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Activation of pre-replication complex

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compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9939640] Elser, Justin, 2025-03-24
dbId	9953541
displayName	Activation of pre-replication complex
eventOf	[Pathway:R-ZMY-9640887] G1/S transition - Zea mays ver5
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Pathway:R-ZMY-9675824] DNA replication Initiation - Zea mays ver5
hasDiagram	false
hasEvent	[Reaction:R-ZMY-9645961] Association of MCM10 with pre-replication complex - Zea mays ver5 [Reaction:R-ZMY-9645867] Recruitment of CDC45 - Zea mays ver5 [Reaction:R-ZMY-9645934] Association of TOPBP1 with CDC45 - Zea mays ver5 [Reaction:R-ZMY-9645845] Association of RPA proteins with Pre-RC at origin - Zea mays ver5 [Reaction:R-ZMY-9645813] Binding of DNA polymerase alpha:primase at origin - Zea mays ver5 [Reaction:R-ZMY-9645988] Binding of DNA polymerase epsilon at origin - Zea mays ver5 [Reaction:R-ZMY-9645996] Displacement of CDC6 from pre-replication complex - Zea mays ver5
inferredFrom	[Pathway:R-OSA-9645850] Activation of pre-replication complex - Oryza sativa
isInDisease	false
isInferred	true
name	Activation of pre-replication complex
precedingEvent	[Pathway:R-ZMY-9640882] Assembly of pre-replication complex - Zea mays ver5
releaseDate	2025-02-15
schemaClass	Pathway
species	[Species:9728693] Zea mays ver5
stId	R-ZMY-9645850
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(precedingEvent)	[Pathway:R-ZMY-9675824] DNA replication Initiation - Zea mays ver5
(hasEvent)	[Pathway:R-ZMY-9640887] G1/S transition - Zea mays ver5
(inferredTo)	[Pathway:R-OSA-9645850] Activation of pre-replication complex - Oryza sativa

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