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pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+

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catalystActivity	[CatalystActivity:11199028] pyruvate dehydrogenase activity of PDH complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11195174] Elser, Justin, 2025-03-26
dbId	11199030
displayName	pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+
eventOf	[Pathway:R-CML-1119351] Mitochondrial pyruvate metabolism - Cucumis melo
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-CML-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cucumis melo
inferredFrom	[Reaction:R-OSA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza sativa
input	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isInDisease	false
isInferred	true
name	pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9764158] Cucumis melo
stId	R-CML-1169121
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(precedingEvent)	[Reaction:R-CML-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Cucumis melo
(hasEvent)	[Pathway:R-CML-1119351] Mitochondrial pyruvate metabolism - Cucumis melo
(inferredTo)	[Reaction:R-OSA-1169121] pyruvate + CoA-SH + NAD+ => acetyl-CoA + CO2 + NADH + H+ - Oryza sativa

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