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glutathione synthetase

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catalystActivity	[CatalystActivity:1118835] glutathione synthase activity of Glutathione synthase. [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:28143] EC:6.3.2.3 [DatabaseIdentifier:1146414] RiceCyc:GLUTATHIONE-SYN-RXN
dbId	1120163
displayName	glutathione synthetase
eventOf	[Pathway:R-OSA-1119483] Glutathione biosynthesis - Oryza sativa [Pathway:R-OSA-1119342] Gamma-glutamyl cycle - Oryza sativa
followingEvent	[Reaction:R-OSA-1120948] a 5-L-glutamyl-L-amino acid+Cys-Gly->a standard alpha amino acid+glutathione - Oryza sativa
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-174393] gGluCys [cytosol] [SimpleEntity:R-ALL-29424] Gly [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	glutathione synthetase GSH synthetase biochemicalReaction6836
orthologousEvent	[Reaction:R-ETE-1120163] glutathione synthetase - Eragrostis tef [Reaction:R-CCA-1120163] glutathione synthetase - Cajanus cajan [Reaction:R-PPE-1120163] glutathione synthetase - Prunus persica [Reaction:R-LPE-1120163] glutathione synthetase - Leersia perrieri [Reaction:R-ATH-1120163] glutathione synthetase - Arabidopsis thaliana [Reaction:R-CCR-1120163] glutathione synthetase - Chondrus crispus [Reaction:R-ALY-1120163] glutathione synthetase - Arabidopsis lyrata [Reaction:R-RCH-1120163] glutathione synthetase - Rosa chinensis [Reaction:R-CSA-1120163] glutathione synthetase - Cucumis sativus [Reaction:R-ATR-1120163] glutathione synthetase - Amborella trichopoda [Reaction:R-DCA-1120163] glutathione synthetase - Daucus carota [Reaction:R-SHI-1120163] glutathione synthetase - Salvia hispanica [Reaction:R-ORU-1120163] glutathione synthetase - Oryza rufipogon [Reaction:R-VAN-1120163] glutathione synthetase - Vigna angularis [Reaction:R-PPA-1120163] glutathione synthetase - Physcomitrella patens [Reaction:R-OOF-1120163] glutathione synthetase - Oryza officinalis [Reaction:R-SVI-1120163] glutathione synthetase - Setaria viridis [Reaction:R-CST-1120163] glutathione synthetase - Camelina sativa [Reaction:R-CAR-1120163] glutathione synthetase - Cicer arietinum [Reaction:R-TAE-1120163] glutathione synthetase - Triticum aestivum [Reaction:R-HAN-1120163] glutathione synthetase - Helianthus annuus [Reaction:R-PED-1120163] glutathione synthetase - Phyllostachys edulis [Reaction:R-HLP-1120163] glutathione synthetase - Humulus lupulus var. lupulus [Reaction:R-ITR-1120163] glutathione synthetase - Ipomoea triloba [Reaction:R-NAT-1120163] glutathione synthetase - Nicotiana attenuata [Reaction:R-ACO-1120163] glutathione synthetase - Ananas comosus [Reaction:R-CLA-1120163] glutathione synthetase - Citrullus lanatus [Reaction:R-CQI-1120163] glutathione synthetase - Chenopodium quinoa [Reaction:R-VUN-1120163] glutathione synthetase - Vigna unguiculata [Reaction:R-MES-1120163] glutathione synthetase - Manihot esculenta [Reaction:R-OME-1120163] glutathione synthetase - Oryza meridionalis [Reaction:R-LPR-1120163] glutathione synthetase - Lolium perenne [Reaction:R-TTI-1120163] glutathione synthetase - Triticum timopheevii subsp. timopheevii [Reaction:R-DEX-1120163] glutathione synthetase - Digitaria exilis [Reaction:R-PHA-1120163] glutathione synthetase - Panicum hallii ("FIL2") [Reaction:R-LSA-1120163] glutathione synthetase - Lactuca sativa [Reaction:R-FCR-1120163] glutathione synthetase - Ficus carica [Reaction:R-TCA-1120163] glutathione synthetase - Theobroma cacao [Reaction:R-CCD-1120163] glutathione synthetase - Cynara cardunculus var. scolymus [Reaction:R-BRA-1120163] glutathione synthetase - Brassica rapa [Reaction:R-OES-1120163] glutathione synthetase - Olea europaea var. sylvestris [Reaction:R-CSC-1120163] glutathione synthetase - Cannabis sativa [Reaction:R-AHY-1120163] glutathione synthetase - Arachis hypogaea [Reaction:R-TTU-1120163] glutathione synthetase - Triticum turgidum [Reaction:R-JCU-1120163] glutathione synthetase - Jatropha curcas [Reaction:R-AUM-1120163] glutathione synthetase - Aegilops umbellulata [Reaction:R-OMI-1120163] glutathione synthetase - Oryza minuta [Reaction:R-GRA-1120163] glutathione synthetase - Gossypium raimondii [Reaction:R-SSP-1120163] glutathione synthetase - Saccharum spontaneum [Reaction:R-ADU-1120163] glutathione synthetase - Arachis duranensis [Reaction:R-CAN-1120163] glutathione synthetase - Capsicum annuum [Reaction:R-TPR-1120163] glutathione synthetase - Trifolium pratense [Reaction:R-GSU-1120163] glutathione synthetase - Galdieria sulphuraria [Reaction:R-BNA-1120163] glutathione synthetase - Brassica napus [Reaction:R-ECU-1120163] glutathione synthetase - Eragrostis curvula [Reaction:R-MTR-1120163] glutathione synthetase - Medicago truncatula [Reaction:R-PSA-1120163] glutathione synthetase - Pisum sativum [Reaction:R-HVU-1120163] glutathione synthetase - Hordeum vulgare [Reaction:R-SIN-1120163] glutathione synthetase - Sesamum indicum [Reaction:R-PTA-1120163] glutathione synthetase - Pinus taeda [Reaction:R-QLO-1120163] glutathione synthetase - Quercus lobata [Reaction:R-MAC-1120163] glutathione synthetase - Musa acuminata [Reaction:R-LAN-1120163] glutathione synthetase - Lupinus angustifolius [Reaction:R-MGU-1120163] glutathione synthetase - Erythranthe guttata [Reaction:R-ATA-1120163] glutathione synthetase - Aegilops tauschii [Reaction:R-CRU-1120163] glutathione synthetase - Capsella rubella [Reaction:R-COL-1120163] glutathione synthetase - Corchorus olitorius [Reaction:R-NCO-1120163] glutathione synthetase - Nymphaea colorata [Reaction:R-CME-1120163] glutathione synthetase - Cyanidioschyzon merolae [Reaction:R-ECG-1120163] glutathione synthetase - Echinochloa crus-galli [Reaction:R-ASA-1120163] glutathione synthetase - Avena sativa [Reaction:R-PSO-1120163] glutathione synthetase - Papaver somniferum [Reaction:R-SBI-1120163] glutathione synthetase - Sorghum bicolor [Reaction:R-PVU-1120163] glutathione synthetase - Phaseolus vulgaris [Reaction:R-CRE-1120163] glutathione synthetase - Chlamydomonas reinhardtii [Reaction:R-JRE-1120163] glutathione synthetase - Juglans regia [Reaction:R-OGR-1120163] glutathione synthetase - Oryza meyeriana var. granulata [Reaction:R-ZMY-1120163] glutathione synthetase - Zea mays ver5 [Reaction:R-AIP-1120163] glutathione synthetase - Arachis ipaensis [Reaction:R-OGU-1120163] glutathione synthetase - Oryza glumaepatula [Reaction:R-PHH-1120163] glutathione synthetase - Panicum hallii var. hallii ("HAL2") [Reaction:R-CML-1120163] glutathione synthetase - Cucumis melo [Reaction:R-OAU-1120163] glutathione synthetase - Oryza australiensis [Reaction:R-CCN-1120163] glutathione synthetase - Coffea canephora [Reaction:R-DRO-1120163] glutathione synthetase - Dioscorea rotundata [Reaction:R-OLO-1120163] glutathione synthetase - Oryza longistaminata [Reaction:R-MDO-1120163] glutathione synthetase - Malus domestica [Reaction:R-OLU-1120163] glutathione synthetase - Ostreococcus lucimarinus [Reaction:R-CSI-1120163] glutathione synthetase - Citrus sinensis [Reaction:R-AHA-1120163] glutathione synthetase - Arabidopsis halleri [Reaction:R-PAB-1120163] glutathione synthetase - Picea abies [Reaction:R-OEU-1120163] glutathione synthetase - Olea europaea [Reaction:R-STU-1120163] glutathione synthetase - Solanum tuberosum [Reaction:R-AOF-1120163] glutathione synthetase - Asparagus officinalis [Reaction:R-OBR-1120163] glutathione synthetase - Oryza brachyantha [Reaction:R-FVE-1120163] glutathione synthetase - Fragaria vesca [Reaction:R-SCR-1120163] glutathione synthetase - Secale cereale [Reaction:R-SMO-1120163] glutathione synthetase - Selaginella moellendorffii [Reaction:R-VFA-1120163] glutathione synthetase - Vicia faba var. faba [Reaction:R-OGL-1120163] glutathione synthetase - Oryza glaberrima [Reaction:R-TDI-1120163] glutathione synthetase - Triticum dicoccoides [Reaction:R-ACH-1120163] glutathione synthetase - Actinidia chinensis [Reaction:R-VVN-1120163] glutathione synthetase - Vitis vinifera [Reaction:R-OPU-1120163] glutathione synthetase - Oryza punctata [Reaction:R-SIT-1120163] glutathione synthetase - Setaria italica [Reaction:R-PTI-1120163] glutathione synthetase - Populus trichocarpa [Reaction:R-OBA-1120163] glutathione synthetase - Oryza barthii [Reaction:R-GMA-1120163] glutathione synthetase - Glycine max [Reaction:R-BVU-1120163] glutathione synthetase - Beta vulgaris [Reaction:R-ZMA-1120163] glutathione synthetase - Zea mays [Reaction:R-QSU-1120163] glutathione synthetase - Quercus suber [Reaction:R-GSO-1120163] glutathione synthetase - Glycine soja [Reaction:R-SLY-1120163] glutathione synthetase - Solanum lycopersicum [Reaction:R-MPO-1120163] glutathione synthetase - Marchantia polymorpha [Reaction:R-FEX-1120163] glutathione synthetase - Fraxinus excelsior (European ash) [Reaction:R-OSI-1120163] glutathione synthetase - Oryza sativa Indica Group [Reaction:R-NNU-1120163] glutathione synthetase - Nelumbo nucifera [Reaction:R-ZJA-1120163] glutathione synthetase - Zoysia japonica [Reaction:R-CCI-1120163] glutathione synthetase - Corymbia citriodora [Reaction:R-BDI-1120163] glutathione synthetase - Brachypodium distachyon [Reaction:R-TSP-1120163] glutathione synthetase - Triticum spelta subsp. spelta [Reaction:R-LST-1120163] glutathione synthetase - Lathyrus sativus [Reaction:R-BJU-1120163] glutathione synthetase - Brassica juncea [Reaction:R-PDA-1120163] glutathione synthetase - Phoenix dactylifera [Reaction:R-CSK-1120163] glutathione synthetase - Cannabis sativa subsp. indica [Reaction:R-CCP-1120163] glutathione synthetase - Corchorus capsularis [Reaction:R-PVE-1120163] glutathione synthetase - Pistacia vera [Reaction:R-CBA-1120163] glutathione synthetase - Chara braunii [Reaction:R-CCL-1120163] glutathione synthetase - Citrus clementina [Reaction:R-EGR-1120163] glutathione synthetase - Eucalyptus grandis [Reaction:R-BOL-1120163] glutathione synthetase - Brassica oleracea [Reaction:R-PAV-1120163] glutathione synthetase - Prunus avium [Reaction:R-TUR-1120163] glutathione synthetase - Triticum urartu [Reaction:R-ONI-1120163] glutathione synthetase - Oryza nivara
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-OSA-1120528] Glutamate--cysteine ligase - Oryza sativa
reviewed	[InstanceEdit:3901113] Dharmawardhana, DP, 2013-07-11
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120163
summation	[Summation:3315092] L-gamma-glutamylcysteine is converted into glutathione by en...

Referrals

(hasEvent)	[Pathway:R-OSA-1119342] Gamma-glutamyl cycle - Oryza sativa [Pathway:R-OSA-1119483] Glutathione biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120948] a 5-L-glutamyl-L-amino acid+Cys-Gly->a standard alpha amino acid+glutathione - Oryza sativa