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Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde

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catalystActivity	[CatalystActivity:11450291] 3-hydroxyisobutyrate dehydrogenase activity of 3-hydroxyisobutyrate dehydrogenase [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11440306] Elser, Justin, 2025-03-26
dbId	11450293
displayName	Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde
eventOf	[Pathway:R-FEX-1119479] Valine degradation - Fraxinus excelsior (European ash)
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-FEX-9611884] Conversion of methylmalonate-semialdehyde to Propionyl-CoA - Fraxinus excelsior (European ash)
inferredFrom	[Reaction:R-OSA-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Oryza sativa
input	[SimpleEntity:R-ALL-9611886] 3-hydroxy-isobutyrate [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde
output	[SimpleEntity:R-ALL-9611873] methylmalonate-semialdehyde [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-FEX-9611885] Conversion of 3-hydroxy-isobutyryl-CoA to 3-hydroxy-isobutyrate - Fraxinus excelsior (European ash)
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9933481] Fraxinus excelsior (European ash)
stId	R-FEX-9611895
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-FEX-1119479] Valine degradation - Fraxinus excelsior (European ash)
(precedingEvent)	[Reaction:R-FEX-9611884] Conversion of methylmalonate-semialdehyde to Propionyl-CoA - Fraxinus excelsior (European ash)
(inferredTo)	[Reaction:R-OSA-9611895] Conversion of 3-hydroxy-isobutyrate to methylmalonate-semialdehyde - Oryza sativa