{
  "dbId" : 10359432,
  "stableId" : "R-SPC-1119325",
  "displayName" : "Sphingolipid metabolism",
  "nodes" : [ {
    "id" : 6272,
    "reactomeId" : 29366,
    "displayName" : "NADP+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 724,
      "y" : 715
    },
    "minX" : 694,
    "maxX" : 755,
    "minY" : 665,
    "maxY" : 730,
    "prop" : {
      "x" : 694,
      "y" : 700,
      "width" : 60,
      "height" : 30
    },
    "textPosition" : {
      "x" : 700,
      "y" : 704
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 749,
          "y" : 705
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 724,
          "y" : 697
        },
        "to" : {
          "x" : 724,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 720,
          "y" : 690
        },
        "b" : {
          "x" : 724,
          "y" : 697
        },
        "c" : {
          "x" : 728,
          "y" : 690
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 6273,
    "reactomeId" : 10358958,
    "displayName" : "BAA17001",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 664,
      "y" : 619
    },
    "minX" : 639,
    "maxX" : 689,
    "minY" : 606,
    "maxY" : 657,
    "prop" : {
      "x" : 639,
      "y" : 606,
      "width" : 50,
      "height" : 27
    },
    "textPosition" : {
      "x" : 641,
      "y" : 602
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 665,
          "y" : 639
        },
        "to" : {
          "x" : 666,
          "y" : 649
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 667,
          "y" : 653
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true
      }
    } ]
  }, {
    "id" : 6275,
    "reactomeId" : 200993,
    "displayName" : "PALM-CoA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 639,
      "y" : 84
    },
    "minX" : 600,
    "maxX" : 679,
    "minY" : 68,
    "maxY" : 129,
    "prop" : {
      "x" : 600,
      "y" : 69,
      "width" : 78,
      "height" : 30
    },
    "textPosition" : {
      "x" : 606,
      "y" : 73
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 673,
          "y" : 74
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6274,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 629,
          "y" : 102
        },
        "to" : {
          "x" : 610,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 6276,
    "reactomeId" : 200736,
    "displayName" : "L-Ser",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 732,
      "y" : 90
    },
    "minX" : 610,
    "maxX" : 759,
    "minY" : 74,
    "maxY" : 129,
    "prop" : {
      "x" : 706,
      "y" : 75,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 715,
      "y" : 79
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 753,
          "y" : 80
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6274,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 703,
          "y" : 98
        },
        "to" : {
          "x" : 610,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 6277,
    "reactomeId" : 113528,
    "displayName" : "CO2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 459,
      "y" : 80
    },
    "minX" : 438,
    "maxX" : 544,
    "minY" : 64,
    "maxY" : 155,
    "prop" : {
      "x" : 438,
      "y" : 65,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 443,
      "y" : 69
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 475,
          "y" : 70
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6274,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 476,
          "y" : 98
        },
        "to" : {
          "x" : 544,
          "y" : 155
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 484,
          "y" : 99
        },
        "b" : {
          "x" : 476,
          "y" : 98
        },
        "c" : {
          "x" : 479,
          "y" : 106
        },
        "type" : "ARROW"
      }
    } ],
    "trivial" : true
  }, {
    "id" : 6278,
    "reactomeId" : 76194,
    "displayName" : "CoA-SH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 536,
      "y" : 64
    },
    "minX" : 505,
    "maxX" : 569,
    "minY" : 49,
    "maxY" : 155,
    "prop" : {
      "x" : 505,
      "y" : 50,
      "width" : 63,
      "height" : 29
    },
    "textPosition" : {
      "x" : 512,
      "y" : 53
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 563,
          "y" : 55
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6274,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 537,
          "y" : 82
        },
        "to" : {
          "x" : 544,
          "y" : 155
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 542,
          "y" : 89
        },
        "b" : {
          "x" : 537,
          "y" : 82
        },
        "c" : {
          "x" : 534,
          "y" : 89
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 6279,
    "reactomeId" : 428182,
    "displayName" : "3-ketosphinganine",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 434,
      "y" : 156
    },
    "minX" : 368,
    "maxX" : 544,
    "minY" : 140,
    "maxY" : 171,
    "prop" : {
      "x" : 368,
      "y" : 141,
      "width" : 133,
      "height" : 30
    },
    "textPosition" : {
      "x" : 380,
      "y" : 145
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 496,
          "y" : 146
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6274,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 504,
          "y" : 155
        },
        "to" : {
          "x" : 544,
          "y" : 155
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 511,
          "y" : 151
        },
        "b" : {
          "x" : 504,
          "y" : 155
        },
        "c" : {
          "x" : 511,
          "y" : 159
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 6280,
    "reactomeId" : 10358963,
    "displayName" : "BAA10465",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 689,
      "y" : 158
    },
    "minX" : 593,
    "maxX" : 715,
    "minY" : 143,
    "maxY" : 173,
    "prop" : {
      "x" : 664,
      "y" : 143,
      "width" : 51,
      "height" : 30
    },
    "textPosition" : {
      "x" : 666,
      "y" : 140
    },
    "connectors" : [ {
      "edgeId" : 6274,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 658,
          "y" : 157
        },
        "to" : {
          "x" : 601,
          "y" : 156
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 597,
          "y" : 156
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true
      }
    } ]
  }, {
    "id" : 6267,
    "reactomeId" : 29368,
    "displayName" : "O2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 588,
      "y" : 706
    },
    "minX" : 546,
    "maxX" : 606,
    "minY" : 664,
    "maxY" : 721,
    "prop" : {
      "x" : 571,
      "y" : 691,
      "width" : 34,
      "height" : 30
    },
    "textPosition" : {
      "x" : 576,
      "y" : 695
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 600,
          "y" : 696
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 573,
          "y" : 688
        },
        "to" : {
          "x" : 546,
          "y" : 664
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 6268,
    "reactomeId" : 428126,
    "displayName" : "DHCE",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 529,
      "y" : 624
    },
    "minX" : 504,
    "maxX" : 555,
    "minY" : 608,
    "maxY" : 664,
    "prop" : {
      "x" : 504,
      "y" : 609,
      "width" : 50,
      "height" : 30
    },
    "textPosition" : {
      "x" : 509,
      "y" : 613
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 549,
          "y" : 614
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 535,
          "y" : 642
        },
        "to" : {
          "x" : 546,
          "y" : 664
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 6269,
    "reactomeId" : 29364,
    "displayName" : "NADPH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 511,
      "y" : 703
    },
    "minX" : 482,
    "maxX" : 546,
    "minY" : 664,
    "maxY" : 718,
    "prop" : {
      "x" : 482,
      "y" : 688,
      "width" : 59,
      "height" : 30
    },
    "textPosition" : {
      "x" : 488,
      "y" : 692
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 536,
          "y" : 693
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 524,
          "y" : 685
        },
        "to" : {
          "x" : 546,
          "y" : 664
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 6270,
    "reactomeId" : 1131965,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 782,
      "y" : 674
    },
    "minX" : 724,
    "maxX" : 805,
    "minY" : 658,
    "maxY" : 689,
    "prop" : {
      "x" : 761,
      "y" : 659,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 766,
      "y" : 663
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 799,
          "y" : 664
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 758,
          "y" : 670
        },
        "to" : {
          "x" : 724,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 751,
          "y" : 673
        },
        "b" : {
          "x" : 758,
          "y" : 670
        },
        "c" : {
          "x" : 752,
          "y" : 665
        },
        "type" : "ARROW"
      }
    } ],
    "trivial" : true
  }, {
    "id" : 6271,
    "reactomeId" : 9025544,
    "displayName" : "N-acylphytosphingosine",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 797,
      "y" : 597
    },
    "minX" : 724,
    "maxX" : 845,
    "minY" : 579,
    "maxY" : 665,
    "prop" : {
      "x" : 750,
      "y" : 580,
      "width" : 94,
      "height" : 34
    },
    "textPosition" : {
      "x" : 752,
      "y" : 572
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 839,
          "y" : 585
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 6266,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 778,
          "y" : 617
        },
        "to" : {
          "x" : 724,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 775,
          "y" : 625
        },
        "b" : {
          "x" : 778,
          "y" : 617
        },
        "c" : {
          "x" : 770,
          "y" : 619
        },
        "type" : "ARROW"
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 6274,
    "reactomeId" : 10358966,
    "displayName" : "Formation of 3-ketosphinganine",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 585,
      "y" : 156
    },
    "minX" : 544,
    "maxX" : 610,
    "minY" : 129,
    "maxY" : 162,
    "segments" : [ {
      "from" : {
        "x" : 610,
        "y" : 129
      },
      "to" : {
        "x" : 585,
        "y" : 156
      }
    }, {
      "from" : {
        "x" : 585,
        "y" : 156
      },
      "to" : {
        "x" : 544,
        "y" : 155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 579,
        "y" : 150
      },
      "b" : {
        "x" : 591,
        "y" : 162
      },
      "type" : "BOX",
      "empty" : true
    },
    "inputs" : [ {
      "id" : 6275,
      "points" : [ {
        "x" : 629,
        "y" : 102
      } ]
    }, {
      "id" : 6276,
      "points" : [ {
        "x" : 703,
        "y" : 98
      } ]
    } ],
    "outputs" : [ {
      "id" : 6277,
      "points" : [ {
        "x" : 476,
        "y" : 98
      } ]
    }, {
      "id" : 6278,
      "points" : [ {
        "x" : 537,
        "y" : 82
      } ]
    }, {
      "id" : 6279,
      "points" : [ {
        "x" : 504,
        "y" : 155
      } ]
    } ],
    "catalysts" : [ {
      "id" : 6280,
      "points" : [ {
        "x" : 658,
        "y" : 157
      } ]
    } ]
  }, {
    "id" : 6266,
    "reactomeId" : 10358961,
    "displayName" : "Formation of phytoceramide",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 668,
      "y" : 665
    },
    "minX" : 546,
    "maxX" : 724,
    "minY" : 659,
    "maxY" : 671,
    "segments" : [ {
      "from" : {
        "x" : 546,
        "y" : 664
      },
      "to" : {
        "x" : 668,
        "y" : 665
      }
    }, {
      "from" : {
        "x" : 668,
        "y" : 665
      },
      "to" : {
        "x" : 724,
        "y" : 665
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 662,
        "y" : 659
      },
      "b" : {
        "x" : 674,
        "y" : 671
      },
      "type" : "BOX",
      "empty" : true
    },
    "inputs" : [ {
      "id" : 6267,
      "points" : [ {
        "x" : 573,
        "y" : 688
      } ]
    }, {
      "id" : 6268,
      "points" : [ {
        "x" : 535,
        "y" : 642
      } ]
    }, {
      "id" : 6269,
      "points" : [ {
        "x" : 524,
        "y" : 685
      } ]
    } ],
    "outputs" : [ {
      "id" : 6270,
      "points" : [ {
        "x" : 758,
        "y" : 670
      } ]
    }, {
      "id" : 6271,
      "points" : [ {
        "x" : 778,
        "y" : 617
      } ]
    }, {
      "id" : 6272,
      "points" : [ {
        "x" : 724,
        "y" : 697
      } ]
    } ],
    "catalysts" : [ {
      "id" : 6273,
      "points" : [ {
        "x" : 665,
        "y" : 639
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 6281,
    "reactomeId" : 70260,
    "displayName" : "endoplasmic reticulum",
    "schemaClass" : "GO_CellularComponent",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 532,
      "y" : 393
    },
    "minX" : 256,
    "maxX" : 808,
    "minY" : 151,
    "maxY" : 635,
    "prop" : {
      "x" : 256,
      "y" : 151,
      "width" : 552,
      "height" : 484
    },
    "textPosition" : {
      "x" : 444,
      "y" : 356
    },
    "insets" : {
      "x" : 266,
      "y" : 161,
      "width" : 532,
      "height" : 464
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 6280, 6279, 6268, 6271, 6273, 6274 ]
  }, {
    "id" : 6282,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 516,
      "y" : 404
    },
    "minX" : 7,
    "maxX" : 1025,
    "minY" : 5,
    "maxY" : 803,
    "prop" : {
      "x" : 7,
      "y" : 5,
      "width" : 1018,
      "height" : 798
    },
    "textPosition" : {
      "x" : 34,
      "y" : 25
    },
    "insets" : {
      "x" : 17,
      "y" : 15,
      "width" : 998,
      "height" : 778
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 6281, 6267, 6270, 6275, 6277, 6278, 6269, 6275, 6272, 6276, 6266 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 7,
  "maxX" : 1025,
  "minY" : 5,
  "maxY" : 803,
  "disease" : false
}