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Glutamate degradation

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authored	[InstanceEdit:9005377] Gupta, Parul, 2017-05-08
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1149093] RiceCyc:GLUDEG-I-PWY
dbId	1119458
displayName	Glutamate degradation
eventOf	[Pathway:R-OSA-5655124] Amino acid catabolism - Oryza sativa
goBiologicalProcess	[GO_BiologicalProcess:19348] gamma-aminobutyrate shunt
hasDiagram	true
hasEvent	[Reaction:R-OSA-1121221] Formation of GABA - Oryza sativa [Reaction:R-OSA-1120519] Formation of succinic semialdehyde - Oryza sativa [Reaction:R-OSA-1121368] Formation of succinate - Oryza sativa [BlackBoxEvent:R-OSA-9026105] GABA transport - Oryza sativa
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8986563] Amino Acid Catabolism in Plants [LiteratureReference:9026124] Activation of a recombinant petunia glutamate decarboxylase by calcium/calmodulin or by a monoclonal antibody which recognizes the calmodulin binding domain [LiteratureReference:9026107] Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined? [LiteratureReference:9026145] Differential subcellular localization, enzymatic properties and expression patterns of ?-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa) [LiteratureReference:9026110] Exogenous glutamate rapidly induces the expression of genes involved in metabolism and defense responses in rice roots [LiteratureReference:9026138] Exogenous ?-aminobutyric acid (GABA) affects pollen tube growth via modulating putative Ca2+-permeable membrane channels and is coupled to negative regulation on glutamate decarboxylase [LiteratureReference:5308751] GABA in plants: just a metabolite? [LiteratureReference:9026147] Genetic manipulation of the ?-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of ?-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels [LiteratureReference:2672116] Glutamate in plants: metabolism, regulation, and signalling [LiteratureReference:9026100] Glutamate-gated calcium fluxes in Arabidopsis [LiteratureReference:9026103] Metabolism and functions of gamma-aminobutyric acid [LiteratureReference:9026116] Metabolism, enzymology and possible roles of 4-aminobutyrate in higher plants [LiteratureReference:5308434] Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants [LiteratureReference:5308433] Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides [LiteratureReference:9026104] Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin [LiteratureReference:9026118] Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus [LiteratureReference:9026153] The 58-Kilodalton Calmodulin-Binding Glutamate Decarboxylase Is a Ubiquitous Protein in Petunia Organs and Its Expression Is Developmentally Regulated
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Glutamate degradation GABA shunt pathway99618 Glutamate degradation III
orthologousEvent	[Pathway:R-OLU-1119458] Glutamate degradation - Ostreococcus lucimarinus [Pathway:R-CSA-1119458] Glutamate degradation - Cucumis sativus [Pathway:R-CLA-1119458] Glutamate degradation - Citrullus lanatus [Pathway:R-FVE-1119458] Glutamate degradation - Fragaria vesca [Pathway:R-PAV-1119458] Glutamate degradation - Prunus avium [Pathway:R-SCR-1119458] Glutamate degradation - Secale cereale [Pathway:R-LSA-1119458] Glutamate degradation - Lactuca sativa [Pathway:R-OEU-1119458] Glutamate degradation - Olea europaea [Pathway:R-DRO-1119458] Glutamate degradation - Dioscorea rotundata [Pathway:R-SVI-1119458] Glutamate degradation - Setaria viridis [Pathway:R-DCA-1119458] Glutamate degradation - Daucus carota [Pathway:R-LST-1119458] Glutamate degradation - Lathyrus sativus [Pathway:R-SMO-1119458] Glutamate degradation - Selaginella moellendorffii [Pathway:R-BJU-1119458] Glutamate degradation - Brassica juncea [Pathway:R-PPA-1119458] Glutamate degradation - Physcomitrella patens [Pathway:R-TCA-1119458] Glutamate degradation - Theobroma cacao [Pathway:R-CAR-1119458] Glutamate degradation - Cicer arietinum [Pathway:R-OOF-1119458] Glutamate degradation - Oryza officinalis [Pathway:R-QLO-1119458] Glutamate degradation - Quercus lobata [Pathway:R-ZMY-1119458] Glutamate degradation - Zea mays ver5 [Pathway:R-OLO-1119458] Glutamate degradation - Oryza longistaminata [Pathway:R-OSI-1119458] Glutamate degradation - Oryza sativa Indica Group [Pathway:R-ONI-1119458] Glutamate degradation - Oryza nivara [Pathway:R-FCR-1119458] Glutamate degradation - Ficus carica [Pathway:R-ACO-1119458] Glutamate degradation - Ananas comosus [Pathway:R-TSP-1119458] Glutamate degradation - Triticum spelta subsp. spelta [Pathway:R-CME-1119458] Glutamate degradation - Cyanidioschyzon merolae [Pathway:R-ECU-1119458] Glutamate degradation - Eragrostis curvula [Pathway:R-PVE-1119458] Glutamate degradation - Pistacia vera [Pathway:R-OES-1119458] Glutamate degradation - Olea europaea var. sylvestris [Pathway:R-PSA-1119458] Glutamate degradation - Pisum sativum [Pathway:R-ALY-1119458] Glutamate degradation - Arabidopsis lyrata [Pathway:R-RCH-1119458] Glutamate degradation - Rosa chinensis [Pathway:R-OKA-1119458] Glutamate degradation - Oryza sativa aus subgroup [Pathway:R-GMA-1119458] Glutamate degradation - Glycine max [Pathway:R-CCD-1119458] Glutamate degradation - Cynara cardunculus var. scolymus [Pathway:R-OPU-1119458] Glutamate degradation - Oryza punctata [Pathway:R-TUR-1119458] Glutamate degradation - Triticum urartu [Pathway:R-CRU-1119458] Glutamate degradation - Capsella rubella [Pathway:R-CSI-1119458] Glutamate degradation - Citrus sinensis [Pathway:R-ITR-1119458] Glutamate degradation - Ipomoea triloba [Pathway:R-LPR-1119458] Glutamate degradation - Lolium perenne [Pathway:R-BNA-1119458] Glutamate degradation - Brassica napus [Pathway:R-EGR-1119458] Glutamate degradation - Eucalyptus grandis [Pathway:R-MPO-1119458] Glutamate degradation - Marchantia polymorpha [Pathway:R-NCO-1119458] Glutamate degradation - Nymphaea colorata [Pathway:R-SIT-1119458] Glutamate degradation - Setaria italica [Pathway:R-OAU-1119458] Glutamate degradation - Oryza australiensis [Pathway:R-SPC-1119458] Glutamate degradation - Synechocystis sp. PCC 6803 [Pathway:R-AOF-1119458] Glutamate degradation - Asparagus officinalis [Pathway:R-CCA-1119458] Glutamate degradation - Cajanus cajan [Pathway:R-BDI-1119458] Glutamate degradation - Brachypodium distachyon [Pathway:R-OMI-1119458] Glutamate degradation - Oryza minuta [Pathway:R-ADU-1119458] Glutamate degradation - Arachis duranensis [Pathway:R-JRE-1119458] Glutamate degradation - Juglans regia [Pathway:R-ASA-1119458] Glutamate degradation - Avena sativa [Pathway:R-STU-1119458] Glutamate degradation - Solanum tuberosum [Pathway:R-VUN-1119458] Glutamate degradation - Vigna unguiculata [Pathway:R-TPR-1119458] Glutamate degradation - Trifolium pratense [Pathway:R-PED-1119458] Glutamate degradation - Phyllostachys edulis [Pathway:R-HLH-1119458] Glutamate degradation - Humulus lupulus [Pathway:R-CQI-1119458] Glutamate degradation - Chenopodium quinoa [Pathway:R-HAN-1119458] Glutamate degradation - Helianthus annuus [Pathway:R-VVN-1119458] Glutamate degradation - Vitis vinifera [Pathway:R-MGU-1119458] Glutamate degradation - Erythranthe guttata [Pathway:R-PAB-1119458] Glutamate degradation - Picea abies [Pathway:R-ACH-1119458] Glutamate degradation - Actinidia chinensis [Pathway:R-TAE-1119458] Glutamate degradation - Triticum aestivum [Pathway:R-OBR-1119458] Glutamate degradation - Oryza brachyantha [Pathway:R-PPE-1119458] Glutamate degradation - Prunus persica [Pathway:R-LPE-1119458] Glutamate degradation - Leersia perrieri [Pathway:R-SLY-1119458] Glutamate degradation - Solanum lycopersicum [Pathway:R-TTU-1119458] Glutamate degradation - Triticum turgidum [Pathway:R-CCN-1119458] Glutamate degradation - Coffea canephora [Pathway:R-OGU-1119458] Glutamate degradation - Oryza glumaepatula [Pathway:R-CST-1119458] Glutamate degradation - Camelina sativa [Pathway:R-OGL-1119458] Glutamate degradation - Oryza glaberrima [Pathway:R-ORU-1119458] Glutamate degradation - Oryza rufipogon [Pathway:R-MTR-1119458] Glutamate degradation - Medicago truncatula [Pathway:R-ETE-1119458] Glutamate degradation - Eragrostis tef [Pathway:R-SSP-1119458] Glutamate degradation - Saccharum spontaneum [Pathway:R-CSC-1119458] Glutamate degradation - Cannabis sativa [Pathway:R-AHY-1119458] Glutamate degradation - Arachis hypogaea [Pathway:R-ATR-1119458] Glutamate degradation - Amborella trichopoda [Pathway:R-FEX-1119458] Glutamate degradation - Fraxinus excelsior (European ash) [Pathway:R-QSU-1119458] Glutamate degradation - Quercus suber [Pathway:R-ECG-1119458] Glutamate degradation - Echinochloa crus-galli [Pathway:R-ATA-1119458] Glutamate degradation - Aegilops tauschii [Pathway:R-DEX-1119458] Glutamate degradation - Digitaria exilis [Pathway:R-AUM-1119458] Glutamate degradation - Aegilops umbellulata [Pathway:R-OME-1119458] Glutamate degradation - Oryza meridionalis [Pathway:R-BVU-1119458] Glutamate degradation - Beta vulgaris [Pathway:R-CSK-1119458] Glutamate degradation - Cannabis sativa subsp. indica [Pathway:R-LAN-1119458] Glutamate degradation - Lupinus angustifolius [Pathway:R-BRA-1119458] Glutamate degradation - Brassica rapa [Pathway:R-TTI-1119458] Glutamate degradation - Triticum timopheevii subsp. timopheevii [Pathway:R-MDO-1119458] Glutamate degradation - Malus domestica [Pathway:R-PSO-1119458] Glutamate degradation - Papaver somniferum [Pathway:R-JCU-1119458] Glutamate degradation - Jatropha curcas [Pathway:R-AHA-1119458] Glutamate degradation - Arabidopsis halleri [Pathway:R-CBA-1119458] Glutamate degradation - Chara braunii [Pathway:R-HVU-1119458] Glutamate degradation - Hordeum vulgare [Pathway:R-ZMA-1119458] Glutamate degradation - Zea mays [Pathway:R-PTA-1119458] Glutamate degradation - Pinus taeda [Pathway:R-CML-1119458] Glutamate degradation - Cucumis melo [Pathway:R-HLP-1119458] Glutamate degradation - Humulus lupulus var. lupulus [Pathway:R-MES-1119458] Glutamate degradation - Manihot esculenta [Pathway:R-AIP-1119458] Glutamate degradation - Arachis ipaensis [Pathway:R-VRA-1119458] Glutamate degradation - Vigna radiata [Pathway:R-PHA-1119458] Glutamate degradation - Panicum hallii ("FIL2") [Pathway:R-PVU-1119458] Glutamate degradation - Phaseolus vulgaris [Pathway:R-CCP-1119458] Glutamate degradation - Corchorus capsularis [Pathway:R-MAC-1119458] Glutamate degradation - Musa acuminata [Pathway:R-OGR-1119458] Glutamate degradation - Oryza meyeriana var. granulata [Pathway:R-PDA-1119458] Glutamate degradation - Phoenix dactylifera [Pathway:R-NNU-1119458] Glutamate degradation - Nelumbo nucifera [Pathway:R-TDI-1119458] Glutamate degradation - Triticum dicoccoides [Pathway:R-CCI-1119458] Glutamate degradation - Corymbia citriodora [Pathway:R-VFA-1119458] Glutamate degradation - Vicia faba var. faba [Pathway:R-CAN-1119458] Glutamate degradation - Capsicum annuum [Pathway:R-CCL-1119458] Glutamate degradation - Citrus clementina [Pathway:R-PTI-1119458] Glutamate degradation - Populus trichocarpa [Pathway:R-PHH-1119458] Glutamate degradation - Panicum hallii var. hallii ("HAL2") [Pathway:R-GRA-1119458] Glutamate degradation - Gossypium raimondii [Pathway:R-OBA-1119458] Glutamate degradation - Oryza barthii [Pathway:R-NAT-1119458] Glutamate degradation - Nicotiana attenuata [Pathway:R-SIN-1119458] Glutamate degradation - Sesamum indicum [Pathway:R-GSU-1119458] Glutamate degradation - Galdieria sulphuraria [Pathway:R-SBI-1119458] Glutamate degradation - Sorghum bicolor [Pathway:R-COL-1119458] Glutamate degradation - Corchorus olitorius [Pathway:R-SHI-1119458] Glutamate degradation - Salvia hispanica [Pathway:R-BOL-1119458] Glutamate degradation - Brassica oleracea [Pathway:R-ATH-1119458] Glutamate degradation - Arabidopsis thaliana [Pathway:R-VAN-1119458] Glutamate degradation - Vigna angularis [Pathway:R-ZJA-1119458] Glutamate degradation - Zoysia japonica [Pathway:R-GSO-1119458] Glutamate degradation - Glycine soja
precedingEvent	[Pathway:R-OSA-1119535] Glutamate biosynthesis IV - Oryza sativa [Pathway:R-OSA-1119596] Glutamate biosynthesis I - Oryza sativa [Pathway:R-OSA-1119420] Glutamate biosynthesis V - Oryza sativa
schemaClass	Pathway
species	[Species:186860] Oryza sativa
stId	R-OSA-1119458
summation	[Summation:9026151] Glutamate is a major amino donor for the synthesis of amino ... [Summation:1119236] Data source: RiceCyc

Referrals

(hasEvent)

[Pathway:R-OSA-5655124] Amino acid catabolism - Oryza sativa