tuberosum [Reaction:R-NCO-1120960] tetrahydrofolate synthase - Nymphaea colorata [Reaction:R-BNA-1120960] tetrahydrofolate synthase - Brassica napus [Reaction:R-CCL-1120960] tetrahydrofolate synthase - Citrus clementina [Reaction:R-HVU-1120960] tetrahydrofolate synthase - Hordeum vulgare [Reaction:R-VRA-1120960] tetrahydrofolate synthase - Vigna radiata [Reaction:R-DCA-1120960] tetrahydrofolate synthase - Daucus carota [Reaction:R-MDO-1120960] tetrahydrofolate synthase - Malus domestica [Reaction:R-LAN-1120960] tetrahydrofolate synthase - Lupinus angustifolius [Reaction:R-LPR-1120960] tetrahydrofolate synthase - Lolium perenne [Reaction:R-TTI-1120960] tetrahydrofolate synthase - Triticum timopheevii subsp. timopheevii [Reaction:R-SIT-1120960] tetrahydrofolate synthase - Setaria italica [Reaction:R-PDA-1120960] tetrahydrofolate synthase - Phoenix dactylifera [Reaction:R-ACO-1120960] tetrahydrofolate synthase - Ananas comosus [Reaction:R-AOF-1120960] tetrahydrofolate synthase - Asparagus officinalis [Reaction:R-CML-1120960] tetrahydrofolate synthase - Cucumis melo [Reaction:R-PAV-1120960] tetrahydrofolate synthase - Prunus avium [Reaction:R-PVE-1120960] tetrahydrofolate synthase - Pistacia vera [Reaction:R-TSP-1120960] tetrahydrofolate synthase - Triticum spelta subsp. spelta [Reaction:R-HLP-1120960] tetrahydrofolate synthase - Humulus lupulus var. lupulus [Reaction:R-PHH-1120960] tetrahydrofolate synthase - Panicum hallii var. hallii ("HAL2") [Reaction:R-PVU-1120960] tetrahydrofolate synthase - Phaseolus vulgaris [Reaction:R-QLO-1120960] tetrahydrofolate synthase - Quercus lobata [Reaction:R-CCN-1120960] tetrahydrofolate synthase - Coffea canephora [Reaction:R-FCR-1120960] tetrahydrofolate synthase - Ficus carica [Reaction:R-CQI-1120960] tetrahydrofolate synthase - Chenopodium quinoa [Reaction:R-PED-1120960] tetrahydrofolate synthase - Phyllostachys edulis [Reaction:R-OPU-1120960] tetrahydrofolate synthase - Oryza punctata [Reaction:R-DRO-1120960] tetrahydrofolate synthase - Dioscorea rotundata [Reaction:R-OBR-1120960] tetrahydrofolate synthase - Oryza brachyantha [Reaction:R-ETE-1120960] tetrahydrofolate synthase - Eragrostis tef [Reaction:R-PPA-1120960] tetrahydrofolate synthase - Physcomitrella patens [Reaction:R-FVE-1120960] tetrahydrofolate synthase - Fragaria vesca [Reaction:R-MAC-1120960] tetrahydrofolate synthase - Musa acuminata [Reaction:R-ALY-1120960] tetrahydrofolate synthase - Arabidopsis lyrata [Reaction:R-SBI-1120960] tetrahydrofolate synthase - Sorghum bicolor [Reaction:R-TAE-1120960] tetrahydrofolate synthase - Triticum aestivum [Reaction:R-TDI-1120960] tetrahydrofolate synthase - Triticum dicoccoides [Reaction:R-PSO-1120960] tetrahydrofolate synthase - Papaver somniferum [Reaction:R-PHA-1120960] tetrahydrofolate synthase - Panicum hallii ("FIL2") [Reaction:R-CSK-1120960] tetrahydrofolate synthase - Cannabis sativa subsp. indica [Reaction:R-SPC-1120960] tetrahydrofolate synthase - Synechocystis sp. PCC 6803 [Reaction:R-OSI-1120960] tetrahydrofolate synthase - Oryza sativa Indica Group [Reaction:R-OLO-1120960] tetrahydrofolate synthase - Oryza longistaminata [Reaction:R-ZJA-1120960] tetrahydrofolate synthase - Zoysia japonica [Reaction:R-BOL-1120960] tetrahydrofolate synthase - Brassica oleracea [Reaction:R-DEX-1120960] tetrahydrofolate synthase - Digitaria exilis [Reaction:R-ECG-1120960] tetrahydrofolate synthase - Echinochloa crus-galli [Reaction:R-NAT-1120960] tetrahydrofolate synthase - Nicotiana attenuata [Reaction:R-OES-1120960] tetrahydrofolate synthase - Olea europaea var. sylvestris [Reaction:R-SIN-1120960] tetrahydrofolate synthase - Sesamum indicum [Reaction:R-GSO-1120960] tetrahydrofolate synthase - Glycine soja [Reaction:R-PAB-1120960] tetrahydrofolate synthase - Picea abies [Reaction:R-CSC-1120960] tetrahydrofolate synthase - Cannabis sativa [Reaction:R-LSA-1120960] tetrahydrofolate synthase - Lactuca sativa [Reaction:R-BDI-1120960] tetrahydrofolate synthase - Brachypodium distachyon [Reaction:R-OMI-1120960] tetrahydrofolate synthase - Oryza minuta [Reaction:R-ATH-1120960] tetrahydrofolate synthase - Arabidopsis thaliana [Reaction:R-CCP-1120960] tetrahydrofolate synthase - Corchorus capsularis [Reaction:R-GMA-1120960] tetrahydrofolate synthase - Glycine max [Reaction:R-ATR-1120960] tetrahydrofolate synthase - Amborella trichopoda [Reaction:R-AUM-1120960] tetrahydrofolate synthase - Aegilops umbellulata [Reaction:R-AHA-1120960] tetrahydrofolate synthase - Arabidopsis halleri [Reaction:R-OAU-1120960] tetrahydrofolate synthase - Oryza australiensis [Reaction:R-OEU-1120960] tetrahydrofolate synthase - Olea europaea [Reaction:R-ONI-1120960] tetrahydrofolate synthase - Oryza nivara [Reaction:R-FEX-1120960] tetrahydrofolate synthase - Fraxinus excelsior (European ash) [Reaction:R-PTA-1120960] tetrahydrofolate synthase - Pinus taeda [Reaction:R-NNU-1120960] tetrahydrofolate synthase - Nelumbo nucifera [Reaction:R-TTU-1120960] tetrahydrofolate synthase - Triticum turgidum [Reaction:R-PPE-1120960] tetrahydrofolate synthase - Prunus persica [Reaction:R-CSA-1120960] tetrahydrofolate synthase - Cucumis sativus [Reaction:R-ACH-1120960] tetrahydrofolate synthase - Actinidia chinensis [Reaction:R-AHY-1120960] tetrahydrofolate synthase - Arachis hypogaea [Reaction:R-AIP-1120960] tetrahydrofolate synthase - Arachis ipaensis [Reaction:R-OGU-1120960] tetrahydrofolate synthase - Oryza glumaepatula [Reaction:R-ATA-1120960] tetrahydrofolate synthase - Aegilops tauschii [Reaction:R-VFA-1120960] tetrahydrofolate synthase - Vicia faba var. faba [Reaction:R-VVN-1120960] tetrahydrofolate synthase - Vitis vinifera [Reaction:R-CCI-1120960] tetrahydrofolate synthase - Corymbia citriodora [Reaction:R-MGU-1120960] tetrahydrofolate synthase - Erythranthe guttata [Reaction:R-RCH-1120960] tetrahydrofolate synthase - Rosa chinensis [Reaction:R-PSA-1120960] tetrahydrofolate synthase - Pisum sativum [Reaction:R-CCD-1120960] tetrahydrofolate synthase - Cynara cardunculus var. scolymus [Reaction:R-OME-1120960] tetrahydrofolate synthase - Oryza meridionalis [Reaction:R-ZMA-1120960] tetrahydrofolate synthase - Zea mays [Reaction:R-ECU-1120960] tetrahydrofolate synthase - Eragrostis curvula [Reaction:R-ADU-1120960] tetrahydrofolate synthase - Arachis duranensis [Reaction:R-BVU-1120960] tetrahydrofolate synthase - Beta vulgaris [Reaction:R-SHI-1120960] tetrahydrofolate synthase - Salvia hispanica [Reaction:R-CAR-1120960] tetrahydrofolate synthase - Cicer arietinum [Reaction:R-TPR-1120960] tetrahydrofolate synthase - Trifolium pratense [Reaction:R-OBA-1120960] tetrahydrofolate synthase - Oryza barthii [Reaction:R-BRA-1120960] tetrahydrofolate synthase - Brassica rapa [Reaction:R-HLH-1120960] tetrahydrofolate synthase - Humulus lupulus [Reaction:R-OGL-1120960] tetrahydrofolate synthase - Oryza glaberrima [Reaction:R-CAN-1120960] tetrahydrofolate synthase - Capsicum annuum [Reaction:R-JCU-1120960] tetrahydrofolate synthase - Jatropha curcas [Reaction:R-EGR-1120960] tetrahydrofolate synthase - Eucalyptus grandis [Reaction:R-CCA-1120960] tetrahydrofolate synthase - Cajanus cajan [Reaction:R-VUN-1120960] tetrahydrofolate synthase - Vigna unguiculata [Reaction:R-GRA-1120960] tetrahydrofolate synthase - Gossypium raimondii [Reaction:R-SLY-1120960] tetrahydrofolate synthase - Solanum lycopersicum [Reaction:R-CRE-1120960] tetrahydrofolate synthase - Chlamydomonas reinhardtii [Reaction:R-OLU-1120960] tetrahydrofolate synthase - Ostreococcus lucimarinus [Reaction:R-TUR-1120960] tetrahydrofolate synthase - Triticum urartu [Reaction:R-MPO-1120960] tetrahydrofolate synthase - Marchantia polymorpha [Reaction:R-HAN-1120960] tetrahydrofolate synthase - Helianthus annuus [Reaction:R-JRE-1120960] tetrahydrofolate synthase - Juglans regia [Reaction:R-ASA-1120960] tetrahydrofolate synthase - Avena sativa [Reaction:R-CRU-1120960] tetrahydrofolate synthase - Capsella rubella [Reaction:R-ORU-1120960] tetrahydrofolate synthase - Oryza rufipogon [Reaction:R-CLA-1120960] tetrahydrofolate synthase - Citrullus lanatus [Reaction:R-VAN-1120960] tetrahydrofolate synthase - Vigna angularis [Reaction:R-CSI-1120960] tetrahydrofolate synthase - Citrus sinensis [Reaction:R-COL-1120960] tetrahydrofolate synthase - Corchorus olitorius [Reaction:R-SMO-1120960] tetrahydrofolate synthase - Selaginella moellendorffii [Reaction:R-SSP-1120960] tetrahydrofolate synthase - Saccharum spontaneum [Reaction:R-BJU-1120960] tetrahydrofolate synthase - Brassica juncea [Reaction:R-LPE-1120960] tetrahydrofolate synthase - Leersia perrieri [Reaction:R-SCR-1120960] tetrahydrofolate synthase - Secale cereale [Reaction:R-LST-1120960] tetrahydrofolate synthase - Lathyrus sativus [Reaction:R-ITR-1120960] tetrahydrofolate synthase - Ipomoea triloba [Reaction:R-SVI-1120960] tetrahydrofolate synthase - Setaria viridis [Reaction:R-PTI-1120960] tetrahydrofolate synthase - Populus trichocarpa [Reaction:R-QSU-1120960] tetrahydrofolate synthase - Quercus suber [Reaction:R-CBA-1120960] tetrahydrofolate synthase - Chara braunii [Reaction:R-OOF-1120960] tetrahydrofolate synthase - Oryza officinalis [Reaction:R-TCA-1120960] tetrahydrofolate synthase - Theobroma cacao
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-197980] THF-L-glutamate [cytosol]
precedingEvent	[Reaction:R-OSA-1120019] dihydrofolate reductase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120960
summation	[Summation:2874301] Tetrahydrofolate is converted to THF-L-glutamate by enzymati...

Referrals

(hasEvent)

[Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa

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