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3-isopropylmalate dehydrogenase

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catalystActivity	[CatalystActivity:1118246] 3-isopropylmalate dehydrogenase activity of 3-isopropylmalate dehydrogenase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26580] EC:1.1.1.85 [DatabaseIdentifier:1151456] RiceCyc:3-ISOPROPYLMALDEHYDROG-RXN
dbId	1120159
displayName	3-isopropylmalate dehydrogenase
eventOf	[Pathway:R-OSA-1119540] Leucine biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120593] 2-isopropyl-3-oxosuccinate->2-ketoisocaproate+CO2 - Oryza sativa
input	[SimpleEntity:R-ALL-1130810] 3-isopropylmalate [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	3-isopropylmalate dehydrogenase β-isopropylmalate dehydrogenase IMDH β-IPM dehydrogenase biochemicalReaction94307
orthologousEvent	[Reaction:R-TSP-1120159] 3-isopropylmalate dehydrogenase - Triticum spelta subsp. spelta [Reaction:R-BRA-1120159] 3-isopropylmalate dehydrogenase - Brassica rapa [Reaction:R-ACO-1120159] 3-isopropylmalate dehydrogenase - Ananas comosus [Reaction:R-BOL-1120159] 3-isopropylmalate dehydrogenase - Brassica oleracea [Reaction:R-ATA-1120159] 3-isopropylmalate dehydrogenase - Aegilops tauschii [Reaction:R-FEX-1120159] 3-isopropylmalate dehydrogenase - Fraxinus excelsior (European ash) [Reaction:R-SCR-1120159] 3-isopropylmalate dehydrogenase - Secale cereale [Reaction:R-TDI-1120159] 3-isopropylmalate dehydrogenase - Triticum dicoccoides [Reaction:R-OBR-1120159] 3-isopropylmalate dehydrogenase - Oryza brachyantha [Reaction:R-ONI-1120159] 3-isopropylmalate dehydrogenase - Oryza nivara [Reaction:R-OGL-1120159] 3-isopropylmalate dehydrogenase - Oryza glaberrima [Reaction:R-SPC-1120159] 3-isopropylmalate dehydrogenase - Synechocystis sp. PCC 6803 [Reaction:R-TCA-1120159] 3-isopropylmalate dehydrogenase - Theobroma cacao [Reaction:R-NAT-1120159] 3-isopropylmalate dehydrogenase - Nicotiana attenuata [Reaction:R-OES-1120159] 3-isopropylmalate dehydrogenase - Olea europaea var. sylvestris [Reaction:R-QSU-1120159] 3-isopropylmalate dehydrogenase - Quercus suber [Reaction:R-HAN-1120159] 3-isopropylmalate dehydrogenase - Helianthus annuus [Reaction:R-OOF-1120159] 3-isopropylmalate dehydrogenase - Oryza officinalis [Reaction:R-PDA-1120159] 3-isopropylmalate dehydrogenase - Phoenix dactylifera [Reaction:R-CSK-1120159] 3-isopropylmalate dehydrogenase - Cannabis sativa subsp. indica [Reaction:R-PTA-1120159] 3-isopropylmalate dehydrogenase - Pinus taeda [Reaction:R-PED-1120159] 3-isopropylmalate dehydrogenase - Phyllostachys edulis [Reaction:R-PVE-1120159] 3-isopropylmalate dehydrogenase - Pistacia vera [Reaction:R-MDO-1120159] 3-isopropylmalate dehydrogenase - Malus domestica [Reaction:R-HLH-1120159] 3-isopropylmalate dehydrogenase - Humulus lupulus [Reaction:R-GSU-1120159] 3-isopropylmalate dehydrogenase - Galdieria sulphuraria [Reaction:R-HVU-1120159] 3-isopropylmalate dehydrogenase - Hordeum vulgare [Reaction:R-LST-1120159] 3-isopropylmalate dehydrogenase - Lathyrus sativus [Reaction:R-BNA-1120159] 3-isopropylmalate dehydrogenase - Brassica napus [Reaction:R-CSC-1120159] 3-isopropylmalate dehydrogenase - Cannabis sativa [Reaction:R-CCL-1120159] 3-isopropylmalate dehydrogenase - Citrus clementina [Reaction:R-EGR-1120159] 3-isopropylmalate dehydrogenase - Eucalyptus grandis [Reaction:R-MGU-1120159] 3-isopropylmalate dehydrogenase - Erythranthe guttata [Reaction:R-CRE-1120159] 3-isopropylmalate dehydrogenase - Chlamydomonas reinhardtii [Reaction:R-PAV-1120159] 3-isopropylmalate dehydrogenase - Prunus avium [Reaction:R-ATH-1120159] 3-isopropylmalate dehydrogenase - Arabidopsis thaliana [Reaction:R-PPE-1120159] 3-isopropylmalate dehydrogenase - Prunus persica [Reaction:R-CBA-1120159] 3-isopropylmalate dehydrogenase - Chara braunii [Reaction:R-JCU-1120159] 3-isopropylmalate dehydrogenase - Jatropha curcas [Reaction:R-ALY-1120159] 3-isopropylmalate dehydrogenase - Arabidopsis lyrata [Reaction:R-SIN-1120159] 3-isopropylmalate dehydrogenase - Sesamum indicum [Reaction:R-AIP-1120159] 3-isopropylmalate dehydrogenase - Arachis ipaensis [Reaction:R-PAB-1120159] 3-isopropylmalate dehydrogenase - Picea abies [Reaction:R-ATR-1120159] 3-isopropylmalate dehydrogenase - Amborella trichopoda [Reaction:R-OEU-1120159] 3-isopropylmalate dehydrogenase - Olea europaea [Reaction:R-PSO-1120159] 3-isopropylmalate dehydrogenase - Papaver somniferum [Reaction:R-STU-1120159] 3-isopropylmalate dehydrogenase - Solanum tuberosum [Reaction:R-CCN-1120159] 3-isopropylmalate dehydrogenase - Coffea canephora [Reaction:R-DRO-1120159] 3-isopropylmalate dehydrogenase - Dioscorea rotundata [Reaction:R-BVU-1120159] 3-isopropylmalate dehydrogenase - Beta vulgaris [Reaction:R-SLY-1120159] 3-isopropylmalate dehydrogenase - Solanum lycopersicum [Reaction:R-TUR-1120159] 3-isopropylmalate dehydrogenase - Triticum urartu [Reaction:R-OGR-1120159] 3-isopropylmalate dehydrogenase - Oryza meyeriana var. granulata [Reaction:R-OMI-1120159] 3-isopropylmalate dehydrogenase - Oryza minuta [Reaction:R-COL-1120159] 3-isopropylmalate dehydrogenase - Corchorus olitorius [Reaction:R-DCA-1120159] 3-isopropylmalate dehydrogenase - Daucus carota [Reaction:R-SVI-1120159] 3-isopropylmalate dehydrogenase - Setaria viridis [Reaction:R-VVN-1120159] 3-isopropylmalate dehydrogenase - Vitis vinifera [Reaction:R-MES-1120159] 3-isopropylmalate dehydrogenase - Manihot esculenta [Reaction:R-ECU-1120159] 3-isopropylmalate dehydrogenase - Eragrostis curvula [Reaction:R-CME-1120159] 3-isopropylmalate dehydrogenase - Cyanidioschyzon merolae [Reaction:R-LPR-1120159] 3-isopropylmalate dehydrogenase - Lolium perenne [Reaction:R-MTR-1120159] 3-isopropylmalate dehydrogenase - Medicago truncatula [Reaction:R-NCO-1120159] 3-isopropylmalate dehydrogenase - Nymphaea colorata [Reaction:R-VAN-1120159] 3-isopropylmalate dehydrogenase - Vigna angularis [Reaction:R-FVE-1120159] 3-isopropylmalate dehydrogenase - Fragaria vesca [Reaction:R-VRA-1120159] 3-isopropylmalate dehydrogenase - Vigna radiata [Reaction:R-SSP-1120159] 3-isopropylmalate dehydrogenase - Saccharum spontaneum [Reaction:R-ASA-1120159] 3-isopropylmalate dehydrogenase - Avena sativa [Reaction:R-AHA-1120159] 3-isopropylmalate dehydrogenase - Arabidopsis halleri [Reaction:R-LPE-1120159] 3-isopropylmalate dehydrogenase - Leersia perrieri [Reaction:R-TAE-1120159] 3-isopropylmalate dehydrogenase - Triticum aestivum [Reaction:R-CCP-1120159] 3-isopropylmalate dehydrogenase - Corchorus capsularis [Reaction:R-ADU-1120159] 3-isopropylmalate dehydrogenase - Arachis duranensis [Reaction:R-TTI-1120159] 3-isopropylmalate dehydrogenase - Triticum timopheevii subsp. timopheevii [Reaction:R-OPU-1120159] 3-isopropylmalate dehydrogenase - Oryza punctata [Reaction:R-OBA-1120159] 3-isopropylmalate dehydrogenase - Oryza barthii [Reaction:R-DEX-1120159] 3-isopropylmalate dehydrogenase - Digitaria exilis [Reaction:R-LSA-1120159] 3-isopropylmalate dehydrogenase - Lactuca sativa [Reaction:R-ACH-1120159] 3-isopropylmalate dehydrogenase - Actinidia chinensis [Reaction:R-LAN-1120159] 3-isopropylmalate dehydrogenase - Lupinus angustifolius [Reaction:R-CCD-1120159] 3-isopropylmalate dehydrogenase - Cynara cardunculus var. scolymus [Reaction:R-SMO-1120159] 3-isopropylmalate dehydrogenase - Selaginella moellendorffii [Reaction:R-OSI-1120159] 3-isopropylmalate dehydrogenase - Oryza sativa Indica Group [Reaction:R-CSI-1120159] 3-isopropylmalate dehydrogenase - Citrus sinensis [Reaction:R-AHY-1120159] 3-isopropylmalate dehydrogenase - Arachis hypogaea [Reaction:R-GRA-1120159] 3-isopropylmalate dehydrogenase - Gossypium raimondii [Reaction:R-JRE-1120159] 3-isopropylmalate dehydrogenase - Juglans regia [Reaction:R-PSA-1120159] 3-isopropylmalate dehydrogenase - Pisum sativum [Reaction:R-CML-1120159] 3-isopropylmalate dehydrogenase - Cucumis melo [Reaction:R-CAR-1120159] 3-isopropylmalate dehydrogenase - Cicer arietinum [Reaction:R-FCR-1120159] 3-isopropylmalate dehydrogenase - Ficus carica [Reaction:R-CAN-1120159] 3-isopropylmalate dehydrogenase - Capsicum annuum [Reaction:R-TPR-1120159] 3-isopropylmalate dehydrogenase - Trifolium pratense [Reaction:R-ZJA-1120159] 3-isopropylmalate dehydrogenase - Zoysia japonica [Reaction:R-CCI-1120159] 3-isopropylmalate dehydrogenase - Corymbia citriodora [Reaction:R-CCR-1120159] 3-isopropylmalate dehydrogenase - Chondrus crispus [Reaction:R-QLO-1120159] 3-isopropylmalate dehydrogenase - Quercus lobata [Reaction:R-ETE-1120159] 3-isopropylmalate dehydrogenase - Eragrostis tef [Reaction:R-AUM-1120159] 3-isopropylmalate dehydrogenase - Aegilops umbellulata [Reaction:R-BDI-1120159] 3-isopropylmalate dehydrogenase - Brachypodium distachyon [Reaction:R-OAU-1120159] 3-isopropylmalate dehydrogenase - Oryza australiensis [Reaction:R-OGU-1120159] 3-isopropylmalate dehydrogenase - Oryza glumaepatula [Reaction:R-SBI-1120159] 3-isopropylmalate dehydrogenase - Sorghum bicolor [Reaction:R-PHH-1120159] 3-isopropylmalate dehydrogenase - Panicum hallii var. hallii ("HAL2") [Reaction:R-VUN-1120159] 3-isopropylmalate dehydrogenase - Vigna unguiculata [Reaction:R-ECG-1120159] 3-isopropylmalate dehydrogenase - Echinochloa crus-galli [Reaction:R-CRU-1120159] 3-isopropylmalate dehydrogenase - Capsella rubella [Reaction:R-MPO-1120159] 3-isopropylmalate dehydrogenase - Marchantia polymorpha [Reaction:R-CCA-1120159] 3-isopropylmalate dehydrogenase - Cajanus cajan [Reaction:R-MAC-1120159] 3-isopropylmalate dehydrogenase - Musa acuminata [Reaction:R-ZMA-1120159] 3-isopropylmalate dehydrogenase - Zea mays [Reaction:R-ITR-1120159] 3-isopropylmalate dehydrogenase - Ipomoea triloba [Reaction:R-BJU-1120159] 3-isopropylmalate dehydrogenase - Brassica juncea [Reaction:R-PVU-1120159] 3-isopropylmalate dehydrogenase - Phaseolus vulgaris [Reaction:R-RCH-1120159] 3-isopropylmalate dehydrogenase - Rosa chinensis [Reaction:R-ORU-1120159] 3-isopropylmalate dehydrogenase - Oryza rufipogon [Reaction:R-ZMY-1120159] 3-isopropylmalate dehydrogenase - Zea mays ver5 [Reaction:R-PPA-1120159] 3-isopropylmalate dehydrogenase - Physcomitrella patens [Reaction:R-HLP-1120159] 3-isopropylmalate dehydrogenase - Humulus lupulus var. lupulus [Reaction:R-CQI-1120159] 3-isopropylmalate dehydrogenase - Chenopodium quinoa [Reaction:R-NNU-1120159] 3-isopropylmalate dehydrogenase - Nelumbo nucifera [Reaction:R-OLO-1120159] 3-isopropylmalate dehydrogenase - Oryza longistaminata [Reaction:R-CSA-1120159] 3-isopropylmalate dehydrogenase - Cucumis sativus [Reaction:R-SHI-1120159] 3-isopropylmalate dehydrogenase - Salvia hispanica [Reaction:R-OME-1120159] 3-isopropylmalate dehydrogenase - Oryza meridionalis [Reaction:R-CST-1120159] 3-isopropylmalate dehydrogenase - Camelina sativa [Reaction:R-CLA-1120159] 3-isopropylmalate dehydrogenase - Citrullus lanatus [Reaction:R-GMA-1120159] 3-isopropylmalate dehydrogenase - Glycine max [Reaction:R-VFA-1120159] 3-isopropylmalate dehydrogenase - Vicia faba var. faba [Reaction:R-GSO-1120159] 3-isopropylmalate dehydrogenase - Glycine soja [Reaction:R-TTU-1120159] 3-isopropylmalate dehydrogenase - Triticum turgidum [Reaction:R-PTI-1120159] 3-isopropylmalate dehydrogenase - Populus trichocarpa [Reaction:R-AOF-1120159] 3-isopropylmalate dehydrogenase - Asparagus officinalis [Reaction:R-PHA-1120159] 3-isopropylmalate dehydrogenase - Panicum hallii ("FIL2") [Reaction:R-SIT-1120159] 3-isopropylmalate dehydrogenase - Setaria italica
output	[SimpleEntity:R-ALL-1131395] 2-isopropyl-3-oxosuccinate [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-OSA-1120935] 3-isopropylmalate dehydratase - Oryza sativa
reviewed	[InstanceEdit:2879498] Dharmawardhana, DP, 2012-12-20
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120159
summation	[Summation:2879493] 3-isopropylmalate is converted to 2-isopropyl-3-oxosuccinate...

Referrals

(hasEvent)	[Pathway:R-OSA-1119540] Leucine biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120593] 2-isopropyl-3-oxosuccinate->2-ketoisocaproate+CO2 - Oryza sativa