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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

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catalystActivity	[CatalystActivity:1119124] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity of 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:27302] EC:2.7.6.3 [DatabaseIdentifier:1141833] RiceCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
dbId	1119912
displayName	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
eventOf	[Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa [Pathway:R-OSA-1119265] Tetrahydrofolate biosynthesis I - Oryza sativa
followingEvent	[Reaction:R-OSA-1120495] Dihydropteroate synthase - Oryza sativa
input	[SimpleEntity:R-ALL-1130806] 6-hydroxymethyl-dihydropterin [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 7,8-dihydro-6-hydroxymethylpterin diphosphokinase 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase 6-hydroxymethyl-7,8-dihydropterin diphosphokinase 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase biochemicalReaction56940
orthologousEvent	[Reaction:R-ZMY-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Zea mays ver5 [Reaction:R-CBA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Chara braunii [Reaction:R-GSO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Glycine soja [Reaction:R-PAB-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Picea abies [Reaction:R-PED-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Phyllostachys edulis [Reaction:R-ECG-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Echinochloa crus-galli [Reaction:R-OLU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Ostreococcus lucimarinus [Reaction:R-OKA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza sativa aus subgroup [Reaction:R-ACH-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Actinidia chinensis [Reaction:R-LPE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Leersia perrieri [Reaction:R-CSK-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cannabis sativa subsp. indica [Reaction:R-TSP-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Triticum spelta subsp. spelta [Reaction:R-OBR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza brachyantha [Reaction:R-BDI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Brachypodium distachyon [Reaction:R-RCH-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Rosa chinensis [Reaction:R-OEU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Olea europaea [Reaction:R-SBI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Sorghum bicolor [Reaction:R-SIN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Sesamum indicum [Reaction:R-HVU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Hordeum vulgare [Reaction:R-EGR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Eucalyptus grandis [Reaction:R-ONI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza nivara [Reaction:R-SMO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Selaginella moellendorffii [Reaction:R-ATH-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Arabidopsis thaliana [Reaction:R-AOF-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Asparagus officinalis [Reaction:R-HLP-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Humulus lupulus var. lupulus [Reaction:R-TCA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Theobroma cacao [Reaction:R-SVI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Setaria viridis [Reaction:R-ZMA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Zea mays [Reaction:R-VAN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Vigna angularis [Reaction:R-CSI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Citrus sinensis [Reaction:R-OBA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza barthii [Reaction:R-NAT-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Nicotiana attenuata [Reaction:R-PSO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Papaver somniferum [Reaction:R-SIT-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Setaria italica [Reaction:R-PTA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Pinus taeda [Reaction:R-FEX-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Fraxinus excelsior (European ash) [Reaction:R-BVU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Beta vulgaris [Reaction:R-SCR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Secale cereale [Reaction:R-DRO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Dioscorea rotundata [Reaction:R-FCR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Ficus carica [Reaction:R-PDA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Phoenix dactylifera [Reaction:R-TTU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Triticum turgidum [Reaction:R-NCO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Nymphaea colorata [Reaction:R-CCL-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Citrus clementina [Reaction:R-SPC-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Synechocystis sp. PCC 6803 [Reaction:R-FVE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Fragaria vesca [Reaction:R-CSA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cucumis sativus [Reaction:R-OES-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Olea europaea var. sylvestris [Reaction:R-QSU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Quercus suber [Reaction:R-CCN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Coffea canephora [Reaction:R-CRU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Capsella rubella [Reaction:R-VRA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Vigna radiata [Reaction:R-STU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Solanum tuberosum [Reaction:R-PTI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Populus trichocarpa [Reaction:R-LSA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Lactuca sativa [Reaction:R-CQI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Chenopodium quinoa [Reaction:R-CML-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cucumis melo [Reaction:R-MPO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Marchantia polymorpha [Reaction:R-PVU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Phaseolus vulgaris [Reaction:R-NNU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Nelumbo nucifera [Reaction:R-CSC-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cannabis sativa [Reaction:R-LAN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Lupinus angustifolius [Reaction:R-BNA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Brassica napus [Reaction:R-CLA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Citrullus lanatus [Reaction:R-AIP-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Arachis ipaensis [Reaction:R-CCA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cajanus cajan [Reaction:R-TPR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Trifolium pratense [Reaction:R-ORU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza rufipogon [Reaction:R-PSA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Pisum sativum [Reaction:R-GRA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Gossypium raimondii [Reaction:R-VUN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Vigna unguiculata [Reaction:R-ATR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Amborella trichopoda [Reaction:R-OMI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza minuta [Reaction:R-OGR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza meyeriana var. granulata [Reaction:R-JRE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Juglans regia [Reaction:R-LST-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Lathyrus sativus [Reaction:R-SHI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Salvia hispanica [Reaction:R-OME-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza meridionalis [Reaction:R-CME-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cyanidioschyzon merolae [Reaction:R-AUM-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Aegilops umbellulata [Reaction:R-ATA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Aegilops tauschii [Reaction:R-ADU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Arachis duranensis [Reaction:R-PPE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Prunus persica [Reaction:R-COL-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Corchorus olitorius [Reaction:R-MES-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Manihot esculenta [Reaction:R-ASA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Avena sativa [Reaction:R-TUR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Triticum urartu [Reaction:R-CCD-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cynara cardunculus var. scolymus [Reaction:R-SSP-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Saccharum spontaneum [Reaction:R-VVN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Vitis vinifera [Reaction:R-BOL-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Brassica oleracea [Reaction:R-MDO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Malus domestica [Reaction:R-MAC-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Musa acuminata [Reaction:R-OGL-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza glaberrima [Reaction:R-PAV-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Prunus avium [Reaction:R-PVE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Pistacia vera [Reaction:R-AHY-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Arachis hypogaea [Reaction:R-GSU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Galdieria sulphuraria [Reaction:R-ZJA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Zoysia japonica [Reaction:R-ETE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Eragrostis tef [Reaction:R-TAE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Triticum aestivum [Reaction:R-MGU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Erythranthe guttata [Reaction:R-DEX-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Digitaria exilis [Reaction:R-TDI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Triticum dicoccoides [Reaction:R-OLO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza longistaminata [Reaction:R-OAU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza australiensis [Reaction:R-PPA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Physcomitrella patens [Reaction:R-MTR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Medicago truncatula [Reaction:R-OSI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza sativa Indica Group [Reaction:R-GMA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Glycine max [Reaction:R-ECU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Eragrostis curvula [Reaction:R-CCI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Corymbia citriodora [Reaction:R-JCU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Jatropha curcas [Reaction:R-SLY-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Solanum lycopersicum [Reaction:R-CST-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Camelina sativa [Reaction:R-PHA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Panicum hallii ("FIL2") [Reaction:R-ITR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Ipomoea triloba [Reaction:R-OGU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza glumaepatula [Reaction:R-TTI-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Triticum timopheevii subsp. timopheevii [Reaction:R-VFA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Vicia faba var. faba [Reaction:R-CAR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Cicer arietinum [Reaction:R-OPU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza punctata [Reaction:R-PHH-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Panicum hallii var. hallii ("HAL2") [Reaction:R-CRE-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Chlamydomonas reinhardtii [Reaction:R-BRA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Brassica rapa [Reaction:R-ALY-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Arabidopsis lyrata [Reaction:R-BJU-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Brassica juncea [Reaction:R-OOF-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza officinalis [Reaction:R-HAN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Helianthus annuus [Reaction:R-AHA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Arabidopsis halleri [Reaction:R-DCA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Daucus carota [Reaction:R-CCP-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Corchorus capsularis [Reaction:R-ACO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Ananas comosus [Reaction:R-HLH-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Humulus lupulus [Reaction:R-QLO-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Quercus lobata [Reaction:R-LPR-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Lolium perenne [Reaction:R-CAN-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Capsicum annuum
output	[SimpleEntity:R-ALL-1131536] 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol]
precedingEvent	[Reaction:R-OSA-1120141] dihydroneopterin aldolase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1119912
summation	[Summation:2873203] 6-hydroxymethyl-dihydropterin is converted to 2-amino-4-hydr...

Referrals

(hasEvent)	[Pathway:R-OSA-1119523] Tetrahydrofolate biosynthesis II - Oryza sativa [Pathway:R-OSA-1119265] Tetrahydrofolate biosynthesis I - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120495] Dihydropteroate synthase - Oryza sativa