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UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase

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catalystActivity	[CatalystActivity:1118394] UDP-N-acetylmuramoylalanine-D-glutamate ligase activity of Mur ligase family protein (LOC_OS10G40130.1) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:28136] EC:6.3.2.13 [DatabaseIdentifier:1150354] RiceCyc:UDP-NACMURALGLDAPLIG-RXN
dbId	1120870
displayName	UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
edited	[InstanceEdit:3239856] Beorchia, Dylan, 2013-01-31
eventOf	[Pathway:R-OSA-1119436] Peptidoglycan biosynthesis I - Oryza sativa
followingEvent	[Reaction:R-OSA-1120868] UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase - Oryza sativa
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1131733] meso-diaminopimelate [cytosol] [SimpleEntity:R-ALL-1131663] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase UDP-N-acetylmuramyl-tripeptide synthetase synthetase UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate biochemicalReaction6550
orthologousEvent	[Reaction:R-MAC-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Musa acuminata [Reaction:R-CCD-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cynara cardunculus var. scolymus [Reaction:R-AIP-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Arachis ipaensis [Reaction:R-ZJA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Zoysia japonica [Reaction:R-GSO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Glycine soja [Reaction:R-DCA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Daucus carota [Reaction:R-LPE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Leersia perrieri [Reaction:R-JRE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Juglans regia [Reaction:R-ATA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Aegilops tauschii [Reaction:R-CCA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cajanus cajan [Reaction:R-FVE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Fragaria vesca [Reaction:R-RCH-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Rosa chinensis [Reaction:R-PVU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Phaseolus vulgaris [Reaction:R-TDI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Triticum dicoccoides [Reaction:R-MES-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Manihot esculenta [Reaction:R-ACH-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Actinidia chinensis [Reaction:R-CST-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Camelina sativa [Reaction:R-CML-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cucumis melo [Reaction:R-ONI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza nivara [Reaction:R-OGU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza glumaepatula [Reaction:R-CQI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Chenopodium quinoa [Reaction:R-ADU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Arachis duranensis [Reaction:R-PPE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Prunus persica [Reaction:R-SCR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Secale cereale [Reaction:R-GRA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Gossypium raimondii [Reaction:R-HLP-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Humulus lupulus var. lupulus [Reaction:R-BDI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Brachypodium distachyon [Reaction:R-TPR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Trifolium pratense [Reaction:R-ALY-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Arabidopsis lyrata [Reaction:R-LSA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Lactuca sativa [Reaction:R-OLU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Ostreococcus lucimarinus [Reaction:R-SMO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Selaginella moellendorffii [Reaction:R-SSP-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Saccharum spontaneum [Reaction:R-OBR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza brachyantha [Reaction:R-CAR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cicer arietinum [Reaction:R-LAN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Lupinus angustifolius [Reaction:R-CSA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cucumis sativus [Reaction:R-BNA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Brassica napus [Reaction:R-TAE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Triticum aestivum [Reaction:R-STU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Solanum tuberosum [Reaction:R-FCR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Ficus carica [Reaction:R-AHA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Arabidopsis halleri [Reaction:R-NNU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Nelumbo nucifera [Reaction:R-BJU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Brassica juncea [Reaction:R-PTI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Populus trichocarpa [Reaction:R-PAB-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Picea abies [Reaction:R-NAT-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Nicotiana attenuata [Reaction:R-TTI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Triticum timopheevii subsp. timopheevii [Reaction:R-MGU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Erythranthe guttata [Reaction:R-PHH-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Panicum hallii var. hallii ("HAL2") [Reaction:R-CLA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Citrullus lanatus [Reaction:R-DRO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Dioscorea rotundata [Reaction:R-PSA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Pisum sativum [Reaction:R-OBA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza barthii [Reaction:R-PDA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Phoenix dactylifera [Reaction:R-ASA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Avena sativa [Reaction:R-BVU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Beta vulgaris [Reaction:R-SPC-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Synechocystis sp. PCC 6803 [Reaction:R-HAN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Helianthus annuus [Reaction:R-MDO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Malus domestica [Reaction:R-DEX-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Digitaria exilis [Reaction:R-CCN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Coffea canephora [Reaction:R-SBI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Sorghum bicolor [Reaction:R-OSI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza sativa Indica Group [Reaction:R-BOL-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Brassica oleracea [Reaction:R-COL-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Corchorus olitorius [Reaction:R-TSP-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Triticum spelta subsp. spelta [Reaction:R-VVN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Vitis vinifera [Reaction:R-VFA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Vicia faba var. faba [Reaction:R-PHA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Panicum hallii ("FIL2") [Reaction:R-NCO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Nymphaea colorata [Reaction:R-AHY-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Arachis hypogaea [Reaction:R-ATH-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Arabidopsis thaliana [Reaction:R-AOF-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Asparagus officinalis [Reaction:R-ECU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Eragrostis curvula [Reaction:R-OAU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza australiensis [Reaction:R-AUM-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Aegilops umbellulata [Reaction:R-TCA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Theobroma cacao [Reaction:R-BRA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Brassica rapa [Reaction:R-CCP-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Corchorus capsularis [Reaction:R-CRU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Capsella rubella [Reaction:R-QSU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Quercus suber [Reaction:R-PED-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Phyllostachys edulis [Reaction:R-PVE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Pistacia vera [Reaction:R-ETE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Eragrostis tef [Reaction:R-OEU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Olea europaea [Reaction:R-VRA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Vigna radiata [Reaction:R-CBA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Chara braunii [Reaction:R-MPO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Marchantia polymorpha [Reaction:R-CSI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Citrus sinensis [Reaction:R-FEX-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Fraxinus excelsior (European ash) [Reaction:R-ATR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Amborella trichopoda [Reaction:R-CRE-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Chlamydomonas reinhardtii [Reaction:R-HVU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Hordeum vulgare [Reaction:R-OGL-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza glaberrima [Reaction:R-QLO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Quercus lobata [Reaction:R-TUR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Triticum urartu [Reaction:R-OMI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza minuta [Reaction:R-OME-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza meridionalis [Reaction:R-CCI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Corymbia citriodora [Reaction:R-VUN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Vigna unguiculata [Reaction:R-GMA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Glycine max [Reaction:R-ITR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Ipomoea triloba [Reaction:R-EGR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Eucalyptus grandis [Reaction:R-ZMA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Zea mays [Reaction:R-CAN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Capsicum annuum [Reaction:R-OOF-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza officinalis [Reaction:R-SLY-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Solanum lycopersicum [Reaction:R-OGR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Oryza meyeriana var. granulata [Reaction:R-LPR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Lolium perenne [Reaction:R-PAV-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Prunus avium [Reaction:R-ZMY-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Zea mays ver5 [Reaction:R-ECG-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Echinochloa crus-galli [Reaction:R-TTU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Triticum turgidum [Reaction:R-SVI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Setaria viridis [Reaction:R-MTR-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Medicago truncatula [Reaction:R-PSO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Papaver somniferum [Reaction:R-SIN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Sesamum indicum [Reaction:R-SHI-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Salvia hispanica [Reaction:R-CSC-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cannabis sativa [Reaction:R-LST-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Lathyrus sativus [Reaction:R-JCU-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Jatropha curcas [Reaction:R-OES-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Olea europaea var. sylvestris [Reaction:R-ACO-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Ananas comosus [Reaction:R-CCL-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Citrus clementina [Reaction:R-VAN-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Vigna angularis [Reaction:R-PTA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Pinus taeda [Reaction:R-PPA-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Physcomitrella patens [Reaction:R-CSK-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Cannabis sativa subsp. indica [Reaction:R-SIT-1120870] UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase - Setaria italica
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1131879] UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate [cytosol]
precedingEvent	[Reaction:R-OSA-1120897] UDP-N-acetylmuramoylalanine--D-glutamate ligase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120870
summation	[Summation:3239839] UDP-N-acetylmuramoyl-L-alanyl-D-glutamate is converted into ...

Referrals

(hasEvent)	[Pathway:R-OSA-1119436] Peptidoglycan biosynthesis I - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120868] UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase - Oryza sativa