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3-isopropylmalate dehydratase

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catalystActivity	[CatalystActivity:1119145] 3-isopropylmalate dehydratase activity of 3-isopropylmalate dehydratase [cytosol]
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:27946] EC:4.2.1.33 [DatabaseIdentifier:1132516] RiceCyc:3-ISOPROPYLMALISOM-RXN
dbId	1120935
displayName	3-isopropylmalate dehydratase
eventOf	[Pathway:R-OSA-1119540] Leucine biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120159] 3-isopropylmalate dehydrogenase - Oryza sativa
input	[SimpleEntity:R-ALL-1131112] 2-isopropylmalate [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	3-isopropylmalate dehydratase α-IPM isomerase Isopropylmalate isomerase biochemicalReaction12869
orthologousEvent	[Reaction:R-TAE-1120935] 3-isopropylmalate dehydratase - Triticum aestivum [Reaction:R-SLY-1120935] 3-isopropylmalate dehydratase - Solanum lycopersicum [Reaction:R-PED-1120935] 3-isopropylmalate dehydratase - Phyllostachys edulis [Reaction:R-VFA-1120935] 3-isopropylmalate dehydratase - Vicia faba var. faba [Reaction:R-VVN-1120935] 3-isopropylmalate dehydratase - Vitis vinifera [Reaction:R-OKA-1120935] 3-isopropylmalate dehydratase - Oryza sativa aus subgroup [Reaction:R-CCI-1120935] 3-isopropylmalate dehydratase - Corymbia citriodora [Reaction:R-CCD-1120935] 3-isopropylmalate dehydratase - Cynara cardunculus var. scolymus [Reaction:R-ECG-1120935] 3-isopropylmalate dehydratase - Echinochloa crus-galli [Reaction:R-CME-1120935] 3-isopropylmalate dehydratase - Cyanidioschyzon merolae [Reaction:R-ACO-1120935] 3-isopropylmalate dehydratase - Ananas comosus [Reaction:R-SPC-1120935] 3-isopropylmalate dehydratase - Synechocystis sp. PCC 6803 [Reaction:R-OBA-1120935] 3-isopropylmalate dehydratase - Oryza barthii [Reaction:R-PSA-1120935] 3-isopropylmalate dehydratase - Pisum sativum [Reaction:R-RCH-1120935] 3-isopropylmalate dehydratase - Rosa chinensis [Reaction:R-HVU-1120935] 3-isopropylmalate dehydratase - Hordeum vulgare [Reaction:R-OSI-1120935] 3-isopropylmalate dehydratase - Oryza sativa Indica Group [Reaction:R-PPE-1120935] 3-isopropylmalate dehydratase - Prunus persica [Reaction:R-HLH-1120935] 3-isopropylmalate dehydratase - Humulus lupulus [Reaction:R-ZMA-1120935] 3-isopropylmalate dehydratase - Zea mays [Reaction:R-GSU-1120935] 3-isopropylmalate dehydratase - Galdieria sulphuraria [Reaction:R-COL-1120935] 3-isopropylmalate dehydratase - Corchorus olitorius [Reaction:R-GSO-1120935] 3-isopropylmalate dehydratase - Glycine soja [Reaction:R-VAN-1120935] 3-isopropylmalate dehydratase - Vigna angularis [Reaction:R-FEX-1120935] 3-isopropylmalate dehydratase - Fraxinus excelsior (European ash) [Reaction:R-SVI-1120935] 3-isopropylmalate dehydratase - Setaria viridis [Reaction:R-PPA-1120935] 3-isopropylmalate dehydratase - Physcomitrella patens [Reaction:R-LST-1120935] 3-isopropylmalate dehydratase - Lathyrus sativus [Reaction:R-ACH-1120935] 3-isopropylmalate dehydratase - Actinidia chinensis [Reaction:R-CAR-1120935] 3-isopropylmalate dehydratase - Cicer arietinum [Reaction:R-JRE-1120935] 3-isopropylmalate dehydratase - Juglans regia [Reaction:R-ITR-1120935] 3-isopropylmalate dehydratase - Ipomoea triloba [Reaction:R-BDI-1120935] 3-isopropylmalate dehydratase - Brachypodium distachyon [Reaction:R-LSA-1120935] 3-isopropylmalate dehydratase - Lactuca sativa [Reaction:R-OEU-1120935] 3-isopropylmalate dehydratase - Olea europaea [Reaction:R-VRA-1120935] 3-isopropylmalate dehydratase - Vigna radiata [Reaction:R-GRA-1120935] 3-isopropylmalate dehydratase - Gossypium raimondii [Reaction:R-TCA-1120935] 3-isopropylmalate dehydratase - Theobroma cacao [Reaction:R-ATA-1120935] 3-isopropylmalate dehydratase - Aegilops tauschii [Reaction:R-PTI-1120935] 3-isopropylmalate dehydratase - Populus trichocarpa [Reaction:R-ALY-1120935] 3-isopropylmalate dehydratase - Arabidopsis lyrata [Reaction:R-AOF-1120935] 3-isopropylmalate dehydratase - Asparagus officinalis [Reaction:R-OGR-1120935] 3-isopropylmalate dehydratase - Oryza meyeriana var. granulata [Reaction:R-BJU-1120935] 3-isopropylmalate dehydratase - Brassica juncea [Reaction:R-AUM-1120935] 3-isopropylmalate dehydratase - Aegilops umbellulata [Reaction:R-DEX-1120935] 3-isopropylmalate dehydratase - Digitaria exilis [Reaction:R-PHA-1120935] 3-isopropylmalate dehydratase - Panicum hallii ("FIL2") [Reaction:R-ORU-1120935] 3-isopropylmalate dehydratase - Oryza rufipogon [Reaction:R-ATR-1120935] 3-isopropylmalate dehydratase - Amborella trichopoda [Reaction:R-PVU-1120935] 3-isopropylmalate dehydratase - Phaseolus vulgaris [Reaction:R-PTA-1120935] 3-isopropylmalate dehydratase - Pinus taeda [Reaction:R-PVE-1120935] 3-isopropylmalate dehydratase - Pistacia vera [Reaction:R-CCA-1120935] 3-isopropylmalate dehydratase - Cajanus cajan [Reaction:R-ECU-1120935] 3-isopropylmalate dehydratase - Eragrostis curvula [Reaction:R-CML-1120935] 3-isopropylmalate dehydratase - Cucumis melo [Reaction:R-CQI-1120935] 3-isopropylmalate dehydratase - Chenopodium quinoa [Reaction:R-LPR-1120935] 3-isopropylmalate dehydratase - Lolium perenne [Reaction:R-TDI-1120935] 3-isopropylmalate dehydratase - Triticum dicoccoides [Reaction:R-MAC-1120935] 3-isopropylmalate dehydratase - Musa acuminata [Reaction:R-CAN-1120935] 3-isopropylmalate dehydratase - Capsicum annuum [Reaction:R-TTU-1120935] 3-isopropylmalate dehydratase - Triticum turgidum [Reaction:R-VUN-1120935] 3-isopropylmalate dehydratase - Vigna unguiculata [Reaction:R-OPU-1120935] 3-isopropylmalate dehydratase - Oryza punctata [Reaction:R-DCA-1120935] 3-isopropylmalate dehydratase - Daucus carota [Reaction:R-CCL-1120935] 3-isopropylmalate dehydratase - Citrus clementina [Reaction:R-NNU-1120935] 3-isopropylmalate dehydratase - Nelumbo nucifera [Reaction:R-ZMY-1120935] 3-isopropylmalate dehydratase - Zea mays ver5 [Reaction:R-MDO-1120935] 3-isopropylmalate dehydratase - Malus domestica [Reaction:R-CSK-1120935] 3-isopropylmalate dehydratase - Cannabis sativa subsp. indica [Reaction:R-MTR-1120935] 3-isopropylmalate dehydratase - Medicago truncatula [Reaction:R-CST-1120935] 3-isopropylmalate dehydratase - Camelina sativa [Reaction:R-NCO-1120935] 3-isopropylmalate dehydratase - Nymphaea colorata [Reaction:R-ZJA-1120935] 3-isopropylmalate dehydratase - Zoysia japonica [Reaction:R-CRE-1120935] 3-isopropylmalate dehydratase - Chlamydomonas reinhardtii [Reaction:R-JCU-1120935] 3-isopropylmalate dehydratase - Jatropha curcas [Reaction:R-QLO-1120935] 3-isopropylmalate dehydratase - Quercus lobata [Reaction:R-OAU-1120935] 3-isopropylmalate dehydratase - Oryza australiensis [Reaction:R-SIT-1120935] 3-isopropylmalate dehydratase - Setaria italica [Reaction:R-PAB-1120935] 3-isopropylmalate dehydratase - Picea abies [Reaction:R-MES-1120935] 3-isopropylmalate dehydratase - Manihot esculenta [Reaction:R-OMI-1120935] 3-isopropylmalate dehydratase - Oryza minuta [Reaction:R-STU-1120935] 3-isopropylmalate dehydratase - Solanum tuberosum [Reaction:R-ASA-1120935] 3-isopropylmalate dehydratase - Avena sativa [Reaction:R-OBR-1120935] 3-isopropylmalate dehydratase - Oryza brachyantha [Reaction:R-CSA-1120935] 3-isopropylmalate dehydratase - Cucumis sativus [Reaction:R-NAT-1120935] 3-isopropylmalate dehydratase - Nicotiana attenuata [Reaction:R-AHA-1120935] 3-isopropylmalate dehydratase - Arabidopsis halleri [Reaction:R-SMO-1120935] 3-isopropylmalate dehydratase - Selaginella moellendorffii [Reaction:R-TSP-1120935] 3-isopropylmalate dehydratase - Triticum spelta subsp. spelta [Reaction:R-SSP-1120935] 3-isopropylmalate dehydratase - Saccharum spontaneum [Reaction:R-HLP-1120935] 3-isopropylmalate dehydratase - Humulus lupulus var. lupulus [Reaction:R-QSU-1120935] 3-isopropylmalate dehydratase - Quercus suber [Reaction:R-GMA-1120935] 3-isopropylmalate dehydratase - Glycine max [Reaction:R-OLO-1120935] 3-isopropylmalate dehydratase - Oryza longistaminata [Reaction:R-LAN-1120935] 3-isopropylmalate dehydratase - Lupinus angustifolius [Reaction:R-FVE-1120935] 3-isopropylmalate dehydratase - Fragaria vesca [Reaction:R-AHY-1120935] 3-isopropylmalate dehydratase - Arachis hypogaea [Reaction:R-ONI-1120935] 3-isopropylmalate dehydratase - Oryza nivara [Reaction:R-MPO-1120935] 3-isopropylmalate dehydratase - Marchantia polymorpha [Reaction:R-CCR-1120935] 3-isopropylmalate dehydratase - Chondrus crispus [Reaction:R-ADU-1120935] 3-isopropylmalate dehydratase - Arachis duranensis [Reaction:R-BNA-1120935] 3-isopropylmalate dehydratase - Brassica napus [Reaction:R-MGU-1120935] 3-isopropylmalate dehydratase - Erythranthe guttata [Reaction:R-TTI-1120935] 3-isopropylmalate dehydratase - Triticum timopheevii subsp. timopheevii [Reaction:R-TUR-1120935] 3-isopropylmalate dehydratase - Triticum urartu [Reaction:R-PSO-1120935] 3-isopropylmalate dehydratase - Papaver somniferum [Reaction:R-OGU-1120935] 3-isopropylmalate dehydratase - Oryza glumaepatula [Reaction:R-CSC-1120935] 3-isopropylmalate dehydratase - Cannabis sativa [Reaction:R-AIP-1120935] 3-isopropylmalate dehydratase - Arachis ipaensis [Reaction:R-CBA-1120935] 3-isopropylmalate dehydratase - Chara braunii [Reaction:R-OGL-1120935] 3-isopropylmalate dehydratase - Oryza glaberrima [Reaction:R-SHI-1120935] 3-isopropylmalate dehydratase - Salvia hispanica [Reaction:R-SIN-1120935] 3-isopropylmalate dehydratase - Sesamum indicum [Reaction:R-BRA-1120935] 3-isopropylmalate dehydratase - Brassica rapa [Reaction:R-OES-1120935] 3-isopropylmalate dehydratase - Olea europaea var. sylvestris [Reaction:R-PDA-1120935] 3-isopropylmalate dehydratase - Phoenix dactylifera [Reaction:R-HAN-1120935] 3-isopropylmalate dehydratase - Helianthus annuus [Reaction:R-OME-1120935] 3-isopropylmalate dehydratase - Oryza meridionalis [Reaction:R-CRU-1120935] 3-isopropylmalate dehydratase - Capsella rubella [Reaction:R-CCN-1120935] 3-isopropylmalate dehydratase - Coffea canephora [Reaction:R-ATH-1120935] 3-isopropylmalate dehydratase - Arabidopsis thaliana [Reaction:R-SCR-1120935] 3-isopropylmalate dehydratase - Secale cereale [Reaction:R-CLA-1120935] 3-isopropylmalate dehydratase - Citrullus lanatus [Reaction:R-TPR-1120935] 3-isopropylmalate dehydratase - Trifolium pratense [Reaction:R-CSI-1120935] 3-isopropylmalate dehydratase - Citrus sinensis [Reaction:R-PAV-1120935] 3-isopropylmalate dehydratase - Prunus avium [Reaction:R-BOL-1120935] 3-isopropylmalate dehydratase - Brassica oleracea [Reaction:R-ETE-1120935] 3-isopropylmalate dehydratase - Eragrostis tef [Reaction:R-LPE-1120935] 3-isopropylmalate dehydratase - Leersia perrieri [Reaction:R-CCP-1120935] 3-isopropylmalate dehydratase - Corchorus capsularis [Reaction:R-EGR-1120935] 3-isopropylmalate dehydratase - Eucalyptus grandis [Reaction:R-DRO-1120935] 3-isopropylmalate dehydratase - Dioscorea rotundata [Reaction:R-SBI-1120935] 3-isopropylmalate dehydratase - Sorghum bicolor [Reaction:R-OOF-1120935] 3-isopropylmalate dehydratase - Oryza officinalis [Reaction:R-FCR-1120935] 3-isopropylmalate dehydratase - Ficus carica [Reaction:R-PHH-1120935] 3-isopropylmalate dehydratase - Panicum hallii var. hallii ("HAL2") [Reaction:R-BVU-1120935] 3-isopropylmalate dehydratase - Beta vulgaris
output	[SimpleEntity:R-ALL-1130810] 3-isopropylmalate [cytosol]
precedingEvent	[Reaction:R-OSA-1120496] 2-isopropylmalate synthase - Oryza sativa
reviewed	[InstanceEdit:2879498] Dharmawardhana, DP, 2012-12-20
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120935
summation	[Summation:2879491] 2-isopropylmalate is converted to 3-isopropylmalate by enzym...

Referrals

(hasEvent)	[Pathway:R-OSA-1119540] Leucine biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120159] 3-isopropylmalate dehydrogenase - Oryza sativa