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GTP cyclohydrolase II

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catalystActivity	[CatalystActivity:1118710] GTP cyclohydrolase II activity of GTP cyclohydrolase II [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:27743] EC:3.5.4.25 [DatabaseIdentifier:1149444] RiceCyc:GTP-CYCLOHYDRO-II-RXN
dbId	1120402
displayName	GTP cyclohydrolase II
eventOf	[Pathway:R-OSA-1119379] Flavin biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120864] diaminohydroxyphosphoribosylaminopyrimidine deaminase - Oryza sativa
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] 3 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11529250] Elser, Justin, 2025-03-27
name	GTP cyclohydrolase II biochemicalReaction32654
orthologousEvent	[Reaction:R-TTI-1120402] GTP cyclohydrolase II - Triticum timopheevii subsp. timopheevii [Reaction:R-CCP-1120402] GTP cyclohydrolase II - Corchorus capsularis [Reaction:R-AHY-1120402] GTP cyclohydrolase II - Arachis hypogaea [Reaction:R-TUR-1120402] GTP cyclohydrolase II - Triticum urartu [Reaction:R-BNA-1120402] GTP cyclohydrolase II - Brassica napus [Reaction:R-ASA-1120402] GTP cyclohydrolase II - Avena sativa [Reaction:R-ORU-1120402] GTP cyclohydrolase II - Oryza rufipogon [Reaction:R-FEX-1120402] GTP cyclohydrolase II - Fraxinus excelsior (European ash) [Reaction:R-OLU-1120402] GTP cyclohydrolase II - Ostreococcus lucimarinus [Reaction:R-CSC-1120402] GTP cyclohydrolase II - Cannabis sativa [Reaction:R-LSA-1120402] GTP cyclohydrolase II - Lactuca sativa [Reaction:R-PAV-1120402] GTP cyclohydrolase II - Prunus avium [Reaction:R-HVU-1120402] GTP cyclohydrolase II - Hordeum vulgare [Reaction:R-VFA-1120402] GTP cyclohydrolase II - Vicia faba var. faba [Reaction:R-JRE-1120402] GTP cyclohydrolase II - Juglans regia [Reaction:R-AUM-1120402] GTP cyclohydrolase II - Aegilops umbellulata [Reaction:R-CME-1120402] GTP cyclohydrolase II - Cyanidioschyzon merolae [Reaction:R-AHA-1120402] GTP cyclohydrolase II - Arabidopsis halleri [Reaction:R-GSU-1120402] GTP cyclohydrolase II - Galdieria sulphuraria [Reaction:R-CCA-1120402] GTP cyclohydrolase II - Cajanus cajan [Reaction:R-MES-1120402] GTP cyclohydrolase II - Manihot esculenta [Reaction:R-ZMA-1120402] GTP cyclohydrolase II - Zea mays [Reaction:R-ATH-1120402] GTP cyclohydrolase II - Arabidopsis thaliana [Reaction:R-ECU-1120402] GTP cyclohydrolase II - Eragrostis curvula [Reaction:R-ZMY-1120402] GTP cyclohydrolase II - Zea mays ver5 [Reaction:R-PVE-1120402] GTP cyclohydrolase II - Pistacia vera [Reaction:R-RCH-1120402] GTP cyclohydrolase II - Rosa chinensis [Reaction:R-PSO-1120402] GTP cyclohydrolase II - Papaver somniferum [Reaction:R-QLO-1120402] GTP cyclohydrolase II - Quercus lobata [Reaction:R-BOL-1120402] GTP cyclohydrolase II - Brassica oleracea [Reaction:R-TTU-1120402] GTP cyclohydrolase II - Triticum turgidum [Reaction:R-CST-1120402] GTP cyclohydrolase II - Camelina sativa [Reaction:R-OEU-1120402] GTP cyclohydrolase II - Olea europaea [Reaction:R-PVU-1120402] GTP cyclohydrolase II - Phaseolus vulgaris [Reaction:R-ECG-1120402] GTP cyclohydrolase II - Echinochloa crus-galli [Reaction:R-ONI-1120402] GTP cyclohydrolase II - Oryza nivara [Reaction:R-ALY-1120402] GTP cyclohydrolase II - Arabidopsis lyrata [Reaction:R-MPO-1120402] GTP cyclohydrolase II - Marchantia polymorpha [Reaction:R-NCO-1120402] GTP cyclohydrolase II - Nymphaea colorata [Reaction:R-NAT-1120402] GTP cyclohydrolase II - Nicotiana attenuata [Reaction:R-OSI-1120402] GTP cyclohydrolase II - Oryza sativa Indica Group [Reaction:R-GRA-1120402] GTP cyclohydrolase II - Gossypium raimondii [Reaction:R-CSA-1120402] GTP cyclohydrolase II - Cucumis sativus [Reaction:R-CML-1120402] GTP cyclohydrolase II - Cucumis melo [Reaction:R-BJU-1120402] GTP cyclohydrolase II - Brassica juncea [Reaction:R-OBA-1120402] GTP cyclohydrolase II - Oryza barthii [Reaction:R-VAN-1120402] GTP cyclohydrolase II - Vigna angularis [Reaction:R-CCL-1120402] GTP cyclohydrolase II - Citrus clementina [Reaction:R-CCN-1120402] GTP cyclohydrolase II - Coffea canephora [Reaction:R-CAN-1120402] GTP cyclohydrolase II - Capsicum annuum [Reaction:R-LAN-1120402] GTP cyclohydrolase II - Lupinus angustifolius [Reaction:R-ITR-1120402] GTP cyclohydrolase II - Ipomoea triloba [Reaction:R-EGR-1120402] GTP cyclohydrolase II - Eucalyptus grandis [Reaction:R-CCD-1120402] GTP cyclohydrolase II - Cynara cardunculus var. scolymus [Reaction:R-PSA-1120402] GTP cyclohydrolase II - Pisum sativum [Reaction:R-PTI-1120402] GTP cyclohydrolase II - Populus trichocarpa [Reaction:R-OES-1120402] GTP cyclohydrolase II - Olea europaea var. sylvestris [Reaction:R-VUN-1120402] GTP cyclohydrolase II - Vigna unguiculata [Reaction:R-SIN-1120402] GTP cyclohydrolase II - Sesamum indicum [Reaction:R-ACO-1120402] GTP cyclohydrolase II - Ananas comosus [Reaction:R-FCR-1120402] GTP cyclohydrolase II - Ficus carica [Reaction:R-CCR-1120402] GTP cyclohydrolase II - Chondrus crispus [Reaction:R-TSP-1120402] GTP cyclohydrolase II - Triticum spelta subsp. spelta [Reaction:R-QSU-1120402] GTP cyclohydrolase II - Quercus suber [Reaction:R-OME-1120402] GTP cyclohydrolase II - Oryza meridionalis [Reaction:R-PHA-1120402] GTP cyclohydrolase II - Panicum hallii ("FIL2") [Reaction:R-ADU-1120402] GTP cyclohydrolase II - Arachis duranensis [Reaction:R-SLY-1120402] GTP cyclohydrolase II - Solanum lycopersicum [Reaction:R-OBR-1120402] GTP cyclohydrolase II - Oryza brachyantha [Reaction:R-LPR-1120402] GTP cyclohydrolase II - Lolium perenne [Reaction:R-TAE-1120402] GTP cyclohydrolase II - Triticum aestivum [Reaction:R-TDI-1120402] GTP cyclohydrolase II - Triticum dicoccoides [Reaction:R-HAN-1120402] GTP cyclohydrolase II - Helianthus annuus [Reaction:R-SIT-1120402] GTP cyclohydrolase II - Setaria italica [Reaction:R-ATA-1120402] GTP cyclohydrolase II - Aegilops tauschii [Reaction:R-MAC-1120402] GTP cyclohydrolase II - Musa acuminata [Reaction:R-TPR-1120402] GTP cyclohydrolase II - Trifolium pratense [Reaction:R-OPU-1120402] GTP cyclohydrolase II - Oryza punctata [Reaction:R-BVU-1120402] GTP cyclohydrolase II - Beta vulgaris [Reaction:R-SBI-1120402] GTP cyclohydrolase II - Sorghum bicolor [Reaction:R-PPA-1120402] GTP cyclohydrolase II - Physcomitrella patens [Reaction:R-SMO-1120402] GTP cyclohydrolase II - Selaginella moellendorffii [Reaction:R-MDO-1120402] GTP cyclohydrolase II - Malus domestica [Reaction:R-ACH-1120402] GTP cyclohydrolase II - Actinidia chinensis [Reaction:R-GSO-1120402] GTP cyclohydrolase II - Glycine soja [Reaction:R-BDI-1120402] GTP cyclohydrolase II - Brachypodium distachyon [Reaction:R-VRA-1120402] GTP cyclohydrolase II - Vigna radiata [Reaction:R-STU-1120402] GTP cyclohydrolase II - Solanum tuberosum [Reaction:R-SVI-1120402] GTP cyclohydrolase II - Setaria viridis [Reaction:R-DCA-1120402] GTP cyclohydrolase II - Daucus carota [Reaction:R-VVN-1120402] GTP cyclohydrolase II - Vitis vinifera [Reaction:R-MTR-1120402] GTP cyclohydrolase II - Medicago truncatula [Reaction:R-CQI-1120402] GTP cyclohydrolase II - Chenopodium quinoa [Reaction:R-PHH-1120402] GTP cyclohydrolase II - Panicum hallii var. hallii ("HAL2") [Reaction:R-DRO-1120402] GTP cyclohydrolase II - Dioscorea rotundata [Reaction:R-SSP-1120402] GTP cyclohydrolase II - Saccharum spontaneum [Reaction:R-LST-1120402] GTP cyclohydrolase II - Lathyrus sativus [Reaction:R-CBA-1120402] GTP cyclohydrolase II - Chara braunii [Reaction:R-PPE-1120402] GTP cyclohydrolase II - Prunus persica [Reaction:R-SCR-1120402] GTP cyclohydrolase II - Secale cereale [Reaction:R-DEX-1120402] GTP cyclohydrolase II - Digitaria exilis [Reaction:R-OGU-1120402] GTP cyclohydrolase II - Oryza glumaepatula [Reaction:R-ATR-1120402] GTP cyclohydrolase II - Amborella trichopoda [Reaction:R-OGL-1120402] GTP cyclohydrolase II - Oryza glaberrima [Reaction:R-AOF-1120402] GTP cyclohydrolase II - Asparagus officinalis [Reaction:R-CRE-1120402] GTP cyclohydrolase II - Chlamydomonas reinhardtii [Reaction:R-TCA-1120402] GTP cyclohydrolase II - Theobroma cacao [Reaction:R-BRA-1120402] GTP cyclohydrolase II - Brassica rapa [Reaction:R-CCI-1120402] GTP cyclohydrolase II - Corymbia citriodora [Reaction:R-ETE-1120402] GTP cyclohydrolase II - Eragrostis tef [Reaction:R-GMA-1120402] GTP cyclohydrolase II - Glycine max [Reaction:R-OLO-1120402] GTP cyclohydrolase II - Oryza longistaminata [Reaction:R-LPE-1120402] GTP cyclohydrolase II - Leersia perrieri
output	[SimpleEntity:R-ALL-1131435] 2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120402
summation	[Summation:2870717] GTP is converted to 2,5-diamino-6-(ribosylamino)-4-(3H)-pyri...

Referrals

(hasEvent)	[Pathway:R-OSA-1119379] Flavin biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120864] diaminohydroxyphosphoribosylaminopyrimidine deaminase - Oryza sativa

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