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Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate

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catalystActivity	[CatalystActivity:9611882] 3-hydroxyisobutyryl-CoA hydrolase activity of Hydroxyisobutyryl-CoA hydrolase [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9611891] Gupta, Parul, 2018-06-21
crossReference	[DatabaseIdentifier:27414] EC:3.1.2.4
dbId	9611885
displayName	Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate
eventOf	[Pathway:R-OSA-1119479] Valine degradation - Oryza sativa
followingEvent	[Reaction:R-OSA-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Oryza sativa
input	[SimpleEntity:R-ALL-9611893] 3-hydroxy-isobutyryl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate
orthologousEvent	[Reaction:R-TTI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Triticum timopheevii subsp. timopheevii [Reaction:R-GSO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Glycine soja [Reaction:R-CAN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Capsicum annuum [Reaction:R-LAN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Lupinus angustifolius [Reaction:R-ECU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Eragrostis curvula [Reaction:R-CCN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Coffea canephora [Reaction:R-AIP-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Arachis ipaensis [Reaction:R-ATA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Aegilops tauschii [Reaction:R-CCI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Corymbia citriodora [Reaction:R-MES-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Manihot esculenta [Reaction:R-LSA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Lactuca sativa [Reaction:R-OOF-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza officinalis [Reaction:R-GRA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Gossypium raimondii [Reaction:R-PED-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Phyllostachys edulis [Reaction:R-SCR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Secale cereale [Reaction:R-QSU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Quercus suber [Reaction:R-OEU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Olea europaea [Reaction:R-PHA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Panicum hallii ("FIL2") [Reaction:R-VAN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Vigna angularis [Reaction:R-PVU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Phaseolus vulgaris [Reaction:R-ALY-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Arabidopsis lyrata [Reaction:R-CCP-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Corchorus capsularis [Reaction:R-MTR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Medicago truncatula [Reaction:R-TPR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Trifolium pratense [Reaction:R-ECG-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Echinochloa crus-galli [Reaction:R-SVI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Setaria viridis [Reaction:R-MAC-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Musa acuminata [Reaction:R-PHH-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Panicum hallii var. hallii ("HAL2") [Reaction:R-ACO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Ananas comosus [Reaction:R-VVN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Vitis vinifera [Reaction:R-HAN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Helianthus annuus [Reaction:R-GMA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Glycine max [Reaction:R-BVU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Beta vulgaris [Reaction:R-PDA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Phoenix dactylifera [Reaction:R-TDI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Triticum dicoccoides [Reaction:R-JCU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Jatropha curcas [Reaction:R-CSC-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cannabis sativa [Reaction:R-NCO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Nymphaea colorata [Reaction:R-CST-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Camelina sativa [Reaction:R-BRA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Brassica rapa [Reaction:R-OBA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza barthii [Reaction:R-HLP-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Humulus lupulus var. lupulus [Reaction:R-ATH-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Arabidopsis thaliana [Reaction:R-SIT-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Setaria italica [Reaction:R-FCR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Ficus carica [Reaction:R-ORU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza rufipogon [Reaction:R-ADU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Arachis duranensis [Reaction:R-TAE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Triticum aestivum [Reaction:R-CSI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Citrus sinensis [Reaction:R-PSO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Papaver somniferum [Reaction:R-RCH-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Rosa chinensis [Reaction:R-ACH-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Actinidia chinensis [Reaction:R-OES-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Olea europaea var. sylvestris [Reaction:R-OMI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza minuta [Reaction:R-PAV-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Prunus avium [Reaction:R-MGU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Erythranthe guttata [Reaction:R-SHI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Salvia hispanica [Reaction:R-BOL-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Brassica oleracea [Reaction:R-TCA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Theobroma cacao [Reaction:R-DCA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Daucus carota [Reaction:R-OAU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza australiensis [Reaction:R-CCL-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Citrus clementina [Reaction:R-EGR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Eucalyptus grandis [Reaction:R-LPE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Leersia perrieri [Reaction:R-TTU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Triticum turgidum [Reaction:R-OLO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza longistaminata [Reaction:R-OGR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza meyeriana var. granulata [Reaction:R-AHY-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Arachis hypogaea [Reaction:R-ONI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza nivara [Reaction:R-TUR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Triticum urartu [Reaction:R-OPU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza punctata [Reaction:R-NNU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Nelumbo nucifera [Reaction:R-LPR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Lolium perenne [Reaction:R-MDO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Malus domestica [Reaction:R-SSP-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Saccharum spontaneum [Reaction:R-ZMA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Zea mays [Reaction:R-CCD-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cynara cardunculus var. scolymus [Reaction:R-OBR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza brachyantha [Reaction:R-COL-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Corchorus olitorius [Reaction:R-JRE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Juglans regia [Reaction:R-CRU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Capsella rubella [Reaction:R-SLY-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Solanum lycopersicum [Reaction:R-AHA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Arabidopsis halleri [Reaction:R-CQI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Chenopodium quinoa [Reaction:R-CSA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cucumis sativus [Reaction:R-FEX-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Fraxinus excelsior (European ash) [Reaction:R-VRA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Vigna radiata [Reaction:R-ZMY-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Zea mays ver5 [Reaction:R-PVE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Pistacia vera [Reaction:R-AOF-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Asparagus officinalis [Reaction:R-VFA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Vicia faba var. faba [Reaction:R-PSA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Pisum sativum [Reaction:R-DEX-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Digitaria exilis [Reaction:R-OSI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza sativa Indica Group [Reaction:R-FVE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Fragaria vesca [Reaction:R-PAB-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Picea abies [Reaction:R-AUM-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Aegilops umbellulata [Reaction:R-ASA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Avena sativa [Reaction:R-ITR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Ipomoea triloba [Reaction:R-CSK-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cannabis sativa subsp. indica [Reaction:R-SBI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Sorghum bicolor [Reaction:R-VUN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Vigna unguiculata [Reaction:R-BNA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Brassica napus [Reaction:R-ZJA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Zoysia japonica [Reaction:R-QLO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Quercus lobata [Reaction:R-BJU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Brassica juncea [Reaction:R-CAR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cicer arietinum [Reaction:R-NAT-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Nicotiana attenuata [Reaction:R-PTA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Pinus taeda [Reaction:R-PTI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Populus trichocarpa [Reaction:R-ETE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Eragrostis tef [Reaction:R-OGU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza glumaepatula [Reaction:R-BDI-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Brachypodium distachyon [Reaction:R-CCA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cajanus cajan [Reaction:R-ATR-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Amborella trichopoda [Reaction:R-CML-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Cucumis melo [Reaction:R-HVU-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Hordeum vulgare [Reaction:R-OKA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza sativa aus subgroup [Reaction:R-TSP-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Triticum spelta subsp. spelta [Reaction:R-DRO-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Dioscorea rotundata [Reaction:R-PPE-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Prunus persica [Reaction:R-OGL-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza glaberrima [Reaction:R-LST-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Lathyrus sativus [Reaction:R-SIN-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Sesamum indicum [Reaction:R-HLH-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Humulus lupulus [Reaction:R-CLA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Citrullus lanatus
output	[SimpleEntity:R-ALL-9611886] 3-hydroxy-isobutyrate [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:R-OSA-9611868] Conversion of MACR-CoA to 3-hydroxy-isobutyryl-CoA - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-9611885

Referrals

(hasEvent)	[Pathway:R-OSA-1119479] Valine degradation - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Oryza sativa

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