Plant Reactome Pathway Database - Plant Reactome Pathway Database

Schema > Reaction > Entries

Sterol 14-demethylase

Go to Details

catalystActivity	[CatalystActivity:1118879] sterol 14-demethylase activity of Sterol 14-demethylase. [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26696] EC:1.14.13.70 [DatabaseIdentifier:1144877] RiceCyc:1.14.13.70-RXN
dbId	1119691
displayName	Sterol 14-demethylase
eventOf	[Pathway:R-OSA-1119370] Sterol biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120757] (4alpha)-methyl-(5alpha)-ergosta-8,14,24(28)-trien-3beta-ol+NADPH->4alpha-methylfecosterol+NADP+ - Oryza sativa
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-1130880] obtusifoliol [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11507626] Elser, Justin, 2025-03-27
name	Sterol 14-demethylase Obtusufoliol 14-demethylase Lanosterol 14-demethylase Lanosterol 14-α-demethylase Sterol 14-α-demethylase Cytochrome P450 51 biochemicalReaction86544
orthologousEvent	[Reaction:R-OGL-1119691] Sterol 14-demethylase - Oryza glaberrima [Reaction:R-LPE-1119691] Sterol 14-demethylase - Leersia perrieri [Reaction:R-OAU-1119691] Sterol 14-demethylase - Oryza australiensis [Reaction:R-TAE-1119691] Sterol 14-demethylase - Triticum aestivum [Reaction:R-JCU-1119691] Sterol 14-demethylase - Jatropha curcas [Reaction:R-ORU-1119691] Sterol 14-demethylase - Oryza rufipogon [Reaction:R-ETE-1119691] Sterol 14-demethylase - Eragrostis tef [Reaction:R-GSU-1119691] Sterol 14-demethylase - Galdieria sulphuraria [Reaction:R-ASA-1119691] Sterol 14-demethylase - Avena sativa [Reaction:R-AUM-1119691] Sterol 14-demethylase - Aegilops umbellulata [Reaction:R-SBI-1119691] Sterol 14-demethylase - Sorghum bicolor [Reaction:R-PPA-1119691] Sterol 14-demethylase - Physcomitrella patens [Reaction:R-SCR-1119691] Sterol 14-demethylase - Secale cereale [Reaction:R-OME-1119691] Sterol 14-demethylase - Oryza meridionalis [Reaction:R-OBA-1119691] Sterol 14-demethylase - Oryza barthii [Reaction:R-ECG-1119691] Sterol 14-demethylase - Echinochloa crus-galli [Reaction:R-OMI-1119691] Sterol 14-demethylase - Oryza minuta [Reaction:R-PHA-1119691] Sterol 14-demethylase - Panicum hallii ("FIL2") [Reaction:R-LPR-1119691] Sterol 14-demethylase - Lolium perenne [Reaction:R-ZJA-1119691] Sterol 14-demethylase - Zoysia japonica [Reaction:R-TTU-1119691] Sterol 14-demethylase - Triticum turgidum [Reaction:R-TUR-1119691] Sterol 14-demethylase - Triticum urartu [Reaction:R-ECU-1119691] Sterol 14-demethylase - Eragrostis curvula [Reaction:R-BDI-1119691] Sterol 14-demethylase - Brachypodium distachyon [Reaction:R-CBA-1119691] Sterol 14-demethylase - Chara braunii [Reaction:R-ATA-1119691] Sterol 14-demethylase - Aegilops tauschii [Reaction:R-OSI-1119691] Sterol 14-demethylase - Oryza sativa Indica Group [Reaction:R-ZMY-1119691] Sterol 14-demethylase - Zea mays ver5 [Reaction:R-CRE-1119691] Sterol 14-demethylase - Chlamydomonas reinhardtii [Reaction:R-SMO-1119691] Sterol 14-demethylase - Selaginella moellendorffii [Reaction:R-TDI-1119691] Sterol 14-demethylase - Triticum dicoccoides [Reaction:R-DEX-1119691] Sterol 14-demethylase - Digitaria exilis [Reaction:R-CME-1119691] Sterol 14-demethylase - Cyanidioschyzon merolae [Reaction:R-PED-1119691] Sterol 14-demethylase - Phyllostachys edulis [Reaction:R-OBR-1119691] Sterol 14-demethylase - Oryza brachyantha [Reaction:R-ZMA-1119691] Sterol 14-demethylase - Zea mays [Reaction:R-OGU-1119691] Sterol 14-demethylase - Oryza glumaepatula [Reaction:R-PHH-1119691] Sterol 14-demethylase - Panicum hallii var. hallii ("HAL2") [Reaction:R-TSP-1119691] Sterol 14-demethylase - Triticum spelta subsp. spelta [Reaction:R-CCR-1119691] Sterol 14-demethylase - Chondrus crispus [Reaction:R-SSP-1119691] Sterol 14-demethylase - Saccharum spontaneum [Reaction:R-ONI-1119691] Sterol 14-demethylase - Oryza nivara [Reaction:R-MPO-1119691] Sterol 14-demethylase - Marchantia polymorpha [Reaction:R-OKA-1119691] Sterol 14-demethylase - Oryza sativa aus subgroup [Reaction:R-OPU-1119691] Sterol 14-demethylase - Oryza punctata [Reaction:R-TTI-1119691] Sterol 14-demethylase - Triticum timopheevii subsp. timopheevii [Reaction:R-OLU-1119691] Sterol 14-demethylase - Ostreococcus lucimarinus [Reaction:R-OLO-1119691] Sterol 14-demethylase - Oryza longistaminata [Reaction:R-OGR-1119691] Sterol 14-demethylase - Oryza meyeriana var. granulata
output	[SimpleEntity:R-ALL-1131565] (4alpha)-methyl-(5alpha)-ergosta-8,14,24(28)-trien-3beta-ol [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-OSA-1120875] Cycloeucalenol cycloisomerase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1119691
summation	[Summation:3320158] Obtusifoliol is converted into (4alpha)-methyl-(5alpha)-ergo...

Referrals

(hasEvent)	[Pathway:R-OSA-1119370] Sterol biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120757] (4alpha)-methyl-(5alpha)-ergosta-8,14,24(28)-trien-3beta-ol+NADPH->4alpha-methylfecosterol+NADP+ - Oryza sativa