{
  "dbId" : 10035192,
  "stableId" : "R-PVE-1119337",
  "displayName" : "Proline degradation",
  "nodes" : [ {
    "id" : 14416,
    "reactomeId" : 29362,
    "displayName" : "NADH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 110,
      "y" : 410
    },
    "minX" : 84,
    "maxX" : 169,
    "minY" : 379,
    "maxY" : 425,
    "prop" : {
      "x" : 84,
      "y" : 395,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 90,
      "y" : 399
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 131,
          "y" : 400
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14413,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 139,
          "y" : 396
        },
        "to" : {
          "x" : 169,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 143,
          "y" : 389
        },
        "b" : {
          "x" : 139,
          "y" : 396
        },
        "c" : {
          "x" : 147,
          "y" : 396
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 14417,
    "reactomeId" : 113552,
    "displayName" : "L-Glu",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 169,
      "y" : 442
    },
    "minX" : 145,
    "maxX" : 195,
    "minY" : 379,
    "maxY" : 457,
    "prop" : {
      "x" : 145,
      "y" : 427,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 152,
      "y" : 431
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 189,
          "y" : 432
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14413,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 169,
          "y" : 424
        },
        "to" : {
          "x" : 169,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 165,
          "y" : 417
        },
        "b" : {
          "x" : 169,
          "y" : 424
        },
        "c" : {
          "x" : 173,
          "y" : 417
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 14418,
    "reactomeId" : 10025241,
    "displayName" : "Aldehyde dehydrogenase",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 249,
      "y" : 333
    },
    "minX" : 177,
    "maxX" : 298,
    "minY" : 315,
    "maxY" : 351,
    "prop" : {
      "x" : 200,
      "y" : 315,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 203,
      "y" : 315
    },
    "connectors" : [ {
      "edgeId" : 14413,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 194,
          "y" : 335
        },
        "to" : {
          "x" : 185,
          "y" : 336
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 181,
          "y" : 336
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true
      }
    } ]
  }, {
    "id" : 14408,
    "reactomeId" : 379717,
    "displayName" : "L-Pro",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 169,
      "y" : 81
    },
    "minX" : 144,
    "maxX" : 195,
    "minY" : 65,
    "maxY" : 128,
    "prop" : {
      "x" : 144,
      "y" : 66,
      "width" : 50,
      "height" : 30
    },
    "textPosition" : {
      "x" : 151,
      "y" : 70
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 189,
          "y" : 71
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14407,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 168,
          "y" : 99
        },
        "to" : {
          "x" : 168,
          "y" : 128
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 14409,
    "reactomeId" : 113596,
    "displayName" : "FAD",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 110,
      "y" : 114
    },
    "minX" : 90,
    "maxX" : 168,
    "minY" : 98,
    "maxY" : 129,
    "prop" : {
      "x" : 90,
      "y" : 99,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 95,
      "y" : 103
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 125,
          "y" : 104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14407,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 133,
          "y" : 118
        },
        "to" : {
          "x" : 168,
          "y" : 128
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 14410,
    "reactomeId" : 113590,
    "displayName" : "1PYR-5COOH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 169,
      "y" : 246
    },
    "minX" : 120,
    "maxX" : 220,
    "minY" : 191,
    "maxY" : 294,
    "prop" : {
      "x" : 120,
      "y" : 231,
      "width" : 99,
      "height" : 30
    },
    "textPosition" : {
      "x" : 129,
      "y" : 235
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 214,
          "y" : 236
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14407,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 168,
          "y" : 228
        },
        "to" : {
          "x" : 168,
          "y" : 191
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 164,
          "y" : 221
        },
        "b" : {
          "x" : 168,
          "y" : 228
        },
        "c" : {
          "x" : 172,
          "y" : 221
        },
        "type" : "ARROW"
      }
    }, {
      "edgeId" : 14413,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 168,
          "y" : 264
        },
        "to" : {
          "x" : 168,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 14411,
    "reactomeId" : 31649,
    "displayName" : "FADH2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 110,
      "y" : 204
    },
    "minX" : 82,
    "maxX" : 168,
    "minY" : 188,
    "maxY" : 219,
    "prop" : {
      "x" : 82,
      "y" : 189,
      "width" : 57,
      "height" : 30
    },
    "textPosition" : {
      "x" : 88,
      "y" : 193
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 134,
          "y" : 194
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14407,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 142,
          "y" : 197
        },
        "to" : {
          "x" : 168,
          "y" : 191
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 148,
          "y" : 192
        },
        "b" : {
          "x" : 142,
          "y" : 197
        },
        "c" : {
          "x" : 150,
          "y" : 199
        },
        "type" : "ARROW"
      }
    } ]
  }, {
    "id" : 14412,
    "reactomeId" : 10026385,
    "displayName" : "EVM0003259",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 249,
      "y" : 168
    },
    "minX" : 177,
    "maxX" : 306,
    "minY" : 144,
    "maxY" : 186,
    "prop" : {
      "x" : 199,
      "y" : 150,
      "width" : 101,
      "height" : 36
    },
    "textPosition" : {
      "x" : 208,
      "y" : 157
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 300,
          "y" : 150
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14407,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 196,
          "y" : 164
        },
        "to" : {
          "x" : 185,
          "y" : 164
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 181,
          "y" : 163
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true
      }
    } ]
  }, {
    "id" : 14414,
    "reactomeId" : 1131965,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 110,
      "y" : 278
    },
    "minX" : 89,
    "maxX" : 168,
    "minY" : 262,
    "maxY" : 294,
    "prop" : {
      "x" : 89,
      "y" : 263,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 94,
      "y" : 267
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 127,
          "y" : 268
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14413,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 135,
          "y" : 283
        },
        "to" : {
          "x" : 168,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 14415,
    "reactomeId" : 113526,
    "displayName" : "NAD+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 110,
      "y" : 325
    },
    "minX" : 84,
    "maxX" : 168,
    "minY" : 294,
    "maxY" : 340,
    "prop" : {
      "x" : 84,
      "y" : 310,
      "width" : 53,
      "height" : 30
    },
    "textPosition" : {
      "x" : 90,
      "y" : 314
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 132,
          "y" : 315
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true
      }
    },
    "connectors" : [ {
      "edgeId" : 14413,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 140,
          "y" : 310
        },
        "to" : {
          "x" : 168,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 14407,
    "reactomeId" : 10026388,
    "displayName" : "Proline dehydrogenase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 169,
      "y" : 163
    },
    "minX" : 163,
    "maxX" : 175,
    "minY" : 128,
    "maxY" : 191,
    "segments" : [ {
      "from" : {
        "x" : 168,
        "y" : 128
      },
      "to" : {
        "x" : 169,
        "y" : 163
      }
    }, {
      "from" : {
        "x" : 169,
        "y" : 163
      },
      "to" : {
        "x" : 168,
        "y" : 191
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 163,
        "y" : 157
      },
      "b" : {
        "x" : 175,
        "y" : 169
      },
      "type" : "BOX",
      "empty" : true
    },
    "inputs" : [ {
      "id" : 14408,
      "points" : [ {
        "x" : 168,
        "y" : 99
      } ]
    }, {
      "id" : 14409,
      "points" : [ {
        "x" : 133,
        "y" : 118
      } ]
    } ],
    "outputs" : [ {
      "id" : 14410,
      "points" : [ {
        "x" : 168,
        "y" : 228
      } ]
    }, {
      "id" : 14411,
      "points" : [ {
        "x" : 142,
        "y" : 197
      } ]
    } ],
    "catalysts" : [ {
      "id" : 14412,
      "points" : [ {
        "x" : 196,
        "y" : 164
      } ]
    } ]
  }, {
    "id" : 14413,
    "reactomeId" : 10025244,
    "displayName" : "1-pyrroline-5-carboxylate dehydrogenase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 169,
      "y" : 337
    },
    "minX" : 163,
    "maxX" : 175,
    "minY" : 294,
    "maxY" : 379,
    "segments" : [ {
      "from" : {
        "x" : 168,
        "y" : 294
      },
      "to" : {
        "x" : 169,
        "y" : 337
      }
    }, {
      "from" : {
        "x" : 169,
        "y" : 337
      },
      "to" : {
        "x" : 169,
        "y" : 379
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 163,
        "y" : 331
      },
      "b" : {
        "x" : 175,
        "y" : 343
      },
      "type" : "BOX",
      "empty" : true
    },
    "inputs" : [ {
      "id" : 14414,
      "points" : [ {
        "x" : 135,
        "y" : 283
      } ]
    }, {
      "id" : 14410,
      "points" : [ {
        "x" : 168,
        "y" : 264
      } ]
    }, {
      "id" : 14415,
      "points" : [ {
        "x" : 140,
        "y" : 310
      } ]
    } ],
    "outputs" : [ {
      "id" : 14416,
      "points" : [ {
        "x" : 139,
        "y" : 396
      } ]
    }, {
      "id" : 14417,
      "points" : [ {
        "x" : 169,
        "y" : 424
      } ]
    } ],
    "catalysts" : [ {
      "id" : 14418,
      "points" : [ {
        "x" : 194,
        "y" : 335
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 14419,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 194,
      "y" : 296
    },
    "minX" : 30,
    "maxX" : 358,
    "minY" : 20,
    "maxY" : 572,
    "prop" : {
      "x" : 30,
      "y" : 20,
      "width" : 328,
      "height" : 552
    },
    "textPosition" : {
      "x" : 43,
      "y" : 522
    },
    "insets" : {
      "x" : 40,
      "y" : 30,
      "width" : 308,
      "height" : 532
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 14420 ]
  }, {
    "id" : 14420,
    "reactomeId" : 5460,
    "displayName" : "mitochondrial matrix",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 194,
      "y" : 281
    },
    "minX" : 58,
    "maxX" : 330,
    "minY" : 44,
    "maxY" : 519,
    "prop" : {
      "x" : 58,
      "y" : 44,
      "width" : 272,
      "height" : 475
    },
    "textPosition" : {
      "x" : 70,
      "y" : 468
    },
    "insets" : {
      "x" : 68,
      "y" : 54,
      "width" : 252,
      "height" : 455
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 14407, 14408, 14409, 14410, 14411, 14412, 14413, 14414, 14415, 14418, 14416, 14417 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 30,
  "maxX" : 358,
  "minY" : 20,
  "maxY" : 572,
  "disease" : false
}