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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

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catalystActivity	[CatalystActivity:10493051] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity of 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10492504] Elser, Justin, 2025-03-25
dbId	10493053
displayName	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
eventOf	[Pathway:R-ATR-1119523] Tetrahydrofolate biosynthesis II - Amborella trichopoda [Pathway:R-ATR-1119265] Tetrahydrofolate biosynthesis I - Amborella trichopoda
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-ATR-1120495] Dihydropteroate synthase - Amborella trichopoda
inferredFrom	[Reaction:R-OSA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza sativa
input	[SimpleEntity:R-ALL-1130806] 6-hydroxymethyl-dihydropterin [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
name	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 7,8-dihydro-6-hydroxymethylpterin diphosphokinase 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase 6-hydroxymethyl-7,8-dihydropterin diphosphokinase 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase biochemicalReaction56940
output	[SimpleEntity:R-ALL-1131536] 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol]
precedingEvent	[Reaction:R-ATR-1120141] dihydroneopterin aldolase - Amborella trichopoda
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9029816] Amborella trichopoda
stId	R-ATR-1119912
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-ATR-1119523] Tetrahydrofolate biosynthesis II - Amborella trichopoda [Pathway:R-ATR-1119265] Tetrahydrofolate biosynthesis I - Amborella trichopoda
(precedingEvent)	[Reaction:R-ATR-1120495] Dihydropteroate synthase - Amborella trichopoda
(inferredTo)	[Reaction:R-OSA-1119912] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - Oryza sativa