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Ascorbate biosynthesis

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authored	[InstanceEdit:9675951] Gupta, Parul, 2020-02-05
compartment	[Compartment:70617] mitochondrial envelope [Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1138081] RiceCyc:PWY-882
dbId	1119410
displayName	Ascorbate biosynthesis
eventOf	[Pathway:R-OSA-2867929] Cofactor biosyntheses - Oryza sativa
goBiologicalProcess	[GO_BiologicalProcess:14549] L-ascorbic acid biosynthetic process
hasDiagram	true
hasEvent	[Reaction:R-OSA-1121447] Conversion of F6P to M6P - Oryza sativa [Reaction:R-OSA-9682529] Conversion of G1P to L-Gal - Oryza sativa [Reaction:R-OSA-1120975] Conversion of G6P to F6P - Oryza sativa [Reaction:R-OSA-9682498] Conversion of GDP-galactose to Gal1P - Oryza sativa [Reaction:R-OSA-9682518] Conversion of GDP-mannose to GDP-galactose - Oryza sativa [Reaction:R-OSA-1119831] Conversion of L-Gal to L-galactono-1,4-lactone - Oryza sativa [Reaction:R-OSA-1121630] Conversion of M1P to GDP-mannose - Oryza sativa [Reaction:R-OSA-1120197] Conversion of M6P to M1P - Oryza sativa [Reaction:R-OSA-1120021] Formation of ascorbate from L-galactono-1,4-lactone - Oryza sativa
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5308407] Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis [LiteratureReference:9682477] A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction [LiteratureReference:5308403] Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants [LiteratureReference:1168467] Characterisation of the ATP-dependent phosphofructokinase gene family from Arabidopsis thaliana [LiteratureReference:5309053] Characterization of a GDP-D-mannose 3'',5''-epimerase from rice [LiteratureReference:9639006] Expression pattern of inositol phosphate-related enzymes in rice (Oryza sativa L.): implications for the phytic acid biosynthetic pathway [LiteratureReference:9682505] Manipulation of the rice L-galactose pathway: evaluation of the effects of transgene overexpression on ascorbate accumulation and abiotic stress tolerance [LiteratureReference:9682478] Rice GDP-mannose pyrophosphorylase OsVTC1-1 and OsVTC1-3 play different roles in ascorbic acid synthesis [LiteratureReference:9682511] Ascorbic acid deficiency leads to increased grain chalkiness in transgenic rice for suppressed of L-GalLDH [LiteratureReference:5308406] BIOSYNTHESIS OF ASCORBIC ACID IN PLANTS: A Renaissance [LiteratureReference:9682507] Ascorbate biosynthesis in mitochondria is linked to the electron transport chain between complexes III and IV [URL:9682497] https://doi.org/10.1080/07352680591002165 [LiteratureReference:5309057] The biosynthetic pathway of vitamin C in higher plants
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Ascorbate biosynthesis Vitamin C biosynthesis Ascorbic acid biosynthesis pathway101286
orthologousEvent	[Pathway:R-SPC-1119410] Ascorbate biosynthesis - Synechocystis sp. PCC 6803 [Pathway:R-PSO-1119410] Ascorbate biosynthesis - Papaver somniferum [Pathway:R-PTI-1119410] Ascorbate biosynthesis - Populus trichocarpa [Pathway:R-FEX-1119410] Ascorbate biosynthesis - Fraxinus excelsior (European ash) [Pathway:R-OBA-1119410] Ascorbate biosynthesis - Oryza barthii [Pathway:R-ECU-1119410] Ascorbate biosynthesis - Eragrostis curvula [Pathway:R-AOF-1119410] Ascorbate biosynthesis - Asparagus officinalis [Pathway:R-TDI-1119410] Ascorbate biosynthesis - Triticum dicoccoides [Pathway:R-GRA-1119410] Ascorbate biosynthesis - Gossypium raimondii [Pathway:R-OME-1119410] Ascorbate biosynthesis - Oryza meridionalis [Pathway:R-HAN-1119410] Ascorbate biosynthesis - Helianthus annuus [Pathway:R-SMO-1119410] Ascorbate biosynthesis - Selaginella moellendorffii [Pathway:R-TPR-1119410] Ascorbate biosynthesis - Trifolium pratense [Pathway:R-CLA-1119410] Ascorbate biosynthesis - Citrullus lanatus [Pathway:R-SCR-1119410] Ascorbate biosynthesis - Secale cereale [Pathway:R-CML-1119410] Ascorbate biosynthesis - Cucumis melo [Pathway:R-AHY-1119410] Ascorbate biosynthesis - Arachis hypogaea [Pathway:R-DCA-1119410] Ascorbate biosynthesis - Daucus carota [Pathway:R-CSI-1119410] Ascorbate biosynthesis - Citrus sinensis [Pathway:R-RCH-1119410] Ascorbate biosynthesis - Rosa chinensis [Pathway:R-ATH-1119410] Ascorbate biosynthesis - Arabidopsis thaliana [Pathway:R-OAU-1119410] Ascorbate biosynthesis - Oryza australiensis [Pathway:R-LPE-1119410] Ascorbate biosynthesis - Leersia perrieri [Pathway:R-VAN-1119410] Ascorbate biosynthesis - Vigna angularis [Pathway:R-GSO-1119410] Ascorbate biosynthesis - Glycine soja [Pathway:R-OES-1119410] Ascorbate biosynthesis - Olea europaea var. sylvestris [Pathway:R-JCU-1119410] Ascorbate biosynthesis - Jatropha curcas [Pathway:R-MDO-1119410] Ascorbate biosynthesis - Malus domestica [Pathway:R-MGU-1119410] Ascorbate biosynthesis - Erythranthe guttata [Pathway:R-CQI-1119410] Ascorbate biosynthesis - Chenopodium quinoa [Pathway:R-PVU-1119410] Ascorbate biosynthesis - Phaseolus vulgaris [Pathway:R-JRE-1119410] Ascorbate biosynthesis - Juglans regia [Pathway:R-BRA-1119410] Ascorbate biosynthesis - Brassica rapa [Pathway:R-CBA-1119410] Ascorbate biosynthesis - Chara braunii [Pathway:R-NCO-1119410] Ascorbate biosynthesis - Nymphaea colorata [Pathway:R-OSI-1119410] Ascorbate biosynthesis - Oryza sativa Indica Group [Pathway:R-GSU-1119410] Ascorbate biosynthesis - Galdieria sulphuraria [Pathway:R-OOF-1119410] Ascorbate biosynthesis - Oryza officinalis [Pathway:R-VFA-1119410] Ascorbate biosynthesis - Vicia faba var. faba [Pathway:R-PAB-1119410] Ascorbate biosynthesis - Picea abies [Pathway:R-CSC-1119410] Ascorbate biosynthesis - Cannabis sativa [Pathway:R-BJU-1119410] Ascorbate biosynthesis - Brassica juncea [Pathway:R-EGR-1119410] Ascorbate biosynthesis - Eucalyptus grandis [Pathway:R-CCA-1119410] Ascorbate biosynthesis - Cajanus cajan [Pathway:R-MAC-1119410] Ascorbate biosynthesis - Musa acuminata [Pathway:R-PED-1119410] Ascorbate biosynthesis - Phyllostachys edulis [Pathway:R-CST-1119410] Ascorbate biosynthesis - Camelina sativa [Pathway:R-PTA-1119410] Ascorbate biosynthesis - Pinus taeda [Pathway:R-SVI-1119410] Ascorbate biosynthesis - Setaria viridis [Pathway:R-DRO-1119410] Ascorbate biosynthesis - Dioscorea rotundata [Pathway:R-HLH-1119410] Ascorbate biosynthesis - Humulus lupulus [Pathway:R-HLP-1119410] Ascorbate biosynthesis - Humulus lupulus var. lupulus [Pathway:R-CCL-1119410] Ascorbate biosynthesis - Citrus clementina [Pathway:R-OMI-1119410] Ascorbate biosynthesis - Oryza minuta [Pathway:R-SIT-1119410] Ascorbate biosynthesis - Setaria italica [Pathway:R-TSP-1119410] Ascorbate biosynthesis - Triticum spelta subsp. spelta [Pathway:R-MTR-1119410] Ascorbate biosynthesis - Medicago truncatula [Pathway:R-SHI-1119410] Ascorbate biosynthesis - Salvia hispanica [Pathway:R-PSA-1119410] Ascorbate biosynthesis - Pisum sativum [Pathway:R-VVN-1119410] Ascorbate biosynthesis - Vitis vinifera [Pathway:R-GMA-1119410] Ascorbate biosynthesis - Glycine max [Pathway:R-OGR-1119410] Ascorbate biosynthesis - Oryza meyeriana var. granulata [Pathway:R-ALY-1119410] Ascorbate biosynthesis - Arabidopsis lyrata [Pathway:R-CCD-1119410] Ascorbate biosynthesis - Cynara cardunculus var. scolymus [Pathway:R-COL-1119410] Ascorbate biosynthesis - Corchorus olitorius [Pathway:R-AUM-1119410] Ascorbate biosynthesis - Aegilops umbellulata [Pathway:R-OGL-1119410] Ascorbate biosynthesis - Oryza glaberrima [Pathway:R-ACO-1119410] Ascorbate biosynthesis - Ananas comosus [Pathway:R-ACH-1119410] Ascorbate biosynthesis - Actinidia chinensis [Pathway:R-ZMY-1119410] Ascorbate biosynthesis - Zea mays ver5 [Pathway:R-CME-1119410] Ascorbate biosynthesis - Cyanidioschyzon merolae [Pathway:R-CAN-1119410] Ascorbate biosynthesis - Capsicum annuum [Pathway:R-NAT-1119410] Ascorbate biosynthesis - Nicotiana attenuata [Pathway:R-SLY-1119410] Ascorbate biosynthesis - Solanum lycopersicum [Pathway:R-SSP-1119410] Ascorbate biosynthesis - Saccharum spontaneum [Pathway:R-CRE-1119410] Ascorbate biosynthesis - Chlamydomonas reinhardtii [Pathway:R-OKA-1119410] Ascorbate biosynthesis - Oryza sativa aus subgroup [Pathway:R-ATR-1119410] Ascorbate biosynthesis - Amborella trichopoda [Pathway:R-BNA-1119410] Ascorbate biosynthesis - Brassica napus [Pathway:R-TCA-1119410] Ascorbate biosynthesis - Theobroma cacao [Pathway:R-OEU-1119410] Ascorbate biosynthesis - Olea europaea [Pathway:R-BDI-1119410] Ascorbate biosynthesis - Brachypodium distachyon [Pathway:R-SIN-1119410] Ascorbate biosynthesis - Sesamum indicum [Pathway:R-NNU-1119410] Ascorbate biosynthesis - Nelumbo nucifera [Pathway:R-BOL-1119410] Ascorbate biosynthesis - Brassica oleracea [Pathway:R-QSU-1119410] Ascorbate biosynthesis - Quercus suber [Pathway:R-BVU-1119410] Ascorbate biosynthesis - Beta vulgaris [Pathway:R-ATA-1119410] Ascorbate biosynthesis - Aegilops tauschii [Pathway:R-DEX-1119410] Ascorbate biosynthesis - Digitaria exilis [Pathway:R-OLO-1119410] Ascorbate biosynthesis - Oryza longistaminata [Pathway:R-CAR-1119410] Ascorbate biosynthesis - Cicer arietinum [Pathway:R-VUN-1119410] Ascorbate biosynthesis - Vigna unguiculata [Pathway:R-MES-1119410] Ascorbate biosynthesis - Manihot esculenta [Pathway:R-CCN-1119410] Ascorbate biosynthesis - Coffea canephora [Pathway:R-QLO-1119410] Ascorbate biosynthesis - Quercus lobata [Pathway:R-ORU-1119410] Ascorbate biosynthesis - Oryza rufipogon [Pathway:R-LSA-1119410] Ascorbate biosynthesis - Lactuca sativa [Pathway:R-ECG-1119410] Ascorbate biosynthesis - Echinochloa crus-galli [Pathway:R-ASA-1119410] Ascorbate biosynthesis - Avena sativa [Pathway:R-ITR-1119410] Ascorbate biosynthesis - Ipomoea triloba [Pathway:R-CSA-1119410] Ascorbate biosynthesis - Cucumis sativus [Pathway:R-MPO-1119410] Ascorbate biosynthesis - Marchantia polymorpha [Pathway:R-PPE-1119410] Ascorbate biosynthesis - Prunus persica [Pathway:R-TAE-1119410] Ascorbate biosynthesis - Triticum aestivum [Pathway:R-ZJA-1119410] Ascorbate biosynthesis - Zoysia japonica [Pathway:R-OGU-1119410] Ascorbate biosynthesis - Oryza glumaepatula [Pathway:R-PHH-1119410] Ascorbate biosynthesis - Panicum hallii var. hallii ("HAL2") [Pathway:R-TTU-1119410] Ascorbate biosynthesis - Triticum turgidum [Pathway:R-FCR-1119410] Ascorbate biosynthesis - Ficus carica [Pathway:R-CCI-1119410] Ascorbate biosynthesis - Corymbia citriodora [Pathway:R-OLU-1119410] Ascorbate biosynthesis - Ostreococcus lucimarinus [Pathway:R-ONI-1119410] Ascorbate biosynthesis - Oryza nivara [Pathway:R-PVE-1119410] Ascorbate biosynthesis - Pistacia vera [Pathway:R-SBI-1119410] Ascorbate biosynthesis - Sorghum bicolor [Pathway:R-OBR-1119410] Ascorbate biosynthesis - Oryza brachyantha [Pathway:R-LAN-1119410] Ascorbate biosynthesis - Lupinus angustifolius [Pathway:R-VRA-1119410] Ascorbate biosynthesis - Vigna radiata [Pathway:R-CSK-1119410] Ascorbate biosynthesis - Cannabis sativa subsp. indica [Pathway:R-CCR-1119410] Ascorbate biosynthesis - Chondrus crispus [Pathway:R-ETE-1119410] Ascorbate biosynthesis - Eragrostis tef [Pathway:R-ADU-1119410] Ascorbate biosynthesis - Arachis duranensis [Pathway:R-LST-1119410] Ascorbate biosynthesis - Lathyrus sativus [Pathway:R-STU-1119410] Ascorbate biosynthesis - Solanum tuberosum [Pathway:R-PHA-1119410] Ascorbate biosynthesis - Panicum hallii ("FIL2") [Pathway:R-PPA-1119410] Ascorbate biosynthesis - Physcomitrella patens [Pathway:R-PDA-1119410] Ascorbate biosynthesis - Phoenix dactylifera [Pathway:R-PAV-1119410] Ascorbate biosynthesis - Prunus avium [Pathway:R-AIP-1119410] Ascorbate biosynthesis - Arachis ipaensis [Pathway:R-CCP-1119410] Ascorbate biosynthesis - Corchorus capsularis [Pathway:R-LPR-1119410] Ascorbate biosynthesis - Lolium perenne [Pathway:R-AHA-1119410] Ascorbate biosynthesis - Arabidopsis halleri [Pathway:R-FVE-1119410] Ascorbate biosynthesis - Fragaria vesca [Pathway:R-TTI-1119410] Ascorbate biosynthesis - Triticum timopheevii subsp. timopheevii [Pathway:R-ZMA-1119410] Ascorbate biosynthesis - Zea mays [Pathway:R-HVU-1119410] Ascorbate biosynthesis - Hordeum vulgare [Pathway:R-CRU-1119410] Ascorbate biosynthesis - Capsella rubella [Pathway:R-OPU-1119410] Ascorbate biosynthesis - Oryza punctata [Pathway:R-TUR-1119410] Ascorbate biosynthesis - Triticum urartu
revised	[InstanceEdit:9675951] Gupta, Parul, 2020-02-05
schemaClass	Pathway
species	[Species:186860] Oryza sativa
stId	R-OSA-1119410
summation	[Summation:9682509] Ascorbate (vitamin C) is an important antioxidant and an enz...

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[Pathway:R-OSA-2867929] Cofactor biosyntheses - Oryza sativa