{ "dbId" : 10764852, "stableId" : "R-PPA-9675868", "displayName" : "Synthesis of DNA", "nodes" : [ { "id" : 9408, "reactomeId" : 10764038, "displayName" : "RFC heteropentamer:RNA primer:DNA primer:origin duplex:PCNA homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 812, "y" : 557 }, "minX" : 739, "maxX" : 885, "minY" : 499, "maxY" : 593, "prop" : { "x" : 739, "y" : 521, "width" : 146, "height" : 72 }, "textPosition" : { "x" : 738, "y" : 543 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9410, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9405, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 810, "y" : 518 }, "to" : { "x" : 810, "y" : 499 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 806, "y" : 511 }, "b" : { "x" : 810, "y" : 518 }, "c" : { "x" : 814, "y" : 511 }, "type" : "ARROW" } } ] }, { "id" : 9409, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 873, "y" : 500 }, "minX" : 810, "maxX" : 894, "minY" : 484, "maxY" : 515, "prop" : { "x" : 853, "y" : 485, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 857, "y" : 489 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 888, "y" : 490 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 9405, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 850, "y" : 499 }, "to" : { "x" : 810, "y" : 499 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 843, "y" : 503 }, "b" : { "x" : 850, "y" : 499 }, "c" : { "x" : 843, "y" : 495 }, "type" : "ARROW" } } ] }, { "id" : 9411, "reactomeId" : 10764040, "displayName" : "RNA primer:DNA primer:origin duplex:PCNA homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 517, "y" : 558 }, "minX" : 430, "maxX" : 614, "minY" : 530, "maxY" : 587, "prop" : { "x" : 451, "y" : 530, "width" : 133, "height" : 57 }, "textPosition" : { "x" : 459, "y" : 537 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9410, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 587, "y" : 556 }, "to" : { "x" : 614, "y" : 556 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 594, "y" : 552 }, "b" : { "x" : 587, "y" : 556 }, "c" : { "x" : 594, "y" : 560 }, "type" : "ARROW" } }, { "edgeId" : 9412, "type" : "INPUT", "segments" : [ { "from" : { "x" : 448, "y" : 558 }, "to" : { "x" : 430, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9413, "reactomeId" : 10764061, "displayName" : "DNA polymerase delta tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 431, "y" : 497 }, "minX" : 198, "maxX" : 484, "minY" : 479, "maxY" : 558, "prop" : { "x" : 378, "y" : 479, "width" : 106, "height" : 36 }, "textPosition" : { "x" : 380, "y" : 479 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9412, "type" : "INPUT", "segments" : [ { "from" : { "x" : 430, "y" : 518 }, "to" : { "x" : 430, "y" : 558 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9415, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 375, "y" : 496 }, "to" : { "x" : 202, "y" : 496 } }, { "from" : { "x" : 202, "y" : 496 }, "to" : { "x" : 202, "y" : 542 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 202, "y" : 546 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 9414, "reactomeId" : 10764063, "displayName" : "Processive complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 299, "y" : 559 }, "minX" : 241, "maxX" : 358, "minY" : 542, "maxY" : 576, "prop" : { "x" : 241, "y" : 542, "width" : 117, "height" : 34 }, "textPosition" : { "x" : 242, "y" : 554 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9412, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9415, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9416, "reactomeId" : 10764065, "displayName" : "Processive complex:Okazaki fragment", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 100, "y" : 560 }, "minX" : 36, "maxX" : 164, "minY" : 543, "maxY" : 578, "prop" : { "x" : 36, "y" : 543, "width" : 128, "height" : 35 }, "textPosition" : { "x" : 41, "y" : 542 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9415, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9417, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9418, "reactomeId" : 10764067, "displayName" : "Processive complex:Okazaki fragment:Flap", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 101, "y" : 673 }, "minX" : 28, "maxX" : 206, "minY" : 656, "maxY" : 690, "prop" : { "x" : 28, "y" : 656, "width" : 146, "height" : 34 }, "textPosition" : { "x" : 35, "y" : 654 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9417, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9419, "type" : "INPUT", "segments" : [ { "from" : { "x" : 177, "y" : 673 }, "to" : { "x" : 206, "y" : 673 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9420, "reactomeId" : 10763742, "displayName" : "RPA-C", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 207, "y" : 620 }, "minX" : 184, "maxX" : 231, "minY" : 609, "maxY" : 673, "prop" : { "x" : 184, "y" : 609, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 186, "y" : 609 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9419, "type" : "INPUT", "segments" : [ { "from" : { "x" : 206, "y" : 634 }, "to" : { "x" : 206, "y" : 673 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9421, "reactomeId" : 10764117, "displayName" : "Processive complex:Okazaki fragment:Flap:RPA heterotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 328, "y" : 673 }, "minX" : 265, "maxX" : 391, "minY" : 641, "maxY" : 705, "prop" : { "x" : 265, "y" : 641, "width" : 126, "height" : 64 }, "textPosition" : { "x" : 265, "y" : 655 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9419, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9423, "reactomeId" : 10764127, "displayName" : "Processive complex:Okazaki fragment:Remaining flap", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 838, "y" : 668 }, "minX" : 775, "maxX" : 901, "minY" : 643, "maxY" : 693, "prop" : { "x" : 775, "y" : 643, "width" : 126, "height" : 50 }, "textPosition" : { "x" : 779, "y" : 643 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9422, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9424, "reactomeId" : 10764129, "displayName" : "Processive complex:nicked DNA from adjacent Okazaki fragments", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 838, "y" : 827 }, "minX" : 775, "maxX" : 901, "minY" : 795, "maxY" : 859, "prop" : { "x" : 775, "y" : 795, "width" : 126, "height" : 64 }, "textPosition" : { "x" : 779, "y" : 795 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9422, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9425, "reactomeId" : 10764139, "displayName" : "Homologues of FEN1A", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 897, "y" : 741 }, "minX" : 846, "maxX" : 921, "minY" : 730, "maxY" : 752, "prop" : { "x" : 874, "y" : 730, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 875, "y" : 709 }, "connectors" : [ { "edgeId" : 9422, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 871, "y" : 741 }, "to" : { "x" : 854, "y" : 742 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 850, "y" : 742 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 9427, "reactomeId" : 1599040, "displayName" : "Okazaki fragment", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 96, "y" : 804 }, "minX" : 40, "maxX" : 153, "minY" : 793, "maxY" : 815, "prop" : { "x" : 40, "y" : 793, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 43, "y" : 793 }, "connectors" : [ { "edgeId" : 9426, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9428, "reactomeId" : 69172, "displayName" : "ligated okazaki fragment", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 321, "y" : 803 }, "minX" : 271, "maxX" : 372, "minY" : 785, "maxY" : 821, "prop" : { "x" : 271, "y" : 785, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 274, "y" : 785 }, "connectors" : [ { "edgeId" : 9426, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9429, "reactomeId" : 10764086, "displayName" : "Homologues of LIG1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 216, "y" : 756 }, "minX" : 199, "maxX" : 234, "minY" : 745, "maxY" : 795, "prop" : { "x" : 199, "y" : 745, "width" : 35, "height" : 22 }, "textPosition" : { "x" : 199, "y" : 717 }, "connectors" : [ { "edgeId" : 9426, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 216, "y" : 770 }, "to" : { "x" : 216, "y" : 787 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 216, "y" : 791 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 9383, "reactomeId" : 1599045, "displayName" : "Replication Fork", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 320, "y" : 53 }, "minX" : 272, "maxX" : 369, "minY" : 38, "maxY" : 123, "prop" : { "x" : 272, "y" : 38, "width" : 97, "height" : 31 }, "textPosition" : { "x" : 273, "y" : 42 }, "connectors" : [ { "edgeId" : 9382, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9386, "type" : "INPUT", "segments" : [ { "from" : { "x" : 319, "y" : 72 }, "to" : { "x" : 318, "y" : 123 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9384, "reactomeId" : 1599049, "displayName" : "Unwound Replication Fork", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 518, "y" : 54 }, "minX" : 452, "maxX" : 585, "minY" : 36, "maxY" : 72, "prop" : { "x" : 452, "y" : 36, "width" : 133, "height" : 36 }, "textPosition" : { "x" : 455, "y" : 36 }, "connectors" : [ { "edgeId" : 9382, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9385, "reactomeId" : 10763664, "displayName" : "MCM2-7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 408, "y" : 109 }, "minX" : 318, "maxX" : 438, "minY" : 61, "maxY" : 123, "prop" : { "x" : 378, "y" : 98, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 381, "y" : 98 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9382, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 407, "y" : 95 }, "to" : { "x" : 407, "y" : 69 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 407, "y" : 65 }, "r" : 4, "type" : "CIRCLE", "empty" : true } }, { "edgeId" : 9386, "type" : "INPUT", "segments" : [ { "from" : { "x" : 375, "y" : 113 }, "to" : { "x" : 318, "y" : 123 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9387, "reactomeId" : 10763708, "displayName" : "Pp3c23_19980", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "EntitySet", "position" : { "x" : 235, "y" : 160 }, "minX" : 210, "maxX" : 318, "minY" : 123, "maxY" : 171, "prop" : { "x" : 210, "y" : 149, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 211, "y" : 142 }, "connectors" : [ { "edgeId" : 9386, "type" : "INPUT", "segments" : [ { "from" : { "x" : 259, "y" : 143 }, "to" : { "x" : 318, "y" : 123 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9388, "reactomeId" : 10764111, "displayName" : "GINS complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 231, "y" : 104 }, "minX" : 196, "maxX" : 318, "minY" : 86, "maxY" : 123, "prop" : { "x" : 196, "y" : 86, "width" : 71, "height" : 36 }, "textPosition" : { "x" : 205, "y" : 86 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9386, "type" : "INPUT", "segments" : [ { "from" : { "x" : 270, "y" : 111 }, "to" : { "x" : 318, "y" : 123 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9389, "reactomeId" : 10764113, "displayName" : "Unwinding complex at replication fork", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 321, "y" : 206 }, "minX" : 258, "maxX" : 384, "minY" : 188, "maxY" : 224, "prop" : { "x" : 258, "y" : 188, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 262, "y" : 188 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9386, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9391, "reactomeId" : 30595, "displayName" : "NTP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 132, "y" : 307 }, "minX" : 117, "maxX" : 181, "minY" : 274, "maxY" : 318, "prop" : { "x" : 117, "y" : 296, "width" : 31, "height" : 22 }, "textPosition" : { "x" : 120, "y" : 289 }, "connectors" : [ { "edgeId" : 9390, "type" : "INPUT", "segments" : [ { "from" : { "x" : 154, "y" : 296 }, "to" : { "x" : 181, "y" : 274 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9392, "reactomeId" : 10763704, "displayName" : "DNA polymerase alpha:primase:POLE:origin complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 116, "y" : 217 }, "minX" : 43, "maxX" : 241, "minY" : 192, "maxY" : 274, "prop" : { "x" : 43, "y" : 192, "width" : 146, "height" : 50 }, "textPosition" : { "x" : 49, "y" : 192 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9390, "type" : "INPUT", "segments" : [ { "from" : { "x" : 144, "y" : 245 }, "to" : { "x" : 181, "y" : 274 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9390, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 192, "y" : 216 }, "to" : { "x" : 235, "y" : 216 } }, { "from" : { "x" : 235, "y" : 216 }, "to" : { "x" : 236, "y" : 258 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 237, "y" : 262 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 9393, "reactomeId" : 10763698, "displayName" : "POLE", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 329, "y" : 245 }, "minX" : 270, "maxX" : 351, "minY" : 234, "maxY" : 274, "prop" : { "x" : 307, "y" : 234, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 310, "y" : 235 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9390, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 304, "y" : 255 }, "to" : { "x" : 270, "y" : 274 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 300, "y" : 262 }, "b" : { "x" : 304, "y" : 255 }, "c" : { "x" : 296, "y" : 255 }, "type" : "ARROW" } } ] }, { "id" : 9394, "reactomeId" : 10764022, "displayName" : "RNA primer:origin duplex:DNA polymerase alpha:primase complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 337, "y" : 322 }, "minX" : 261, "maxX" : 457, "minY" : 274, "maxY" : 347, "prop" : { "x" : 261, "y" : 298, "width" : 153, "height" : 49 }, "textPosition" : { "x" : 265, "y" : 297 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9390, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 302, "y" : 295 }, "to" : { "x" : 270, "y" : 274 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 294, "y" : 295 }, "b" : { "x" : 302, "y" : 295 }, "c" : { "x" : 298, "y" : 288 }, "type" : "ARROW" } }, { "edgeId" : 9395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 417, "y" : 322 }, "to" : { "x" : 457, "y" : 322 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9396, "reactomeId" : 30187, "displayName" : "dTTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 402, "y" : 273 }, "minX" : 380, "maxX" : 457, "minY" : 257, "maxY" : 322, "prop" : { "x" : 380, "y" : 258, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 382, "y" : 262 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 420, "y" : 263 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 9395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 418, "y" : 291 }, "to" : { "x" : 457, "y" : 322 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9397, "reactomeId" : 29892, "displayName" : "dGTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 457, "y" : 367 }, "minX" : 434, "maxX" : 481, "minY" : 322, "maxY" : 382, "prop" : { "x" : 434, "y" : 352, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 437, "y" : 356 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 475, "y" : 357 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 9395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 457, "y" : 349 }, "to" : { "x" : 457, "y" : 322 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9398, "reactomeId" : 29604, "displayName" : "dATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 457, "y" : 277 }, "minX" : 434, "maxX" : 481, "minY" : 261, "maxY" : 322, "prop" : { "x" : 434, "y" : 262, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 437, "y" : 266 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 475, "y" : 267 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 9395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 457, "y" : 295 }, "to" : { "x" : 457, "y" : 322 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9399, "reactomeId" : 30185, "displayName" : "dCTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 408, "y" : 372 }, "minX" : 385, "maxX" : 457, "minY" : 322, "maxY" : 387, "prop" : { "x" : 385, "y" : 357, "width" : 46, "height" : 30 }, "textPosition" : { "x" : 388, "y" : 361 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 426, "y" : 362 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 9395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 422, "y" : 354 }, "to" : { "x" : 457, "y" : 322 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9400, "reactomeId" : 10764024, "displayName" : "RNA primer:origin duplex:DNA primer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 596, "y" : 324 }, "minX" : 533, "maxX" : 667, "minY" : 306, "maxY" : 362, "prop" : { "x" : 533, "y" : 306, "width" : 127, "height" : 37 }, "textPosition" : { "x" : 543, "y" : 307 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9395, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9402, "type" : "INPUT", "segments" : [ { "from" : { "x" : 630, "y" : 346 }, "to" : { "x" : 667, "y" : 362 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9401, "reactomeId" : 10763690, "displayName" : "DNA polymerase alpha:primase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 490, "y" : 232 }, "minX" : 437, "maxX" : 543, "minY" : 214, "maxY" : 314, "prop" : { "x" : 437, "y" : 214, "width" : 106, "height" : 36 }, "textPosition" : { "x" : 439, "y" : 214 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9395, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 490, "y" : 253 }, "to" : { "x" : 492, "y" : 306 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 492, "y" : 310 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 9403, "reactomeId" : 10764020, "displayName" : "RFC heteropentamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 613, "y" : 396 }, "minX" : 560, "maxX" : 667, "minY" : 362, "maxY" : 556, "prop" : { "x" : 560, "y" : 378, "width" : 106, "height" : 36 }, "textPosition" : { "x" : 566, "y" : 378 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9410, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 613, "y" : 417 }, "to" : { "x" : 614, "y" : 556 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 617, "y" : 424 }, "b" : { "x" : 613, "y" : 417 }, "c" : { "x" : 609, "y" : 424 }, "type" : "ARROW" } }, { "edgeId" : 9402, "type" : "INPUT", "segments" : [ { "from" : { "x" : 641, "y" : 375 }, "to" : { "x" : 667, "y" : 362 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9404, "reactomeId" : 10764071, "displayName" : "RFC heteropentamer:RNA primer:DNA primer:origin duplex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 812, "y" : 361 }, "minX" : 748, "maxX" : 877, "minY" : 330, "maxY" : 429, "prop" : { "x" : 748, "y" : 330, "width" : 129, "height" : 63 }, "textPosition" : { "x" : 752, "y" : 343 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9402, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9405, "type" : "INPUT", "segments" : [ { "from" : { "x" : 811, "y" : 396 }, "to" : { "x" : 810, "y" : 429 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9406, "reactomeId" : 10764036, "displayName" : "PCNA homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 704, "y" : 467 }, "minX" : 659, "maxX" : 810, "minY" : 429, "maxY" : 485, "prop" : { "x" : 659, "y" : 450, "width" : 91, "height" : 35 }, "textPosition" : { "x" : 668, "y" : 449 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 9405, "type" : "INPUT", "segments" : [ { "from" : { "x" : 753, "y" : 450 }, "to" : { "x" : 810, "y" : 429 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9407, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 725, "y" : 414 }, "minX" : 706, "maxX" : 810, "minY" : 398, "maxY" : 429, "prop" : { "x" : 706, "y" : 399, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 709, "y" : 403 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 740, "y" : 404 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 9405, "type" : "INPUT", "segments" : [ { "from" : { "x" : 748, "y" : 417 }, "to" : { "x" : 810, "y" : 429 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 9410, "reactomeId" : 10764042, "displayName" : "Dissociation of RFC after sliding clamp formation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 694, "y" : 556 }, "minX" : 614, "maxX" : 736, "minY" : 550, "maxY" : 562, "segments" : [ { "from" : { "x" : 736, "y" : 556 }, "to" : { "x" : 694, "y" : 556 } }, { "from" : { "x" : 694, "y" : 556 }, "to" : { "x" : 614, "y" : 556 } } ], "reactionShape" : { "a" : { "x" : 688, "y" : 550 }, "b" : { "x" : 700, "y" : 562 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9408 } ], "outputs" : [ { "id" : 9411, "points" : [ { "x" : 587, "y" : 556 } ] }, { "id" : 9403, "points" : [ { "x" : 613, "y" : 417 } ] } ] }, { "id" : 9412, "reactomeId" : 10764144, "displayName" : "Formation of Processive complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 392, "y" : 558 }, "minX" : 361, "maxX" : 430, "minY" : 552, "maxY" : 564, "segments" : [ { "from" : { "x" : 430, "y" : 558 }, "to" : { "x" : 392, "y" : 558 } }, { "from" : { "x" : 392, "y" : 558 }, "to" : { "x" : 361, "y" : 558 } } ], "endShape" : { "a" : { "x" : 368, "y" : 554 }, "b" : { "x" : 361, "y" : 558 }, "c" : { "x" : 368, "y" : 562 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 386, "y" : 552 }, "b" : { "x" : 398, "y" : 564 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9411, "points" : [ { "x" : 448, "y" : 558 } ] }, { "id" : 9413, "points" : [ { "x" : 430, "y" : 518 } ] } ], "outputs" : [ { "id" : 9414 } ] }, { "id" : 9382, "reactomeId" : 10764076, "displayName" : "MCM2-7 mediated fork unwinding", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 407, "y" : 53 }, "minX" : 372, "maxX" : 449, "minY" : 47, "maxY" : 59, "segments" : [ { "from" : { "x" : 372, "y" : 53 }, "to" : { "x" : 407, "y" : 53 } }, { "from" : { "x" : 407, "y" : 53 }, "to" : { "x" : 449, "y" : 53 } } ], "endShape" : { "a" : { "x" : 442, "y" : 57 }, "b" : { "x" : 449, "y" : 53 }, "c" : { "x" : 442, "y" : 49 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 401, "y" : 47 }, "b" : { "x" : 413, "y" : 59 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9383 } ], "outputs" : [ { "id" : 9384 } ], "catalysts" : [ { "id" : 9385, "points" : [ { "x" : 407, "y" : 95 } ] } ] }, { "id" : 9415, "reactomeId" : 10764150, "displayName" : "Formation of Okazaki fragments", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 202, "y" : 558 }, "minX" : 167, "maxX" : 238, "minY" : 552, "maxY" : 564, "segments" : [ { "from" : { "x" : 238, "y" : 558 }, "to" : { "x" : 202, "y" : 558 } }, { "from" : { "x" : 202, "y" : 558 }, "to" : { "x" : 167, "y" : 558 } } ], "endShape" : { "a" : { "x" : 174, "y" : 554 }, "b" : { "x" : 167, "y" : 558 }, "c" : { "x" : 174, "y" : 562 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 196, "y" : 552 }, "b" : { "x" : 208, "y" : 564 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9414 } ], "outputs" : [ { "id" : 9416 } ], "catalysts" : [ { "id" : 9413, "points" : [ { "x" : 375, "y" : 496 }, { "x" : 202, "y" : 496 } ] } ] }, { "id" : 9417, "reactomeId" : 10764069, "displayName" : "Formation of Flap intermediate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 100, "y" : 619 }, "minX" : 94, "maxX" : 106, "minY" : 581, "maxY" : 653, "segments" : [ { "from" : { "x" : 100, "y" : 581 }, "to" : { "x" : 100, "y" : 619 } }, { "from" : { "x" : 100, "y" : 619 }, "to" : { "x" : 100, "y" : 653 } } ], "endShape" : { "a" : { "x" : 96, "y" : 646 }, "b" : { "x" : 100, "y" : 653 }, "c" : { "x" : 104, "y" : 646 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 94, "y" : 613 }, "b" : { "x" : 106, "y" : 625 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9416 } ], "outputs" : [ { "id" : 9418 } ] }, { "id" : 9386, "reactomeId" : 10764115, "displayName" : "Recruitment of multiple proteins at replication fork", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 320, "y" : 159 }, "minX" : 314, "maxX" : 326, "minY" : 123, "maxY" : 185, "segments" : [ { "from" : { "x" : 318, "y" : 123 }, "to" : { "x" : 320, "y" : 159 } }, { "from" : { "x" : 320, "y" : 159 }, "to" : { "x" : 320, "y" : 185 } } ], "endShape" : { "a" : { "x" : 316, "y" : 178 }, "b" : { "x" : 320, "y" : 185 }, "c" : { "x" : 324, "y" : 178 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 314, "y" : 153 }, "b" : { "x" : 326, "y" : 165 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9385, "points" : [ { "x" : 375, "y" : 113 } ] }, { "id" : 9383, "points" : [ { "x" : 319, "y" : 72 } ] }, { "id" : 9387, "points" : [ { "x" : 259, "y" : 143 } ] }, { "id" : 9388, "points" : [ { "x" : 270, "y" : 111 } ] } ], "outputs" : [ { "id" : 9389 } ] }, { "id" : 9419, "reactomeId" : 10764119, "displayName" : "Binding of RPA to the Flap", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 229, "y" : 673 }, "minX" : 206, "maxX" : 262, "minY" : 667, "maxY" : 679, "segments" : [ { "from" : { "x" : 206, "y" : 673 }, "to" : { "x" : 229, "y" : 673 } }, { "from" : { "x" : 229, "y" : 673 }, "to" : { "x" : 262, "y" : 673 } } ], "endShape" : { "a" : { "x" : 255, "y" : 677 }, "b" : { "x" : 262, "y" : 673 }, "c" : { "x" : 255, "y" : 669 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 223, "y" : 667 }, "b" : { "x" : 235, "y" : 679 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9420, "points" : [ { "x" : 206, "y" : 634 } ] }, { "id" : 9418, "points" : [ { "x" : 177, "y" : 673 } ] } ], "outputs" : [ { "id" : 9421 } ] }, { "id" : 9422, "reactomeId" : 10764142, "displayName" : "Removal of remaining Flap", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 838, "y" : 742 }, "minX" : 832, "maxX" : 844, "minY" : 696, "maxY" : 792, "segments" : [ { "from" : { "x" : 838, "y" : 696 }, "to" : { "x" : 838, "y" : 742 } }, { "from" : { "x" : 838, "y" : 742 }, "to" : { "x" : 838, "y" : 792 } } ], "endShape" : { "a" : { "x" : 834, "y" : 785 }, "b" : { "x" : 838, "y" : 792 }, "c" : { "x" : 842, "y" : 785 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 832, "y" : 736 }, "b" : { "x" : 844, "y" : 748 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9423 } ], "outputs" : [ { "id" : 9424 } ], "catalysts" : [ { "id" : 9425, "points" : [ { "x" : 871, "y" : 741 } ] } ] }, { "id" : 9390, "reactomeId" : 10764147, "displayName" : "Synthesis of 6-10 nucelotide RNA primer at origin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 237, "y" : 274 }, "minX" : 181, "maxX" : 270, "minY" : 268, "maxY" : 280, "segments" : [ { "from" : { "x" : 181, "y" : 274 }, "to" : { "x" : 237, "y" : 274 } }, { "from" : { "x" : 237, "y" : 274 }, "to" : { "x" : 270, "y" : 274 } } ], "reactionShape" : { "a" : { "x" : 231, "y" : 268 }, "b" : { "x" : 243, "y" : 280 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9391, "points" : [ { "x" : 154, "y" : 296 } ] }, { "id" : 9392, "points" : [ { "x" : 144, "y" : 245 } ] } ], "outputs" : [ { "id" : 9393, "points" : [ { "x" : 304, "y" : 255 } ] }, { "id" : 9394, "points" : [ { "x" : 302, "y" : 295 } ] } ], "catalysts" : [ { "id" : 9392, "points" : [ { "x" : 192, "y" : 216 }, { "x" : 235, "y" : 216 } ] } ] }, { "id" : 9426, "reactomeId" : 10764089, "displayName" : "Joining of adjacent Okazaki fragments", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 216, "y" : 803 }, "minX" : 156, "maxX" : 268, "minY" : 797, "maxY" : 809, "segments" : [ { "from" : { "x" : 156, "y" : 803 }, "to" : { "x" : 216, "y" : 803 } }, { "from" : { "x" : 216, "y" : 803 }, "to" : { "x" : 268, "y" : 803 } } ], "endShape" : { "a" : { "x" : 261, "y" : 807 }, "b" : { "x" : 268, "y" : 803 }, "c" : { "x" : 261, "y" : 799 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 210, "y" : 797 }, "b" : { "x" : 222, "y" : 809 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9427 } ], "outputs" : [ { "id" : 9428 } ], "catalysts" : [ { "id" : 9429, "points" : [ { "x" : 216, "y" : 770 } ] } ] }, { "id" : 9395, "reactomeId" : 10764045, "displayName" : "Synthesis of 20 nucelotide primer at origin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 492, "y" : 322 }, "minX" : 457, "maxX" : 530, "minY" : 316, "maxY" : 328, "segments" : [ { "from" : { "x" : 457, "y" : 322 }, "to" : { "x" : 492, "y" : 322 } }, { "from" : { "x" : 492, "y" : 322 }, "to" : { "x" : 530, "y" : 322 } } ], "endShape" : { "a" : { "x" : 523, "y" : 326 }, "b" : { "x" : 530, "y" : 322 }, "c" : { "x" : 523, "y" : 318 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 486, "y" : 316 }, "b" : { "x" : 498, "y" : 328 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9396, "points" : [ { "x" : 418, "y" : 291 } ] }, { "id" : 9397, "points" : [ { "x" : 457, "y" : 349 } ] }, { "id" : 9394, "points" : [ { "x" : 417, "y" : 322 } ] }, { "id" : 9398, "points" : [ { "x" : 457, "y" : 295 } ] }, { "id" : 9399, "points" : [ { "x" : 422, "y" : 354 } ] } ], "outputs" : [ { "id" : 9400 } ], "catalysts" : [ { "id" : 9401, "points" : [ { "x" : 490, "y" : 253 } ] } ] }, { "id" : 9402, "reactomeId" : 10764121, "displayName" : "Binding of RFC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 363 }, "minX" : 667, "maxX" : 745, "minY" : 357, "maxY" : 369, "segments" : [ { "from" : { "x" : 667, "y" : 362 }, "to" : { "x" : 704, "y" : 363 } }, { "from" : { "x" : 704, "y" : 363 }, "to" : { "x" : 745, "y" : 362 } } ], "endShape" : { "a" : { "x" : 738, "y" : 366 }, "b" : { "x" : 745, "y" : 362 }, "c" : { "x" : 738, "y" : 358 }, "type" : "ARROW" }, "reactionShape" : { "a" : { "x" : 698, "y" : 357 }, "b" : { "x" : 710, "y" : 369 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9403, "points" : [ { "x" : 641, "y" : 375 } ] }, { "id" : 9400, "points" : [ { "x" : 630, "y" : 346 } ] } ], "outputs" : [ { "id" : 9404 } ] }, { "id" : 9405, "reactomeId" : 10764073, "displayName" : "Formation of sliding clamp", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 810, "y" : 475 }, "minX" : 804, "maxX" : 816, "minY" : 429, "maxY" : 499, "segments" : [ { "from" : { "x" : 810, "y" : 429 }, "to" : { "x" : 810, "y" : 475 } }, { "from" : { "x" : 810, "y" : 475 }, "to" : { "x" : 810, "y" : 499 } } ], "reactionShape" : { "a" : { "x" : 804, "y" : 469 }, "b" : { "x" : 816, "y" : 481 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 9406, "points" : [ { "x" : 753, "y" : 450 } ] }, { "id" : 9407, "points" : [ { "x" : 748, "y" : 417 } ] }, { "id" : 9404, "points" : [ { "x" : 811, "y" : 396 } ] } ], "outputs" : [ { "id" : 9408, "points" : [ { "x" : 810, "y" : 518 } ] }, { "id" : 9409, "points" : [ { "x" : 850, "y" : 499 } ] } ] } ], "compartments" : [ { "id" : 9430, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 476, "y" : 447 }, "minX" : 10, "maxX" : 942, "minY" : 10, "maxY" : 884, "prop" : { "x" : 10, "y" : 10, "width" : 932, "height" : 874 }, "textPosition" : { "x" : 806, "y" : 21 }, "insets" : { "x" : 20, "y" : 20, "width" : 912, "height" : 854 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 9388, 9382, 9383, 9384, 9385, 9386, 9389, 9390, 9391, 9392, 9393, 9394, 9395, 9396, 9397, 9398, 9399, 9400, 9401, 9402, 9403, 9404, 9405, 9406, 9407, 9408, 9409, 9410, 9411, 9412, 9414, 9413, 9415, 9416, 9417, 9418, 9419, 9420, 9421, 9423, 9424, 9422, 9425, 9426, 9427, 9428, 9429, 9387 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 9431, "reactomeId" : 10764850, "displayName" : "DNA strand Elongation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 460, "y" : 505 }, "minX" : 18, "maxX" : 903, "minY" : 296, "maxY" : 715, "prop" : { "x" : 18, "y" : 397, "width" : 885, "height" : 236 }, "points" : [ { "x" : 18, "y" : 296 }, { "x" : 903, "y" : 296 }, { "x" : 903, "y" : 715 }, { "x" : 18, "y" : 715 } ], "colour" : "#4684ee" }, { "id" : 9432, "reactomeId" : 10764856, "displayName" : "DNA replication Initiation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 351, "y" : 211 }, "minX" : 33, "maxX" : 670, "minY" : 26, "maxY" : 397, "prop" : { "x" : 33, "y" : 26, "width" : 637, "height" : 270 }, "points" : [ { "x" : 33, "y" : 26 }, { "x" : 670, "y" : 26 }, { "x" : 670, "y" : 397 }, { "x" : 33, "y" : 397 } ], "colour" : "#dc3912" }, { "id" : 9433, "reactomeId" : 10764860, "displayName" : "Maturation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 480, "y" : 751 }, "minX" : 30, "maxX" : 931, "minY" : 633, "maxY" : 869, "prop" : { "x" : 30, "y" : 715, "width" : 901, "height" : 154 }, "points" : [ { "x" : 30, "y" : 633 }, { "x" : 931, "y" : 633 }, { "x" : 931, "y" : 869 }, { "x" : 30, "y" : 869 } ], "colour" : "#008000" } ], "minX" : 10, "maxX" : 942, "minY" : 10, "maxY" : 884, "disease" : false }