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2-ketoadipate + lipoamide ---> S-glutaryldihydroliopamide + CO2

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catalystActivity	[CatalystActivity:11200867] oxoglutarate dehydrogenase (succinyl-transferring) activity of 2-oxoglutarate dehydrogenase E1 component [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11195174] Elser, Justin, 2025-03-26
dbId	11200869
displayName	2-ketoadipate + lipoamide ---> S-glutaryldihydroliopamide + CO2
eventOf	[Pathway:R-CML-1119365] Lysine degradation II - Cucumis melo
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-CML-8986553] S-glutaryldihydrolipoamide + succinyl-CoA ----> Glutaryl-CoA + S-succinyldihydrolipoamide - Cucumis melo
inferredFrom	[Reaction:R-OSA-8986551] 2-ketoadipate + lipoamide ---> S-glutaryldihydroliopamide + CO2 - Oryza sativa
input	[SimpleEntity:R-ALL-70951] 2-OA [mitochondrial matrix] [SimpleEntity:R-ALL-29824] LIPAM [mitochondrial matrix]
isInDisease	false
isInferred	true
name	2-ketoadipate + lipoamide ---> S-glutaryldihydroliopamide + CO2
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-70006] S-glutaryldihydrolipoamide [mitochondrial matrix]
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9764158] Cucumis melo
stId	R-CML-8986551
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-CML-1119365] Lysine degradation II - Cucumis melo
(precedingEvent)	[Reaction:R-CML-8986553] S-glutaryldihydrolipoamide + succinyl-CoA ----> Glutaryl-CoA + S-succinyldihydrolipoamide - Cucumis melo
(inferredTo)	[Reaction:R-OSA-8986551] 2-ketoadipate + lipoamide ---> S-glutaryldihydroliopamide + CO2 - Oryza sativa

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