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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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catalystActivity	[CatalystActivity:1118228] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. [plastid stroma]
compartment	[Compartment:1141] plastid stroma
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1154312] EC-NUMBER:4.6.1.12 [DatabaseIdentifier:1149283] RiceCyc:RXN0-302
dbId	1120374
displayName	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
eventOf	[Pathway:R-OSA-1119464] Methylerythritol phosphate pathway - Oryza sativa
followingEvent	[Reaction:R-OSA-4723700] 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate+H2O+a protein disulfide->2-C-methyl-D-erythritol-2,4-cyclodiphosphate+a protein dithiol - Oryza sativa
input	[SimpleEntity:R-ALL-1131978] 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [plastid stroma]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MECDP-synthase biochemicalReaction9758
orthologousEvent	[Reaction:R-TSP-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Triticum spelta subsp. spelta [Reaction:R-ECU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Eragrostis curvula [Reaction:R-AHA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Arabidopsis halleri [Reaction:R-CCN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Coffea canephora [Reaction:R-TDI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Triticum dicoccoides [Reaction:R-ZMY-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Zea mays ver5 [Reaction:R-TCA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Theobroma cacao [Reaction:R-QSU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Quercus suber [Reaction:R-CRE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Chlamydomonas reinhardtii [Reaction:R-CSK-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cannabis sativa subsp. indica [Reaction:R-ATA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Aegilops tauschii [Reaction:R-SHI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Salvia hispanica [Reaction:R-PPE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Prunus persica [Reaction:R-SBI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Sorghum bicolor [Reaction:R-HAN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Helianthus annuus [Reaction:R-ITR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Ipomoea triloba [Reaction:R-CQI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Chenopodium quinoa [Reaction:R-OEU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Olea europaea [Reaction:R-ATR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Amborella trichopoda [Reaction:R-DEX-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Digitaria exilis [Reaction:R-PTI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Populus trichocarpa [Reaction:R-CME-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cyanidioschyzon merolae [Reaction:R-BJU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Brassica juncea [Reaction:R-ORU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza rufipogon [Reaction:R-BRA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Brassica rapa [Reaction:R-CSC-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cannabis sativa [Reaction:R-ZJA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Zoysia japonica [Reaction:R-SLY-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Solanum lycopersicum [Reaction:R-NNU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Nelumbo nucifera [Reaction:R-AHY-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Arachis hypogaea [Reaction:R-NCO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Nymphaea colorata [Reaction:R-EGR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Eucalyptus grandis [Reaction:R-BDI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Brachypodium distachyon [Reaction:R-ALY-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Arabidopsis lyrata [Reaction:R-OMI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza minuta [Reaction:R-PVE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Pistacia vera [Reaction:R-OKA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza sativa aus subgroup [Reaction:R-ZMA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Zea mays [Reaction:R-OBR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza brachyantha [Reaction:R-VFA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Vicia faba var. faba [Reaction:R-PAB-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Picea abies [Reaction:R-ECG-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Echinochloa crus-galli [Reaction:R-MGU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Erythranthe guttata [Reaction:R-PPA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Physcomitrella patens [Reaction:R-GRA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Gossypium raimondii [Reaction:R-MTR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Medicago truncatula [Reaction:R-PSO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Papaver somniferum [Reaction:R-OGL-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza glaberrima [Reaction:R-VUN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Vigna unguiculata [Reaction:R-LAN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Lupinus angustifolius [Reaction:R-AUM-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Aegilops umbellulata [Reaction:R-CCP-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Corchorus capsularis [Reaction:R-VVN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Vitis vinifera [Reaction:R-OOF-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza officinalis [Reaction:R-CRU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Capsella rubella [Reaction:R-PDA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Phoenix dactylifera [Reaction:R-MPO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Marchantia polymorpha [Reaction:R-TTI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Triticum timopheevii subsp. timopheevii [Reaction:R-VAN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Vigna angularis [Reaction:R-OLU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Ostreococcus lucimarinus [Reaction:R-COL-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Corchorus olitorius [Reaction:R-JCU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Jatropha curcas [Reaction:R-CSA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cucumis sativus [Reaction:R-ATH-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Arabidopsis thaliana [Reaction:R-CML-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cucumis melo [Reaction:R-ADU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Arachis duranensis [Reaction:R-DRO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Dioscorea rotundata [Reaction:R-STU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Solanum tuberosum [Reaction:R-CCR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Chondrus crispus [Reaction:R-CSI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Citrus sinensis [Reaction:R-TAE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Triticum aestivum [Reaction:R-PVU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Phaseolus vulgaris [Reaction:R-CAR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cicer arietinum [Reaction:R-MAC-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Musa acuminata [Reaction:R-ACH-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Actinidia chinensis [Reaction:R-CCL-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Citrus clementina [Reaction:R-OPU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza punctata [Reaction:R-PED-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Phyllostachys edulis [Reaction:R-OSI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza sativa Indica Group [Reaction:R-LSA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Lactuca sativa [Reaction:R-ETE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Eragrostis tef [Reaction:R-CCA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cajanus cajan [Reaction:R-GSU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Galdieria sulphuraria [Reaction:R-PAV-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Prunus avium [Reaction:R-SIN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Sesamum indicum [Reaction:R-SIT-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Setaria italica [Reaction:R-NAT-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Nicotiana attenuata [Reaction:R-CCD-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Cynara cardunculus var. scolymus [Reaction:R-GSO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Glycine soja [Reaction:R-GMA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Glycine max [Reaction:R-RCH-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Rosa chinensis [Reaction:R-MES-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Manihot esculenta [Reaction:R-OGU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza glumaepatula [Reaction:R-PHH-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Panicum hallii var. hallii ("HAL2") [Reaction:R-CST-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Camelina sativa [Reaction:R-FEX-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Fraxinus excelsior (European ash) [Reaction:R-PSA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Pisum sativum [Reaction:R-CLA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Citrullus lanatus [Reaction:R-DCA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Daucus carota [Reaction:R-OAU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza australiensis [Reaction:R-JRE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Juglans regia [Reaction:R-CAN-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Capsicum annuum [Reaction:R-OLO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza longistaminata [Reaction:R-AOF-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Asparagus officinalis [Reaction:R-OBA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza barthii [Reaction:R-AIP-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Arachis ipaensis [Reaction:R-OES-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Olea europaea var. sylvestris [Reaction:R-ONI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza nivara [Reaction:R-SCR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Secale cereale [Reaction:R-SMO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Selaginella moellendorffii [Reaction:R-HVU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Hordeum vulgare [Reaction:R-HLP-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Humulus lupulus var. lupulus [Reaction:R-LST-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Lathyrus sativus [Reaction:R-OME-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza meridionalis [Reaction:R-MDO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Malus domestica [Reaction:R-CCI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Corymbia citriodora [Reaction:R-VRA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Vigna radiata [Reaction:R-LPR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Lolium perenne [Reaction:R-ACO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Ananas comosus [Reaction:R-CBA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Chara braunii [Reaction:R-FCR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Ficus carica [Reaction:R-BOL-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Brassica oleracea [Reaction:R-PTA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Pinus taeda [Reaction:R-ASA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Avena sativa [Reaction:R-BVU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Beta vulgaris [Reaction:R-PHA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Panicum hallii ("FIL2") [Reaction:R-SVI-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Setaria viridis [Reaction:R-TTU-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Triticum turgidum [Reaction:R-LPE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Leersia perrieri [Reaction:R-TPR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Trifolium pratense [Reaction:R-SPC-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Synechocystis sp. PCC 6803 [Reaction:R-FVE-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Fragaria vesca [Reaction:R-TUR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Triticum urartu [Reaction:R-QLO-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Quercus lobata [Reaction:R-OGR-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Oryza meyeriana var. granulata [Reaction:R-BNA-1120374] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Brassica napus
output	[SimpleEntity:R-ALL-4723650] 2-C-methyl-D-erythritol-2,4-cyclodiphosphate [plastid stroma] [SimpleEntity:R-ALL-4723662] cytidine 5'-monophosphate [plastid stroma]
precedingEvent	[Reaction:R-OSA-1121196] 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120374
summation	[Summation:4723697] 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ...

Referrals

(hasEvent)	[Pathway:R-OSA-1119464] Methylerythritol phosphate pathway - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-4723700] 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate+H2O+a protein disulfide->2-C-methyl-D-erythritol-2,4-cyclodiphosphate+a protein dithiol - Oryza sativa