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3-methyl-2-oxobutanoate hydroxymethyltransferase

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catalystActivity	[CatalystActivity:10075264] 3-methyl-2-oxobutanoate hydroxymethyltransferase activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10074907] Elser, Justin, 2025-03-24
dbId	10075266
displayName	3-methyl-2-oxobutanoate hydroxymethyltransferase
eventOf	[Pathway:R-CSK-1119544] Pantothenate biosynthesis II - Cannabis sativa subsp. indica [Pathway:R-CSK-1119496] Pantothenate biosynthesis I - Cannabis sativa subsp. indica
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-CSK-1121249] 2-dehydropantoate 2-reductase - Cannabis sativa subsp. indica
inferredFrom	[Reaction:R-OSA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza sativa
input	[SimpleEntity:R-ALL-1130724] 5,10-methylene-THF [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-70846] KIV [cytosol]
isInDisease	false
isInferred	true
name	3-methyl-2-oxobutanoate hydroxymethyltransferase Ketopantoate hydroxymethyltransferase Dehydropantoate hydroxymethyltransferase α-ketoisovalerate hydroxymethyltransferase biochemicalReaction76489
output	[SimpleEntity:R-ALL-1131524] 2-dehydropantoate [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-CSK-1121514] Branched-chain amino acid aminotransferase - Cannabis sativa subsp. indica
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9659007] Cannabis sativa subsp. indica
stId	R-CSK-1119703
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-CSK-1119544] Pantothenate biosynthesis II - Cannabis sativa subsp. indica [Pathway:R-CSK-1119496] Pantothenate biosynthesis I - Cannabis sativa subsp. indica
(precedingEvent)	[Reaction:R-CSK-1121249] 2-dehydropantoate 2-reductase - Cannabis sativa subsp. indica
(inferredTo)	[Reaction:R-OSA-1119703] 3-methyl-2-oxobutanoate hydroxymethyltransferase - Oryza sativa