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2-isopropylmalate synthase

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catalystActivity	[CatalystActivity:1118882] 2-isopropylmalate synthase activity of 2-isopropylmalate synthase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1154332] EC-NUMBER:2.3.3.13 [DatabaseIdentifier:1151566] RiceCyc:2-ISOPROPYLMALATESYN-RXN
dbId	1120496
displayName	2-isopropylmalate synthase
eventOf	[Pathway:R-OSA-1119540] Leucine biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120935] 3-isopropylmalate dehydratase - Oryza sativa
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-70846] KIV [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	2-isopropylmalate synthase α-IPM synthase α-isopropylmalate synthase biochemicalReaction74743
orthologousEvent	[Reaction:R-HAN-1120496] 2-isopropylmalate synthase - Helianthus annuus [Reaction:R-ECU-1120496] 2-isopropylmalate synthase - Eragrostis curvula [Reaction:R-OOF-1120496] 2-isopropylmalate synthase - Oryza officinalis [Reaction:R-OAU-1120496] 2-isopropylmalate synthase - Oryza australiensis [Reaction:R-OBR-1120496] 2-isopropylmalate synthase - Oryza brachyantha [Reaction:R-AHY-1120496] 2-isopropylmalate synthase - Arachis hypogaea [Reaction:R-EGR-1120496] 2-isopropylmalate synthase - Eucalyptus grandis [Reaction:R-ZMY-1120496] 2-isopropylmalate synthase - Zea mays ver5 [Reaction:R-SHI-1120496] 2-isopropylmalate synthase - Salvia hispanica [Reaction:R-VRA-1120496] 2-isopropylmalate synthase - Vigna radiata [Reaction:R-ONI-1120496] 2-isopropylmalate synthase - Oryza nivara [Reaction:R-CCN-1120496] 2-isopropylmalate synthase - Coffea canephora [Reaction:R-HLH-1120496] 2-isopropylmalate synthase - Humulus lupulus [Reaction:R-VUN-1120496] 2-isopropylmalate synthase - Vigna unguiculata [Reaction:R-CSA-1120496] 2-isopropylmalate synthase - Cucumis sativus [Reaction:R-HLP-1120496] 2-isopropylmalate synthase - Humulus lupulus var. lupulus [Reaction:R-TCA-1120496] 2-isopropylmalate synthase - Theobroma cacao [Reaction:R-AHA-1120496] 2-isopropylmalate synthase - Arabidopsis halleri [Reaction:R-ETE-1120496] 2-isopropylmalate synthase - Eragrostis tef [Reaction:R-PAV-1120496] 2-isopropylmalate synthase - Prunus avium [Reaction:R-FEX-1120496] 2-isopropylmalate synthase - Fraxinus excelsior (European ash) [Reaction:R-BNA-1120496] 2-isopropylmalate synthase - Brassica napus [Reaction:R-JCU-1120496] 2-isopropylmalate synthase - Jatropha curcas [Reaction:R-GSU-1120496] 2-isopropylmalate synthase - Galdieria sulphuraria [Reaction:R-CSC-1120496] 2-isopropylmalate synthase - Cannabis sativa [Reaction:R-RCH-1120496] 2-isopropylmalate synthase - Rosa chinensis [Reaction:R-OES-1120496] 2-isopropylmalate synthase - Olea europaea var. sylvestris [Reaction:R-OGU-1120496] 2-isopropylmalate synthase - Oryza glumaepatula [Reaction:R-OGL-1120496] 2-isopropylmalate synthase - Oryza glaberrima [Reaction:R-PPA-1120496] 2-isopropylmalate synthase - Physcomitrella patens [Reaction:R-OBA-1120496] 2-isopropylmalate synthase - Oryza barthii [Reaction:R-CCP-1120496] 2-isopropylmalate synthase - Corchorus capsularis [Reaction:R-PPE-1120496] 2-isopropylmalate synthase - Prunus persica [Reaction:R-CSK-1120496] 2-isopropylmalate synthase - Cannabis sativa subsp. indica [Reaction:R-SIT-1120496] 2-isopropylmalate synthase - Setaria italica [Reaction:R-HVU-1120496] 2-isopropylmalate synthase - Hordeum vulgare [Reaction:R-TSP-1120496] 2-isopropylmalate synthase - Triticum spelta subsp. spelta [Reaction:R-PVE-1120496] 2-isopropylmalate synthase - Pistacia vera [Reaction:R-SCR-1120496] 2-isopropylmalate synthase - Secale cereale [Reaction:R-OSI-1120496] 2-isopropylmalate synthase - Oryza sativa Indica Group [Reaction:R-SSP-1120496] 2-isopropylmalate synthase - Saccharum spontaneum [Reaction:R-SBI-1120496] 2-isopropylmalate synthase - Sorghum bicolor [Reaction:R-FVE-1120496] 2-isopropylmalate synthase - Fragaria vesca [Reaction:R-ATA-1120496] 2-isopropylmalate synthase - Aegilops tauschii [Reaction:R-CBA-1120496] 2-isopropylmalate synthase - Chara braunii [Reaction:R-ITR-1120496] 2-isopropylmalate synthase - Ipomoea triloba [Reaction:R-DEX-1120496] 2-isopropylmalate synthase - Digitaria exilis [Reaction:R-MES-1120496] 2-isopropylmalate synthase - Manihot esculenta [Reaction:R-BDI-1120496] 2-isopropylmalate synthase - Brachypodium distachyon [Reaction:R-AIP-1120496] 2-isopropylmalate synthase - Arachis ipaensis [Reaction:R-NAT-1120496] 2-isopropylmalate synthase - Nicotiana attenuata [Reaction:R-PDA-1120496] 2-isopropylmalate synthase - Phoenix dactylifera [Reaction:R-CRE-1120496] 2-isopropylmalate synthase - Chlamydomonas reinhardtii [Reaction:R-ZJA-1120496] 2-isopropylmalate synthase - Zoysia japonica [Reaction:R-CLA-1120496] 2-isopropylmalate synthase - Citrullus lanatus [Reaction:R-MDO-1120496] 2-isopropylmalate synthase - Malus domestica [Reaction:R-ACH-1120496] 2-isopropylmalate synthase - Actinidia chinensis [Reaction:R-CCD-1120496] 2-isopropylmalate synthase - Cynara cardunculus var. scolymus [Reaction:R-NCO-1120496] 2-isopropylmalate synthase - Nymphaea colorata [Reaction:R-TAE-1120496] 2-isopropylmalate synthase - Triticum aestivum [Reaction:R-TUR-1120496] 2-isopropylmalate synthase - Triticum urartu [Reaction:R-MAC-1120496] 2-isopropylmalate synthase - Musa acuminata [Reaction:R-ATR-1120496] 2-isopropylmalate synthase - Amborella trichopoda [Reaction:R-PVU-1120496] 2-isopropylmalate synthase - Phaseolus vulgaris [Reaction:R-AUM-1120496] 2-isopropylmalate synthase - Aegilops umbellulata [Reaction:R-OPU-1120496] 2-isopropylmalate synthase - Oryza punctata [Reaction:R-CCI-1120496] 2-isopropylmalate synthase - Corymbia citriodora [Reaction:R-TDI-1120496] 2-isopropylmalate synthase - Triticum dicoccoides [Reaction:R-PHH-1120496] 2-isopropylmalate synthase - Panicum hallii var. hallii ("HAL2") [Reaction:R-GRA-1120496] 2-isopropylmalate synthase - Gossypium raimondii [Reaction:R-STU-1120496] 2-isopropylmalate synthase - Solanum tuberosum [Reaction:R-DCA-1120496] 2-isopropylmalate synthase - Daucus carota [Reaction:R-ATH-1120496] 2-isopropylmalate synthase - Arabidopsis thaliana [Reaction:R-ALY-1120496] 2-isopropylmalate synthase - Arabidopsis lyrata [Reaction:R-CCL-1120496] 2-isopropylmalate synthase - Citrus clementina [Reaction:R-CRU-1120496] 2-isopropylmalate synthase - Capsella rubella [Reaction:R-VFA-1120496] 2-isopropylmalate synthase - Vicia faba var. faba [Reaction:R-OGR-1120496] 2-isopropylmalate synthase - Oryza meyeriana var. granulata [Reaction:R-SIN-1120496] 2-isopropylmalate synthase - Sesamum indicum [Reaction:R-PTI-1120496] 2-isopropylmalate synthase - Populus trichocarpa [Reaction:R-CSI-1120496] 2-isopropylmalate synthase - Citrus sinensis [Reaction:R-PHA-1120496] 2-isopropylmalate synthase - Panicum hallii ("FIL2") [Reaction:R-CME-1120496] 2-isopropylmalate synthase - Cyanidioschyzon merolae [Reaction:R-CQI-1120496] 2-isopropylmalate synthase - Chenopodium quinoa [Reaction:R-QLO-1120496] 2-isopropylmalate synthase - Quercus lobata [Reaction:R-PED-1120496] 2-isopropylmalate synthase - Phyllostachys edulis [Reaction:R-LST-1120496] 2-isopropylmalate synthase - Lathyrus sativus [Reaction:R-OEU-1120496] 2-isopropylmalate synthase - Olea europaea [Reaction:R-TPR-1120496] 2-isopropylmalate synthase - Trifolium pratense [Reaction:R-GMA-1120496] 2-isopropylmalate synthase - Glycine max [Reaction:R-PSO-1120496] 2-isopropylmalate synthase - Papaver somniferum [Reaction:R-MTR-1120496] 2-isopropylmalate synthase - Medicago truncatula [Reaction:R-BOL-1120496] 2-isopropylmalate synthase - Brassica oleracea [Reaction:R-CST-1120496] 2-isopropylmalate synthase - Camelina sativa [Reaction:R-FCR-1120496] 2-isopropylmalate synthase - Ficus carica [Reaction:R-BRA-1120496] 2-isopropylmalate synthase - Brassica rapa [Reaction:R-ADU-1120496] 2-isopropylmalate synthase - Arachis duranensis [Reaction:R-MGU-1120496] 2-isopropylmalate synthase - Erythranthe guttata [Reaction:R-VAN-1120496] 2-isopropylmalate synthase - Vigna angularis [Reaction:R-BJU-1120496] 2-isopropylmalate synthase - Brassica juncea [Reaction:R-LPE-1120496] 2-isopropylmalate synthase - Leersia perrieri [Reaction:R-CCR-1120496] 2-isopropylmalate synthase - Chondrus crispus [Reaction:R-PTA-1120496] 2-isopropylmalate synthase - Pinus taeda [Reaction:R-ORU-1120496] 2-isopropylmalate synthase - Oryza rufipogon [Reaction:R-TTI-1120496] 2-isopropylmalate synthase - Triticum timopheevii subsp. timopheevii [Reaction:R-OME-1120496] 2-isopropylmalate synthase - Oryza meridionalis [Reaction:R-CCA-1120496] 2-isopropylmalate synthase - Cajanus cajan [Reaction:R-SLY-1120496] 2-isopropylmalate synthase - Solanum lycopersicum [Reaction:R-GSO-1120496] 2-isopropylmalate synthase - Glycine soja [Reaction:R-ECG-1120496] 2-isopropylmalate synthase - Echinochloa crus-galli [Reaction:R-CAR-1120496] 2-isopropylmalate synthase - Cicer arietinum [Reaction:R-LSA-1120496] 2-isopropylmalate synthase - Lactuca sativa [Reaction:R-SVI-1120496] 2-isopropylmalate synthase - Setaria viridis [Reaction:R-CAN-1120496] 2-isopropylmalate synthase - Capsicum annuum [Reaction:R-LPR-1120496] 2-isopropylmalate synthase - Lolium perenne [Reaction:R-VVN-1120496] 2-isopropylmalate synthase - Vitis vinifera [Reaction:R-CML-1120496] 2-isopropylmalate synthase - Cucumis melo [Reaction:R-OLU-1120496] 2-isopropylmalate synthase - Ostreococcus lucimarinus [Reaction:R-BVU-1120496] 2-isopropylmalate synthase - Beta vulgaris [Reaction:R-SPC-1120496] 2-isopropylmalate synthase - Synechocystis sp. PCC 6803 [Reaction:R-ZMA-1120496] 2-isopropylmalate synthase - Zea mays [Reaction:R-SMO-1120496] 2-isopropylmalate synthase - Selaginella moellendorffii [Reaction:R-JRE-1120496] 2-isopropylmalate synthase - Juglans regia [Reaction:R-LAN-1120496] 2-isopropylmalate synthase - Lupinus angustifolius [Reaction:R-TTU-1120496] 2-isopropylmalate synthase - Triticum turgidum [Reaction:R-QSU-1120496] 2-isopropylmalate synthase - Quercus suber [Reaction:R-DRO-1120496] 2-isopropylmalate synthase - Dioscorea rotundata [Reaction:R-OMI-1120496] 2-isopropylmalate synthase - Oryza minuta [Reaction:R-PSA-1120496] 2-isopropylmalate synthase - Pisum sativum [Reaction:R-MPO-1120496] 2-isopropylmalate synthase - Marchantia polymorpha [Reaction:R-ASA-1120496] 2-isopropylmalate synthase - Avena sativa
output	[SimpleEntity:R-ALL-1131112] 2-isopropylmalate [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-OSA-1120582] dihydroxy-acid dehydratase - Oryza sativa
reviewed	[InstanceEdit:2879498] Dharmawardhana, DP, 2012-12-20
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120496
summation	[Summation:2879494] 2-keto-isovalerate is converted to 2-isopropylmalate by enzy...

Referrals

(hasEvent)	[Pathway:R-OSA-1119540] Leucine biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120935] 3-isopropylmalate dehydratase - Oryza sativa