{ "dbId" : 10608304, "stableId" : "R-CCR-1119265", "displayName" : "Tetrahydrofolate biosynthesis I", "nodes" : [ { "id" : 5712, "reactomeId" : 111338, "displayName" : "PRGA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 596, "y" : 1001 }, "minX" : 572, "maxX" : 691, "minY" : 985, "maxY" : 1021, "prop" : { "x" : 572, "y" : 986, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 577, "y" : 990 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 616, "y" : 991 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5710, "type" : "INPUT", "segments" : [ { "from" : { "x" : 624, "y" : 1006 }, "to" : { "x" : 691, "y" : 1021 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5713, "reactomeId" : 111354, "displayName" : "N-Formyl-GAR", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 596, "y" : 1077 }, "minX" : 544, "maxX" : 691, "minY" : 1061, "maxY" : 1112, "prop" : { "x" : 544, "y" : 1062, "width" : 105, "height" : 30 }, "textPosition" : { "x" : 555, "y" : 1066 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 644, "y" : 1067 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5710, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 636, "y" : 1095 }, "to" : { "x" : 691, "y" : 1112 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 644, "y" : 1093 }, "b" : { "x" : 636, "y" : 1095 }, "c" : { "x" : 641, "y" : 1101 }, "type" : "ARROW" } } ] }, { "id" : 5714, "reactomeId" : 10607214, "displayName" : "CHC_T00006609001", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "EntitySet", "position" : { "x" : 805, "y" : 1053 }, "minX" : 699, "maxX" : 870, "minY" : 1021, "maxY" : 1085, "prop" : { "x" : 741, "y" : 1021, "width" : 129, "height" : 64 }, "textPosition" : { "x" : 744, "y" : 1042 }, "connectors" : [ { "edgeId" : 5710, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 735, "y" : 1052 }, "to" : { "x" : 707, "y" : 1052 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 703, "y" : 1052 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 5704, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 215, "y" : 1096 }, "minX" : 197, "maxX" : 316, "minY" : 1057, "maxY" : 1111, "prop" : { "x" : 197, "y" : 1081, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 203, "y" : 1085 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 228, "y" : 1086 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5703, "type" : "INPUT", "segments" : [ { "from" : { "x" : 236, "y" : 1089 }, "to" : { "x" : 316, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 5705, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 215, "y" : 1060 }, "minX" : 182, "maxX" : 316, "minY" : 1044, "maxY" : 1075, "prop" : { "x" : 182, "y" : 1045, "width" : 67, "height" : 30 }, "textPosition" : { "x" : 192, "y" : 1049 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 244, "y" : 1050 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5703, "type" : "INPUT", "segments" : [ { "from" : { "x" : 252, "y" : 1059 }, "to" : { "x" : 316, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5706, "reactomeId" : 73604, "displayName" : "DHF", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 317, "y" : 1017 }, "minX" : 297, "maxX" : 338, "minY" : 1001, "maxY" : 1057, "prop" : { "x" : 297, "y" : 1002, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 302, "y" : 1006 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 332, "y" : 1007 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5703, "type" : "INPUT", "segments" : [ { "from" : { "x" : 316, "y" : 1035 }, "to" : { "x" : 316, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5707, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 219, "y" : 1145 }, "minX" : 189, "maxX" : 317, "minY" : 1123, "maxY" : 1161, "prop" : { "x" : 189, "y" : 1129, "width" : 61, "height" : 32 }, "textPosition" : { "x" : 196, "y" : 1134 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 245, "y" : 1134 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5703, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 253, "y" : 1138 }, "to" : { "x" : 317, "y" : 1123 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 259, "y" : 1133 }, "b" : { "x" : 253, "y" : 1138 }, "c" : { "x" : 261, "y" : 1140 }, "type" : "ARROW" } } ] }, { "id" : 5708, "reactomeId" : 111355, "displayName" : "THF", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 478, "y" : 1194 }, "minX" : 317, "maxX" : 691, "minY" : 1112, "maxY" : 1208, "prop" : { "x" : 455, "y" : 1181, "width" : 46, "height" : 27 }, "textPosition" : { "x" : 462, "y" : 1183 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 496, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5703, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 452, "y" : 1183 }, "to" : { "x" : 317, "y" : 1123 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 444, "y" : 1184 }, "b" : { "x" : 452, "y" : 1183 }, "c" : { "x" : 447, "y" : 1177 }, "type" : "ARROW" } }, { "edgeId" : 5710, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 504, "y" : 1185 }, "to" : { "x" : 691, "y" : 1112 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 509, "y" : 1179 }, "b" : { "x" : 504, "y" : 1185 }, "c" : { "x" : 512, "y" : 1186 }, "type" : "ARROW" } } ] }, { "id" : 5709, "reactomeId" : 10606363, "displayName" : "CHC_T00010030001", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "EntitySet", "position" : { "x" : 423, "y" : 1085 }, "minX" : 324, "maxX" : 470, "minY" : 1067, "maxY" : 1103, "prop" : { "x" : 377, "y" : 1067, "width" : 93, "height" : 36 }, "textPosition" : { "x" : 379, "y" : 1067 }, "connectors" : [ { "edgeId" : 5703, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 371, "y" : 1085 }, "to" : { "x" : 332, "y" : 1085 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 328, "y" : 1085 }, "r" : 4, "type" : "CIRCLE", "empty" : true } } ] }, { "id" : 5711, "reactomeId" : 419151, "displayName" : "10-formyl-THF", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 691, "y" : 974 }, "minX" : 637, "maxX" : 746, "minY" : 958, "maxY" : 1021, "prop" : { "x" : 637, "y" : 959, "width" : 108, "height" : 30 }, "textPosition" : { "x" : 648, "y" : 963 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 740, "y" : 964 }, "r" : 6, "type" : "CIRCLE", "empty" : true } }, "connectors" : [ { "edgeId" : 5710, "type" : "INPUT", "segments" : [ { "from" : { "x" : 691, "y" : 992 }, "to" : { "x" : 691, "y" : 1021 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 5703, "reactomeId" : 10606366, "displayName" : "dihydrofolate reductase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 316, "y" : 1085 }, "minX" : 310, "maxX" : 322, "minY" : 1057, "maxY" : 1123, "segments" : [ { "from" : { "x" : 316, "y" : 1057 }, "to" : { "x" : 316, "y" : 1085 } }, { "from" : { "x" : 316, "y" : 1085 }, "to" : { "x" : 317, "y" : 1123 } } ], "reactionShape" : { "a" : { "x" : 310, "y" : 1079 }, "b" : { "x" : 322, "y" : 1091 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 5704, "points" : [ { "x" : 236, "y" : 1089 } ] }, { "id" : 5705, "points" : [ { "x" : 252, "y" : 1059 } ] }, { "id" : 5706, "points" : [ { "x" : 316, "y" : 1035 } ] } ], "outputs" : [ { "id" : 5707, "points" : [ { "x" : 253, "y" : 1138 } ] }, { "id" : 5708, "points" : [ { "x" : 452, "y" : 1183 } ] } ], "catalysts" : [ { "id" : 5709, "points" : [ { "x" : 371, "y" : 1085 } ] } ] }, { "id" : 5710, "reactomeId" : 10607217, "displayName" : "phosphoribosylglycinamide formyltransferase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 691, "y" : 1052 }, "minX" : 685, "maxX" : 697, "minY" : 1021, "maxY" : 1112, "segments" : [ { "from" : { "x" : 691, "y" : 1021 }, "to" : { "x" : 691, "y" : 1052 } }, { "from" : { "x" : 691, "y" : 1052 }, "to" : { "x" : 691, "y" : 1112 } } ], "reactionShape" : { "a" : { "x" : 685, "y" : 1046 }, "b" : { "x" : 697, "y" : 1058 }, "type" : "BOX", "empty" : true }, "inputs" : [ { "id" : 5711, "points" : [ { "x" : 691, "y" : 992 } ] }, { "id" : 5712, "points" : [ { "x" : 624, "y" : 1006 } ] } ], "outputs" : [ { "id" : 5708, "points" : [ { "x" : 504, "y" : 1185 } ] }, { "id" : 5713, "points" : [ { "x" : 636, "y" : 1095 } ] } ], "catalysts" : [ { "id" : 5714, "points" : [ { "x" : 735, "y" : 1052 } ] } ] } ], "compartments" : [ { "id" : 5715, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 455, "y" : 628 }, "minX" : 4, "maxX" : 907, "minY" : 4, "maxY" : 1252, "prop" : { "x" : 4, "y" : 4, "width" : 903, "height" : 1248 }, "textPosition" : { "x" : 24, "y" : 1205 }, "insets" : { "x" : 14, "y" : 14, "width" : 883, "height" : 1228 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 5745, 5703, 5709, 5710, 5714, 5705, 5707, 5708, 5704, 5711, 5706, 5712, 5713 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ ], "minX" : 4, "maxX" : 907, "minY" : 4, "maxY" : 1252, "disease" : false }