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3-methyl-2-oxobutanoate hydroxymethyltransferase

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catalystActivity	[CatalystActivity:1118683] 3-methyl-2-oxobutanoate hydroxymethyltransferase activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26981] EC:2.1.2.11 [DatabaseIdentifier:1145612] RiceCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
dbId	1119703
displayName	3-methyl-2-oxobutanoate hydroxymethyltransferase
eventOf	[Pathway:R-OSA-1119544] Pantothenate biosynthesis II - Oryza sativa [Pathway:R-OSA-1119496] Pantothenate biosynthesis I - Oryza sativa
followingEvent	[Reaction:R-OSA-1121249] 2-dehydropantoate 2-reductase - Oryza sativa
input	[SimpleEntity:R-ALL-1130724] 5,10-methylene-THF [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-70846] KIV [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	3-methyl-2-oxobutanoate hydroxymethyltransferase Ketopantoate hydroxymethyltransferase Dehydropantoate hydroxymethyltransferase α-ketoisovalerate hydroxymethyltransferase biochemicalReaction76489
orthologousEvent	[Reaction:R-CST-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Camelina sativa [Reaction:R-GRA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Gossypium raimondii [Reaction:R-ACO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Ananas comosus [Reaction:R-SBI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Sorghum bicolor [Reaction:R-BOL-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Brassica oleracea [Reaction:R-HLP-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Humulus lupulus var. lupulus [Reaction:R-AUM-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Aegilops umbellulata [Reaction:R-NCO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Nymphaea colorata [Reaction:R-ETE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Eragrostis tef [Reaction:R-PVE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Pistacia vera [Reaction:R-PAV-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Prunus avium [Reaction:R-CCN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Coffea canephora [Reaction:R-BRA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Brassica rapa [Reaction:R-OGR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza meyeriana var. granulata [Reaction:R-OES-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Olea europaea var. sylvestris [Reaction:R-DRO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Dioscorea rotundata [Reaction:R-MDO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Malus domestica [Reaction:R-GMA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Glycine max [Reaction:R-JCU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Jatropha curcas [Reaction:R-ECG-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Echinochloa crus-galli [Reaction:R-DEX-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Digitaria exilis [Reaction:R-CCP-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Corchorus capsularis [Reaction:R-FEX-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Fraxinus excelsior (European ash) [Reaction:R-CML-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cucumis melo [Reaction:R-PAB-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Picea abies [Reaction:R-SIN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Sesamum indicum [Reaction:R-DCA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Daucus carota [Reaction:R-OLO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza longistaminata [Reaction:R-CLA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Citrullus lanatus [Reaction:R-ADU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Arachis duranensis [Reaction:R-VAN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Vigna angularis [Reaction:R-AHY-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Arachis hypogaea [Reaction:R-OBR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza brachyantha [Reaction:R-ATR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Amborella trichopoda [Reaction:R-OGL-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza glaberrima [Reaction:R-AHA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Arabidopsis halleri [Reaction:R-OGU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza glumaepatula [Reaction:R-BNA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Brassica napus [Reaction:R-MPO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Marchantia polymorpha [Reaction:R-PSO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Papaver somniferum [Reaction:R-ONI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza nivara [Reaction:R-CCI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Corymbia citriodora [Reaction:R-PHA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Panicum hallii ("FIL2") [Reaction:R-RCH-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Rosa chinensis [Reaction:R-QLO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Quercus lobata [Reaction:R-CQI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Chenopodium quinoa [Reaction:R-SHI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Salvia hispanica [Reaction:R-SSP-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Saccharum spontaneum [Reaction:R-OEU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Olea europaea [Reaction:R-GSU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Galdieria sulphuraria [Reaction:R-PDA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Phoenix dactylifera [Reaction:R-TCA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Theobroma cacao [Reaction:R-TTI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Triticum timopheevii subsp. timopheevii [Reaction:R-PHH-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Panicum hallii var. hallii ("HAL2") [Reaction:R-LST-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Lathyrus sativus [Reaction:R-OSI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza sativa Indica Group [Reaction:R-ZJA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Zoysia japonica [Reaction:R-MTR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Medicago truncatula [Reaction:R-CCA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cajanus cajan [Reaction:R-PPA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Physcomitrella patens [Reaction:R-ITR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Ipomoea triloba [Reaction:R-ASA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Avena sativa [Reaction:R-OMI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza minuta [Reaction:R-GSO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Glycine soja [Reaction:R-SPC-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Synechocystis sp. PCC 6803 [Reaction:R-NNU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Nelumbo nucifera [Reaction:R-OLU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Ostreococcus lucimarinus [Reaction:R-PED-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Phyllostachys edulis [Reaction:R-TSP-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Triticum spelta subsp. spelta [Reaction:R-OOF-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza officinalis [Reaction:R-LPE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Leersia perrieri [Reaction:R-MAC-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Musa acuminata [Reaction:R-LSA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Lactuca sativa [Reaction:R-HAN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Helianthus annuus [Reaction:R-CCD-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cynara cardunculus var. scolymus [Reaction:R-PTA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Pinus taeda [Reaction:R-CSI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Citrus sinensis [Reaction:R-FVE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Fragaria vesca [Reaction:R-VUN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Vigna unguiculata [Reaction:R-AIP-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Arachis ipaensis [Reaction:R-JRE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Juglans regia [Reaction:R-VFA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Vicia faba var. faba [Reaction:R-BVU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Beta vulgaris [Reaction:R-CRU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Capsella rubella [Reaction:R-SMO-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Selaginella moellendorffii [Reaction:R-ORU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza rufipogon [Reaction:R-VRA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Vigna radiata [Reaction:R-PSA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Pisum sativum [Reaction:R-MGU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Erythranthe guttata [Reaction:R-NAT-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Nicotiana attenuata [Reaction:R-PTI-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Populus trichocarpa [Reaction:R-CCR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Chondrus crispus [Reaction:R-TTU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Triticum turgidum [Reaction:R-FCR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Ficus carica [Reaction:R-CSC-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cannabis sativa [Reaction:R-SLY-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Solanum lycopersicum [Reaction:R-CSA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cucumis sativus [Reaction:R-ALY-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Arabidopsis lyrata [Reaction:R-TPR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Trifolium pratense [Reaction:R-VVN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Vitis vinifera [Reaction:R-LAN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Lupinus angustifolius [Reaction:R-CSK-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cannabis sativa subsp. indica [Reaction:R-MES-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Manihot esculenta [Reaction:R-STU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Solanum tuberosum [Reaction:R-OPU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza punctata [Reaction:R-CBA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Chara braunii [Reaction:R-CAR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Cicer arietinum [Reaction:R-CAN-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Capsicum annuum [Reaction:R-AOF-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Asparagus officinalis [Reaction:R-EGR-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Eucalyptus grandis [Reaction:R-ATH-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Arabidopsis thaliana [Reaction:R-COL-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Corchorus olitorius [Reaction:R-BJU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Brassica juncea [Reaction:R-QSU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Quercus suber [Reaction:R-CRE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Chlamydomonas reinhardtii [Reaction:R-PPE-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Prunus persica [Reaction:R-PVU-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Phaseolus vulgaris [Reaction:R-CCL-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Citrus clementina
output	[SimpleEntity:R-ALL-1131524] 2-dehydropantoate [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-OSA-1121514] Branched-chain amino acid aminotransferase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1119703
summation	[Summation:2871774] 2-keto-isovalerate is converted to 2-dehydropantoate by enzy...

Referrals

(hasEvent)	[Pathway:R-OSA-1119544] Pantothenate biosynthesis II - Oryza sativa [Pathway:R-OSA-1119496] Pantothenate biosynthesis I - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1121249] 2-dehydropantoate 2-reductase - Oryza sativa