{
  "dbId" : 10173522,
  "stableId" : "R-ZJA-5633340",
  "displayName" : "Citrulline-nitric oxide cycle",
  "nodes" : [ {
    "id" : 4560,
    "reactomeId" : 10165372,
    "displayName" : "Zjn_sc00003.1.g02860.1.sm.mkhc",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 145,
      "y" : 157
    },
    "minX" : 72,
    "maxX" : 247,
    "minY" : 127,
    "maxY" : 229,
    "prop" : {
      "x" : 72,
      "y" : 133,
      "width" : 146,
      "height" : 49
    },
    "textPosition" : {
      "x" : 76,
      "y" : 139
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 218,
          "y" : 133
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4557,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 180,
          "y" : 185
        },
        "to" : {
          "x" : 239,
          "y" : 222
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 243,
          "y" : 225
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true
      }
    } ]
  }, {
    "id" : 4550,
    "reactomeId" : 1168674,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 506,
      "y" : 446
    },
    "minX" : 486,
    "maxX" : 527,
    "minY" : 400,
    "maxY" : 461,
    "prop" : {
      "x" : 486,
      "y" : 431,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 490,
      "y" : 435
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 521,
          "y" : 436
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 509,
          "y" : 428
        },
        "to" : {
          "x" : 518,
          "y" : 400
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4551,
    "reactomeId" : 5138391,
    "displayName" : "L-Asp",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 560,
      "y" : 435
    },
    "minX" : 518,
    "maxX" : 588,
    "minY" : 400,
    "maxY" : 450,
    "prop" : {
      "x" : 534,
      "y" : 420,
      "width" : 53,
      "height" : 30
    },
    "textPosition" : {
      "x" : 541,
      "y" : 424
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 582,
          "y" : 425
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 542,
          "y" : 417
        },
        "to" : {
          "x" : 518,
          "y" : 400
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4552,
    "reactomeId" : 5138394,
    "displayName" : "L-Cit",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 598,
      "y" : 400
    },
    "minX" : 518,
    "maxX" : 623,
    "minY" : 384,
    "maxY" : 415,
    "prop" : {
      "x" : 574,
      "y" : 385,
      "width" : 48,
      "height" : 30
    },
    "textPosition" : {
      "x" : 582,
      "y" : 389
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 617,
          "y" : 390
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 571,
          "y" : 400
        },
        "to" : {
          "x" : 518,
          "y" : 400
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4553,
    "reactomeId" : 5138385,
    "displayName" : "N-(L-Arginino)succinate",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 144,
      "y" : 400
    },
    "minX" : 92,
    "maxX" : 241,
    "minY" : 377,
    "maxY" : 422,
    "prop" : {
      "x" : 92,
      "y" : 378,
      "width" : 105,
      "height" : 44
    },
    "textPosition" : {
      "x" : 103,
      "y" : 382
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 192,
          "y" : 383
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 200,
          "y" : 399
        },
        "to" : {
          "x" : 241,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 207,
          "y" : 395
        },
        "b" : {
          "x" : 200,
          "y" : 399
        },
        "c" : {
          "x" : 207,
          "y" : 403
        },
        "type" : "ARROW"
      }
    }, {
      "edgeId" : 4557,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4554,
    "reactomeId" : 4655227,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 238,
      "y" : 450
    },
    "minX" : 221,
    "maxX" : 257,
    "minY" : 399,
    "maxY" : 465,
    "prop" : {
      "x" : 221,
      "y" : 435,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 226,
      "y" : 439
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 251,
          "y" : 440
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 238,
          "y" : 432
        },
        "to" : {
          "x" : 241,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 235,
          "y" : 425
        },
        "b" : {
          "x" : 238,
          "y" : 432
        },
        "c" : {
          "x" : 243,
          "y" : 425
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 4555,
    "reactomeId" : 4752556,
    "displayName" : "adenosine 5'-monophosphate",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 180,
      "y" : 443
    },
    "minX" : 158,
    "maxX" : 241,
    "minY" : 399,
    "maxY" : 458,
    "prop" : {
      "x" : 158,
      "y" : 428,
      "width" : 44,
      "height" : 30
    },
    "textPosition" : {
      "x" : 159,
      "y" : 397
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 197,
          "y" : 433
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 200,
          "y" : 425
        },
        "to" : {
          "x" : 241,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 204,
          "y" : 418
        },
        "b" : {
          "x" : 200,
          "y" : 425
        },
        "c" : {
          "x" : 208,
          "y" : 425
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 4556,
    "reactomeId" : 10165266,
    "displayName" : "Argininosuccinate synthase",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 379,
      "y" : 512
    },
    "minX" : 319,
    "maxX" : 440,
    "minY" : 408,
    "maxY" : 530,
    "prop" : {
      "x" : 319,
      "y" : 494,
      "width" : 121,
      "height" : 36
    },
    "textPosition" : {
      "x" : 324,
      "y" : 494
    },
    "connectors" : [ {
      "edgeId" : 4549,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 379,
          "y" : 488
        },
        "to" : {
          "x" : 380,
          "y" : 416
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 380,
          "y" : 412
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true
      }
    } ]
  }, {
    "id" : 4558,
    "reactomeId" : 5138390,
    "displayName" : "FUMA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 310,
      "y" : 75
    },
    "minX" : 284,
    "maxX" : 338,
    "minY" : 59,
    "maxY" : 115,
    "prop" : {
      "x" : 284,
      "y" : 60,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 290,
      "y" : 64
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 331,
          "y" : 65
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4557,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 320,
          "y" : 93
        },
        "to" : {
          "x" : 338,
          "y" : 115
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 327,
          "y" : 96
        },
        "b" : {
          "x" : 320,
          "y" : 93
        },
        "c" : {
          "x" : 321,
          "y" : 101
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 4559,
    "reactomeId" : 5138386,
    "displayName" : "L-Arg",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 374,
      "y" : 62
    },
    "minX" : 338,
    "maxX" : 401,
    "minY" : 46,
    "maxY" : 115,
    "prop" : {
      "x" : 348,
      "y" : 47,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 356,
      "y" : 51
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 395,
          "y" : 52
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 4557,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 363,
          "y" : 80
        },
        "to" : {
          "x" : 338,
          "y" : 115
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 362,
          "y" : 88
        },
        "b" : {
          "x" : 363,
          "y" : 80
        },
        "c" : {
          "x" : 356,
          "y" : 83
        },
        "type" : "ARROW"
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 4549,
    "reactomeId" : 10165269,
    "displayName" : "Conversion of L-citrulline to L-argininosuccinate",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 380,
      "y" : 400
    },
    "minX" : 241,
    "maxX" : 518,
    "minY" : 394,
    "maxY" : 406,
    "segments" : [ {
      "from" : {
        "x" : 518,
        "y" : 400
      },
      "to" : {
        "x" : 380,
        "y" : 400
      }
    }, {
      "from" : {
        "x" : 380,
        "y" : 400
      },
      "to" : {
        "x" : 241,
        "y" : 399
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 374,
        "y" : 394
      },
      "b" : {
        "x" : 386,
        "y" : 406
      },
      "type" : "BOX",
      "empty" : true
    },
    "inputs" : [ {
      "id" : 4550,
      "points" : [ {
        "x" : 509,
        "y" : 428
      } ]
    }, {
      "id" : 4551,
      "points" : [ {
        "x" : 542,
        "y" : 417
      } ]
    }, {
      "id" : 4552,
      "points" : [ {
        "x" : 571,
        "y" : 400
      } ]
    } ],
    "outputs" : [ {
      "id" : 4553,
      "points" : [ {
        "x" : 200,
        "y" : 399
      } ]
    }, {
      "id" : 4554,
      "points" : [ {
        "x" : 238,
        "y" : 432
      } ]
    }, {
      "id" : 4555,
      "points" : [ {
        "x" : 200,
        "y" : 425
      } ]
    } ],
    "catalysts" : [ {
      "id" : 4556,
      "points" : [ {
        "x" : 379,
        "y" : 488
      } ]
    } ]
  }, {
    "id" : 4557,
    "reactomeId" : 10165375,
    "displayName" : "Synthesis of Arginine from L-argininosuccinate",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 253,
      "y" : 231
    },
    "minX" : 158,
    "maxX" : 338,
    "minY" : 115,
    "maxY" : 375,
    "segments" : [ {
      "from" : {
        "x" : 158,
        "y" : 375
      },
      "to" : {
        "x" : 253,
        "y" : 231
      }
    }, {
      "from" : {
        "x" : 253,
        "y" : 231
      },
      "to" : {
        "x" : 338,
        "y" : 115
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 247,
        "y" : 225
      },
      "b" : {
        "x" : 259,
        "y" : 237
      },
      "type" : "BOX",
      "empty" : true
    },
    "inputs" : [ {
      "id" : 4553
    } ],
    "outputs" : [ {
      "id" : 4558,
      "points" : [ {
        "x" : 320,
        "y" : 93
      } ]
    }, {
      "id" : 4559,
      "points" : [ {
        "x" : 363,
        "y" : 80
      } ]
    } ],
    "catalysts" : [ {
      "id" : 4560,
      "points" : [ {
        "x" : 180,
        "y" : 185
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 4567,
    "reactomeId" : 1141,
    "displayName" : "plastid stroma",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 382,
      "y" : 289
    },
    "minX" : 19,
    "maxX" : 746,
    "minY" : 12,
    "maxY" : 566,
    "prop" : {
      "x" : 19,
      "y" : 12,
      "width" : 727,
      "height" : 554
    },
    "textPosition" : {
      "x" : 628,
      "y" : 504
    },
    "insets" : {
      "x" : 29,
      "y" : 22,
      "width" : 707,
      "height" : 534
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 4557, 4558, 4559, 4560, 4549, 4550, 4551, 4552, 4553, 4554, 4555, 4556 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 19,
  "maxX" : 746,
  "minY" : 12,
  "maxY" : 566,
  "disease" : false
}