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Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde

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catalystActivity	[CatalystActivity:10949308] 3-hydroxyisobutyrate dehydrogenase activity of 3-hydroxyisobutyrate dehydrogenase [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10941596] Elser, Justin, 2025-03-25
dbId	10949310
displayName	Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde
eventOf	[Pathway:R-SIT-1119479] Valine degradation - Setaria italica
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-SIT-9611884] Conversion of methylmalonate-semialdehyde to Propionyl-CoA - Setaria italica
inferredFrom	[Reaction:R-OSA-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Oryza sativa
input	[SimpleEntity:R-ALL-9611886] 3-hydroxy-isobutyrate [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde
output	[SimpleEntity:R-ALL-9611873] methylmalonate-semialdehyde [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-SIT-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Setaria italica
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9030295] Setaria italica
stId	R-SIT-9611895
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-SIT-1119479] Valine degradation - Setaria italica
(precedingEvent)	[Reaction:R-SIT-9611884] Conversion of methylmalonate-semialdehyde to Propionyl-CoA - Setaria italica
(inferredTo)	[Reaction:R-OSA-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Oryza sativa