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fumarate + H2O <=> malate

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catalystActivity	[CatalystActivity:1119209] fumarate hydratase activity of FUM1 (LOC_Os03g21950.1) [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1139190] RiceCyc:FUMHYDR-RXN
dbId	1121548
displayName	fumarate + H2O <=> malate
eventOf	[Pathway:R-OSA-1119533] TCA cycle (plant) - Oryza sativa
followingEvent	[Reaction:R-OSA-5146775] MAL [mitochondrial matrix]->PYR [mitochondrial matrix] - Oryza sativa [Reaction:R-OSA-1120787] malate + NAD+ <=> oxaloacetate + NADH + H+ - Oryza sativa
input	[SimpleEntity:R-ALL-113588] FUMA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	fumarate + H2O <=> malate Fumarate hydratase
orthologousEvent	[Reaction:R-MPO-1121548] fumarate + H2O <=> malate - Marchantia polymorpha [Reaction:R-TSP-1121548] fumarate + H2O <=> malate - Triticum spelta subsp. spelta [Reaction:R-FEX-1121548] fumarate + H2O <=> malate - Fraxinus excelsior (European ash) [Reaction:R-OSI-1121548] fumarate + H2O <=> malate - Oryza sativa Indica Group [Reaction:R-NNU-1121548] fumarate + H2O <=> malate - Nelumbo nucifera [Reaction:R-PPA-1121548] fumarate + H2O <=> malate - Physcomitrella patens [Reaction:R-CAN-1121548] fumarate + H2O <=> malate - Capsicum annuum [Reaction:R-MGU-1121548] fumarate + H2O <=> malate - Erythranthe guttata [Reaction:R-OMI-1121548] fumarate + H2O <=> malate - Oryza minuta [Reaction:R-GMA-1121548] fumarate + H2O <=> malate - Glycine max [Reaction:R-CCN-1121548] fumarate + H2O <=> malate - Coffea canephora [Reaction:R-MDO-1121548] fumarate + H2O <=> malate - Malus domestica [Reaction:R-VUN-1121548] fumarate + H2O <=> malate - Vigna unguiculata [Reaction:R-FVE-1121548] fumarate + H2O <=> malate - Fragaria vesca [Reaction:R-DRO-1121548] fumarate + H2O <=> malate - Dioscorea rotundata [Reaction:R-DEX-1121548] fumarate + H2O <=> malate - Digitaria exilis [Reaction:R-PAV-1121548] fumarate + H2O <=> malate - Prunus avium [Reaction:R-PVU-1121548] fumarate + H2O <=> malate - Phaseolus vulgaris [Reaction:R-OEU-1121548] fumarate + H2O <=> malate - Olea europaea [Reaction:R-LSA-1121548] fumarate + H2O <=> malate - Lactuca sativa [Reaction:R-SHI-1121548] fumarate + H2O <=> malate - Salvia hispanica [Reaction:R-MAC-1121548] fumarate + H2O <=> malate - Musa acuminata [Reaction:R-ETE-1121548] fumarate + H2O <=> malate - Eragrostis tef [Reaction:R-CSC-1121548] fumarate + H2O <=> malate - Cannabis sativa [Reaction:R-CAR-1121548] fumarate + H2O <=> malate - Cicer arietinum [Reaction:R-PHA-1121548] fumarate + H2O <=> malate - Panicum hallii ("FIL2") [Reaction:R-JCU-1121548] fumarate + H2O <=> malate - Jatropha curcas [Reaction:R-ATA-1121548] fumarate + H2O <=> malate - Aegilops tauschii [Reaction:R-ZMY-1121548] fumarate + H2O <=> malate - Zea mays ver5 [Reaction:R-VRA-1121548] fumarate + H2O <=> malate - Vigna radiata [Reaction:R-MES-1121548] fumarate + H2O <=> malate - Manihot esculenta [Reaction:R-GRA-1121548] fumarate + H2O <=> malate - Gossypium raimondii [Reaction:R-HLP-1121548] fumarate + H2O <=> malate - Humulus lupulus var. lupulus [Reaction:R-OME-1121548] fumarate + H2O <=> malate - Oryza meridionalis [Reaction:R-BOL-1121548] fumarate + H2O <=> malate - Brassica oleracea [Reaction:R-PPE-1121548] fumarate + H2O <=> malate - Prunus persica [Reaction:R-ATR-1121548] fumarate + H2O <=> malate - Amborella trichopoda [Reaction:R-AHY-1121548] fumarate + H2O <=> malate - Arachis hypogaea [Reaction:R-VAN-1121548] fumarate + H2O <=> malate - Vigna angularis [Reaction:R-OAU-1121548] fumarate + H2O <=> malate - Oryza australiensis [Reaction:R-GSO-1121548] fumarate + H2O <=> malate - Glycine soja [Reaction:R-ASA-1121548] fumarate + H2O <=> malate - Avena sativa [Reaction:R-OGR-1121548] fumarate + H2O <=> malate - Oryza meyeriana var. granulata [Reaction:R-CBA-1121548] fumarate + H2O <=> malate - Chara braunii [Reaction:R-LPR-1121548] fumarate + H2O <=> malate - Lolium perenne [Reaction:R-CCR-1121548] fumarate + H2O <=> malate - Chondrus crispus [Reaction:R-TUR-1121548] fumarate + H2O <=> malate - Triticum urartu [Reaction:R-ZJA-1121548] fumarate + H2O <=> malate - Zoysia japonica [Reaction:R-QSU-1121548] fumarate + H2O <=> malate - Quercus suber [Reaction:R-AOF-1121548] fumarate + H2O <=> malate - Asparagus officinalis [Reaction:R-ECG-1121548] fumarate + H2O <=> malate - Echinochloa crus-galli [Reaction:R-CML-1121548] fumarate + H2O <=> malate - Cucumis melo [Reaction:R-CST-1121548] fumarate + H2O <=> malate - Camelina sativa [Reaction:R-TAE-1121548] fumarate + H2O <=> malate - Triticum aestivum [Reaction:R-PTA-1121548] fumarate + H2O <=> malate - Pinus taeda [Reaction:R-PHH-1121548] fumarate + H2O <=> malate - Panicum hallii var. hallii ("HAL2") [Reaction:R-BVU-1121548] fumarate + H2O <=> malate - Beta vulgaris [Reaction:R-AHA-1121548] fumarate + H2O <=> malate - Arabidopsis halleri [Reaction:R-BDI-1121548] fumarate + H2O <=> malate - Brachypodium distachyon [Reaction:R-RCH-1121548] fumarate + H2O <=> malate - Rosa chinensis [Reaction:R-OLO-1121548] fumarate + H2O <=> malate - Oryza longistaminata [Reaction:R-OGL-1121548] fumarate + H2O <=> malate - Oryza glaberrima [Reaction:R-PVE-1121548] fumarate + H2O <=> malate - Pistacia vera [Reaction:R-BJU-1121548] fumarate + H2O <=> malate - Brassica juncea [Reaction:R-HAN-1121548] fumarate + H2O <=> malate - Helianthus annuus [Reaction:R-ECU-1121548] fumarate + H2O <=> malate - Eragrostis curvula [Reaction:R-CCP-1121548] fumarate + H2O <=> malate - Corchorus capsularis [Reaction:R-SSP-1121548] fumarate + H2O <=> malate - Saccharum spontaneum [Reaction:R-TPR-1121548] fumarate + H2O <=> malate - Trifolium pratense [Reaction:R-ORU-1121548] fumarate + H2O <=> malate - Oryza rufipogon [Reaction:R-AUM-1121548] fumarate + H2O <=> malate - Aegilops umbellulata [Reaction:R-LAN-1121548] fumarate + H2O <=> malate - Lupinus angustifolius [Reaction:R-OBR-1121548] fumarate + H2O <=> malate - Oryza brachyantha [Reaction:R-FCR-1121548] fumarate + H2O <=> malate - Ficus carica [Reaction:R-PED-1121548] fumarate + H2O <=> malate - Phyllostachys edulis [Reaction:R-CCA-1121548] fumarate + H2O <=> malate - Cajanus cajan [Reaction:R-VFA-1121548] fumarate + H2O <=> malate - Vicia faba var. faba [Reaction:R-PSA-1121548] fumarate + H2O <=> malate - Pisum sativum [Reaction:R-HVU-1121548] fumarate + H2O <=> malate - Hordeum vulgare [Reaction:R-PDA-1121548] fumarate + H2O <=> malate - Phoenix dactylifera [Reaction:R-GSU-1121548] fumarate + H2O <=> malate - Galdieria sulphuraria [Reaction:R-CRU-1121548] fumarate + H2O <=> malate - Capsella rubella [Reaction:R-OBA-1121548] fumarate + H2O <=> malate - Oryza barthii [Reaction:R-TTI-1121548] fumarate + H2O <=> malate - Triticum timopheevii subsp. timopheevii [Reaction:R-MTR-1121548] fumarate + H2O <=> malate - Medicago truncatula [Reaction:R-SBI-1121548] fumarate + H2O <=> malate - Sorghum bicolor [Reaction:R-OLU-1121548] fumarate + H2O <=> malate - Ostreococcus lucimarinus [Reaction:R-PTI-1121548] fumarate + H2O <=> malate - Populus trichocarpa [Reaction:R-NAT-1121548] fumarate + H2O <=> malate - Nicotiana attenuata [Reaction:R-ZMA-1121548] fumarate + H2O <=> malate - Zea mays [Reaction:R-SPC-1121548] fumarate + H2O <=> malate - Synechocystis sp. PCC 6803 [Reaction:R-OES-1121548] fumarate + H2O <=> malate - Olea europaea var. sylvestris [Reaction:R-SIT-1121548] fumarate + H2O <=> malate - Setaria italica [Reaction:R-COL-1121548] fumarate + H2O <=> malate - Corchorus olitorius [Reaction:R-TCA-1121548] fumarate + H2O <=> malate - Theobroma cacao [Reaction:R-QLO-1121548] fumarate + H2O <=> malate - Quercus lobata [Reaction:R-TDI-1121548] fumarate + H2O <=> malate - Triticum dicoccoides [Reaction:R-SIN-1121548] fumarate + H2O <=> malate - Sesamum indicum [Reaction:R-ACH-1121548] fumarate + H2O <=> malate - Actinidia chinensis [Reaction:R-ATH-1121548] fumarate + H2O <=> malate - Arabidopsis thaliana [Reaction:R-SLY-1121548] fumarate + H2O <=> malate - Solanum lycopersicum [Reaction:R-AIP-1121548] fumarate + H2O <=> malate - Arachis ipaensis [Reaction:R-ALY-1121548] fumarate + H2O <=> malate - Arabidopsis lyrata [Reaction:R-CCL-1121548] fumarate + H2O <=> malate - Citrus clementina [Reaction:R-EGR-1121548] fumarate + H2O <=> malate - Eucalyptus grandis [Reaction:R-CQI-1121548] fumarate + H2O <=> malate - Chenopodium quinoa [Reaction:R-SVI-1121548] fumarate + H2O <=> malate - Setaria viridis [Reaction:R-ITR-1121548] fumarate + H2O <=> malate - Ipomoea triloba [Reaction:R-ACO-1121548] fumarate + H2O <=> malate - Ananas comosus [Reaction:R-BNA-1121548] fumarate + H2O <=> malate - Brassica napus [Reaction:R-LPE-1121548] fumarate + H2O <=> malate - Leersia perrieri [Reaction:R-CCD-1121548] fumarate + H2O <=> malate - Cynara cardunculus var. scolymus [Reaction:R-CCI-1121548] fumarate + H2O <=> malate - Corymbia citriodora [Reaction:R-ONI-1121548] fumarate + H2O <=> malate - Oryza nivara [Reaction:R-OGU-1121548] fumarate + H2O <=> malate - Oryza glumaepatula [Reaction:R-CSI-1121548] fumarate + H2O <=> malate - Citrus sinensis [Reaction:R-OOF-1121548] fumarate + H2O <=> malate - Oryza officinalis [Reaction:R-TTU-1121548] fumarate + H2O <=> malate - Triticum turgidum [Reaction:R-CME-1121548] fumarate + H2O <=> malate - Cyanidioschyzon merolae [Reaction:R-CSK-1121548] fumarate + H2O <=> malate - Cannabis sativa subsp. indica [Reaction:R-PAB-1121548] fumarate + H2O <=> malate - Picea abies [Reaction:R-LST-1121548] fumarate + H2O <=> malate - Lathyrus sativus [Reaction:R-CLA-1121548] fumarate + H2O <=> malate - Citrullus lanatus [Reaction:R-CSA-1121548] fumarate + H2O <=> malate - Cucumis sativus [Reaction:R-BRA-1121548] fumarate + H2O <=> malate - Brassica rapa [Reaction:R-OPU-1121548] fumarate + H2O <=> malate - Oryza punctata [Reaction:R-VVN-1121548] fumarate + H2O <=> malate - Vitis vinifera [Reaction:R-CRE-1121548] fumarate + H2O <=> malate - Chlamydomonas reinhardtii [Reaction:R-SMO-1121548] fumarate + H2O <=> malate - Selaginella moellendorffii [Reaction:R-SCR-1121548] fumarate + H2O <=> malate - Secale cereale [Reaction:R-JRE-1121548] fumarate + H2O <=> malate - Juglans regia [Reaction:R-ADU-1121548] fumarate + H2O <=> malate - Arachis duranensis
output	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
precedingEvent	[Reaction:R-OSA-1120286] succinate + ubiquinone => fumarate + ubiquinol - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1121548
summation	[Summation:1173268] Mitochondrial fumarate hydratase (FUM1) catalyzes the revers...

Referrals

(hasEvent)	[Pathway:R-OSA-1119533] TCA cycle (plant) - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-5146775] MAL [mitochondrial matrix]->PYR [mitochondrial matrix] - Oryza sativa [Reaction:R-OSA-1120787] malate + NAD+ <=> oxaloacetate + NADH + H+ - Oryza sativa