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Formate--tetrahydrofolate ligase

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catalystActivity	[CatalystActivity:1118195] formate-tetrahydrofolate ligase activity of formate--tetrahydrofolate ligase (LOC_OS09G27420.1) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:28160] EC:6.3.4.3 [DatabaseIdentifier:1153942] RiceCyc:FORMATETHFLIG-RXN
dbId	1120232
displayName	Formate--tetrahydrofolate ligase
eventOf	[Pathway:R-OSA-1119617] Folate polyglutamylation I - Oryza sativa
followingEvent	[Reaction:R-OSA-1121062] an N10-formyl-tetrahydrofolate+L-glutamate+ATP->an N10-formyl-tetrahydrofolate+ADP+phosphate - Oryza sativa [Reaction:R-OSA-1120397] methenyltetrahydrofolate cyclohydrolase - Oryza sativa
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Formate--tetrahydrofolate ligase Tetrahydrofolic formylase Tetrahydrofolate formylase Formyltetrahydrofolate synthetase biochemicalReaction6240
orthologousEvent	[Reaction:R-HLH-1120232] Formate--tetrahydrofolate ligase - Humulus lupulus [Reaction:R-PAV-1120232] Formate--tetrahydrofolate ligase - Prunus avium [Reaction:R-BOL-1120232] Formate--tetrahydrofolate ligase - Brassica oleracea [Reaction:R-PHA-1120232] Formate--tetrahydrofolate ligase - Panicum hallii ("FIL2") [Reaction:R-ECG-1120232] Formate--tetrahydrofolate ligase - Echinochloa crus-galli [Reaction:R-BRA-1120232] Formate--tetrahydrofolate ligase - Brassica rapa [Reaction:R-EGR-1120232] Formate--tetrahydrofolate ligase - Eucalyptus grandis [Reaction:R-PDA-1120232] Formate--tetrahydrofolate ligase - Phoenix dactylifera [Reaction:R-QLO-1120232] Formate--tetrahydrofolate ligase - Quercus lobata [Reaction:R-TCA-1120232] Formate--tetrahydrofolate ligase - Theobroma cacao [Reaction:R-OBA-1120232] Formate--tetrahydrofolate ligase - Oryza barthii [Reaction:R-OPU-1120232] Formate--tetrahydrofolate ligase - Oryza punctata [Reaction:R-GSO-1120232] Formate--tetrahydrofolate ligase - Glycine soja [Reaction:R-ASA-1120232] Formate--tetrahydrofolate ligase - Avena sativa [Reaction:R-FCR-1120232] Formate--tetrahydrofolate ligase - Ficus carica [Reaction:R-CCA-1120232] Formate--tetrahydrofolate ligase - Cajanus cajan [Reaction:R-VUN-1120232] Formate--tetrahydrofolate ligase - Vigna unguiculata [Reaction:R-TSP-1120232] Formate--tetrahydrofolate ligase - Triticum spelta subsp. spelta [Reaction:R-QSU-1120232] Formate--tetrahydrofolate ligase - Quercus suber [Reaction:R-FEX-1120232] Formate--tetrahydrofolate ligase - Fraxinus excelsior (European ash) [Reaction:R-OMI-1120232] Formate--tetrahydrofolate ligase - Oryza minuta [Reaction:R-CML-1120232] Formate--tetrahydrofolate ligase - Cucumis melo [Reaction:R-VRA-1120232] Formate--tetrahydrofolate ligase - Vigna radiata [Reaction:R-PPA-1120232] Formate--tetrahydrofolate ligase - Physcomitrella patens [Reaction:R-BJU-1120232] Formate--tetrahydrofolate ligase - Brassica juncea [Reaction:R-ZMA-1120232] Formate--tetrahydrofolate ligase - Zea mays [Reaction:R-HAN-1120232] Formate--tetrahydrofolate ligase - Helianthus annuus [Reaction:R-CRU-1120232] Formate--tetrahydrofolate ligase - Capsella rubella [Reaction:R-ATA-1120232] Formate--tetrahydrofolate ligase - Aegilops tauschii [Reaction:R-PTI-1120232] Formate--tetrahydrofolate ligase - Populus trichocarpa [Reaction:R-CCL-1120232] Formate--tetrahydrofolate ligase - Citrus clementina [Reaction:R-AHA-1120232] Formate--tetrahydrofolate ligase - Arabidopsis halleri [Reaction:R-LPR-1120232] Formate--tetrahydrofolate ligase - Lolium perenne [Reaction:R-CSI-1120232] Formate--tetrahydrofolate ligase - Citrus sinensis [Reaction:R-OEU-1120232] Formate--tetrahydrofolate ligase - Olea europaea [Reaction:R-RCH-1120232] Formate--tetrahydrofolate ligase - Rosa chinensis [Reaction:R-BNA-1120232] Formate--tetrahydrofolate ligase - Brassica napus [Reaction:R-LSA-1120232] Formate--tetrahydrofolate ligase - Lactuca sativa [Reaction:R-TTI-1120232] Formate--tetrahydrofolate ligase - Triticum timopheevii subsp. timopheevii [Reaction:R-ZMY-1120232] Formate--tetrahydrofolate ligase - Zea mays ver5 [Reaction:R-OSI-1120232] Formate--tetrahydrofolate ligase - Oryza sativa Indica Group [Reaction:R-ATH-1120232] Formate--tetrahydrofolate ligase - Arabidopsis thaliana [Reaction:R-PAB-1120232] Formate--tetrahydrofolate ligase - Picea abies [Reaction:R-OME-1120232] Formate--tetrahydrofolate ligase - Oryza meridionalis [Reaction:R-PVU-1120232] Formate--tetrahydrofolate ligase - Phaseolus vulgaris [Reaction:R-STU-1120232] Formate--tetrahydrofolate ligase - Solanum tuberosum [Reaction:R-GMA-1120232] Formate--tetrahydrofolate ligase - Glycine max [Reaction:R-ALY-1120232] Formate--tetrahydrofolate ligase - Arabidopsis lyrata [Reaction:R-AOF-1120232] Formate--tetrahydrofolate ligase - Asparagus officinalis [Reaction:R-PPE-1120232] Formate--tetrahydrofolate ligase - Prunus persica [Reaction:R-TPR-1120232] Formate--tetrahydrofolate ligase - Trifolium pratense [Reaction:R-NNU-1120232] Formate--tetrahydrofolate ligase - Nelumbo nucifera [Reaction:R-OLO-1120232] Formate--tetrahydrofolate ligase - Oryza longistaminata [Reaction:R-CSA-1120232] Formate--tetrahydrofolate ligase - Cucumis sativus [Reaction:R-PSA-1120232] Formate--tetrahydrofolate ligase - Pisum sativum [Reaction:R-GRA-1120232] Formate--tetrahydrofolate ligase - Gossypium raimondii [Reaction:R-TAE-1120232] Formate--tetrahydrofolate ligase - Triticum aestivum [Reaction:R-SHI-1120232] Formate--tetrahydrofolate ligase - Salvia hispanica [Reaction:R-ATR-1120232] Formate--tetrahydrofolate ligase - Amborella trichopoda [Reaction:R-LPE-1120232] Formate--tetrahydrofolate ligase - Leersia perrieri [Reaction:R-HLP-1120232] Formate--tetrahydrofolate ligase - Humulus lupulus var. lupulus [Reaction:R-JCU-1120232] Formate--tetrahydrofolate ligase - Jatropha curcas [Reaction:R-VVN-1120232] Formate--tetrahydrofolate ligase - Vitis vinifera [Reaction:R-FVE-1120232] Formate--tetrahydrofolate ligase - Fragaria vesca [Reaction:R-VFA-1120232] Formate--tetrahydrofolate ligase - Vicia faba var. faba [Reaction:R-SLY-1120232] Formate--tetrahydrofolate ligase - Solanum lycopersicum [Reaction:R-LST-1120232] Formate--tetrahydrofolate ligase - Lathyrus sativus [Reaction:R-TTU-1120232] Formate--tetrahydrofolate ligase - Triticum turgidum [Reaction:R-VAN-1120232] Formate--tetrahydrofolate ligase - Vigna angularis [Reaction:R-MDO-1120232] Formate--tetrahydrofolate ligase - Malus domestica [Reaction:R-OES-1120232] Formate--tetrahydrofolate ligase - Olea europaea var. sylvestris [Reaction:R-NCO-1120232] Formate--tetrahydrofolate ligase - Nymphaea colorata [Reaction:R-ONI-1120232] Formate--tetrahydrofolate ligase - Oryza nivara [Reaction:R-MTR-1120232] Formate--tetrahydrofolate ligase - Medicago truncatula [Reaction:R-AUM-1120232] Formate--tetrahydrofolate ligase - Aegilops umbellulata [Reaction:R-ECU-1120232] Formate--tetrahydrofolate ligase - Eragrostis curvula [Reaction:R-MES-1120232] Formate--tetrahydrofolate ligase - Manihot esculenta [Reaction:R-PED-1120232] Formate--tetrahydrofolate ligase - Phyllostachys edulis [Reaction:R-CAN-1120232] Formate--tetrahydrofolate ligase - Capsicum annuum [Reaction:R-ACH-1120232] Formate--tetrahydrofolate ligase - Actinidia chinensis [Reaction:R-CCP-1120232] Formate--tetrahydrofolate ligase - Corchorus capsularis [Reaction:R-ITR-1120232] Formate--tetrahydrofolate ligase - Ipomoea triloba [Reaction:R-AHY-1120232] Formate--tetrahydrofolate ligase - Arachis hypogaea [Reaction:R-PSO-1120232] Formate--tetrahydrofolate ligase - Papaver somniferum [Reaction:R-OGU-1120232] Formate--tetrahydrofolate ligase - Oryza glumaepatula [Reaction:R-CQI-1120232] Formate--tetrahydrofolate ligase - Chenopodium quinoa [Reaction:R-PTA-1120232] Formate--tetrahydrofolate ligase - Pinus taeda [Reaction:R-NAT-1120232] Formate--tetrahydrofolate ligase - Nicotiana attenuata [Reaction:R-ETE-1120232] Formate--tetrahydrofolate ligase - Eragrostis tef [Reaction:R-JRE-1120232] Formate--tetrahydrofolate ligase - Juglans regia [Reaction:R-CCN-1120232] Formate--tetrahydrofolate ligase - Coffea canephora [Reaction:R-AIP-1120232] Formate--tetrahydrofolate ligase - Arachis ipaensis [Reaction:R-ACO-1120232] Formate--tetrahydrofolate ligase - Ananas comosus [Reaction:R-PVE-1120232] Formate--tetrahydrofolate ligase - Pistacia vera [Reaction:R-CCI-1120232] Formate--tetrahydrofolate ligase - Corymbia citriodora [Reaction:R-OOF-1120232] Formate--tetrahydrofolate ligase - Oryza officinalis [Reaction:R-OGR-1120232] Formate--tetrahydrofolate ligase - Oryza meyeriana var. granulata [Reaction:R-SMO-1120232] Formate--tetrahydrofolate ligase - Selaginella moellendorffii [Reaction:R-ZJA-1120232] Formate--tetrahydrofolate ligase - Zoysia japonica [Reaction:R-LAN-1120232] Formate--tetrahydrofolate ligase - Lupinus angustifolius [Reaction:R-MAC-1120232] Formate--tetrahydrofolate ligase - Musa acuminata [Reaction:R-PHH-1120232] Formate--tetrahydrofolate ligase - Panicum hallii var. hallii ("HAL2") [Reaction:R-OBR-1120232] Formate--tetrahydrofolate ligase - Oryza brachyantha [Reaction:R-CAR-1120232] Formate--tetrahydrofolate ligase - Cicer arietinum [Reaction:R-CLA-1120232] Formate--tetrahydrofolate ligase - Citrullus lanatus [Reaction:R-MPO-1120232] Formate--tetrahydrofolate ligase - Marchantia polymorpha [Reaction:R-ORU-1120232] Formate--tetrahydrofolate ligase - Oryza rufipogon [Reaction:R-BVU-1120232] Formate--tetrahydrofolate ligase - Beta vulgaris [Reaction:R-CSC-1120232] Formate--tetrahydrofolate ligase - Cannabis sativa [Reaction:R-MGU-1120232] Formate--tetrahydrofolate ligase - Erythranthe guttata [Reaction:R-CCD-1120232] Formate--tetrahydrofolate ligase - Cynara cardunculus var. scolymus [Reaction:R-TDI-1120232] Formate--tetrahydrofolate ligase - Triticum dicoccoides [Reaction:R-BDI-1120232] Formate--tetrahydrofolate ligase - Brachypodium distachyon [Reaction:R-SVI-1120232] Formate--tetrahydrofolate ligase - Setaria viridis [Reaction:R-CSK-1120232] Formate--tetrahydrofolate ligase - Cannabis sativa subsp. indica [Reaction:R-SCR-1120232] Formate--tetrahydrofolate ligase - Secale cereale [Reaction:R-OAU-1120232] Formate--tetrahydrofolate ligase - Oryza australiensis [Reaction:R-DCA-1120232] Formate--tetrahydrofolate ligase - Daucus carota [Reaction:R-DEX-1120232] Formate--tetrahydrofolate ligase - Digitaria exilis [Reaction:R-SIT-1120232] Formate--tetrahydrofolate ligase - Setaria italica [Reaction:R-SIN-1120232] Formate--tetrahydrofolate ligase - Sesamum indicum [Reaction:R-CST-1120232] Formate--tetrahydrofolate ligase - Camelina sativa [Reaction:R-HVU-1120232] Formate--tetrahydrofolate ligase - Hordeum vulgare [Reaction:R-SBI-1120232] Formate--tetrahydrofolate ligase - Sorghum bicolor [Reaction:R-ADU-1120232] Formate--tetrahydrofolate ligase - Arachis duranensis [Reaction:R-DRO-1120232] Formate--tetrahydrofolate ligase - Dioscorea rotundata
output	[SimpleEntity:R-ALL-419151] 10-formyl-THF [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-OSA-1121174] Glycine hydroxymethyltransferase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120232
summation	[Summation:2871177] Tetrahydrofolate is converted into N10-formyl-THF by enzymat...

Referrals

(hasEvent)	[Pathway:R-OSA-1119617] Folate polyglutamylation I - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120397] methenyltetrahydrofolate cyclohydrolase - Oryza sativa [Reaction:R-OSA-1121062] an N10-formyl-tetrahydrofolate+L-glutamate+ATP->an N10-formyl-tetrahydrofolate+ADP+phosphate - Oryza sativa