Plant Reactome Pathway Database - Plant Reactome Pathway Database

Iron uptake and transport in root vascular system

Stable Identifier

R-OSA-9025727

Type

Pathway

Species

Oryza sativa

Compartment

extracellular region, cytosol, nucleoplasm, plasma membrane

Locations in the PathwayBrowser

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Summation

Genes involved in Fe acquisition are transcriptionally upregulated under conditions of Fe deficiency. MAs secreted to the rhizosphere via plasma membrane TOM transporters and the resulting Fe(III)?MAs complexes are taken up by roots through Fe(III)?MAs transporters (YSL15 and YSL16) in the plasma membrane. Rice takes up Fe from the rhizosphere using the ferrous Fe transporter IRT1, IRT2 and NRAMP1. YSL15 transports Fe(III)?DMA, but not Fe(II)?NA and Fe(III)?NA. YSL2 transports Fe(II)?NA but not Fe(III)?MAs. YSL18, a functional Fe(III)?DMA transporter that may be involved in DMA-mediated Fe distribution in the reproductive organs, lamina joints, and phloem cells at the base of the leaf sheath. IDEF1 and IDEF2 transcription factors are involved in activation of various genes of Fe acquisition; e.g., IRT1, YSl15 and YSL2. Rice plants translocate iron from the roots to old leaves mainly via xylem and to new leaves mainly via phloem (Kakei et al., 2012).

Literature References

PubMed ID	Title	Journal	Year
24280375	Rice genes involved in phytosiderophore biosynthesis are synchronously regulated during the early stages of iron deficiency in roots	Rice (N Y)	2013
18308732	A novel NAC transcription factor, IDEF2, that recognizes the iron deficiency-responsive element 2 regulates the genes involved in iron homeostasis in plants	J. Biol. Chem.	2008
27502932	Comparison on cellular mechanisms of iron and cadmium accumulation in rice: prospects for cultivating Fe-rich but Cd-free rice	Rice (N Y)	2016
19468840	OsYSL18 is a rice iron(III)-deoxymugineic acid transporter specifically expressed in reproductive organs and phloem of lamina joints	Plant Mol. Biol.	2009
21156806	Phytosiderophore efflux transporters are crucial for iron acquisition in graminaceous plants	J. Biol. Chem.	2011
24843126	Polarization of IRON-REGULATED TRANSPORTER 1 (IRT1) to the plant-soil interface plays crucial role in metal homeostasis	Proc. Natl. Acad. Sci. U.S.A.	2014
22228180	Activation of rice Yellow Stripe1-Like 16 (OsYSL16) enhances iron efficiency	Mol. Cells	2012
21084773	Recent insights into iron homeostasis and their application in graminaceous crops	Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci.	2010
19049971	Rice OsYSL15 is an iron-regulated iron(III)-deoxymugineic acid transporter expressed in the roots and is essential for iron uptake in early growth of the seedlings	J. Biol. Chem.	2009
22589467	Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice	Plant Cell	2012
26432636	The Phytosiderophore Efflux Transporter TOM2 Is Involved in Metal Transport in Rice	J. Biol. Chem.	2015
22644443	OsYSL16 plays a role in the allocation of iron	Plant Mol. Biol.	2012
12096107	Cloning an iron-regulated metal transporter from rice	J. Exp. Bot.	2002
15255870	OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem	Plant J.	2004
18025467	The transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants	Proc. Natl. Acad. Sci. U.S.A.	2007
22067109	Role of the iron transporter OsNRAMP1 in cadmium uptake and accumulation in rice	Plant Signal Behav	2011
16412081	Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+	Plant J.	2006
21447758	Transporters contributing to iron trafficking in plants	Mol Plant	2011
19737364	The rice transcription factor IDEF1 is essential for the early response to iron deficiency, and induces vegetative expression of late embryogenesis abundant genes	Plant J.	2009