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Glycine hydroxymethyltransferase II

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catalystActivity	[CatalystActivity:1119077] glycine hydroxymethyltransferase activity of SHMT [mitochondrial matrix]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2871175] D'Eustachio, P, 2012-12-20
crossReference	[DatabaseIdentifier:26979] EC:2.1.2.1 [DatabaseIdentifier:1137128] RiceCyc:GLYOHMETRANS-RXN
dbId	2871176
displayName	Glycine hydroxymethyltransferase II
eventOf	[Pathway:R-OSA-1119617] Folate polyglutamylation I - Oryza sativa
input	[SimpleEntity:R-ALL-1130724] 5,10-methylene-THF [cytosol] [SimpleEntity:R-ALL-29424] Gly [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Glycine hydroxymethyltransferase II Serine hydroxymethylase Threonine aldolase Serine aldolase Serine hydroxymethyltransferase biochemicalReaction76395
orthologousEvent	[Reaction:R-OEU-2871176] Glycine hydroxymethyltransferase II - Olea europaea [Reaction:R-JRE-2871176] Glycine hydroxymethyltransferase II - Juglans regia [Reaction:R-SLY-2871176] Glycine hydroxymethyltransferase II - Solanum lycopersicum [Reaction:R-MPO-2871176] Glycine hydroxymethyltransferase II - Marchantia polymorpha [Reaction:R-FCR-2871176] Glycine hydroxymethyltransferase II - Ficus carica [Reaction:R-NAT-2871176] Glycine hydroxymethyltransferase II - Nicotiana attenuata [Reaction:R-CRE-2871176] Glycine hydroxymethyltransferase II - Chlamydomonas reinhardtii [Reaction:R-CLA-2871176] Glycine hydroxymethyltransferase II - Citrullus lanatus [Reaction:R-PDA-2871176] Glycine hydroxymethyltransferase II - Phoenix dactylifera [Reaction:R-NCO-2871176] Glycine hydroxymethyltransferase II - Nymphaea colorata [Reaction:R-OGL-2871176] Glycine hydroxymethyltransferase II - Oryza glaberrima [Reaction:R-TTI-2871176] Glycine hydroxymethyltransferase II - Triticum timopheevii subsp. timopheevii [Reaction:R-JCU-2871176] Glycine hydroxymethyltransferase II - Jatropha curcas [Reaction:R-OAU-2871176] Glycine hydroxymethyltransferase II - Oryza australiensis [Reaction:R-OBR-2871176] Glycine hydroxymethyltransferase II - Oryza brachyantha [Reaction:R-MDO-2871176] Glycine hydroxymethyltransferase II - Malus domestica [Reaction:R-DEX-2871176] Glycine hydroxymethyltransferase II - Digitaria exilis [Reaction:R-PTI-2871176] Glycine hydroxymethyltransferase II - Populus trichocarpa [Reaction:R-PAB-2871176] Glycine hydroxymethyltransferase II - Picea abies [Reaction:R-PED-2871176] Glycine hydroxymethyltransferase II - Phyllostachys edulis [Reaction:R-LSA-2871176] Glycine hydroxymethyltransferase II - Lactuca sativa [Reaction:R-CCD-2871176] Glycine hydroxymethyltransferase II - Cynara cardunculus var. scolymus [Reaction:R-ALY-2871176] Glycine hydroxymethyltransferase II - Arabidopsis lyrata [Reaction:R-CQI-2871176] Glycine hydroxymethyltransferase II - Chenopodium quinoa [Reaction:R-CBA-2871176] Glycine hydroxymethyltransferase II - Chara braunii [Reaction:R-CCP-2871176] Glycine hydroxymethyltransferase II - Corchorus capsularis [Reaction:R-STU-2871176] Glycine hydroxymethyltransferase II - Solanum tuberosum [Reaction:R-PPA-2871176] Glycine hydroxymethyltransferase II - Physcomitrella patens [Reaction:R-CST-2871176] Glycine hydroxymethyltransferase II - Camelina sativa [Reaction:R-ECU-2871176] Glycine hydroxymethyltransferase II - Eragrostis curvula [Reaction:R-PVU-2871176] Glycine hydroxymethyltransferase II - Phaseolus vulgaris [Reaction:R-SMO-2871176] Glycine hydroxymethyltransferase II - Selaginella moellendorffii [Reaction:R-OES-2871176] Glycine hydroxymethyltransferase II - Olea europaea var. sylvestris [Reaction:R-SIN-2871176] Glycine hydroxymethyltransferase II - Sesamum indicum [Reaction:R-CME-2871176] Glycine hydroxymethyltransferase II - Cyanidioschyzon merolae [Reaction:R-GSU-2871176] Glycine hydroxymethyltransferase II - Galdieria sulphuraria [Reaction:R-PSA-2871176] Glycine hydroxymethyltransferase II - Pisum sativum [Reaction:R-OKA-2871176] Glycine hydroxymethyltransferase II - Oryza sativa aus subgroup [Reaction:R-PVE-2871176] Glycine hydroxymethyltransferase II - Pistacia vera [Reaction:R-AHY-2871176] Glycine hydroxymethyltransferase II - Arachis hypogaea [Reaction:R-VUN-2871176] Glycine hydroxymethyltransferase II - Vigna unguiculata [Reaction:R-CCN-2871176] Glycine hydroxymethyltransferase II - Coffea canephora [Reaction:R-CCR-2871176] Glycine hydroxymethyltransferase II - Chondrus crispus [Reaction:R-PHA-2871176] Glycine hydroxymethyltransferase II - Panicum hallii ("FIL2") [Reaction:R-AHA-2871176] Glycine hydroxymethyltransferase II - Arabidopsis halleri [Reaction:R-BVU-2871176] Glycine hydroxymethyltransferase II - Beta vulgaris [Reaction:R-SBI-2871176] Glycine hydroxymethyltransferase II - Sorghum bicolor [Reaction:R-AUM-2871176] Glycine hydroxymethyltransferase II - Aegilops umbellulata [Reaction:R-SHI-2871176] Glycine hydroxymethyltransferase II - Salvia hispanica [Reaction:R-TAE-2871176] Glycine hydroxymethyltransferase II - Triticum aestivum [Reaction:R-BJU-2871176] Glycine hydroxymethyltransferase II - Brassica juncea [Reaction:R-BRA-2871176] Glycine hydroxymethyltransferase II - Brassica rapa [Reaction:R-ORU-2871176] Glycine hydroxymethyltransferase II - Oryza rufipogon [Reaction:R-OOF-2871176] Glycine hydroxymethyltransferase II - Oryza officinalis [Reaction:R-SCR-2871176] Glycine hydroxymethyltransferase II - Secale cereale [Reaction:R-LAN-2871176] Glycine hydroxymethyltransferase II - Lupinus angustifolius [Reaction:R-BDI-2871176] Glycine hydroxymethyltransferase II - Brachypodium distachyon [Reaction:R-GSO-2871176] Glycine hydroxymethyltransferase II - Glycine soja [Reaction:R-SVI-2871176] Glycine hydroxymethyltransferase II - Setaria viridis [Reaction:R-MAC-2871176] Glycine hydroxymethyltransferase II - Musa acuminata [Reaction:R-TUR-2871176] Glycine hydroxymethyltransferase II - Triticum urartu [Reaction:R-AOF-2871176] Glycine hydroxymethyltransferase II - Asparagus officinalis [Reaction:R-PPE-2871176] Glycine hydroxymethyltransferase II - Prunus persica [Reaction:R-TCA-2871176] Glycine hydroxymethyltransferase II - Theobroma cacao [Reaction:R-CSC-2871176] Glycine hydroxymethyltransferase II - Cannabis sativa [Reaction:R-CCI-2871176] Glycine hydroxymethyltransferase II - Corymbia citriodora [Reaction:R-ZMY-2871176] Glycine hydroxymethyltransferase II - Zea mays ver5 [Reaction:R-ASA-2871176] Glycine hydroxymethyltransferase II - Avena sativa [Reaction:R-MES-2871176] Glycine hydroxymethyltransferase II - Manihot esculenta [Reaction:R-HAN-2871176] Glycine hydroxymethyltransferase II - Helianthus annuus [Reaction:R-QLO-2871176] Glycine hydroxymethyltransferase II - Quercus lobata [Reaction:R-VFA-2871176] Glycine hydroxymethyltransferase II - Vicia faba var. faba [Reaction:R-NNU-2871176] Glycine hydroxymethyltransferase II - Nelumbo nucifera [Reaction:R-CAN-2871176] Glycine hydroxymethyltransferase II - Capsicum annuum [Reaction:R-OGR-2871176] Glycine hydroxymethyltransferase II - Oryza meyeriana var. granulata [Reaction:R-PHH-2871176] Glycine hydroxymethyltransferase II - Panicum hallii var. hallii ("HAL2") [Reaction:R-CSK-2871176] Glycine hydroxymethyltransferase II - Cannabis sativa subsp. indica [Reaction:R-SIT-2871176] Glycine hydroxymethyltransferase II - Setaria italica [Reaction:R-ECG-2871176] Glycine hydroxymethyltransferase II - Echinochloa crus-galli [Reaction:R-LST-2871176] Glycine hydroxymethyltransferase II - Lathyrus sativus [Reaction:R-GMA-2871176] Glycine hydroxymethyltransferase II - Glycine max [Reaction:R-SPC-2871176] Glycine hydroxymethyltransferase II - Synechocystis sp. PCC 6803 [Reaction:R-ITR-2871176] Glycine hydroxymethyltransferase II - Ipomoea triloba [Reaction:R-COL-2871176] Glycine hydroxymethyltransferase II - Corchorus olitorius [Reaction:R-ZJA-2871176] Glycine hydroxymethyltransferase II - Zoysia japonica [Reaction:R-OLO-2871176] Glycine hydroxymethyltransferase II - Oryza longistaminata [Reaction:R-LPE-2871176] Glycine hydroxymethyltransferase II - Leersia perrieri [Reaction:R-TPR-2871176] Glycine hydroxymethyltransferase II - Trifolium pratense [Reaction:R-CCA-2871176] Glycine hydroxymethyltransferase II - Cajanus cajan [Reaction:R-CAR-2871176] Glycine hydroxymethyltransferase II - Cicer arietinum [Reaction:R-ADU-2871176] Glycine hydroxymethyltransferase II - Arachis duranensis [Reaction:R-TDI-2871176] Glycine hydroxymethyltransferase II - Triticum dicoccoides [Reaction:R-VAN-2871176] Glycine hydroxymethyltransferase II - Vigna angularis [Reaction:R-BOL-2871176] Glycine hydroxymethyltransferase II - Brassica oleracea [Reaction:R-BNA-2871176] Glycine hydroxymethyltransferase II - Brassica napus [Reaction:R-ATA-2871176] Glycine hydroxymethyltransferase II - Aegilops tauschii [Reaction:R-PTA-2871176] Glycine hydroxymethyltransferase II - Pinus taeda [Reaction:R-FVE-2871176] Glycine hydroxymethyltransferase II - Fragaria vesca [Reaction:R-CSA-2871176] Glycine hydroxymethyltransferase II - Cucumis sativus [Reaction:R-VRA-2871176] Glycine hydroxymethyltransferase II - Vigna radiata [Reaction:R-HVU-2871176] Glycine hydroxymethyltransferase II - Hordeum vulgare [Reaction:R-CRU-2871176] Glycine hydroxymethyltransferase II - Capsella rubella [Reaction:R-VVN-2871176] Glycine hydroxymethyltransferase II - Vitis vinifera [Reaction:R-QSU-2871176] Glycine hydroxymethyltransferase II - Quercus suber [Reaction:R-OGU-2871176] Glycine hydroxymethyltransferase II - Oryza glumaepatula [Reaction:R-RCH-2871176] Glycine hydroxymethyltransferase II - Rosa chinensis [Reaction:R-CSI-2871176] Glycine hydroxymethyltransferase II - Citrus sinensis [Reaction:R-PAV-2871176] Glycine hydroxymethyltransferase II - Prunus avium [Reaction:R-EGR-2871176] Glycine hydroxymethyltransferase II - Eucalyptus grandis [Reaction:R-MTR-2871176] Glycine hydroxymethyltransferase II - Medicago truncatula [Reaction:R-AIP-2871176] Glycine hydroxymethyltransferase II - Arachis ipaensis [Reaction:R-MGU-2871176] Glycine hydroxymethyltransferase II - Erythranthe guttata [Reaction:R-ACO-2871176] Glycine hydroxymethyltransferase II - Ananas comosus [Reaction:R-OSI-2871176] Glycine hydroxymethyltransferase II - Oryza sativa Indica Group [Reaction:R-CML-2871176] Glycine hydroxymethyltransferase II - Cucumis melo [Reaction:R-ACH-2871176] Glycine hydroxymethyltransferase II - Actinidia chinensis [Reaction:R-OLU-2871176] Glycine hydroxymethyltransferase II - Ostreococcus lucimarinus [Reaction:R-DRO-2871176] Glycine hydroxymethyltransferase II - Dioscorea rotundata [Reaction:R-ETE-2871176] Glycine hydroxymethyltransferase II - Eragrostis tef [Reaction:R-OPU-2871176] Glycine hydroxymethyltransferase II - Oryza punctata [Reaction:R-ATH-2871176] Glycine hydroxymethyltransferase II - Arabidopsis thaliana [Reaction:R-CCL-2871176] Glycine hydroxymethyltransferase II - Citrus clementina [Reaction:R-ATR-2871176] Glycine hydroxymethyltransferase II - Amborella trichopoda [Reaction:R-OBA-2871176] Glycine hydroxymethyltransferase II - Oryza barthii [Reaction:R-OMI-2871176] Glycine hydroxymethyltransferase II - Oryza minuta [Reaction:R-GRA-2871176] Glycine hydroxymethyltransferase II - Gossypium raimondii [Reaction:R-ONI-2871176] Glycine hydroxymethyltransferase II - Oryza nivara [Reaction:R-DCA-2871176] Glycine hydroxymethyltransferase II - Daucus carota [Reaction:R-FEX-2871176] Glycine hydroxymethyltransferase II - Fraxinus excelsior (European ash) [Reaction:R-OME-2871176] Glycine hydroxymethyltransferase II - Oryza meridionalis [Reaction:R-TSP-2871176] Glycine hydroxymethyltransferase II - Triticum spelta subsp. spelta [Reaction:R-HLP-2871176] Glycine hydroxymethyltransferase II - Humulus lupulus var. lupulus [Reaction:R-PSO-2871176] Glycine hydroxymethyltransferase II - Papaver somniferum
output	[SimpleEntity:R-ALL-200736] L-Ser [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-OSA-1120019] dihydrofolate reductase - Oryza sativa
reverseReaction	[Reaction:R-OSA-1121174] Glycine hydroxymethyltransferase
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-2871176
summation	[Summation:2871173] 5,10-methylene-THF is converted into tetrahydrofolate by enz...

Referrals

(hasEvent)

[Pathway:R-OSA-1119617] Folate polyglutamylation I - Oryza sativa