Plant Reactome Pathway Database - Plant Reactome Pathway Database

Schema > Reaction > Entries

hydroxymethylbilane synthase

Go to Details

catalystActivity	[CatalystActivity:4827084] hydroxymethylbilane synthase activity of hydroxymethylbilane synthase (LOC_OS02G07230.1) [plastid stroma]
compartment	[Compartment:1141] plastid stroma
created	[InstanceEdit:4827073] D'Eustachio, P, 2013-10-29
crossReference	[DatabaseIdentifier:1154243] EC-NUMBER:2.5.1.61
dbId	4827045
displayName	hydroxymethylbilane synthase
eventOf	[Pathway:R-OSA-4827054] Tetrapyrrole biosynthesis I - Oryza sativa
followingEvent	[Reaction:R-OSA-4827058] uroporphyrinogen-III synthase - Oryza sativa
input	[SimpleEntity:R-ALL-1168755] H2O [plastid stroma] 4 × [SimpleEntity:R-ALL-4827082] PBG [plastid stroma]
isChimeric	false
isInDisease	false
isInferred	false
modified	[InstanceEdit:11529250] Elser, Justin, 2025-03-27
name	hydroxymethylbilane synthase
orthologousEvent	[Reaction:R-ORU-4827045] hydroxymethylbilane synthase - Oryza rufipogon [Reaction:R-SPC-4827045] hydroxymethylbilane synthase - Synechocystis sp. PCC 6803 [Reaction:R-CST-4827045] hydroxymethylbilane synthase - Camelina sativa [Reaction:R-CME-4827045] hydroxymethylbilane synthase - Cyanidioschyzon merolae [Reaction:R-ITR-4827045] hydroxymethylbilane synthase - Ipomoea triloba [Reaction:R-MTR-4827045] hydroxymethylbilane synthase - Medicago truncatula [Reaction:R-CSK-4827045] hydroxymethylbilane synthase - Cannabis sativa subsp. indica [Reaction:R-CCL-4827045] hydroxymethylbilane synthase - Citrus clementina [Reaction:R-TCA-4827045] hydroxymethylbilane synthase - Theobroma cacao [Reaction:R-ATA-4827045] hydroxymethylbilane synthase - Aegilops tauschii [Reaction:R-LAN-4827045] hydroxymethylbilane synthase - Lupinus angustifolius [Reaction:R-LSA-4827045] hydroxymethylbilane synthase - Lactuca sativa [Reaction:R-CRU-4827045] hydroxymethylbilane synthase - Capsella rubella [Reaction:R-PVE-4827045] hydroxymethylbilane synthase - Pistacia vera [Reaction:R-OME-4827045] hydroxymethylbilane synthase - Oryza meridionalis [Reaction:R-CCN-4827045] hydroxymethylbilane synthase - Coffea canephora [Reaction:R-VRA-4827045] hydroxymethylbilane synthase - Vigna radiata [Reaction:R-ATH-4827045] hydroxymethylbilane synthase - Arabidopsis thaliana [Reaction:R-QSU-4827045] hydroxymethylbilane synthase - Quercus suber [Reaction:R-NAT-4827045] hydroxymethylbilane synthase - Nicotiana attenuata [Reaction:R-QLO-4827045] hydroxymethylbilane synthase - Quercus lobata [Reaction:R-ONI-4827045] hydroxymethylbilane synthase - Oryza nivara [Reaction:R-CAN-4827045] hydroxymethylbilane synthase - Capsicum annuum [Reaction:R-VFA-4827045] hydroxymethylbilane synthase - Vicia faba var. faba [Reaction:R-HLH-4827045] hydroxymethylbilane synthase - Humulus lupulus [Reaction:R-TDI-4827045] hydroxymethylbilane synthase - Triticum dicoccoides [Reaction:R-AUM-4827045] hydroxymethylbilane synthase - Aegilops umbellulata [Reaction:R-GSU-4827045] hydroxymethylbilane synthase - Galdieria sulphuraria [Reaction:R-TAE-4827045] hydroxymethylbilane synthase - Triticum aestivum [Reaction:R-SIT-4827045] hydroxymethylbilane synthase - Setaria italica [Reaction:R-SIN-4827045] hydroxymethylbilane synthase - Sesamum indicum [Reaction:R-HVU-4827045] hydroxymethylbilane synthase - Hordeum vulgare [Reaction:R-BJU-4827045] hydroxymethylbilane synthase - Brassica juncea [Reaction:R-ACO-4827045] hydroxymethylbilane synthase - Ananas comosus [Reaction:R-ETE-4827045] hydroxymethylbilane synthase - Eragrostis tef [Reaction:R-PDA-4827045] hydroxymethylbilane synthase - Phoenix dactylifera [Reaction:R-TPR-4827045] hydroxymethylbilane synthase - Trifolium pratense [Reaction:R-GRA-4827045] hydroxymethylbilane synthase - Gossypium raimondii [Reaction:R-RCH-4827045] hydroxymethylbilane synthase - Rosa chinensis [Reaction:R-SSP-4827045] hydroxymethylbilane synthase - Saccharum spontaneum [Reaction:R-OES-4827045] hydroxymethylbilane synthase - Olea europaea var. sylvestris [Reaction:R-VVN-4827045] hydroxymethylbilane synthase - Vitis vinifera [Reaction:R-CLA-4827045] hydroxymethylbilane synthase - Citrullus lanatus [Reaction:R-EGR-4827045] hydroxymethylbilane synthase - Eucalyptus grandis [Reaction:R-CCP-4827045] hydroxymethylbilane synthase - Corchorus capsularis [Reaction:R-AHA-4827045] hydroxymethylbilane synthase - Arabidopsis halleri [Reaction:R-MGU-4827045] hydroxymethylbilane synthase - Erythranthe guttata [Reaction:R-JRE-4827045] hydroxymethylbilane synthase - Juglans regia [Reaction:R-AOF-4827045] hydroxymethylbilane synthase - Asparagus officinalis [Reaction:R-HAN-4827045] hydroxymethylbilane synthase - Helianthus annuus [Reaction:R-OGR-4827045] hydroxymethylbilane synthase - Oryza meyeriana var. granulata [Reaction:R-ASA-4827045] hydroxymethylbilane synthase - Avena sativa [Reaction:R-PPA-4827045] hydroxymethylbilane synthase - Physcomitrella patens [Reaction:R-CSA-4827045] hydroxymethylbilane synthase - Cucumis sativus [Reaction:R-HLP-4827045] hydroxymethylbilane synthase - Humulus lupulus var. lupulus [Reaction:R-FVE-4827045] hydroxymethylbilane synthase - Fragaria vesca [Reaction:R-ZMY-4827045] hydroxymethylbilane synthase - Zea mays ver5 [Reaction:R-ZMA-4827045] hydroxymethylbilane synthase - Zea mays [Reaction:R-PSA-4827045] hydroxymethylbilane synthase - Pisum sativum [Reaction:R-LPR-4827045] hydroxymethylbilane synthase - Lolium perenne [Reaction:R-TTI-4827045] hydroxymethylbilane synthase - Triticum timopheevii subsp. timopheevii [Reaction:R-PHH-4827045] hydroxymethylbilane synthase - Panicum hallii var. hallii ("HAL2") [Reaction:R-FEX-4827045] hydroxymethylbilane synthase - Fraxinus excelsior (European ash) [Reaction:R-DEX-4827045] hydroxymethylbilane synthase - Digitaria exilis [Reaction:R-OMI-4827045] hydroxymethylbilane synthase - Oryza minuta [Reaction:R-CQI-4827045] hydroxymethylbilane synthase - Chenopodium quinoa [Reaction:R-VUN-4827045] hydroxymethylbilane synthase - Vigna unguiculata [Reaction:R-PAB-4827045] hydroxymethylbilane synthase - Picea abies [Reaction:R-MAC-4827045] hydroxymethylbilane synthase - Musa acuminata [Reaction:R-BVU-4827045] hydroxymethylbilane synthase - Beta vulgaris [Reaction:R-PHA-4827045] hydroxymethylbilane synthase - Panicum hallii ("FIL2") [Reaction:R-BDI-4827045] hydroxymethylbilane synthase - Brachypodium distachyon [Reaction:R-PSO-4827045] hydroxymethylbilane synthase - Papaver somniferum [Reaction:R-SVI-4827045] hydroxymethylbilane synthase - Setaria viridis [Reaction:R-NNU-4827045] hydroxymethylbilane synthase - Nelumbo nucifera [Reaction:R-BNA-4827045] hydroxymethylbilane synthase - Brassica napus [Reaction:R-ALY-4827045] hydroxymethylbilane synthase - Arabidopsis lyrata [Reaction:R-ECU-4827045] hydroxymethylbilane synthase - Eragrostis curvula [Reaction:R-SBI-4827045] hydroxymethylbilane synthase - Sorghum bicolor [Reaction:R-PVU-4827045] hydroxymethylbilane synthase - Phaseolus vulgaris [Reaction:R-OSI-4827045] hydroxymethylbilane synthase - Oryza sativa Indica Group [Reaction:R-CML-4827045] hydroxymethylbilane synthase - Cucumis melo [Reaction:R-MES-4827045] hydroxymethylbilane synthase - Manihot esculenta [Reaction:R-DCA-4827045] hydroxymethylbilane synthase - Daucus carota [Reaction:R-TUR-4827045] hydroxymethylbilane synthase - Triticum urartu [Reaction:R-ACH-4827045] hydroxymethylbilane synthase - Actinidia chinensis [Reaction:R-CCD-4827045] hydroxymethylbilane synthase - Cynara cardunculus var. scolymus [Reaction:R-ZJA-4827045] hydroxymethylbilane synthase - Zoysia japonica [Reaction:R-VAN-4827045] hydroxymethylbilane synthase - Vigna angularis [Reaction:R-LST-4827045] hydroxymethylbilane synthase - Lathyrus sativus [Reaction:R-TSP-4827045] hydroxymethylbilane synthase - Triticum spelta subsp. spelta [Reaction:R-MDO-4827045] hydroxymethylbilane synthase - Malus domestica [Reaction:R-OGU-4827045] hydroxymethylbilane synthase - Oryza glumaepatula [Reaction:R-PPE-4827045] hydroxymethylbilane synthase - Prunus persica [Reaction:R-MPO-4827045] hydroxymethylbilane synthase - Marchantia polymorpha [Reaction:R-OLU-4827045] hydroxymethylbilane synthase - Ostreococcus lucimarinus [Reaction:R-OEU-4827045] hydroxymethylbilane synthase - Olea europaea [Reaction:R-OPU-4827045] hydroxymethylbilane synthase - Oryza punctata [Reaction:R-NCO-4827045] hydroxymethylbilane synthase - Nymphaea colorata [Reaction:R-PTI-4827045] hydroxymethylbilane synthase - Populus trichocarpa [Reaction:R-CAR-4827045] hydroxymethylbilane synthase - Cicer arietinum [Reaction:R-OBR-4827045] hydroxymethylbilane synthase - Oryza brachyantha [Reaction:R-FCR-4827045] hydroxymethylbilane synthase - Ficus carica [Reaction:R-OBA-4827045] hydroxymethylbilane synthase - Oryza barthii [Reaction:R-CBA-4827045] hydroxymethylbilane synthase - Chara braunii [Reaction:R-TTU-4827045] hydroxymethylbilane synthase - Triticum turgidum [Reaction:R-SLY-4827045] hydroxymethylbilane synthase - Solanum lycopersicum [Reaction:R-OGL-4827045] hydroxymethylbilane synthase - Oryza glaberrima [Reaction:R-CCI-4827045] hydroxymethylbilane synthase - Corymbia citriodora [Reaction:R-ECG-4827045] hydroxymethylbilane synthase - Echinochloa crus-galli [Reaction:R-JCU-4827045] hydroxymethylbilane synthase - Jatropha curcas [Reaction:R-STU-4827045] hydroxymethylbilane synthase - Solanum tuberosum [Reaction:R-LPE-4827045] hydroxymethylbilane synthase - Leersia perrieri [Reaction:R-SMO-4827045] hydroxymethylbilane synthase - Selaginella moellendorffii [Reaction:R-PED-4827045] hydroxymethylbilane synthase - Phyllostachys edulis [Reaction:R-OLO-4827045] hydroxymethylbilane synthase - Oryza longistaminata [Reaction:R-BRA-4827045] hydroxymethylbilane synthase - Brassica rapa [Reaction:R-AHY-4827045] hydroxymethylbilane synthase - Arachis hypogaea [Reaction:R-OAU-4827045] hydroxymethylbilane synthase - Oryza australiensis [Reaction:R-SCR-4827045] hydroxymethylbilane synthase - Secale cereale [Reaction:R-PAV-4827045] hydroxymethylbilane synthase - Prunus avium [Reaction:R-DRO-4827045] hydroxymethylbilane synthase - Dioscorea rotundata [Reaction:R-AIP-4827045] hydroxymethylbilane synthase - Arachis ipaensis [Reaction:R-GMA-4827045] hydroxymethylbilane synthase - Glycine max [Reaction:R-BOL-4827045] hydroxymethylbilane synthase - Brassica oleracea [Reaction:R-OOF-4827045] hydroxymethylbilane synthase - Oryza officinalis [Reaction:R-CCA-4827045] hydroxymethylbilane synthase - Cajanus cajan [Reaction:R-ADU-4827045] hydroxymethylbilane synthase - Arachis duranensis [Reaction:R-PTA-4827045] hydroxymethylbilane synthase - Pinus taeda [Reaction:R-GSO-4827045] hydroxymethylbilane synthase - Glycine soja [Reaction:R-ATR-4827045] hydroxymethylbilane synthase - Amborella trichopoda [Reaction:R-CSI-4827045] hydroxymethylbilane synthase - Citrus sinensis [Reaction:R-CRE-4827045] hydroxymethylbilane synthase - Chlamydomonas reinhardtii [Reaction:R-COL-4827045] hydroxymethylbilane synthase - Corchorus olitorius
output	[SimpleEntity:R-ALL-4827048] HMBL [plastid stroma] 4 × [SimpleEntity:R-ALL-4789078] NH3 [plastid stroma]
precedingEvent	[Reaction:R-OSA-4827076] porphobilinogen synthase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-4827045
summation	[Summation:4827072] Porphobilinogen is converted to hydroxymethylbilane by enzym...

Referrals

(hasEvent)	[Pathway:R-OSA-4827054] Tetrapyrrole biosynthesis I - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-4827058] uroporphyrinogen-III synthase - Oryza sativa