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dihydroxy-acid dehydratase

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catalystActivity	[CatalystActivity:1118312] dihydroxy-acid dehydratase activity of dihydroxy-acid dehydratase (LOC_OS08G44530.1) [cytosol]
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:27969] EC:4.2.1.9 [DatabaseIdentifier:1150362] RiceCyc:DIHYDROXYISOVALDEHYDRAT-RXN
dbId	1120582
displayName	dihydroxy-acid dehydratase
eventOf	[Pathway:R-OSA-1119600] Valine biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120496] 2-isopropylmalate synthase - Oryza sativa [Reaction:R-OSA-2885728] branched-chain amino acid aminotransferase - reverse - Oryza sativa [Reaction:R-OSA-1121514] Branched-chain amino acid aminotransferase - Oryza sativa
input	[SimpleEntity:R-ALL-1131994] 2,3-dihydroxy-isovalerate [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	dihydroxy-acid dehydratase biochemicalReaction12372
orthologousEvent	[Reaction:R-ATA-1120582] dihydroxy-acid dehydratase - Aegilops tauschii [Reaction:R-AIP-1120582] dihydroxy-acid dehydratase - Arachis ipaensis [Reaction:R-FVE-1120582] dihydroxy-acid dehydratase - Fragaria vesca [Reaction:R-GSU-1120582] dihydroxy-acid dehydratase - Galdieria sulphuraria [Reaction:R-ONI-1120582] dihydroxy-acid dehydratase - Oryza nivara [Reaction:R-BVU-1120582] dihydroxy-acid dehydratase - Beta vulgaris [Reaction:R-HVU-1120582] dihydroxy-acid dehydratase - Hordeum vulgare [Reaction:R-ATH-1120582] dihydroxy-acid dehydratase - Arabidopsis thaliana [Reaction:R-SBI-1120582] dihydroxy-acid dehydratase - Sorghum bicolor [Reaction:R-VAN-1120582] dihydroxy-acid dehydratase - Vigna angularis [Reaction:R-PSA-1120582] dihydroxy-acid dehydratase - Pisum sativum [Reaction:R-SLY-1120582] dihydroxy-acid dehydratase - Solanum lycopersicum [Reaction:R-MGU-1120582] dihydroxy-acid dehydratase - Erythranthe guttata [Reaction:R-PAV-1120582] dihydroxy-acid dehydratase - Prunus avium [Reaction:R-CCN-1120582] dihydroxy-acid dehydratase - Coffea canephora [Reaction:R-OES-1120582] dihydroxy-acid dehydratase - Olea europaea var. sylvestris [Reaction:R-LAN-1120582] dihydroxy-acid dehydratase - Lupinus angustifolius [Reaction:R-DCA-1120582] dihydroxy-acid dehydratase - Daucus carota [Reaction:R-CSA-1120582] dihydroxy-acid dehydratase - Cucumis sativus [Reaction:R-ITR-1120582] dihydroxy-acid dehydratase - Ipomoea triloba [Reaction:R-CRE-1120582] dihydroxy-acid dehydratase - Chlamydomonas reinhardtii [Reaction:R-CME-1120582] dihydroxy-acid dehydratase - Cyanidioschyzon merolae [Reaction:R-OGU-1120582] dihydroxy-acid dehydratase - Oryza glumaepatula [Reaction:R-NNU-1120582] dihydroxy-acid dehydratase - Nelumbo nucifera [Reaction:R-EGR-1120582] dihydroxy-acid dehydratase - Eucalyptus grandis [Reaction:R-SCR-1120582] dihydroxy-acid dehydratase - Secale cereale [Reaction:R-STU-1120582] dihydroxy-acid dehydratase - Solanum tuberosum [Reaction:R-PVE-1120582] dihydroxy-acid dehydratase - Pistacia vera [Reaction:R-NCO-1120582] dihydroxy-acid dehydratase - Nymphaea colorata [Reaction:R-ECG-1120582] dihydroxy-acid dehydratase - Echinochloa crus-galli [Reaction:R-OKA-1120582] dihydroxy-acid dehydratase - Oryza sativa aus subgroup [Reaction:R-ASA-1120582] dihydroxy-acid dehydratase - Avena sativa [Reaction:R-AHA-1120582] dihydroxy-acid dehydratase - Arabidopsis halleri [Reaction:R-ALY-1120582] dihydroxy-acid dehydratase - Arabidopsis lyrata [Reaction:R-OEU-1120582] dihydroxy-acid dehydratase - Olea europaea [Reaction:R-PTI-1120582] dihydroxy-acid dehydratase - Populus trichocarpa [Reaction:R-BRA-1120582] dihydroxy-acid dehydratase - Brassica rapa [Reaction:R-GMA-1120582] dihydroxy-acid dehydratase - Glycine max [Reaction:R-CCA-1120582] dihydroxy-acid dehydratase - Cajanus cajan [Reaction:R-SSP-1120582] dihydroxy-acid dehydratase - Saccharum spontaneum [Reaction:R-PSO-1120582] dihydroxy-acid dehydratase - Papaver somniferum [Reaction:R-BNA-1120582] dihydroxy-acid dehydratase - Brassica napus [Reaction:R-VFA-1120582] dihydroxy-acid dehydratase - Vicia faba var. faba [Reaction:R-LPE-1120582] dihydroxy-acid dehydratase - Leersia perrieri [Reaction:R-TDI-1120582] dihydroxy-acid dehydratase - Triticum dicoccoides [Reaction:R-LST-1120582] dihydroxy-acid dehydratase - Lathyrus sativus [Reaction:R-GRA-1120582] dihydroxy-acid dehydratase - Gossypium raimondii [Reaction:R-CSI-1120582] dihydroxy-acid dehydratase - Citrus sinensis [Reaction:R-QSU-1120582] dihydroxy-acid dehydratase - Quercus suber [Reaction:R-MPO-1120582] dihydroxy-acid dehydratase - Marchantia polymorpha [Reaction:R-DEX-1120582] dihydroxy-acid dehydratase - Digitaria exilis [Reaction:R-AHY-1120582] dihydroxy-acid dehydratase - Arachis hypogaea [Reaction:R-ADU-1120582] dihydroxy-acid dehydratase - Arachis duranensis [Reaction:R-ZJA-1120582] dihydroxy-acid dehydratase - Zoysia japonica [Reaction:R-ACO-1120582] dihydroxy-acid dehydratase - Ananas comosus [Reaction:R-PAB-1120582] dihydroxy-acid dehydratase - Picea abies [Reaction:R-MES-1120582] dihydroxy-acid dehydratase - Manihot esculenta [Reaction:R-ATR-1120582] dihydroxy-acid dehydratase - Amborella trichopoda [Reaction:R-OSI-1120582] dihydroxy-acid dehydratase - Oryza sativa Indica Group [Reaction:R-CSK-1120582] dihydroxy-acid dehydratase - Cannabis sativa subsp. indica [Reaction:R-CRU-1120582] dihydroxy-acid dehydratase - Capsella rubella [Reaction:R-CCI-1120582] dihydroxy-acid dehydratase - Corymbia citriodora [Reaction:R-OPU-1120582] dihydroxy-acid dehydratase - Oryza punctata [Reaction:R-OLO-1120582] dihydroxy-acid dehydratase - Oryza longistaminata [Reaction:R-TUR-1120582] dihydroxy-acid dehydratase - Triticum urartu [Reaction:R-OBR-1120582] dihydroxy-acid dehydratase - Oryza brachyantha [Reaction:R-OAU-1120582] dihydroxy-acid dehydratase - Oryza australiensis [Reaction:R-CCD-1120582] dihydroxy-acid dehydratase - Cynara cardunculus var. scolymus [Reaction:R-TSP-1120582] dihydroxy-acid dehydratase - Triticum spelta subsp. spelta [Reaction:R-FCR-1120582] dihydroxy-acid dehydratase - Ficus carica [Reaction:R-OBA-1120582] dihydroxy-acid dehydratase - Oryza barthii [Reaction:R-QLO-1120582] dihydroxy-acid dehydratase - Quercus lobata [Reaction:R-OGL-1120582] dihydroxy-acid dehydratase - Oryza glaberrima [Reaction:R-CLA-1120582] dihydroxy-acid dehydratase - Citrullus lanatus [Reaction:R-ORU-1120582] dihydroxy-acid dehydratase - Oryza rufipogon [Reaction:R-SMO-1120582] dihydroxy-acid dehydratase - Selaginella moellendorffii [Reaction:R-PDA-1120582] dihydroxy-acid dehydratase - Phoenix dactylifera [Reaction:R-COL-1120582] dihydroxy-acid dehydratase - Corchorus olitorius [Reaction:R-PHA-1120582] dihydroxy-acid dehydratase - Panicum hallii ("FIL2") [Reaction:R-SVI-1120582] dihydroxy-acid dehydratase - Setaria viridis [Reaction:R-JCU-1120582] dihydroxy-acid dehydratase - Jatropha curcas [Reaction:R-MTR-1120582] dihydroxy-acid dehydratase - Medicago truncatula [Reaction:R-PVU-1120582] dihydroxy-acid dehydratase - Phaseolus vulgaris [Reaction:R-PPA-1120582] dihydroxy-acid dehydratase - Physcomitrella patens [Reaction:R-CSC-1120582] dihydroxy-acid dehydratase - Cannabis sativa [Reaction:R-RCH-1120582] dihydroxy-acid dehydratase - Rosa chinensis [Reaction:R-MAC-1120582] dihydroxy-acid dehydratase - Musa acuminata [Reaction:R-TPR-1120582] dihydroxy-acid dehydratase - Trifolium pratense [Reaction:R-OOF-1120582] dihydroxy-acid dehydratase - Oryza officinalis [Reaction:R-TAE-1120582] dihydroxy-acid dehydratase - Triticum aestivum [Reaction:R-VVN-1120582] dihydroxy-acid dehydratase - Vitis vinifera [Reaction:R-HLP-1120582] dihydroxy-acid dehydratase - Humulus lupulus var. lupulus [Reaction:R-SPC-1120582] dihydroxy-acid dehydratase - Synechocystis sp. PCC 6803 [Reaction:R-SHI-1120582] dihydroxy-acid dehydratase - Salvia hispanica [Reaction:R-ZMA-1120582] dihydroxy-acid dehydratase - Zea mays [Reaction:R-PPE-1120582] dihydroxy-acid dehydratase - Prunus persica [Reaction:R-OGR-1120582] dihydroxy-acid dehydratase - Oryza meyeriana var. granulata [Reaction:R-CAR-1120582] dihydroxy-acid dehydratase - Cicer arietinum [Reaction:R-CST-1120582] dihydroxy-acid dehydratase - Camelina sativa [Reaction:R-PHH-1120582] dihydroxy-acid dehydratase - Panicum hallii var. hallii ("HAL2") [Reaction:R-ACH-1120582] dihydroxy-acid dehydratase - Actinidia chinensis [Reaction:R-JRE-1120582] dihydroxy-acid dehydratase - Juglans regia [Reaction:R-ZMY-1120582] dihydroxy-acid dehydratase - Zea mays ver5 [Reaction:R-CCP-1120582] dihydroxy-acid dehydratase - Corchorus capsularis [Reaction:R-PED-1120582] dihydroxy-acid dehydratase - Phyllostachys edulis [Reaction:R-OLU-1120582] dihydroxy-acid dehydratase - Ostreococcus lucimarinus [Reaction:R-GSO-1120582] dihydroxy-acid dehydratase - Glycine soja [Reaction:R-CQI-1120582] dihydroxy-acid dehydratase - Chenopodium quinoa [Reaction:R-CCR-1120582] dihydroxy-acid dehydratase - Chondrus crispus [Reaction:R-TTI-1120582] dihydroxy-acid dehydratase - Triticum timopheevii subsp. timopheevii [Reaction:R-BOL-1120582] dihydroxy-acid dehydratase - Brassica oleracea [Reaction:R-MDO-1120582] dihydroxy-acid dehydratase - Malus domestica [Reaction:R-HAN-1120582] dihydroxy-acid dehydratase - Helianthus annuus [Reaction:R-FEX-1120582] dihydroxy-acid dehydratase - Fraxinus excelsior (European ash) [Reaction:R-AUM-1120582] dihydroxy-acid dehydratase - Aegilops umbellulata [Reaction:R-ETE-1120582] dihydroxy-acid dehydratase - Eragrostis tef [Reaction:R-AOF-1120582] dihydroxy-acid dehydratase - Asparagus officinalis [Reaction:R-CCL-1120582] dihydroxy-acid dehydratase - Citrus clementina [Reaction:R-VRA-1120582] dihydroxy-acid dehydratase - Vigna radiata [Reaction:R-TTU-1120582] dihydroxy-acid dehydratase - Triticum turgidum [Reaction:R-ECU-1120582] dihydroxy-acid dehydratase - Eragrostis curvula [Reaction:R-NAT-1120582] dihydroxy-acid dehydratase - Nicotiana attenuata [Reaction:R-SIT-1120582] dihydroxy-acid dehydratase - Setaria italica [Reaction:R-BJU-1120582] dihydroxy-acid dehydratase - Brassica juncea [Reaction:R-BDI-1120582] dihydroxy-acid dehydratase - Brachypodium distachyon [Reaction:R-CAN-1120582] dihydroxy-acid dehydratase - Capsicum annuum [Reaction:R-PTA-1120582] dihydroxy-acid dehydratase - Pinus taeda [Reaction:R-CBA-1120582] dihydroxy-acid dehydratase - Chara braunii [Reaction:R-VUN-1120582] dihydroxy-acid dehydratase - Vigna unguiculata [Reaction:R-CML-1120582] dihydroxy-acid dehydratase - Cucumis melo [Reaction:R-TCA-1120582] dihydroxy-acid dehydratase - Theobroma cacao [Reaction:R-LSA-1120582] dihydroxy-acid dehydratase - Lactuca sativa [Reaction:R-SIN-1120582] dihydroxy-acid dehydratase - Sesamum indicum [Reaction:R-OMI-1120582] dihydroxy-acid dehydratase - Oryza minuta [Reaction:R-DRO-1120582] dihydroxy-acid dehydratase - Dioscorea rotundata
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-70846] KIV [cytosol]
precedingEvent	[Reaction:R-OSA-1121034] ketol-acid reductoisomerase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120582
summation	[Summation:2885720] 2,3-dihydroxy-isovalerate is converted to 2-keto-isovalerate...

Referrals

(hasEvent)	[Pathway:R-OSA-1119600] Valine biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120496] 2-isopropylmalate synthase - Oryza sativa [Reaction:R-OSA-2885728] branched-chain amino acid aminotransferase - reverse - Oryza sativa [Reaction:R-OSA-1121514] Branched-chain amino acid aminotransferase - Oryza sativa