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Glutamate--cysteine ligase

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catalystActivity	[CatalystActivity:1118826] glutamate-cysteine ligase activity of Glutamate--cysteine ligase. [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:28140] EC:6.3.2.2 [DatabaseIdentifier:1145667] RiceCyc:GLUTCYSLIG-RXN
dbId	1120528
displayName	Glutamate--cysteine ligase
eventOf	[Pathway:R-OSA-1119483] Glutathione biosynthesis - Oryza sativa [Pathway:R-OSA-1119342] Gamma-glutamyl cycle - Oryza sativa
followingEvent	[Reaction:R-OSA-1120163] glutathione synthetase - Oryza sativa
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-111707] L-Cys [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Glutamate--cysteine ligase γ-glutamyl-L-cysteine synthetase γ-glutamylcysteine synthetase biochemicalReaction6805
orthologousEvent	[Reaction:R-TTU-1120528] Glutamate--cysteine ligase - Triticum turgidum [Reaction:R-AUM-1120528] Glutamate--cysteine ligase - Aegilops umbellulata [Reaction:R-TTI-1120528] Glutamate--cysteine ligase - Triticum timopheevii subsp. timopheevii [Reaction:R-ZMA-1120528] Glutamate--cysteine ligase - Zea mays [Reaction:R-SCR-1120528] Glutamate--cysteine ligase - Secale cereale [Reaction:R-ECU-1120528] Glutamate--cysteine ligase - Eragrostis curvula [Reaction:R-CSK-1120528] Glutamate--cysteine ligase - Cannabis sativa subsp. indica [Reaction:R-ADU-1120528] Glutamate--cysteine ligase - Arachis duranensis [Reaction:R-SIT-1120528] Glutamate--cysteine ligase - Setaria italica [Reaction:R-ZMY-1120528] Glutamate--cysteine ligase - Zea mays ver5 [Reaction:R-HLH-1120528] Glutamate--cysteine ligase - Humulus lupulus [Reaction:R-OOF-1120528] Glutamate--cysteine ligase - Oryza officinalis [Reaction:R-COL-1120528] Glutamate--cysteine ligase - Corchorus olitorius [Reaction:R-FVE-1120528] Glutamate--cysteine ligase - Fragaria vesca [Reaction:R-PDA-1120528] Glutamate--cysteine ligase - Phoenix dactylifera [Reaction:R-PAB-1120528] Glutamate--cysteine ligase - Picea abies [Reaction:R-ECG-1120528] Glutamate--cysteine ligase - Echinochloa crus-galli [Reaction:R-MGU-1120528] Glutamate--cysteine ligase - Erythranthe guttata [Reaction:R-PPA-1120528] Glutamate--cysteine ligase - Physcomitrella patens [Reaction:R-NNU-1120528] Glutamate--cysteine ligase - Nelumbo nucifera [Reaction:R-BDI-1120528] Glutamate--cysteine ligase - Brachypodium distachyon [Reaction:R-OGU-1120528] Glutamate--cysteine ligase - Oryza glumaepatula [Reaction:R-ETE-1120528] Glutamate--cysteine ligase - Eragrostis tef [Reaction:R-OAU-1120528] Glutamate--cysteine ligase - Oryza australiensis [Reaction:R-CRE-1120528] Glutamate--cysteine ligase - Chlamydomonas reinhardtii [Reaction:R-SSP-1120528] Glutamate--cysteine ligase - Saccharum spontaneum [Reaction:R-OBR-1120528] Glutamate--cysteine ligase - Oryza brachyantha [Reaction:R-DEX-1120528] Glutamate--cysteine ligase - Digitaria exilis [Reaction:R-TSP-1120528] Glutamate--cysteine ligase - Triticum spelta subsp. spelta [Reaction:R-LPR-1120528] Glutamate--cysteine ligase - Lolium perenne [Reaction:R-ORU-1120528] Glutamate--cysteine ligase - Oryza rufipogon [Reaction:R-OMI-1120528] Glutamate--cysteine ligase - Oryza minuta [Reaction:R-SHI-1120528] Glutamate--cysteine ligase - Salvia hispanica [Reaction:R-JCU-1120528] Glutamate--cysteine ligase - Jatropha curcas [Reaction:R-OME-1120528] Glutamate--cysteine ligase - Oryza meridionalis [Reaction:R-CRU-1120528] Glutamate--cysteine ligase - Capsella rubella [Reaction:R-OSI-1120528] Glutamate--cysteine ligase - Oryza sativa Indica Group [Reaction:R-LPE-1120528] Glutamate--cysteine ligase - Leersia perrieri [Reaction:R-CSI-1120528] Glutamate--cysteine ligase - Citrus sinensis [Reaction:R-OBA-1120528] Glutamate--cysteine ligase - Oryza barthii [Reaction:R-OGL-1120528] Glutamate--cysteine ligase - Oryza glaberrima [Reaction:R-SVI-1120528] Glutamate--cysteine ligase - Setaria viridis [Reaction:R-PHA-1120528] Glutamate--cysteine ligase - Panicum hallii ("FIL2") [Reaction:R-PTA-1120528] Glutamate--cysteine ligase - Pinus taeda [Reaction:R-CAR-1120528] Glutamate--cysteine ligase - Cicer arietinum [Reaction:R-PED-1120528] Glutamate--cysteine ligase - Phyllostachys edulis [Reaction:R-SBI-1120528] Glutamate--cysteine ligase - Sorghum bicolor [Reaction:R-ZJA-1120528] Glutamate--cysteine ligase - Zoysia japonica [Reaction:R-ASA-1120528] Glutamate--cysteine ligase - Avena sativa [Reaction:R-HLP-1120528] Glutamate--cysteine ligase - Humulus lupulus var. lupulus [Reaction:R-TAE-1120528] Glutamate--cysteine ligase - Triticum aestivum [Reaction:R-OGR-1120528] Glutamate--cysteine ligase - Oryza meyeriana var. granulata [Reaction:R-TDI-1120528] Glutamate--cysteine ligase - Triticum dicoccoides [Reaction:R-ATA-1120528] Glutamate--cysteine ligase - Aegilops tauschii [Reaction:R-ONI-1120528] Glutamate--cysteine ligase - Oryza nivara [Reaction:R-OLU-1120528] Glutamate--cysteine ligase - Ostreococcus lucimarinus [Reaction:R-AIP-1120528] Glutamate--cysteine ligase - Arachis ipaensis [Reaction:R-OPU-1120528] Glutamate--cysteine ligase - Oryza punctata [Reaction:R-TUR-1120528] Glutamate--cysteine ligase - Triticum urartu [Reaction:R-PHH-1120528] Glutamate--cysteine ligase - Panicum hallii var. hallii ("HAL2")
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-174393] gGluCys [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-OSA-1119734] 5-oxoprolinase (ATP-hydrolysing) - Oryza sativa
reviewed	[InstanceEdit:3901113] Dharmawardhana, DP, 2013-07-11
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120528
summation	[Summation:3901118] L-glutamate and L-cysteine are combined by enzymatic activit...

Referrals

(hasEvent)	[Pathway:R-OSA-1119342] Gamma-glutamyl cycle - Oryza sativa [Pathway:R-OSA-1119483] Glutathione biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120163] glutathione synthetase - Oryza sativa