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Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate

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catalystActivity	[CatalystActivity:11201634] 3-hydroxyisobutyryl-CoA hydrolase activity of Hydroxyisobutyryl-CoA hydrolase [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11195174] Elser, Justin, 2025-03-26
dbId	11201636
displayName	Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate
eventOf	[Pathway:R-CML-1119479] Valine degradation - Cucumis melo
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-CML-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Cucumis melo
inferredFrom	[Reaction:R-OSA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza sativa
input	[SimpleEntity:R-ALL-9611893] 3-hydroxy-isobutyryl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
name	Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate
output	[SimpleEntity:R-ALL-9611886] 3-hydroxy-isobutyrate [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:R-CML-9611868] Conversion of MACR-CoA to 3-hydroxy-isobutyryl-CoA - Cucumis melo
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9764158] Cucumis melo
stId	R-CML-9611885
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-CML-1119479] Valine degradation - Cucumis melo
(precedingEvent)	[Reaction:R-CML-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Cucumis melo
(inferredTo)	[Reaction:R-OSA-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Oryza sativa