MAPK5 is a kinase Involved in disease resistance and abiotic stress tolerance signaling pathways. It acts as a positive regulator of drought, salt and cold tolerance. SERF1 Is a direct transcriptional regulator of MAPK5 gene, as it has been shown to binds to the promoter of this gene. In turrn, SERF1 Is a Phosphorylation Target of MAPK5 (Schmidt et al., 2013; PMID: 23800963).