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4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol+O2+NAD(P)H->4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+

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catalystActivity	[CatalystActivity:11358057] C-4 methylsterol oxidase activity of Methylsterol monooxygenase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11357575] Elser, Justin, 2025-03-26
dbId	11358059
displayName	4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol+O2+NAD(P)H->4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+
eventOf	[Pathway:R-SCR-1119286] Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) - Secale cereale
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-SCR-1119795] 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Secale cereale
inferredFrom	[Reaction:R-OSA-1119717] 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol+O2+NAD(P)H->4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Oryza sativa
input	[SimpleEntity:R-ALL-1130500] 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol [cytosol] [DefinedSet:R-ALL-428206] NAD(P)H [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
name	4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol+O2+NAD(P)H->4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ RXN66-15 biochemicalReaction85633
output	[SimpleEntity:R-ALL-1130845] 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-428218] NAD(P)+ [cytosol]
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9823417] Secale cereale
stId	R-SCR-1119717
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-SCR-1119286] Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) - Secale cereale
(precedingEvent)	[Reaction:R-SCR-1119795] 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Secale cereale
(inferredTo)	[Reaction:R-OSA-1119717] 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol+O2+NAD(P)H->4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Oryza sativa

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